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1. 发明申请

US20050137334A1 Composite nanospheres and their conjugates with biomolecules 有权
公开(公告)号：US20050137334A1
公开(公告)日：2005-06-23
申请号：US11022885
申请日：2004-12-28
申请人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jerome Bibette
发明人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jerome Bibette
IPC分类号： G01N33/545 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/48 , A61K48/00 , A61P43/00 , C09D11/00 , G01N33/543 , C08L51/04
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

2. 发明授权

US06866838B1 Composite nanospheres and their conjugates with biomolecules 有权
标题翻译：复合纳米球及其与生物分子的共轭物
公开(公告)号：US06866838B1
公开(公告)日：2005-03-15
申请号：US10129141
申请日：2000-11-06
申请人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
发明人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
IPC分类号： G01N33/545 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/48 , A61K48/00 , A61P43/00 , C09D11/00 , G01N33/543 , A61B8/00 , A61K9/14 , B01J13/02
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.
摘要翻译：本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在约100和500nm之间加上或减少5％，并且有利地在100和200nm之间加上或减少5％，并且包括基本上分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 源自所述纳米球的共轭物; 其制备方法及其用途。

3. 发明授权

US07217457B2 Composite particles, derived conjugates, preparation method and applications 有权
标题翻译：复合颗粒，衍生共轭物，制备方法和应用
公开(公告)号：US07217457B2
公开(公告)日：2007-05-15
申请号：US10475709
申请日：2002-05-06
申请人： Abdelhamid Elaissari , Franck Montagne , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette , Olivier Mondain-Monval
发明人： Abdelhamid Elaissari , Franck Montagne , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette , Olivier Mondain-Monval
IPC分类号： B32B5/16 , C08K3/00
CPC分类号： C08K9/08 , A61K41/0052 , A61K49/1854 , A61K49/1857 , A61K49/1887 , C08F291/00 , C08F292/00 , Y10T428/2991 , Y10T428/2998
摘要： The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilized and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphophilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilized in the polymer matrix. The inventor also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.
摘要翻译：本发明涉及包含疏水聚合物芯和无机纳米颗粒的复合颗粒。所述疏水性聚合物形成聚合物基质，无机纳米颗粒在该聚合物基质内稳定并以相对均匀的方式分布。所述颗粒至少部分被包含疏水部分和亲水部分的两亲共聚物包围，所述疏水部分至少部分地固定在聚合物基质中。发明人还涉及其制备方法，包含这种颗粒的配偶体和配体以及其在反应物和治疗组合物中的用途。

4. 发明授权

US07001589B2 Composite nanospheres and their conjugates with biomolecules 有权
标题翻译：复合纳米球及其与生物分子的共轭物
公开(公告)号：US07001589B2
公开(公告)日：2006-02-21
申请号：US11022885
申请日：2004-12-28
申请人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
发明人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
IPC分类号： A61B8/00 , A61K9/14 , B01J13/02
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.
摘要翻译：本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在大约100和500nm之间加或减5％，有利地在100和200nm之间加或减5％，并且包括基本上分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 衍生自所述纳米球的共轭物; 其制备方法及其用途。

5. 发明授权

US6133047A Superparamagnetic monodisperse particles 失效
标题翻译：超顺磁单分散颗粒
公开(公告)号：US6133047A
公开(公告)日：2000-10-17
申请号：US983040
申请日：1998-01-15
申请人： Abdelhamid Elaissari , Christian Pichot , Bernard Mandrand , Florence Sauzedde
发明人： Abdelhamid Elaissari , Christian Pichot , Bernard Mandrand , Florence Sauzedde
IPC分类号： B03C1/01 , G01N33/537 , G01N33/543 , H01F1/37 , H01F1/44 , G01N33/553 , B05D5/12 , B32B5/16 , G01N33/566
CPC分类号： H01F1/37 , B03C1/01 , G01N33/5375 , G01N33/5434 , H01F1/44 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86 , Y10S436/806 , Y10S436/824 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： The superparamagnetic monodispersed particles comprise a core of a first polymer, an internal layer of a second polymer coating the core and in which a magnetic material is distributed, and an external layer of a third polymer coating the magnetic layer and capable of interacting with at least one biological molecule. At least the second polymer is heat sensitive and has a predetermined lower critical solubility temperature (LCST) of 15-65.degree. C. These particles may be used to isolate at least one biological molecule from a liquid specimen.
摘要翻译： PCT No.PCT / FR97 / 00912 Sec。 371日期1998年1月15日 102（e）日期1998年1月15日PCT提交1997年5月23日PCT公布。出版物WO97 / 45202 日本1997年12月4日超顺磁单分散颗粒包括第一聚合物的芯，涂覆芯的第二聚合物的内层，其中分布有磁性材料，以及涂覆磁性层的第三聚合物的外层，与至少一种生物分子相互作用。至少第二聚合物是热敏感的并且具有15-65℃的预定的较低临界溶解温度（LCST）。这些颗粒可用于从液体样品中分离至少一种生物分子。

6. 发明授权

US06521341B1 Magnetic particles, method for obtaining same and uses for separating molecules 有权
标题翻译：磁性粒子，其获得方法和用于分离分子的方法
公开(公告)号：US06521341B1
公开(公告)日：2003-02-18
申请号：US09582352
申请日：2000-09-21
申请人： Abdelhamid Elaissari , Christian Pichot , Bernard Mandrand
发明人： Abdelhamid Elaissari , Christian Pichot , Bernard Mandrand
IPC分类号： G11B516
CPC分类号： H01F1/111 , B03C1/01 , G01N33/5434 , G01N2446/20 , G01N2446/86 , Y10S428/90 , Y10T428/2991 , Y10T428/2998
摘要： The invention concerns magnetic and heat-sensitive particles having a predetermined size between 0.05 and 10 &mgr;m, each particle comprising: an inner composite core consisting of a solid organic or inorganic particle, containing within it a magnetic filler; an outer coati based on a polymer capable of interacting with at least a biological molecule, the outer polymer is heat-sensitive and has a predetermined low critical solubility temperature (LCST) ranging between 10 and 100° C. and preferably between 20 and 60° C. The invention also concerns methods for obtaining said particles and their uses. The particles are characterized in that there is an intermediate layer between the inner core and the outer layer isolating said inner core magnetic filler with respect to said functionalized outer layer. Said invention is particularly useful for separating proteins and/or nucleic acids.
摘要翻译：本发明涉及具有0.05-10μm之间的预定尺寸的磁性和热敏颗粒，每个颗粒包括：由固体有机或无机颗粒组成的内部复合芯，其中含有磁性填料; 基于能够与至少一种生物分子相互作用的聚合物的外涂层，外部聚合物是热敏感的，并且具有在10和100℃之间，优选在20和60℃之间的预定的低临界溶解温度（LCST）本发明还涉及获得所述颗粒及其用途的方法。颗粒的特征在于，在内芯和外层之间存在相对于所述官能化外层隔离所述内芯磁性填料的中间层。所述发明对于分离蛋白质和/或核酸特别有用。

7. 发明授权

US07060804B2 Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses 有权
公开(公告)号：US07060804B2
公开(公告)日：2006-06-13
申请号：US10182126
申请日：2001-01-22
申请人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
发明人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
IPC分类号： A23J1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C12N15/1013 , C07K1/22 , G01N33/5434
摘要： The invention concerns a method for isolating proteins and/or protein and nucleic acid associations in a sample, comprising steps which consist in: contacting said sample and magnetic colloidal particles comprising a core and a coat wherein: the core is magnetic and is coated with at least a polymer comprising functional groups X selected among amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups or mixtures thereof, whereof at least one fraction has reacted with other functional groups of the coat, and the coat consists of a polymer bearing functional groups Z and Z′, capable of ionisation, identical or different, selected among amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulphide, α-halogenocarbonyl, sulphonic acid, maleimide, isocyanate and isothiocyanate groups to form a mixture; incubating said mixture in predetermined conditions; and separating from the mixture the protein and/or protein and nucleic acid associations complexed on the colloidal particles by applying a magnetic field. The invention also concerns a complex consisting of colloidal particles and proteins, a reagent comprising such a complex or colloidal particles.

8. 发明申请

US20100209987A1 Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses 有权
公开(公告)号：US20100209987A1
公开(公告)日：2010-08-19
申请号：US12656821
申请日：2010-02-17
申请人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
发明人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
IPC分类号： C12N13/00
CPC分类号： C12N15/1013 , C07K1/22 , G01N33/5434
摘要： The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z′, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, α-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.

9. 发明授权

US08093026B2 Method for transporting or storing a protein, a virus, a prokaryotic cell, or an eukaryotic cell 有权
标题翻译：运送或储存蛋白质，病毒，原核细胞或真核细胞的方法
公开(公告)号：US08093026B2
公开(公告)日：2012-01-10
申请号：US12656821
申请日：2010-02-17
申请人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
发明人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
IPC分类号： C12N13/00
CPC分类号： C12N15/1013 , C07K1/22 , G01N33/5434
摘要： The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z′, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, α-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.
摘要翻译：磁性胶体颗粒包括核心和外壳，其中芯是磁性的并且涂覆有至少一种包含选自胺，羟基，硫醇，醛，酯，酸酐，酰氯，碳酸酯，氨基甲酸酯，异氰酸酯的官能团X的聚合物和异硫氰酸酯基团或其混合物，其至少一部分已经与外壳的其它官能团反应，并且外壳包含可离子化官能团Z和Z'的聚合物，Z和Z'可以相同或不同，选自胺，羧酸，酯，酸酐，醛，硫醇，二硫化物，α-卤代羰基，磺酸，马来酰亚胺，异氰酸酯和异硫氰酸酯基团，其与核的官能团X部分反应。这些磁性胶体颗粒可用于分离生物材料。

10. 发明申请

US20060105326A1 Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses 有权
标题翻译：用于分离蛋白质或蛋白质和核酸关联的方法，或颗粒和蛋白质复合物，试剂和用途
公开(公告)号：US20060105326A1
公开(公告)日：2006-05-18
申请号：US11320574
申请日：2005-12-30
申请人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
发明人： Abdelhamid Elaissari , Bernard Mandrand , Thierry Delair , Doran Spencer , Ahmed Arkis
IPC分类号： C12Q1/70 , C12Q1/68 , C12N1/08
CPC分类号： C12N15/1013 , C07K1/22 , G01N33/5434
摘要： The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z′, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, α-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.
摘要翻译：磁性胶体颗粒包括核心和外壳，其中芯是磁性的并且涂覆有至少一种包含选自胺，羟基，硫醇，醛，酯，酸酐，酰氯，碳酸酯，氨基甲酸酯，异氰酸酯的官能团X的聚合物和异硫氰酸酯基团或其混合物，其至少一部分已经与外壳的其它官能团反应，并且外壳包含可离子化官能团Z和Z'的聚合物，Z和Z'可以相同或不同，选自胺，羧酸，酯，酸酐，醛，硫醇，二硫化物，α-卤代羰基，磺酸，马来酰亚胺，异氰酸酯和异硫氰酸酯基团，其与核的官能团X部分反应。这些磁性胶体颗粒可用于分离生物材料。

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