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1. 发明授权

US4414325A Method for measurement of trace enzyme 失效
标题翻译：痕量酶的测定方法
公开(公告)号：US4414325A
公开(公告)日：1983-11-08
申请号：US298814
申请日：1981-09-02
申请人： Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Hajime Makiuchi
发明人： Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Hajime Makiuchi
IPC分类号： G01N33/536 , C12Q1/00 , C12Q1/34 , G01N33/53 , G01N33/52 , G01N33/54 , G01N33/58
CPC分类号： C12Q1/34 , C12Q1/00 , C12Q2334/00 , C12Q2337/00 , G01N2333/976 , Y10S435/962 , Y10S436/805
摘要： The amount of enzyme is determined by reacting an enzyme to be measured with a synthetic substrate having at least one structure to be specifically contacted with the enzyme and at least one spectral sensitizer structure, bringing either the reaction product having the spectral sensitizer structure or the unreacted synthetic substrate into contact with a silver halide emulsion layer, exposing the same to light of a spectral sensitizing wavelength region corresponding to the spectral sensitizer structure, developing the silver halide, and then measuring the optical density of developed silver and/or colored dye.
摘要翻译：酶的量通过使待测量的酶与具有至少一种与酶特异性接触的结构的合成底物和至少一种光谱增感剂结构反应，使具有光谱增感剂结构的反应产物或未反应的合成基底与卤化银乳剂层接触，将其暴露于对应于光谱敏化剂结构的光谱增感波长区域的光，显影卤化银，然后测量显影的银和/或着色染料的光密度。

2. 发明授权

US4429050A Competitive immunochemical measurement of plural trace components involving spectral sensitizing dye labels 失效
标题翻译：涉及光谱增感染料标签的多种微量成分的竞争性免疫化学测定
公开(公告)号：US4429050A
公开(公告)日：1984-01-31
申请号：US298811
申请日：1981-09-02
申请人： Yukio Yasuda , Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Nobuo Hiratsuka
发明人： Yukio Yasuda , Nobuhito Masuda , Yuji Mihara , Masaki Okazaki , Nobuo Hiratsuka
IPC分类号： G03C5/00 , G01N33/532 , G01N33/536 , G01N33/58 , G03C1/12 , G03C5/04 , G01N33/54 , G01N33/52 , G01N33/74
CPC分类号： G03C5/04 , G01N33/583 , Y10S436/80 , Y10S436/805 , Y10S436/817
摘要： A method for the simultaneous immunochemical assay of trace components in a sample involving competitively reacting the antigens or antibodies in a sample and labeled antigens or labeled antibodies for limited binding sites. The labels are spectral sensitizing dyes. The reaction products are contacted with silver halide and exposed to light having wavelengths corresponding to the absorption spectra of the spectral sensitizing dyes.
摘要翻译：用于同时免疫化学测定样品中痕量组分的方法，其涉及使样品中的抗原或抗体与标记的抗原或标记的抗体竞争性地反应以用于有限的结合位点。标签是光谱增感染料。反应产物与卤化银接触并暴露于具有对应于光谱增感染料的吸收光谱的波长的光。

3. 发明授权

US4405711A Analysis element for immunochemical measurement of trace components and method for immunochemical measurement using the same 失效
标题翻译：痕量成分的免疫化学测定用分析元素及其免疫化学测定方法
公开(公告)号：US4405711A
公开(公告)日：1983-09-20
申请号：US298812
申请日：1981-09-02
申请人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
发明人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
IPC分类号： G01N33/536 , C12Q1/00 , G01N31/22 , G01N33/53 , G01N33/543 , G01N33/58 , G01N33/54 , G01N33/52
CPC分类号： G01N33/583 , G01N33/53 , Y10S435/805 , Y10S435/962 , Y10S436/805 , Y10S436/807
摘要： In a method of assay for a trace component such as antigen, antibody or enzyme utilizing immunochemical reaction or enzyme reaction in combination with photographic detection system comprising measuring optical density of a silver image formed in proportion to the antigen, antibody or enzyme to be measured, a novel analysis sheet comprising a support having provided thereon, in succession, a water absorbing layer and a silver halide emulsion layer is employed. The analysis sheet essentially increases the amount of water absorbed so that the analysis sheet is extremely effective for improving detection sensitivity.
摘要翻译：在利用免疫化学反应或酶反应的微量组分如抗原，抗体或酶的测定方法中，与照相检测系统组合，包括测量与待测量的抗原，抗体或酶成比例形成的银影像的光密度，一种新颖的分析片，其中包括一个其上提供吸水层和卤化银乳剂层的支撑体。分析表基本上增加了吸收的水分量，使分析纸对提高检测灵敏度非常有效。

4. 发明授权

US4337063A Competitive immunoassay using spectral sensitizer label 失效
标题翻译：使用光谱敏化标签进行竞争性免疫测定
公开(公告)号：US4337063A
公开(公告)日：1982-06-29
申请号：US126920
申请日：1980-03-03
申请人： Yuji Mihara , Nobuhito Masuda , Nobuo Hiratsuka , Takushi, both of Miyazako , Tadashi Ikeda
发明人： Yuji Mihara , Nobuhito Masuda , Nobuo Hiratsuka , Takushi, both of Miyazako , Tadashi Ikeda
IPC分类号： G01N33/536 , G01N33/532 , G01N33/537 , G01N33/54 , G01N33/58
CPC分类号： G01N33/537 , G01N33/532 , Y10S436/805 , Y10S436/815 , Y10S436/817
摘要： Method for immunological analysis of a trace component(s) by labelling an antigen or antibody with a marker comprising causing an immune reaction using an antigen or antibody labelled with a spectral sensitizer as a marker, separating the labelled antigen or antibody from the resulting antigen-antibody reaction product, then bringing either the labelled antigen or antibody and the labelled antigen-antibody reaction product into contact with a silver halide, exposing the resulting system to light having a wavelength which the spectral sensitizer absorbs, developing the thus exposed silver halide and then measuring the resulting density.Trace components can thus be photochemically detected and the amount present quantitatively determined. The method provides high reproducibility and high sensitivity comparable to radioimmunoassay but without any risk of radiation exposure.
摘要翻译：通过使用标记抗原或抗体来标记抗原或抗体的免疫学分析方法，所述标记包括使用用光谱增感剂标记的抗原或抗体作为免疫反应作为标记，从得到的抗原 - 然后使标记的抗原或抗体和标记的抗原 - 抗体反应产物与卤化银接触，将所得体系暴露于具有光谱增感剂吸收的波长的光，从而显现出由此暴露的卤化银，然后测量所得密度。因此可以光化学检测痕量成分，定量确定量。该方法提供了与放射免疫测定相当的高重现性和高灵敏度，但没有任何辐射暴露的风险。

5. 发明授权

US4404289A Method for immunochemical measurement of trace components 失效
标题翻译：微量元素免疫化学测定方法
公开(公告)号：US4404289A
公开(公告)日：1983-09-13
申请号：US298719
申请日：1981-09-02
申请人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
发明人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
IPC分类号： G01N33/58 , G01N33/54 , G01N33/52
CPC分类号： G01N33/583 , Y10S435/805 , Y10S436/805 , Y10S436/807
摘要： In an immunochemical measurement method of an antigen or antibody which comprises competitively reacting an antigen or antibody labelled with spectral sensitizer and an antigen or antibody to be measured, bringing either the reaction product of immune reaction or the unreacted component into contact with silver halide, exposing the same to light having a wavelength which the spectral sensitizer absorbs, developing the exposed silver, and, measuring optical density of the thus formed silver image and/or colored dye, the contact with silver halide is performed in the presence of a specific hydrazine compound. Thus, detection sensitivity is markedly improved.
摘要翻译：在抗原或抗体的免疫化学测定方法中，其包括将标记有光谱敏化剂的抗原或抗体与要测量的抗原或抗体竞争性地反应，使免疫反应的反应产物或未反应的组分与卤化银接触，与具有光谱敏化剂吸收的波长的光相同，曝光的银显影，并且测量由此形成的银图像和/或着色染料的光密度，与卤化银的接触在特定肼化合物的存在下进行。因此，检测灵敏度显着提高。

6. 发明授权

US4337065A Method for immunological assay using multilayer analysis sheet 失效
标题翻译：使用多层分析片的免疫测定方法
公开(公告)号：US4337065A
公开(公告)日：1982-06-29
申请号：US191784
申请日：1980-09-29
申请人： Nobuo Hiratsuka , Yuji Mihara , Nobuhito Masuda , Takushi Miyazako
发明人： Nobuo Hiratsuka , Yuji Mihara , Nobuhito Masuda , Takushi Miyazako
IPC分类号： G03C1/00 , G01N33/536 , G01N33/543 , G01N33/54 , G01N33/52 , G01N33/58
CPC分类号： G01N33/54386
摘要： In a photochemical immunological assay, an antigen or antibody is labelled with a spectral sensitizer or fogging agent for photographic use, and then an immune reaction is caused. The resulting reaction mixture is dropwise added to a multilayer analysis sheet. After either one of the labelled antigen or antibody (F) or the labelled antigen-antibody bound product (B) is brought into contact with silver halide by passing either one through a B/F separating layer provided in the multilayer analysis sheet, the analysis sheet is exposed with a light that the spectral sensitizer or fogging agent absorbs. Then, the resulting optical density obtained by development processing when a spectral sensitizer is used, or without development processing when a fogging agent is used is measured.The multilayer analysis sheet comprises a support having provided thereon a silver halide layer and a B/F separating layer and makes the photochemical immunological assay simpler and more accurate.
摘要翻译：在光化学免疫测定中，抗原或抗体用光谱增感剂或雾化剂标记，用于照相用途，然后引起免疫反应。将所得反应混合物滴加到多层分析片中。将标记的抗原或抗体（F）或标记的抗原 - 抗体结合产物（B）中的任一个通过使任一种通过多层分析片中提供的B / F分离层与卤化银接触，分析片材被光谱增感剂或起雾剂吸收的光暴露。然后，测量当使用光谱增感剂时通过显影处理获得的所得光密度，或者当使用起雾剂时不进行显影处理。多层分析片包括其上设置有卤化银层和B / F分离层的载体，并使光化学免疫测定更简单并且更准确。

7. 发明授权

US4331444A Competitive immunoassay using silver halide fogging agent 失效
标题翻译：使用卤化银雾化剂进行竞争性免疫测定
公开(公告)号：US4331444A
公开(公告)日：1982-05-25
申请号：US126919
申请日：1980-03-03
申请人： Yuji Mihara , Nobuhito Masuda , Nobuo Hiratsuka , Takushi Miyazako , Shigeo Hirano
发明人： Yuji Mihara , Nobuhito Masuda , Nobuo Hiratsuka , Takushi Miyazako , Shigeo Hirano
IPC分类号： G01N33/536 , G01N33/537 , G01N33/54 , G01N33/58
CPC分类号： G01N33/537 , Y10S436/805
摘要： In a method for the immunological analysis of trace components by marking or labelling an antigen or antibody with a marker, an immune reaction is caused using an antigen or antibody marked with a fogging agent for silver halide, the labelled antigen or antibody is separated from the labelled antigen-antibody reaction product, the silver halide is developed in the presence of either one of the labelled antigen or antibody and the labelled antigen-antibody reaction product, and the density obtained is measured.The method is comparable to radioimmunoassay in having high reproductibility and sufficient sensitivity but does not involve any risk due to radiation.
摘要翻译：在通过用标记物标记或标记抗原或抗体来对痕量组分的免疫分析的方法中，使用用卤化银的起雾剂标记的抗原或抗体引起免疫反应，将标记的抗原或抗体从标记的抗原 - 抗体反应产物，在标记的抗原或抗体之一和标记的抗原 - 抗体反应产物的存在下显影卤化银，并测量获得的密度。该方法与放射免疫测定相当，具有高的可再生性和足够的灵敏度，但不涉及由于辐射引起的任何风险。

8. 发明授权

US4552837A Silver halide photographic emulsions 失效
标题翻译：卤化银照相乳剂
公开(公告)号：US4552837A
公开(公告)日：1985-11-12
申请号：US598945
申请日：1984-04-11
申请人： Masaki Okazaki , Osami Tanabe , Satoshi Nagaoka , Yuji Mihara , Toshinao Ukai
发明人： Masaki Okazaki , Osami Tanabe , Satoshi Nagaoka , Yuji Mihara , Toshinao Ukai
IPC分类号： G03C1/28 , G03C7/26 , G03C1/02
CPC分类号： G03C1/28
摘要： A silver halide color photographic emulsion is described, containing at least one sensitizing dye represented by formula (I) and at least one compound represented by formula (II). The use of compounds of formula (I) in combination with compounds of formula (II) permits the spectral sensitization of photographic emulsions without extending the wavelength region of spectral sensitivity, enabling the production of a light-sensitive material of high sensitivity and reduced fog. ##STR1## (The symbols V, W.sub.1, W.sub.2, R.sub.1, R.sub.2, R.sub.3, X, n, R.sub.5, Y, X.sub.1, m.sub.1 and m.sub.2 are as defined in the appended claims).
摘要翻译：描述了含有至少一种由式（I）表示的敏化染料和至少一种由式（II）表示的化合物的卤化银彩色照相乳剂。式（I）化合物与式（II）化合物的组合使用可以使照相乳剂的光谱增感不扩大光谱灵敏度的波长范围，从而能够生产高灵敏度和减少雾的感光材料。（图）（II）（符号V，W1，W2，R1，R2，R3，X，n，R5，Y，X1，m1和m2如所附权利要求所限定）。

9. 发明授权

US4362813A Silver halide photographic emulsions 失效
标题翻译：卤化银照相乳剂
公开(公告)号：US4362813A
公开(公告)日：1982-12-07
申请号：US278031
申请日：1981-06-29
申请人： Yuji Mihara , Tadashi Ikeda , Haruo Takei , Masaki Okazaki , Yasuo Aotsuka
发明人： Yuji Mihara , Tadashi Ikeda , Haruo Takei , Masaki Okazaki , Yasuo Aotsuka
IPC分类号： G03C1/28 , G03C1/29 , G03C1/40 , G03C1/18
CPC分类号： G03C1/29
摘要： A light-sensitive silver halide photographic emulsion characterized by containing a combination of at least one sensitizing dye represented by formula (I) and at least one sensitizing dye represented by formula (II). ##STR1## A silver halide color photographic light-sensitive element comprising a support having thereon at least one light-sensitive emulsion layer comprising a sensitizing dye represented by formula (I) and a sensitizing dye represented by formula (II) is also described.
摘要翻译：一种感光卤化银照相乳剂，其特征在于含有至少一种由式（I）表示的敏化染料和至少一种由式（II）表示的增感染料的组合。（I）一种卤化银彩色摄影感光元件，其包括其上具有至少一个感光乳剂层的载体，所述感光乳剂层包含由式（I）表示的敏化染料和由式（I）表示的增感染料，还描述了式（II）。

10. 发明授权

US5338656A Silver halide photographic material 失效
标题翻译：卤化银照相材料
公开(公告)号：US5338656A
公开(公告)日：1994-08-16
申请号：US49428
申请日：1993-04-21
申请人： Akihiko Ikegawa , Yuji Mihara , Masaki Okazaki
发明人： Akihiko Ikegawa , Yuji Mihara , Masaki Okazaki
IPC分类号： G03C1/22 , G03C1/12
CPC分类号： G03C1/22
摘要： Disclosed is a silver halide photographic material comprising at least one compound (merocyanine dye) represented by the following general formula (I): ##STR1## wherein Z represents nonmetal atoms necessary to complete a 5- or 6-membered heterocyclic ring; X represents non-metal atoms necessary to complete a 5- or 6-membered acidic nucleus; R.sup.2 represents --(CH.sub.2).sub.r --CONHSO.sub.2 --R.sup.3, --(CH.sub.2).sub.s --SO.sub.2 NHCO--R.sup.4, --(CH.sub.2).sub.t --CONHCO--R.sup.5 or --(CH.sub.2).sub.u --SO.sub.2 NHSO.sub.2 --R.sup.6 ; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each represent an alkyl group, an alkoxy group or an amino group; r, s, t and u each represent an integer from 1 to 5; R.sup.1 has the same meaning as R.sup.2 or represents an alkyl group substituted by a sulfo or carboxyl group; p represents 0 or 1; L.sub.1 and L.sub.2 each represent a methine group; and n represents 0, 1, 2 or 3.
摘要翻译：公开了包含由以下通式（I）表示的至少一种化合物（部花青染料）的卤化银照相材料：其中Z表示完成5-或6-元杂环所必需的非金属原子; X表示完成5或6元酸性核所必需的非金属原子; R2表示 - （CH2）r-CONHSO2-R3， - （CH2）s-SO2NHCO-R4， - （CH2）t-CONHCO-R5或 - （CH2）u-SO2NHSO2-R6; R3，R4，R5和R6各自表示烷基，烷氧基或氨基; r，s，t和u各自表示1〜5的整数; R1具有与R 2相同的含义或表示被磺基或羧基取代的烷基; p表示0或1; L1和L2各自表示次甲基; n表示0,1,2或3。

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