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1. 发明授权

US08696570B2 Insertion device and method for inserting a subcutaneously insertable element into body 有权
标题翻译：用于将皮下可插入元件插入体内的插入装置和方法
公开(公告)号：US08696570B2
公开(公告)日：2014-04-15
申请号：US11989684
申请日：2007-11-26
申请人： Ofer Yodfat , Gavriel J. Iddan , Avraham Neta , Ruthy Kaidar
发明人： Ofer Yodfat , Gavriel J. Iddan , Avraham Neta , Ruthy Kaidar
IPC分类号： A61B5/145 , A61M5/00
CPC分类号： A61B5/14503 , A61B5/14532 , A61B5/150022 , A61B5/6848 , A61M5/158 , A61M5/3287 , A61M2005/004 , A61M2005/1581 , A61M2005/1585 , A61M2005/2073
摘要： An insertion device for a fluid delivery device for delivering a therapeutic fluid to a body of a patient and/or for sensing of a bodily analyte is disclosed. The insertion device includes a housing and accommodated therein at least one penetrating cartridge provided with a penetrating member and with a subcutaneously insertable element; The insertion device is provided with a displacement mechanism which upon actuation is capable of protracting the penetrating cartridge towards the said device for delivery and/or sensing, wherein said protracting results in inserting of the penetrating cartridge into subcutaneous compartment of the body via an opening provided at the said device for delivery and/or sensing and said insertion device allows evacuation of the penetrating member from the subcutaneous compartment via the said opening.
摘要翻译：公开了一种用于将治疗流体输送到患者体内和/或感测身体分析物的流体输送装置的插入装置。所述插入装置包括壳体并容纳在其中，所述至少一个穿透筒设置有穿透构件和皮下可插入元件; 所述插入装置设置有位移机构，所述位移机构在致动时能够将所述穿透滤筒向着所述装置延伸以用于传送和/或感测，其中所述伸展导致通过提供的开口将穿透滤筒插入身体的皮下隔室在所述用于输送和/或感测的装置上，并且所述插入装置允许穿透构件经由所述开口从皮下隔室排出。

2. 发明授权

US08814822B2 Reciprocating delivery of fluids to the body with analyte concentration monitoring 有权
标题翻译：通过分析物浓度监测向体内往复运送流体
公开(公告)号：US08814822B2
公开(公告)日：2014-08-26
申请号：US12116546
申请日：2008-05-07
申请人： Ofer Yodfat , Ruthy Kaidar , Gali Shapira
发明人： Ofer Yodfat , Ruthy Kaidar , Gali Shapira
IPC分类号： A61M31/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/150022 , A61B5/150229 , A61B5/150389 , A61B5/150503 , A61B5/157 , A61B5/4839 , A61B5/6848 , A61B2560/0412 , A61B2560/0443 , A61M5/14248 , A61M5/1723 , A61M2005/1726
摘要： A volume of an analyte-enriched fluid can be withdrawn out of a user's subcutaneous compartment using a patch unit that includes a reversible pumping mechanism. The volume can be withdrawn out of the body and into the patch unit through a cannula inserted into the subcutaneous compartment so that an analyte concentration in the volume can be measured using a sensing element within the patch unit. After analyte concentration analysis, at least the volume can be delivered back into the subcutaneous compartment by operating the pumping mechanism in a forward direction. biologically compatible fluid can optionally be pumped into the subcutaneous compartment from a reservoir in the patch unit and then allowed to partially or completely equilibrate with the analyte concentration in the interstitial fluid of the subcutaneous compartment via a permeable or semi-permeable cannula surface before being drawn back into the patch unit for analysis. Related systems, apparatus, methods, and/or articles are also described.
摘要翻译：可以使用包括可逆泵送机构的贴片单元将一定体积的富含分析物的流体从使用者的皮下隔室中取出。体积可以通过插入到皮下室中的插管从体内抽出并进入贴片单元，使得可以使用贴片单元内的感测元件来测量体积中的分析物浓度。在分析物浓度分析之后，通过沿向前的方向操作泵送机构，至少体积可被输送回皮下室。生物相容的流体可以任选地从贴片单元中的储器泵入皮下隔室中，然后在被拉伸之前通过可渗透或半渗透的套管表面部分地或完全地与皮下室的间质液中的分析物浓度平衡回到补丁单位进行分析。还描述了相关系统，装置，方法和/或制品。

3. 发明申请

US20100256593A1 Analyte Monitoring and Fluid Dispensing System 审中-公开
标题翻译：分析物监测和流体分配系统
公开(公告)号：US20100256593A1
公开(公告)日：2010-10-07
申请号：US12744268
申请日：2008-11-20
申请人： Ofer Yodfat , Ruthy Kaidar
发明人： Ofer Yodfat , Ruthy Kaidar
IPC分类号： A61M5/168 , A61M5/142 , A61B5/145 , A61B5/1486
CPC分类号： A61M5/14248 , A61M5/1723 , A61M2005/14268 , A61M2005/1726 , A61M2205/3592 , A61M2205/50 , A61M2205/8206 , A61M2210/04 , A61M2230/201
摘要： Disclosed is a skin adherable device for delivering therapeutic fluid into a body of a patient. The device includes a monitoring apparatus, a dispensing apparatus, and a tip for delivering the therapeutic fluid into the body of the patient and for monitoring bodily analyte in the body of the patient. The dispensing apparatus may continuously deliver the therapeutic fluid to the body of the patient and the monitoring apparatus may continuously monitor bodily analytes of the patient.
摘要翻译：公开了一种用于将治疗性流体输送到患者体内的皮肤粘附装置。该装置包括监测装置，分配装置和用于将治疗流体输送到患者体内并用于监测患者体内的身体分析物的尖端。分配装置可以将治疗流体连续输送到患者体内，并且监测装置可以连续监测患者的身体分析物。

4. 发明申请

US20100217105A1 Insertion device and method for inserting a subcutaneously insertable element into body 有权
标题翻译：用于将皮下可插入元件插入体内的插入装置和方法
公开(公告)号：US20100217105A1
公开(公告)日：2010-08-26
申请号：US11989684
申请日：2007-11-26
申请人： Ofer Yodfat , Gavriel J. Iddan , Avraham Neta , Ruthy Kaidar
发明人： Ofer Yodfat , Gavriel J. Iddan , Avraham Neta , Ruthy Kaidar
IPC分类号： A61M5/31 , A61M5/00 , A61B5/145
CPC分类号： A61B5/14503 , A61B5/14532 , A61B5/150022 , A61B5/6848 , A61M5/158 , A61M5/3287 , A61M2005/004 , A61M2005/1581 , A61M2005/1585 , A61M2005/2073
摘要： An insertion device (100) for a fluid delivery device (105) for delivering a therapeutic fluid to a body of a patient and/or for sensing of a bodily analyte is disclosed. The insertion device includes a housing and accommodated therein at least one penetrating cartridge (150) provided with a penetrating member and with a subcutaneously insertable element; The insertion device is provided with a displacement mechanism which upon actuation is capable of protracting the penetrating cartridge towards the said device for delivery and/or sensing, wherein said protracting results in inserting of the penetrating cartridge into subcutaneous compartment of the body via an opening provided at the said device for delivery and/or sensing and said insertion device allows evacuation of the penetrating member from the subcutaneous compartment via the said opening.
摘要翻译：公开了一种用于将治疗流体输送到患者身体和/或感测身体分析物的流体输送装置（105）的插入装置（100）。所述插入装置包括壳体并容纳在其中，至少一个穿透筒（150）设置有穿透构件和皮下可插入元件; 所述插入装置设置有位移机构，所述位移机构在致动时能够将所述穿透滤筒向着所述装置延伸以用于传送和/或感测，其中所述伸展导致通过提供的开口将穿透滤筒插入身体的皮下隔室在所述用于输送和/或感测的装置上，并且所述插入装置允许穿透构件经由所述开口从皮下隔室排出。

5. 发明申请

US20070191702A1 Systems and methods for sensing analyte and dispensing therapeutic fluid 审中-公开
标题翻译：用于感测分析物和分配治疗液体的系统和方法
公开(公告)号：US20070191702A1
公开(公告)日：2007-08-16
申请号：US11706606
申请日：2007-02-14
申请人： Ofer Yodfat , Ruthy Kaidar
发明人： Ofer Yodfat , Ruthy Kaidar
IPC分类号： A61N1/30 , A61B5/00 , A61B5/05
CPC分类号： A61M5/1723 , A61B5/14525 , A61B5/14532 , A61B5/14546 , A61B5/15 , A61B5/150022 , A61B5/150229 , A61B5/150389 , A61B5/150511 , A61B5/151 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/6848 , A61M5/14248 , A61M2005/1726 , A61M2205/502 , A61M2209/01 , A61N1/05 , A61N1/30
摘要： Systems and methods are provided for sensing analyte (e.g., glucose) and/or dispensing therapeutic fluid (e.g., insulin). The systems and methods are based on transporting the therapeutic fluid through a cannula at least a portion of which is permeable to molecule of the analyte. Sensing and detection of the concentration level of the analyte can be carried out by optical sensing, electrochemical sensing, acoustical sensing etc. Sensing and dispensing can be carried out by sensing and dispensing device operating in either closed or semi-closed loop.
摘要翻译：提供了用于感测分析物（例如葡萄糖）和/或分配治疗流体（例如胰岛素）的系统和方法。系统和方法基于将治疗性流体输送通过其中至少一部分对分析物的分子是可渗透的插管。分析物浓度水平的检测和检测可以通过光学感测，电化学传感，声学传感等进行。感测和分配可以通过在闭合或半闭环中工作的感测和分配装置进行。

6. 发明授权

US09028409B2 Fluid delivery with in vivo electrochemical analyte sensing 有权
标题翻译：流体输送与体内电化学分析物检测
公开(公告)号：US09028409B2
公开(公告)日：2015-05-12
申请号：US11963481
申请日：2007-12-21
申请人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
发明人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1486 , A61M5/172 , A61B5/1495 , A61M5/142
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/1495 , A61M5/14248 , A61M5/1723 , A61M2005/14268 , A61M2205/50 , A61M2230/201
摘要： One or more therapeutic fluids, such as for example insulin can be delivered to a body. In addition or alternatively, the concentrations of one or more analytes can be measured in vivo. A feedback process can be used to regulate levels of the one or more analytes based on the measurements via delivery of the one or more therapeutic fluids. Related systems, apparatus, methods, and/or articles are also described.
摘要翻译：一种或多种治疗性流体，例如胰岛素可被递送至身体。另外或替代地，可以在体内测量一种或多种分析物的浓度。基于通过递送一种或多种治疗性流体的测量，可以使用反馈过程来调节一种或多种分析物的水平。还描述了相关系统，装置，方法和/或制品。

7. 发明授权

US08615281B2 Hypodermic optical monitoring of bodily analyte 失效
标题翻译：身体分析物的皮下光学监测
公开(公告)号：US08615281B2
公开(公告)日：2013-12-24
申请号：US12744260
申请日：2008-11-20
申请人： Ofer Yodfat , Iddo M. Gescheit , Illai Gescheit , Ruthy Kaidar
发明人： Ofer Yodfat , Iddo M. Gescheit , Illai Gescheit , Ruthy Kaidar
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/6833 , A61M5/14248 , A61M2005/14268 , A61M2005/1726 , A61M2205/3561 , A61M2205/3592
摘要： Disclosed is a skin adherable device for monitoring analytes in interstitial fluid. The device includes an electromagnetic radiation emitting source and a transmitter for transmitting the electromagnetic radiation between the electromagnetic radiation emitting source and the interstitial fluid. The device further includes a detector, operating electronics and a power supply. The device may include a reusable part and a disposable part.
摘要翻译：公开了用于监测间质液中分析物的皮肤粘附装置。该装置包括电磁辐射发射源和用于在电磁辐射发射源和间隙液之间传送电磁辐射的发射器。该装置还包括检测器，操作电子装置和电源。该装置可以包括可重复使用部分和一次性部分。

8. 发明申请

US20100298764A1 Fluid delivery system with optical sensing of analyte concentration levels 审中-公开
标题翻译：流体输送系统，具有光学感应分析物浓度水平
公开(公告)号：US20100298764A1
公开(公告)日：2010-11-25
申请号：US11989678
申请日：2007-09-05
申请人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
发明人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
IPC分类号： A61M5/168
CPC分类号： A61B5/1459 , A61B5/14532 , A61M5/14248 , A61M5/1723 , A61M2005/14268
摘要： A system for continuous monitoring of body analytes and controlling delivery of fluids to a body of a user. The system includes a sensing apparatus configured to detect concentration level of analyte in the body of the user using optical means and a dispensing apparatus configured to infuse fluid into the body of the user based on the detected concentration level of analyte.
摘要翻译：用于连续监测身体分析物并控制流体输送到使用者身体的系统。该系统包括感测装置，其被配置为使用光学装置来检测使用者体内的分析物的浓度水平;以及分配装置，其被配置为基于检测到的分析物的浓度水平将流体注入使用者的身体。

9. 发明申请

US20100241086A1 Flluid deliver system with electrochemical sensing of analyte concentration levels 有权
标题翻译： Flluid交付系统具有电化学检测分析物浓度水平
公开(公告)号：US20100241086A1
公开(公告)日：2010-09-23
申请号：US11989665
申请日：2007-09-25
申请人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
发明人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
IPC分类号： A61M5/00 , G01N27/26 , A61B5/1468
CPC分类号： A61M5/14248 , A61B5/14525 , A61B5/1468 , A61B5/1486 , A61B5/4839 , A61B5/6848 , A61M5/1723 , A61M2005/1726 , A61M2230/201
摘要： A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient upon diffusion of the analyte into the fluid to be dispensed by the dispensing apparatus.
摘要翻译：公开了一种用于将流体输送到患者体内并感测患者体内的分析物水平的系统和方法。该系统包括配置成将流体注入到患者体内的分配装置和被配置成与分配装置连通的感测装置，并且还被配置成在分析物扩散时检测患者体内的分析物浓度水平进入待由分配装置分配的流体。

10. 发明授权

US08603075B2 Fluid delivery system with electrochemical sensing of analyte concentration levels 有权
标题翻译：流体输送系统具有电化学检测分析物浓度水平
公开(公告)号：US08603075B2
公开(公告)日：2013-12-10
申请号：US11989665
申请日：2007-09-25
申请人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
发明人： Ofer Yodfat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
IPC分类号： A61K9/22 , A61M5/00 , C12M1/00
CPC分类号： A61M5/14248 , A61B5/14525 , A61B5/1468 , A61B5/1486 , A61B5/4839 , A61B5/6848 , A61M5/1723 , A61M2005/1726 , A61M2230/201
摘要： A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient upon diffusion of the analyte into the fluid to be dispensed by the dispensing apparatus.
摘要翻译：公开了一种用于将流体输送到患者体内并感测患者体内的分析物水平的系统和方法。该系统包括配置成将流体注入到患者体内的分配装置和被配置成与分配装置连通的感测装置，并且还被配置成在分析物扩散时检测患者体内的分析物浓度水平进入待由分配装置分配的流体。

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