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1. 发明公开

US20230355101A1 DEVICE AND METHOD FOR IN VIVO PHOTOACOUSTIC DIAGNOSIS AND PHOTOTHERMAL PURGING OF INFECTED BLOOD 审中-公开
公开(公告)号：US20230355101A1
公开(公告)日：2023-11-09
申请号：US18215635
申请日：2023-06-28
申请人： BioVentures, LLC
发明人： Mark S. Smeltzer , Vladimir Zharov , Ekaterina Galanzha
IPC分类号： A61B5/00 , G01N33/569 , G01N33/487 , A61B5/145 , A61K41/00 , A61K49/22 , A61M5/00
CPC分类号： A61B5/0095 , G01N33/569 , G01N33/48728 , A61B5/14525 , A61B5/4839 , A61K41/00 , A61K49/221 , A61M5/007
摘要： A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.

2. 发明授权

US11723540B2 Device and method for in vivo photoacoustic diagnosis and photothermal purging of infected blood 有权
公开(公告)号：US11723540B2
公开(公告)日：2023-08-15
申请号：US17668909
申请日：2022-02-10
申请人： Bioventures, LLC
发明人： Mark S. Smeltzer , Vladimir Zharov , Ekaterina Galanzha
IPC分类号： A61B5/00 , G01N33/569 , G01N33/487 , A61B5/145 , A61K41/00 , A61K49/22 , A61M5/00
CPC分类号： A61B5/0095 , A61B5/14525 , A61B5/4839 , A61K41/00 , A61K49/221 , A61M5/007 , G01N33/48728 , G01N33/569
摘要： A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.

3. 发明公开

US20230243752A1 SYSTEM AND METHOD FOR MONITORING THE HEALTH OF DIALYSIS PATIENTS 审中-公开
公开(公告)号：US20230243752A1
公开(公告)日：2023-08-03
申请号：US18122180
申请日：2023-03-16
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： John L. Robertson , Ryan Senger , Pang Du
IPC分类号： G01N21/65 , A61M1/16 , A61M1/36 , A61B5/00 , A61B5/145 , A61M1/14 , G16H10/40 , G16H20/40 , A61M1/28 , G01N33/49
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/6866 , A61B5/14525 , A61M1/14 , A61M1/282 , A61M1/1609 , A61M1/1619 , A61M1/1692 , A61M1/3609 , G01N33/492 , G16H10/40 , G16H20/40 , A61M2205/50 , A61M2205/52 , A61M2205/3313 , G01N21/658 , G01N2570/00
摘要： A system and method for monitoring the health of dialysis patients with Raman spectroscopy measurements of one or more target analytes is described. The methods include irradiating one or more fluids of interest with light to produce one or more spectrum and detecting the spectrum with a detector. The fluids of interest are preferably those related to dialysis, including hemodialysis and peritoneal dialysis. In a preferred embodiment, the fluids are irradiated with monochromatic light, and one or more Raman spectra are detected as a result of the irradiation. The fluids may be irradiated within the dialysis tubing itself, or removed from the dialysis tubing and irradiated in a separate chamber. The Raman spectra of one or more target analytes of a dialysis patient may be followed over time or compared to one or more reference spectra, thereby providing information on the health of dialysis patients.

4. 发明授权

US08741555B2 Apparatus and method for perfusion and determining the viability of an organ 有权
标题翻译：用于灌注和确定器官活力的装置和方法
公开(公告)号：US08741555B2
公开(公告)日：2014-06-03
申请号：US10845154
申请日：2004-05-14
申请人： John Brassil , Simona Baicu
发明人： John Brassil , Simona Baicu
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A61B5/14525 , A01N1/02 , A01N1/0247 , A61B5/413
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. During the period in which the organ is preserved and/or maintained, the organ may be additionally be perfused to obtain data regarding the fluid and/or organ. The data may then be used to ultimately provide information regarding the perfusion efficacy and allow for altering of the perfusion parameters.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。在保存和/或保持器官的期间，可以另外灌注器官以获得关于流体和/或器官的数据。然后可以使用数据来最终提供关于灌注功效的信息并允许改变灌注参数。

5. 发明申请

US20140094746A1 Fluid Delivery System With Electrochemical Sensing Of Analyte Concentration Levels 有权
标题翻译：流体输送系统与电化学感应分析物浓度水平
公开(公告)号：US20140094746A1
公开(公告)日：2014-04-03
申请号：US14098091
申请日：2013-12-05
申请人： Roche Diagnostics Operations Inc.
发明人： Ofer Yodat , Gavriel J. Iddan , Ruthy Kaidar , Gali Shapira
IPC分类号： A61M5/142 , A61M5/172 , A61B5/1468
CPC分类号： A61M5/14248 , A61B5/14525 , A61B5/1468 , A61B5/1486 , A61B5/4839 , A61B5/6848 , A61M5/1723 , A61M2005/1726 , A61M2230/201
摘要： A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient.
摘要翻译：公开了一种用于将流体输送到患者体内并感测患者体内的分析物水平的系统和方法。该系统包括配置成将流体注入到患者体内的分配装置和被配置为与分配装置连通并进一步构造成检测患者体内的分析物浓度水平的感测装置。

6. 发明授权

US08602990B2 Method and device for microdialysis sampling 有权
标题翻译：微透析取样方法及装置
公开(公告)号：US08602990B2
公开(公告)日：2013-12-10
申请号：US12633586
申请日：2009-12-08
申请人： Pernilla Birgitta Abrahamsson
发明人： Pernilla Birgitta Abrahamsson
IPC分类号： A61B5/00
CPC分类号： A61M25/00 , A61B5/14525 , A61B5/14528 , A61B10/0045 , A61B2010/008 , A61M25/02 , A61M2025/0286
摘要： Microdialysis sampling methods utilizing at least one microdialysis probe placed on the surface of a vital human or animal organ for sampling metabolic substances that indicate the metabolic conditions of the organ from the surface of the organ. The invention further relates to microdialysis sampling probes for sampling metabolic substances, said probes being adapted to be attached to the surface of a vital human or animal organ.
摘要翻译：微透析取样方法利用至少一个微透析探针放置在重要的人体或动物器官的表面上，用于从器官表面取样表示器官的代谢状态的代谢物质。本发明还涉及用于取代代谢物质的微透析取样探针，所述探针适于附着于重要的人或动物器官的表面。

7. 发明申请

US20110152653A1 SYSTEMS AND METHODS FOR IMPLEMENTING RAPID RESPONSE MONITORING OF BLOOD CONCENTRATION OF A METABOLITE 审中-公开
标题翻译：用于实现代谢物血液浓度快速响应监测的系统和方法
公开(公告)号：US20110152653A1
公开(公告)日：2011-06-23
申请号：US12996419
申请日：2009-06-07
申请人： Avraham Shekalim , Noam Peleg , Erez Yotvat
发明人： Avraham Shekalim , Noam Peleg , Erez Yotvat
IPC分类号： A61B5/1468
CPC分类号： A61B5/1459 , A61B5/14525 , A61B5/14528 , A61B5/14532 , A61B5/686 , A61B2560/063
摘要： Systems and methods for monitoring the concentration of glucose or other metabolites by way of a low-volume microdialysis-probe (10) operative in accordance with a pulsed mode of flow through a flow path (12) defined by a layered structure. Also described are a system and a method for deployment of the microdialysis probe (10) within the body and a technique for deriving a metabolite concentration of the basis of a rate of change of an optical parameter.
摘要翻译：用于通过低体积微量透析探针（10）监测葡萄糖或其它代谢物的浓度的系统和方法，其根据通过由分层结构限定的流动路径（12）的脉冲流动模式操作。还描述了用于在体内部署微透析探针（10）的系统和方法，以及用于导出光学参数的变化率的基础的代谢物浓度的技术。

8. 发明申请

US20100256466A1 Metabolite Management System 审中-公开
标题翻译：代谢物管理系统
公开(公告)号：US20100256466A1
公开(公告)日：2010-10-07
申请号：US12753143
申请日：2010-04-02
申请人： Avraham Shekalim , Noam Peleg , Carmel Zeltser
发明人： Avraham Shekalim , Noam Peleg , Carmel Zeltser
IPC分类号： A61B5/1455 , A61M5/00 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/14525 , A61B5/14532 , A61B5/1459 , A61M5/14248 , A61M2005/14208 , A61M2005/14252 , A61M2005/1726 , A61M2205/3306 , A61M2230/201
摘要： A metabolite monitoring system configured to deliver drugs and obtain metabolite samples via one common skin perforation and measure metabolite content by way of an optical measuring-cell having a primary flow-path of constant cross-sectional area.
摘要翻译：一种代谢物监测系统，其配置为通过一个普通的皮肤穿孔递送药物并获得代谢物样品，并通过具有恒定横截面积的主流动路径的光学测量池测量代谢物含量。

9. 发明授权

US07266403B2 Method and device for treating a protein deficiency 有权
标题翻译：治疗蛋白质缺乏症的方法和装置
公开(公告)号：US07266403B2
公开(公告)日：2007-09-04
申请号：US10725303
申请日：2003-12-01
申请人： Lars Lindberg , Georgios Psaros , Göran Rydgren
发明人： Lars Lindberg , Georgios Psaros , Göran Rydgren
IPC分类号： A61B5/02 , A61B5/05
CPC分类号： A61B5/14525 , A61B5/1459 , A61M16/04 , A61M16/0484 , A61M2202/0488 , A61M2202/0492 , G01N33/6884
摘要： In a method and device for preparation of a medicament for the treatment of lungs having a surfactant deficiency, a sample from a patient is quantitatively analyzed with regard to at least one of the proteins SP-A, SP-B, SP-C and SP-D, a determination is made as to whether a deficiency of one of the analyzed protein SP-A, SP-B, SP-C or SP-D exists and if that is the case, a determination is made of a therapeutically effective dose of a replacement substance for the analyzed protein SP-A, SP-B, SP-C or SP-D, and a medicament containing the therapeutically effective dose of the replacement substance is prepared.
摘要翻译：在用于制备用于治疗具有表面活性剂缺乏的肺的药物的制备方法和装置中，来自患者的样品关于蛋白质SP-A，SP-B，SP-C和SP中的至少一种进行定量分析 -D，确定是否存在分析的蛋白质SP-A，SP-B，SP-C或SP-D中的一种的缺乏，如果是这种情况，则确定治疗有效剂量的分析蛋白质SP-A，SP-B，SP-C或SP-D的替代物质，以及含有治疗有效剂量的替代物质的药物。

10. 发明授权

US07118351B2 Micropump with heating elements for a pulsed operation 失效
公开(公告)号：US07118351B2
公开(公告)日：2006-10-10
申请号：US10436387
申请日：2003-05-12
申请人： Carlo Effenhauser , Herbert Harttig , Tony Ziegler
发明人： Carlo Effenhauser , Herbert Harttig , Tony Ziegler
IPC分类号： F04B19/24
CPC分类号： A61B5/14525 , A61B5/14532 , F04B17/00 , F04B19/006 , F04B19/24
摘要： The invention discloses a micropump having heating elements in which an essentially pulsed operation of the heating elements occurs by means of a control unit. The pulsed operation of the heating elements enables an exact control of the flow rate. With the aid of the control unit it is possible to keep the flow rate constant over a long period of days or to change the flow rate rapidly and precisely.

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