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1. 发明授权

US4405711A Analysis element for immunochemical measurement of trace components and method for immunochemical measurement using the same 失效
标题翻译：痕量成分的免疫化学测定用分析元素及其免疫化学测定方法
公开(公告)号：US4405711A
公开(公告)日：1983-09-20
申请号：US298812
申请日：1981-09-02
申请人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
发明人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
IPC分类号： G01N33/536 , C12Q1/00 , G01N31/22 , G01N33/53 , G01N33/543 , G01N33/58 , G01N33/54 , G01N33/52
CPC分类号： G01N33/583 , G01N33/53 , Y10S435/805 , Y10S435/962 , Y10S436/805 , Y10S436/807
摘要： In a method of assay for a trace component such as antigen, antibody or enzyme utilizing immunochemical reaction or enzyme reaction in combination with photographic detection system comprising measuring optical density of a silver image formed in proportion to the antigen, antibody or enzyme to be measured, a novel analysis sheet comprising a support having provided thereon, in succession, a water absorbing layer and a silver halide emulsion layer is employed. The analysis sheet essentially increases the amount of water absorbed so that the analysis sheet is extremely effective for improving detection sensitivity.
摘要翻译：在利用免疫化学反应或酶反应的微量组分如抗原，抗体或酶的测定方法中，与照相检测系统组合，包括测量与待测量的抗原，抗体或酶成比例形成的银影像的光密度，一种新颖的分析片，其中包括一个其上提供吸水层和卤化银乳剂层的支撑体。分析表基本上增加了吸收的水分量，使分析纸对提高检测灵敏度非常有效。

2. 发明授权

US4404289A Method for immunochemical measurement of trace components 失效
标题翻译：微量元素免疫化学测定方法
公开(公告)号：US4404289A
公开(公告)日：1983-09-13
申请号：US298719
申请日：1981-09-02
申请人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
发明人： Nobuhito Masuda , Shigeru Nagatomo , Yuji Mihara
IPC分类号： G01N33/58 , G01N33/54 , G01N33/52
CPC分类号： G01N33/583 , Y10S435/805 , Y10S436/805 , Y10S436/807
摘要： In an immunochemical measurement method of an antigen or antibody which comprises competitively reacting an antigen or antibody labelled with spectral sensitizer and an antigen or antibody to be measured, bringing either the reaction product of immune reaction or the unreacted component into contact with silver halide, exposing the same to light having a wavelength which the spectral sensitizer absorbs, developing the exposed silver, and, measuring optical density of the thus formed silver image and/or colored dye, the contact with silver halide is performed in the presence of a specific hydrazine compound. Thus, detection sensitivity is markedly improved.
摘要翻译：在抗原或抗体的免疫化学测定方法中，其包括将标记有光谱敏化剂的抗原或抗体与要测量的抗原或抗体竞争性地反应，使免疫反应的反应产物或未反应的组分与卤化银接触，与具有光谱敏化剂吸收的波长的光相同，曝光的银显影，并且测量由此形成的银图像和/或着色染料的光密度，与卤化银的接触在特定肼化合物的存在下进行。因此，检测灵敏度显着提高。

3. 发明授权

US4472498A Analysis film and a method of analysis using the same 失效
标题翻译：分析胶片和使用其的分析方法
公开(公告)号：US4472498A
公开(公告)日：1984-09-18
申请号：US401771
申请日：1982-07-26
申请人： Nobuhito Masuda , Yukio Yasuda , Shigeru Nagatomo , Hajime Makiuchi , Masaki Okazaki
发明人： Nobuhito Masuda , Yukio Yasuda , Shigeru Nagatomo , Hajime Makiuchi , Masaki Okazaki
IPC分类号： G01N33/52 , G01N33/535 , G01N33/542 , G01N33/543 , G01N33/54 , G01N33/78
CPC分类号： G01N33/542 , G01N33/521 , G01N33/535 , G01N33/54386 , Y10S435/805 , Y10S435/97 , Y10S436/81 , Y10S436/815
摘要： An analysis film comprises a reagent layer composed of a porous material which contains an antibody but does not substantially contain a complex of an analyte or a labelled antigen with the antibody. In the analysis film, reagents for enzyme immune reaction of homogenous type are incorporated so that an analyte is analyzed without requiring B/F separation. An analysis method for various analytes using the same provides high sensitivity, high accuracy as well as good reproducibility and is simple and rapid.
摘要翻译：分析膜包括由含有抗体但基本上不含有分析物或标记抗原与抗体的复合物的多孔材料构成的试剂层。在分析膜中，并入用于均匀型酶免疫反应的试剂，从而分析分析物而不需要B / F分离。使用该方法的各种分析物的分析方法提供高灵敏度，高精度以及良好的再现性，并且简单快速。

4. 发明授权

US4861552A Biological reaction layer and its preparation 失效
标题翻译：生物反应层及其制备
公开(公告)号：US4861552A
公开(公告)日：1989-08-29
申请号：US851878
申请日：1986-04-11
申请人： Nobuhito Masuda , Shigeru Nagatomo , Hajime Makiuchi , Yukio Yasuda
发明人： Nobuhito Masuda , Shigeru Nagatomo , Hajime Makiuchi , Yukio Yasuda
IPC分类号： G01N33/52 , C12M1/00 , G01N33/543 , G01N33/78 , C12Q1/00 , G01N33/548
CPC分类号： G01N33/78 , G01N33/54386 , Y10S435/805 , Y10S436/81
摘要： A biological reaction layer of a dry analytical element in the form of a composite porous layer in which a particulate material carrying a biologically active material fixed thereon is dispersed in a fibrous porous matrix, characterized in that the dry weight ratio of said particulate material to said fibrous material contained in said composite porous layer ranges from 1:20 to 1:0.3 and said particulate material is contained therein in the range of 1 to 60 g/m.sup.2.
摘要翻译：复合多孔层形式的干燥分析元件的生物反应层，其中载有固定在其上的生物活性材料的颗粒材料分散在纤维多孔基质中，其特征在于，所述颗粒材料与所述所述复合多孔层中含有的纤维状物质的含量为1:20〜1:0.3，所述粒状物质的含量为1〜60g / m 2。

5. 发明授权

US4587102A Multi-layer analysis element utilizing specific binding reaction 失效
标题翻译：利用特异性结合反应的多层分析元件
公开(公告)号：US4587102A
公开(公告)日：1986-05-06
申请号：US637324
申请日：1984-08-02
申请人： Shigeru Nagatomo , Yukio Yasuda , Nobuhito Masuda , Hajime Makiuchi , Masaki Okazaki
发明人： Shigeru Nagatomo , Yukio Yasuda , Nobuhito Masuda , Hajime Makiuchi , Masaki Okazaki
IPC分类号： G01N33/58 , G01N33/52 , G01N33/543 , G01N21/78 , G01N33/53
CPC分类号： G01N33/54386 , G01N33/525 , Y10S435/805 , Y10S436/81
摘要： A dry type multilayer analysis element for assaying a concentration of a specific component utilizing a competitive immunological reaction comprises a detection element comprising a detection layer which receives a labelled complex formed as a result of the competitive immunological reaction or an optically detectable change formed dependent upon an amount of the labelled complex of the specific component and having further provided thereon the detection layer a reaction layer comprising a fibrous porous medium containing fine particles therein. The multilayer analysis element absorbs an amount of a sample solution necessary for the competitive immunological reaction so that the multilayer analysis element has high sensitivity and high reproducibility.
摘要翻译：用于使用竞争性免疫反应测定特定成分的浓度的干式多层分析元件包括检测元件，其包含检测层，该检测层接受由于竞争性免疫反应而形成的标记复合物，或者由量的特定成分的标记复合物，并且还在其上提供检测层，反应层包含其中含有微粒的纤维状多孔介质。多层分析元件吸收竞争性免疫反应所需的样品溶液的量，使得多层分析元件具有高灵敏度和高再现性。

6. 发明申请

US20060214234A1 Semiconductor integrated circuit 失效
公开(公告)号：US20060214234A1
公开(公告)日：2006-09-28
申请号：US11384361
申请日：2006-03-21
申请人： Shigeru Nagatomo
发明人： Shigeru Nagatomo
IPC分类号： H01L23/62
CPC分类号： H01L27/0921
摘要： A semiconductor integrated circuit has complementary field-effect transistors, one formed in a semiconductor substrate, the other formed in a well in the substrate, and has four power-supply potentials: two supplied to the sources of the field-effect transistors, one supplied to the substrate, and one supplied to the well. An unwanted pair of parasitic bipolar transistors are formed in association with the field-effect transistors. An intentionally formed bipolar transistor operates in series with one of the unwanted parasitic transistors and as a current mirror for the other unwanted parasitic transistor, limiting the flow of unwanted current through the parasitic bipolar transistors.

7. 发明授权

US5880514A Protection circuit for semiconductor device 失效
标题翻译：半导体器件保护电路
公开(公告)号：US5880514A
公开(公告)日：1999-03-09
申请号：US941069
申请日：1997-09-30
申请人： Shigeru Nagatomo
发明人： Shigeru Nagatomo
IPC分类号： H01L27/04 , H01L21/822 , H01L27/02 , H01L29/861 , H01L29/00
CPC分类号： H01L27/0248 , H01L27/0255
摘要： A protection circuit for a semiconductor device, the protection circuit being connected an input terminal of the semiconductor device in parallel with an internal circuit proper of the semiconductor device, comprising a semiconductor substrate having one conductivity, a first diffusion layer having the other conductivity produced along the top surface of the semiconductor substrate, a second diffusion layer having the other conductivity produced along the top surface of the first diffusion layer, the impurity concentration of the second diffusion layer being larger than that of the first diffusion layer, at least one third diffusion layer having one conductivity produced along the top surface of the semiconductor substrate and the first diffusion layer across the junction of the first diffusion layer, the impurity concentration being larger than that of the semiconductor substrate, an insulator film produced to cover a portion of the second and third diffusion layers and the first diffusion layer, a pair of insulator films produced to cover a portion of the remaining area of the third diffusion layers, an electrode arranged to contact the second diffusion layer and to cover the insulator layer covering the first diffusion layer, and the electrode being connected the input terminal and the internal circuit proper of the semiconductor device, whereby the protection circuit allows positive surge voltages to escape, and becomes durable against negative surge voltages.
摘要翻译：一种用于半导体器件的保护电路，所述保护电路与所述半导体器件的内部电路本体并联连接所述半导体器件的输入端，所述半导体器件的内部电路包括具有一个导电性的半导体衬底，所述第一扩散层具有沿着半导体衬底的顶表面，具有沿着第一扩散层的顶表面产生的另一导电性的第二扩散层，第二扩散层的杂质浓度大于第一扩散层的杂质浓度，至少一个第三扩散具有沿着半导体衬底的顶表面产生的一个电导率的层和穿过第一扩散层的结的第一扩散层，杂质浓度大于半导体衬底的杂质浓度;产生的绝缘膜覆盖第二扩散层的一部分和第三扩散层和第一扩散层产生用于覆盖第三扩散层的剩余区域的一部分的一对绝缘膜，布置成接触第二扩散层并覆盖覆盖第一扩散层的绝缘体层的电极，并且电极与输入端子和半导体器件的内部电路，由此保护电路允许正的浪涌电压逸出，并且耐负的浪涌电压耐用。

8. 发明授权

US07511561B2 Boosting circuit 失效
标题翻译：升压电路
公开(公告)号：US07511561B2
公开(公告)日：2009-03-31
申请号：US11765519
申请日：2007-06-20
申请人： Shigeru Nagatomo , Kikuo Utsuno
发明人： Shigeru Nagatomo , Kikuo Utsuno
IPC分类号： G05F1/10 , G05F3/02
CPC分类号： H02M3/07
摘要： The present invention provides a charge-pump boosting circuit. In a charging period of a capacitor C1, a PMOS transistor Q1 and an NMOS transistor Q2 turn on, and the capacitor C1 is charged by voltage between a potential VCC and a potential VSS. On the other hand, in a discharging period of a boosting capacitor, a PMOS transistor Q3 and a PMOS transistor Q4 turn on, and charges accumulated in the boosting capacitor are discharged. In a discharging period of the capacitor C1, a selector SEL1 selects a terminal T1, and a feedback system, in which operation voltage applied to a gate of the PMOS transistor Q3 changes in accordance with fluctuations in output potential VDD2, is formed. At this time, only a resistance component of the PMOS transistor Q3 exists and no differential amplifier is provided, on a path of current flowing-into the capacitor C1 (between the potential VCC and a low voltage side terminal C1N of the boosting capacitor).
摘要翻译：本发明提供一种电荷泵升压电路。在电容器C1的充电期间，PMOS晶体管Q1和NMOS晶体管Q2导通，电容器C1由电位VCC和电位VSS之间的电压充电。另一方面，在升压电容器的放电期间，PMOS晶体管Q3和PMOS晶体管Q4导通，并且积蓄在升压电容器中的电荷被放电。在电容器C1的放电期间，选择器SEL1选择端子T1，并且形成其中施加到PMOS晶体管Q3的栅极的工作电压根据输出电位VDD2的波动而变化的反馈系统。此时，在流入电容器C1（电压VCC与升压电容器的低压侧端子C1N之间）的电流路径上，仅存在PMOS晶体管Q3的电阻成分，并且不设置差分放大器。

9. 发明授权

US06335646B1 Power-on reset circuit for generating a reset pulse signal upon detection of a power supply voltage 失效
标题翻译：上电复位电路，用于在检测到电源电压时产生复位脉冲信号
公开(公告)号：US06335646B1
公开(公告)日：2002-01-01
申请号：US09552315
申请日：2000-04-19
申请人： Shigeru Nagatomo
发明人： Shigeru Nagatomo
IPC分类号： H03K1722
CPC分类号： H03K17/223
摘要： A power-on reset circuit includes a capacitor, an inverter, a resistor and first and second transistors which are connected in series between a power supply line and ground. The electric current flowing through the resistor flow through the first and second transistors with a certain time delay because of an electric charge stored in the capacitor. A rising of a power supply voltage is applied to the inverter with a certain time delay when the power supply voltage goes up. According to the power-on reset circuit, a reset pulse can be generated regardless a speed of rising of the power supply voltage.
摘要翻译：上电复位电路包括在电源线和地之间串联连接的电容器，反相器，电阻器和第一和第二晶体管。由于存储在电容器中的电荷，流经电阻器的电流以一定的时间延迟流过第一和第二晶体管。当电源电压上升时，电源电压的上升以一定的时间延迟施加到逆变器。根据上电复位电路，无论电源电压上升的速度如何，均可产生复位脉冲。

10. 发明授权

US4312940A Photographic material containing a novel polymer mordant 失效
标题翻译：含有新型聚合物媒染剂的摄影材料
公开(公告)号：US4312940A
公开(公告)日：1982-01-26
申请号：US166290
申请日：1980-07-07
申请人： Taku Nakamura , Shigeru Nagatomo
发明人： Taku Nakamura , Shigeru Nagatomo
IPC分类号： G03C8/56 , C08F8/00 , C08F8/44 , C08F12/00 , C08F20/00 , C08F20/34 , C08F20/52 , C08F26/00 , G03C1/005 , G03C1/835 , G03C1/84
CPC分类号： G03C1/835 , Y10S430/142
摘要： A photographic light-sensitive material comprising at least one layer containing a polymer dispersion of the following formula (I) or (II) as a mordant ##STR1## wherein A represents a monomer unit obtained from at least one monomer having at least two copolymerizable ethylenically unsaturated groups at least one of which is in the side chain; B represents a monomer unit obtained from at least one copolymerizable monoethylenically unsaturated monomer; D.sup..sym. represents a 5- or 6-membered heterocyclic group containing one or two nitrogen atoms one of which is positively charged and D may contain one or more substituents; R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aralkyl group, or R.sub.2 and R.sub.3 may combine together with the nitrogen atom to which they are attached and form a 5- or 6-membered ring; X.sup..crclbar. represents an anion; Q represents an alkylene group, a phenylene group, an aralkylene group or a group of the formula ##STR2## wherein Y represents an alkylene group or an aralkylene group and R represents an alkyl group; and x, y and z represent the molar percentage of the respective units in the polymer and x is about 0.5 to 10%, y is about 0 to 60% and z is about 30 to 99.5%.
摘要翻译：包含至少一层包含下式（I）或（II）的聚合物分散体作为媒染剂的影像感光材料（I）其中A表示从至少一种具有至少两个可共聚的烯属不饱和基团的单体，其中至少一种在侧链中; B表示由至少一种可共聚的单烯属不饱和单体获得的单体单元; D（+）表示含有一个或两个氮原子的5-或6-元杂环基团，其中一个带正电荷，D可含有一个或多个取代基; R1表示氢原子或低级烷基; R 2和R 3可以相同或不同，各自表示烷基或芳烷基，或者R 2和R 3可以与它们所连接的氮原子一起形成5-或6-元环; X（ - ）表示阴离子; Q表示亚烷基，亚苯基，亚芳烷基或下式的基团：其中Y表示亚烷基或亚芳烷基，R表示烷基; x，y和z表示聚合物中各单元的摩尔百分比，x为约0.5至10％，y为约0至60％，z为约30至99.5％。

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