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    • 9. 发明授权
    • Reciprocating delivery of fluids to the body with analyte concentration monitoring
    • 通过分析物浓度监测向体内往复运送流体
    • US08814822B2
    • 2014-08-26
    • US12116546
    • 2008-05-07
    • Ofer YodfatRuthy KaidarGali Shapira
    • Ofer YodfatRuthy KaidarGali Shapira
    • A61M31/00
    • A61B5/14865A61B5/14532A61B5/150022A61B5/150229A61B5/150389A61B5/150503A61B5/157A61B5/4839A61B5/6848A61B2560/0412A61B2560/0443A61M5/14248A61M5/1723A61M2005/1726
    • A volume of an analyte-enriched fluid can be withdrawn out of a user's subcutaneous compartment using a patch unit that includes a reversible pumping mechanism. The volume can be withdrawn out of the body and into the patch unit through a cannula inserted into the subcutaneous compartment so that an analyte concentration in the volume can be measured using a sensing element within the patch unit. After analyte concentration analysis, at least the volume can be delivered back into the subcutaneous compartment by operating the pumping mechanism in a forward direction. biologically compatible fluid can optionally be pumped into the subcutaneous compartment from a reservoir in the patch unit and then allowed to partially or completely equilibrate with the analyte concentration in the interstitial fluid of the subcutaneous compartment via a permeable or semi-permeable cannula surface before being drawn back into the patch unit for analysis. Related systems, apparatus, methods, and/or articles are also described.
    • 可以使用包括可逆泵送机构的贴片单元将一定体积的富含分析物的流体从使用者的皮下隔室中取出。 体积可以通过插入到皮下室中的插管从体内抽出并进入贴片单元,使得可以使用贴片单元内的感测元件来测量体积中的分析物浓度。 在分析物浓度分析之后,通过沿向前的方向操作泵送机构,至少体积可被输送回皮下室。 生物相容的流体可以任选地从贴片单元中的储器泵入皮下隔室中,然后在被拉伸之前通过可渗透或半渗透的套管表面部分地或完全地与皮下室的间质液中的分析物浓度平衡 回到补丁单位进行分析。 还描述了相关系统,装置,方法和/或制品。