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1. 发明授权

US5770430A Cellular injury response element and uses thereof 失效
标题翻译：细胞损伤反应元件及其用途
公开(公告)号：US5770430A
公开(公告)日：1998-06-23
申请号：US661649
申请日：1996-06-11
申请人： Stephen B. Howell , Dennis P. Gately
发明人： Stephen B. Howell , Dennis P. Gately
IPC分类号： C12N15/09 , A61K31/00 , A61K35/76 , A61K48/00 , A61P35/00 , C12N1/21 , C12N5/10 , C12N15/85 , C12N5/00 , C07H21/04 , C12N15/63
CPC分类号： C12N15/85 , A61K48/00 , C12N2830/00 , C12N2830/002 , C12N2830/85
摘要： The present invention provides a vector with a DNA sequence coding for a cellular injury element promoter from nucleotides -74 to -35 of the GADD153 promoter, relative to the start of transcription. The vector includes an origin of replication in operable linkage with a DNA sequence coding for the promoter. Also, a host cell is transfected with the vector and expresses the cellular injury response element promoter.
摘要翻译：相对于转录开始，本发明提供了具有编码GADD153启动子的核苷酸-74至-35的细胞损伤元件启动子的DNA序列的载体。载体包括与编码启动子的DNA序列可操作地连接的复制起点。此外，用载体转染宿主细胞，并表达细胞损伤应答元件启动子。

2. 发明授权

US06447997B1 Gene coding for GADD153 as a clinical diagnostic and prognostic in cancer therapy 失效
标题翻译：基因编码GADD153作为癌症治疗中的临床诊断和预后
公开(公告)号：US06447997B1
公开(公告)日：2002-09-10
申请号：US08896406
申请日：1997-07-18
申请人： Gerrit Los , Dennis P Gately
发明人： Gerrit Los , Dennis P Gately
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The GADD153 gene is used herein as a molecular marker for in vivo tumor cell injury which occurs in response to chemotherapy. A GADD153-based prognostic method for tumor clinical response in a patient undergoing chemotherapy is provided. By determination of the magnitude of increase, above baseline, in GADD153 mRNA in a sample derived from a tumor in a patient after administration of a chemotherapeutic agent, the method is able to predict the tumor clinical response and, thus, the patient therapeutic response. This method is advantageous over known prognostic methods for tumor clinical response in that it can accurately and rapidly predict therapeutic responses including tumor progression, partial regression and complete regression for a wide range of tumors and chemotherapeutic agents.
摘要翻译： GADD153基因在本文中用作针对化学疗法发生的体内肿瘤细胞损伤的分子标记。提供了一种基于GADD153的预后化疗方案。通过测定在施用化学治疗剂后来自患者肿瘤的样品中GADD153 mRNA的增加幅度高于基线，该方法能够预测肿瘤临床反应，从而预测患者的治疗反应。该方法对于已知的肿瘤临床反应预后方法是有利的，因为它可以准确和快速地预测治疗反应，包括肿瘤进展，部分回归和广泛的肿瘤和化学治疗剂的完全消退。

3. 发明申请

US20080213166A1 Novel Gene Targets and Ligands that Bind Thereto for Treatment and Diagnosis of Colon Carcinomas 审中-公开
标题翻译：用于治疗和诊断结肠癌的新型基因靶标和配体
公开(公告)号：US20080213166A1
公开(公告)日：2008-09-04
申请号：US10535458
申请日：2003-11-20
申请人： Karen McLachlan , Dennis P. Gately
发明人： Karen McLachlan , Dennis P. Gately
IPC分类号： A61K51/10 , C07H21/00 , C07K16/18 , C12Q1/68 , A61K31/7105 , A61K31/711 , A61K38/00 , G01N33/53 , C07K2/00 , A61K39/395 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Isolated nucleic acids and proteins that are overexpressed in human cancers, and antibodies that specifically bind the proteins, which are useful diagnostic and therapeutic targets.
摘要翻译：在人类癌症中过表达的分离的核酸和蛋白质，以及特异性结合蛋白质的抗体，这是有用的诊断和治疗靶点。

4. 发明授权

US06344324B2 Quantification of cellular injury using expression of a fluorescent protein under the control of the GADD153 promoter 失效
标题翻译：使用在GADD153启动子控制下的荧光蛋白的表达来定量细胞损伤
公开(公告)号：US06344324B2
公开(公告)日：2002-02-05
申请号：US09479529
申请日：2000-01-07
申请人： Stephen B. Howell , Xinjian Lin , Dennis P. Gately
发明人： Stephen B. Howell , Xinjian Lin , Dennis P. Gately
IPC分类号： C12Q168
CPC分类号： A01K67/0271 , C07K14/47
摘要： The present invention features a novel cellular injury reporter system in which a chimeric gene containing the GADD153 promoter linked to the coding region of an enhanced green fluorescent protein (EGFP) gene was stably integrated into the genome of carcinoma cells. Activation of the GADD153 promoter was quantified using flow cytometric measurement of EGFP expression following drug exposure. This reporter system is suitable for high. throughput in vitro and in vivo screening for agents capable of producing cytotoxicity via a wide variety of different mechanisms, and can be utilized to investigate the relative potency of structurally related DNA adducts.
摘要翻译：本发明特征在于一种新的细胞损伤报告系统，其中含有与增强的绿色荧光蛋白（EGFP）基因的编码区连接的GADD153启动子的嵌合基因稳定整合到癌细胞的基因组中。在药物暴露后，使用EGFP表达的流式细胞术测量来定量GADD153启动子的激活。本报记者系统适合高。通过体外和体内筛选能够通过多种不同机制产生细胞毒性的试剂，并且可用于研究结构相关的DNA加合物的相对效力。

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