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1. 发明申请

US20070167836A1 Multi modal spectroscopy 审中-公开
标题翻译：多模光谱
公开(公告)号：US20070167836A1
公开(公告)日：2007-07-19
申请号：US11492301
申请日：2006-07-25
申请人： Obrad Scepanovic , Joseph Gardecki , Michael Feld
发明人： Obrad Scepanovic , Joseph Gardecki , Michael Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0091 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/42 , A61B5/4312 , G01N21/64 , G01N2021/656
摘要： The present invention relates to multimodal spectroscopy (MMS) as a clinical tool for the in vivo diagnosis of disease in humans. The MMS technology combines Raman and fluorescence spectroscopy. A preferred embodiment involves diagnosis cancer of the breast and of vulnerable atherosclerotic plaque, esophageal, colon, cervical and bladder cancer. MMS is used to provide a more comprehensive picture of the metabolic, biochemical and morphological state of a tissue than afforded by either Raman or fluorescence and reflectance spectroscopies alone.
摘要翻译：本发明涉及多峰光谱（MMS）作为人体内疾病体内诊断的临床工具。 MMS技术结合了拉曼和荧光光谱。优选的实施方案涉及诊断乳腺癌和易受损的动脉粥样硬化斑块，食管癌，结肠癌，子宫颈癌和膀胱癌的诊断。 MMS用于提供组织的代谢，生物化学和形态状态的更全面的图像，而不是由单独的拉曼或荧光和反射光谱提供。

2. 发明申请

US20070060806A1 Raman spectroscopy for non-invasive glucose measurements 有权
标题翻译：用于非侵入性葡萄糖测量的拉曼光谱
公开(公告)号：US20070060806A1
公开(公告)日：2007-03-15
申请号：US11412418
申请日：2006-04-27
申请人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
发明人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , G01N21/65
摘要： The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
摘要翻译：本发明涉及拉曼光谱法用于定量，非侵入性经皮测量血液分析物如葡萄糖的用途。在监测血糖水平的患者中，拉曼光谱法用于经皮测量葡萄糖。通过标准毛细管血液分析提供的葡萄糖参考值，经皮收集拉曼光谱。从每个受试者的数据创建偏最小二乘法校准，并使用离开一对交叉验证进行验证。

3. 发明授权

US10780555B2 Combination of control cabinet keys 有权
公开(公告)号：US10780555B2
公开(公告)日：2020-09-22
申请号：US13579353
申请日：2011-02-17
申请人： Ralf Putsch , Michael Feld , Filip Marovic
发明人： Ralf Putsch , Michael Feld , Filip Marovic
IPC分类号： B25F1/04 , E05B35/00 , B25B13/56 , B25B13/00
摘要： The invention relates to a combination (1) of control cabinet keys (2), individual keys being situated in the same plane but extending at a fixed angle (x) relative to one another and connected via a common center part (4, 5). Due to the fixed connection between the keys, during handling, a torque may be applied to a key (2) that is used. For ease of handling, a first unit (E1) and a second unit (E2) of keys extending at a fixed angle (x) relative to one another are provided, all units (E1, E2) have their own center part, and the units are detachably connected at their center parts (4, 5), and/or the keys are rotatable relative to one another, but only in a respective predefined plane.

4. 发明授权

US09433351B2 Tri modal spectroscopic imaging 有权
标题翻译：三态光谱成像
公开(公告)号：US09433351B2
公开(公告)日：2016-09-06
申请号：US13464578
申请日：2012-05-04
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld
IPC分类号： A61B6/00 , A61B5/00 , G01J3/02 , G01J3/10 , G01J3/32 , G01N21/47 , G01N21/49
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

5. 发明授权

US08334982B2 Systems and methods for phase measurements 有权
标题翻译：相位测量的系统和方法
公开(公告)号：US08334982B2
公开(公告)日：2012-12-18
申请号：US12494605
申请日：2009-06-30
申请人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
发明人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
IPC分类号： G01B11/02
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中。

6. 发明申请

US20050105097A1 Systems and methods for phase measurements 有权
公开(公告)号：US20050105097A1
公开(公告)日：2005-05-19
申请号：US10871610
申请日：2004-06-18
申请人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
发明人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
IPC分类号： G01B9/02 , G01J9/04 , G01N21/45
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.

7. 发明授权

US06272018B1 Method for the verification of the polarity and presence of components on a printed circuit board 失效
标题翻译：用于验证印刷电路板上的部件的极性和存在的方法
公开(公告)号：US06272018B1
公开(公告)日：2001-08-07
申请号：US09247811
申请日：1999-02-11
申请人： Michael Feld , David Tordjman , Alex Feld
发明人： Michael Feld , David Tordjman , Alex Feld
IPC分类号： H05K702
CPC分类号： H05K1/0269 , G01R31/2813 , H05K3/303 , H05K2201/10689 , H05K2203/161 , H05K2203/163 , H05K2203/168 , Y10T29/49131 , Y10T29/49133
摘要： The invention relates to a method for the verification of the presence and proper orientation of a component on a printed circuit board. The board has a plurality of areas for receiving a component respectively. Each area is marked in the center thereof with a first marker. Adjacent each area, and indicative of the polarity of the component, a second marker is marked on the board. The presence or absence of a component can be evaluated by inspecting the board after it has been populated and determining whether any of the first markers appear, indicating that a component is missing. Verification of the polarity of a component is done by placing a marker on a portion of a component required to be installed in a predetermined position indicative of polarity. Inspection of the board once it has been populated will determine if the component is in the proper orientation by verifying if the second marker and the marker on the component are in alignment. Preferably, the first marker and the second marker are of different colors, and are preferably UV reflecting coatings.
摘要翻译：本发明涉及一种用于验证印刷电路板上部件的存在和正确取向的方法。该板具有分别用于接收部件的多个区域。每个区域的中心都标有第一个标记。邻近每个区域，并指示组件的极性，在板上标记第二个标记。组件的存在或不存在可以通过在填充板之后检查板来确定是否出现任何第一个标记，指示组件丢失，来评估。通过将标记放置在需要安装在指示极性的预定位置的部件的一部分上来实现部件的极性的验证。一旦填充了板的检查，将通过验证组件上的第二个标记和标记是否对齐来确定组件是否处于正确的方向。优选地，第一标记和第二标记具有不同的颜色，并且优选地是UV反射涂层。

8. 发明申请

US20120035442A1 PORTABLE RAMAN DIAGNOSTIC SYSTEM 有权
标题翻译：便携式拉曼诊断系统
公开(公告)号：US20120035442A1
公开(公告)日：2012-02-09
申请号：US13167445
申请日：2011-06-23
申请人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , David Feld , Alison Hearn , Jonathan Feld
发明人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/4312 , A61B5/444 , A61B2560/0223 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/65 , G01N2201/129
摘要： The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
摘要翻译：本发明还涉及特定过滤器组合的选择，其可以提供足够的信息用于多变量校准以提取复杂生物系统中的精确分析物浓度。本发明还描述了引起小型化设计的波长间隔选择方法。最后，本发明提出了多种波长选择方法和小型化分光设备设计以及从一个域（波长选择）到另一个域（设计参数）映射的必要工具。信息谱带的这种选择在使得特别采用拉曼光谱和其他光谱技术的任何临床诊断仪器的小型化方面具有广泛的范围。

9. 发明申请

US20060291712A1 System and method for Hilbert phase imaging 有权
标题翻译：希尔伯特相位成像系统和方法
公开(公告)号：US20060291712A1
公开(公告)日：2006-12-28
申请号：US11389670
申请日：2006-03-24
申请人： Gabriel Popescu , Ramachandra Dasari , Michael Feld , Takahiro Ikeda
发明人： Gabriel Popescu , Ramachandra Dasari , Michael Feld , Takahiro Ikeda
IPC分类号： G06K9/00
CPC分类号： H01L27/14601 , G01N15/10 , G01N15/1475 , G01N21/453 , G01N33/49 , G01N2015/0073 , G01N2015/008 , G01N2015/145 , G01N2015/1454 , G01N2015/1497 , G06K9/00134
摘要： Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.
摘要翻译：希尔伯特相位显微镜（HPM）作为用于测量与光学透明物体相关的高横向分辨率定量相位图像的光学技术。由于其单次性质，HPM适用于调查在诸如生物细胞的透明结构中发生的快速现象。优选的实施例用于测量生物系统，包括对红血细胞的测量，而其量化毫秒级别的动态过程的能力可以用蒸发微米级水滴的测量来说明。

10. 发明申请

US20050057756A1 Systems and methods for phase measurements 有权
标题翻译：相位测量的系统和方法
公开(公告)号：US20050057756A1
公开(公告)日：2005-03-17
申请号：US10823389
申请日：2004-04-13
申请人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
发明人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
IPC分类号： G01B9/02 , G01J9/04 , G01N21/45
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中。

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