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1. 发明申请

US20110003286A1 REACTOR PLATE AND REACTION PROCESSING METHOD 有权
标题翻译：反应板和反应处理方法
公开(公告)号：US20110003286A1
公开(公告)日：2011-01-06
申请号：US12525947
申请日：2007-11-19
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34
CPC分类号： B01L3/502723 , B01L3/5025 , B01L3/502738 , B01L3/50853 , B01L2200/0684 , B01L2200/141 , B01L2300/046 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2400/0622 , B01L2400/0644 , G01N35/1097
摘要： Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and (21) connected to the reaction well (5). The reaction well channel has a main channel (13), a metering channel (15) branched off the main channel (13), and an injection channel (17) of which one end is connected to the metering channel (15) and the other end is connected to the reaction well (5). The main channel (13) and the reaction well air vent channel (21) can be hermetically sealed. The injection channel (17) is formed narrower than the metering channel (15) not so as to allow the passage of a liquid at a liquid introduction pressure applied to introduce the liquid into the main channel (13) and the metering channel (15) and at a purge pressure applied to purge the liquid from the main channel (13) but so as to allow the passage of the liquid at a pressure higher than the liquid introduction pressure and the purge pressure.
摘要翻译：本文公开了一种反应器板，其防止异物从外部进入并且污染周围环境。反应器板（1）包括反应井（5），连接到反应井（5）的反应井通道和连接到反应井（5）的反应井排气通道（19）和（21）。反应井通道具有主通道（13），从主通道（13）分支的计量通道（15）和注入通道（17），其一端连接到计量通道（15），另一端连接到计量通道末端连接到反应槽（5）。主通道（13）和反应孔排气通道（21）可以密封。注射通道（17）形成得比计量通道（15）窄，使得能够以施加液体引入压力的液体通过以将液体引入主通道（13）和计量通道（15）并且施加吹扫压力以从主通道（13）吹扫液体，但是允许液体在比液体引入压力和吹扫压力高的压力下通过。

2. 发明授权

US09550184B2 Reactor plate and reaction processing method 有权
标题翻译：反应板和反应处理方法
公开(公告)号：US09550184B2
公开(公告)日：2017-01-24
申请号：US12525947
申请日：2007-11-19
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
IPC分类号： C12M1/00 , B01L3/00 , G01N35/10
CPC分类号： B01L3/502723 , B01L3/5025 , B01L3/502738 , B01L3/50853 , B01L2200/0684 , B01L2200/141 , B01L2300/046 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2400/0622 , B01L2400/0644 , G01N35/1097
摘要： Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and (21) connected to the reaction well (5). The reaction well channel has a main channel (13), a metering channel (15) branched off the main channel (13), and an injection channel (17) of which one end is connected to the metering channel (15) and the other end is connected to the reaction well (5). The main channel (13) and the reaction well air vent channel (21) can be hermetically sealed. The injection channel (17) is formed narrower than the metering channel (15) not so as to allow the passage of a liquid at a liquid introduction pressure applied to introduce the liquid into the main channel (13) and the metering channel (15) and at a purge pressure applied to purge the liquid from the main channel (13) but so as to allow the passage of the liquid at a pressure higher than the liquid introduction pressure and the purge pressure.
摘要翻译：本文公开了一种反应器板，其防止异物从外部进入并且污染周围环境。反应器板（1）包括反应井（5），连接到反应井（5）的反应井通道和连接到反应井（5）的反应井排气通道（19）和（21）。反应井通道具有主通道（13），从主通道（13）分支的计量通道（15）和注入通道（17），其一端连接到计量通道（15），另一端连接到计量通道末端连接到反应槽（5）。主通道（13）和反应孔排气通道（21）可以密封。注射通道（17）形成得比计量通道（15）窄，使得能够以施加液体引入压力的液体通过以将液体引入主通道（13）和计量通道（15）并且施加吹扫压力以从主通道（13）吹扫液体，但是允许液体在比液体引入压力和吹扫压力高的压力下通过。

3. 发明授权

US08568668B2 Micro droplet operation device and reaction processing method using the same 有权
标题翻译：微滴操作装置和反应处理方法采用相同的方法
公开(公告)号：US08568668B2
公开(公告)日：2013-10-29
申请号：US12746749
申请日：2007-12-10
申请人： Masakazu Akechi , Masaki Kanai , Takahiro Nishimoto , Nobuhiro Hanafusa
发明人： Masakazu Akechi , Masaki Kanai , Takahiro Nishimoto , Nobuhiro Hanafusa
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/04 , B01L2300/046 , B01L2300/0816 , B01L2300/0858 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2400/0622 , B01L2400/0644 , B01L2400/084 , C12M23/12 , G01N2035/00158 , G01N2035/1034
摘要： Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).
摘要翻译：微滴精确地放置在反应井中。反应井（5）形成在井底（3）的一个表面中。通道底座（11）放置在井底（3）上。通道底座11在其表面上与井底（3）连接，具有液体引入通道（12a）和反应井排气通道（18a）。通道底座（11）还具有与反应槽（5）相对形成并从液体导入通道（12a）的上表面向上凹陷的凹部（27）。当从上方观察时，凹部（27）的肩部（26）放置在反应槽（5）和液体导入通道（12a）之间的连接部分附近，并且更靠近反应槽（5）的中心）比反应井（5）的肩部（16）。

4. 发明授权

US08697010B2 Dispensing device 有权
标题翻译：点胶装置
公开(公告)号：US08697010B2
公开(公告)日：2014-04-15
申请号：US12746698
申请日：2007-12-19
申请人： Masaki Kanai , Takahiro Nishimoto , Masakazu Akechi , Nobuhiro Hanafusa
发明人： Masaki Kanai , Takahiro Nishimoto , Masakazu Akechi , Nobuhiro Hanafusa
IPC分类号： B01L99/00
CPC分类号： B01L3/0293 , B01L3/502723 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/0688 , G01N35/1016 , G01N2035/1039 , G01N2035/1062
摘要： A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.
摘要翻译：用于减少液体样品的死体积的分配装置包括连接到样品入口和样品出口的主通道以及连接到主通道的分支通道。每个分支通道连接到不同的液体储存器。在分支通道之间和分支通道与样品出口之间的主通道中设有高流入耐压部分。每个高流入耐压部分具有与液体样品形成90°或更大接触角的通道内壁。液体样品通过样品入口进入主通道，到达第一分支通道和主通道之间的分支点流入第一分支通道和液体储存器，然后通过高流入耐压部分到达分支点在下一个分支信道和主信道之间。

5. 发明申请

US20110036862A1 DISPENSING DEVICE 有权
标题翻译：分配设备
公开(公告)号：US20110036862A1
公开(公告)日：2011-02-17
申请号：US12746698
申请日：2007-12-19
申请人： Masaki Kanai , Takahiro Nishimoto , Masakazu Akechi , Nobuhiro Hanafusa
发明人： Masaki Kanai , Takahiro Nishimoto , Masakazu Akechi , Nobuhiro Hanafusa
IPC分类号： B67D7/16
CPC分类号： B01L3/0293 , B01L3/502723 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/0688 , G01N35/1016 , G01N2035/1039 , G01N2035/1062
摘要： Disclosed herein is a dispensing device capable of reducing the dead volume of a liquid sample. The dispensing device includes a main channel (3) whose one end is connected to a sample inlet (13) and whose other end is connected to a sample outlet (15), and a plurality of branch channels (5) connected to the main channel (3). The branch channels (5) are each connected to different liquid reservoirs (7) at their ends located on the opposite side from the main channel (3). A plurality of high inflow-withstanding pressure sections (17) having a higher inflow-withstanding pressure than the branch channel (5) are provided in the main channel (3) between the branch channels (5) and (5) and between the branch channel (5) and the sample outlet (15). Each of the high inflow-withstanding pressure sections (17) has a channel inner wall which forms a contact angle of 90° or larger with a liquid sample. A liquid sample introduced into the main channel (3) through the sample inlet (13) reaches a branch point between the first branch channel (5) and the main channel (3). Then, the liquid sample flows into the first branch channel (5) and the liquid reservoir (7) because the high inflow-withstanding pressure section (17) is provided in the main channel (3) between the first branch point and the next branch point. After the first branch channel (5) and the liquid reservoir (7) are filled with the liquid sample, the liquid sample passes through the high inflow-withstanding pressure section (17) and is led to a branch point between the next branch channel and the main channel.
摘要翻译：本文公开了一种能够减少液体样品的死体积的分配装置。分配装置包括主通道（3），其一端连接到样品入口（13）并且另一端连接到样品出口（15），以及多个分支通道（5）连接到主通道（3）。分支通道（5）各自在位于与主通道（3）相反的一侧的端部处连接到不同的液体储存器（7）。在分支通道（5）和（5）之间的主通道（3）中，在分支通道（5）和（5）之间的主通道（3）中设有多个具有比分支通道（5）更高的流入经受压力的高流入耐压部分（17）通道（5）和样品出口（15）。每个高流入耐压部分（17）具有与液体样品形成90°或更大接触角的通道内壁。通过样品入口（13）引入主通道（3）的液体样品到达第一分支通道（5）和主通道（3）之间的分支点。然后，由于在第一分支点和下一分支之间的主通道（3）中设置有高流入耐压部（17），所以液体样品流入第一分支通道（5）和液体储存器（7）点。在第一分支通道（5）和液体储存器（7）填充液体样品之后，液体样品通过高流入耐压部分（17），并被引导到下一个分支通道和主渠道。

6. 发明申请

US20100294811A1 MICRO DROPLET OPERATION DEVICE AND REACTION PROCESSING METHOD USING THE SAME 有权
标题翻译： MICRO DROPLET OPERING DEVICE AND REACTION PROCESSING METHOD WITH THE SAME
公开(公告)号：US20100294811A1
公开(公告)日：2010-11-25
申请号：US12746749
申请日：2007-12-10
申请人： Masakazu Akechi , Masaki Kanai , Takahiro Nishimoto , Nobuhiro Hanafusa
发明人： Masakazu Akechi , Masaki Kanai , Takahiro Nishimoto , Nobuhiro Hanafusa
IPC分类号： B65D47/18
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/04 , B01L2300/046 , B01L2300/0816 , B01L2300/0858 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2400/0622 , B01L2400/0644 , B01L2400/084 , C12M23/12 , G01N2035/00158 , G01N2035/1034
摘要： Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).
摘要翻译：微滴精确地放置在反应井中。反应井（5）形成在井底（3）的一个表面中。通道底座（11）放置在井底（3）上。通道底座11在其表面上与井底（3）连接，具有液体引入通道（12a）和反应井排气通道（18a）。通道底座（11）还具有与反应槽（5）相对形成并从液体导入通道（12a）的上表面向上凹陷的凹部（27）。当从上方观察时，凹部（27）的肩部（26）放置在反应槽（5）和液体导入通道（12a）之间的连接部分附近，并且更靠近反应槽（5）的中心）比反应井（5）的肩部（16）。

7. 发明申请

US20150260694A1 GAS CHROMATOGRAPHY DEVICE 有权
标题翻译：气相色谱仪
公开(公告)号：US20150260694A1
公开(公告)日：2015-09-17
申请号：US14427053
申请日：2012-09-11
申请人： Satoshi Matsuoka , Takahiro Nishimoto , Masaki Kanai , Masanori Nishino
发明人： Satoshi Matsuoka , Takahiro Nishimoto , Masaki Kanai , Masanori Nishino
IPC分类号： G01N30/30 , G01N30/16
CPC分类号： G01N30/30 , G01N30/16 , G01N30/54 , G01N2030/3007 , G01N2030/3046 , G01N2030/3084
摘要： A gas chromatography device includes a sample injection part, a detector, a separation column, and a transfer line connecting between the sample injection part and the separation column and between the sample injection part and the detector. Furthermore, a column temperature adjustment part for adjusting the temperature of the separation column, and a line temperature adjustment part for adjusting the temperature of the transfer line are provided. The line temperature adjustment part is structured to include a heat block which includes a heating element and which is in contact with the transfer line from one side, and a holding member which presses the transfer line toward the heat block side by being in contact from the other side, and to sandwich the transfer line by the heat block and the holding member.
摘要翻译：气相色谱装置包括样品注入部分，检测器，分离柱和连接在样品注射部分和分离柱之间以及样品注射部分和检测器之间的传输线。此外，提供了用于调节分离塔的温度的色谱柱温度调节部分和用于调节传输线的温度的管线温度调节部件。线路温度调节部构成为包括：加热元件，其与一侧的输送线接触的热块，以及通过与传热线接触从而将传送线朝向加热块侧按压的保持部件并且通过加热块和保持构件夹住输送线。

8. 发明授权

US09897576B2 Gas chromatography device 有权
公开(公告)号：US09897576B2
公开(公告)日：2018-02-20
申请号：US14427053
申请日：2012-09-11
申请人： Satoshi Matsuoka , Takahiro Nishimoto , Masaki Kanai , Masanori Nishino
发明人： Satoshi Matsuoka , Takahiro Nishimoto , Masaki Kanai , Masanori Nishino
IPC分类号： G01N30/30 , G01N30/54 , G01N30/16
CPC分类号： G01N30/30 , G01N30/16 , G01N30/54 , G01N2030/3007 , G01N2030/3046 , G01N2030/3084
摘要： A gas chromatography device includes a sample injection part, a detector, a separation column, and a transfer line connecting between the sample injection part and the separation column and between the sample injection part and the detector. Furthermore, a column temperature adjustment part for adjusting the temperature of the separation column, and a line temperature adjustment part for adjusting the temperature of the transfer line are provided. The line temperature adjustment part is structured to include a heat block which includes a heating element and which is in contact with the transfer line from one side, and a holding member which presses the transfer line toward the heat block side by being in contact from the other side, and to sandwich the transfer line by the heat block and the holding member.

9. 发明授权

US08196450B2 Gas chromatograph 有权
标题翻译：气相色谱仪
公开(公告)号：US08196450B2
公开(公告)日：2012-06-12
申请号：US12439159
申请日：2006-08-28
申请人： Masanori Nishino , Takahiro Nishimoto , Masaki Kanai
发明人： Masanori Nishino , Takahiro Nishimoto , Masaki Kanai
IPC分类号： G01N1/00
CPC分类号： G01N30/12 , G01N2030/025 , G01N2030/126 , G01N2030/185
摘要： A sample vaporization unit that attains enhancing of reproducibility through fixing of the sample vaporization unit. Sample vaporization unit (4) at its one end is connected to the distal end of glass insert (2) and at its other end is connected via glass tube (5) to one end of capillary column (6). The other end of the capillary column (6) is led to detector (8). The sample vaporization unit (4) is comprised of base frame (22), flow channel (24) provided in the base frame (22), and rugged portion (26) for sample vaporization provided by microfabrication within the flow channel (24). Any liquid sample flowing through the flow channel (24) is vaporized by feeding of energy to the rugged portion (26), and the vapor is subjected to separation by means of the column (6) and detection by means of the detector (8).
摘要翻译：通过固定样品蒸发单元来提高再现性的样品蒸发单元。样品蒸发单元（4）的一端连接到玻璃插件（2）的远端，另一端通过玻璃管（5）连接到毛细管柱（6）的一端。毛细管柱（6）的另一端被引导到检测器（8）。样品蒸发单元（4）包括底架（22），设置在基架（22）中的流动通道（24）和用于通过流动通道（24）内的微细加工提供的用于样品蒸发的粗糙部分（26）。流经流路（24）的任何液体样品通过将能量供给到粗糙部分（26）而蒸发，并且通过柱（6）对蒸汽进行分离并借助于检测器（8）进行检测，。

10. 发明授权

US09689847B2 Gas chromatography equipment 有权
公开(公告)号：US09689847B2
公开(公告)日：2017-06-27
申请号：US14419513
申请日：2012-08-07
申请人： Satoshi Matsuoka , Takahiro Nishimoto , Masaki Kanai , Masanori Nishino , Masato Morii
发明人： Satoshi Matsuoka , Takahiro Nishimoto , Masaki Kanai , Masanori Nishino , Masato Morii
IPC分类号： G01N30/54 , G01N30/60 , B01D53/02 , G01N30/30 , G01N30/02
CPC分类号： G01N30/54 , B01D53/025 , G01N30/30 , G01N30/6047 , G01N2030/025 , G01N2030/3084
摘要： A gas chromatography equipment includes a sample introducer, a detector, a column module, and an oven including a housing. A sub-space is provided in a projection section projecting downward from a portion of a bottom face of the housing communicates with a main space of the housing. A column module attaching section is provided outside the housing and below the main space. A fixed side face, which faces the column module attaching section, of the projection section serves as an attachment face for attaching the column module. The column module is attached to the housing in such a way that the main flat surface of the column module is horizontally positioned with an end face of the column module being the attachment face.

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