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1. 发明授权

US08269195B2 Patient alignment system with external measurement and object coordination for radiation therapy system 有权
标题翻译：患者对准系统与外部测量和放射治疗系统的对象协调
公开(公告)号：US08269195B2
公开(公告)日：2012-09-18
申请号：US12264854
申请日：2008-11-04
申请人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
发明人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
IPC分类号： A61N5/00 , G21G5/00
CPC分类号： A61N5/107 , A61B6/0442 , A61B6/4092 , A61B6/547 , A61B2090/3937 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.
摘要翻译：用于放射治疗系统的患者对准系统。对准系统包括多个外部测量装置，其获得可移动和/或经受弯曲或其它位置变化的辐射治疗系统的部件的位置测量。对准系统采用外部测量来提供校正定位反馈，以更精确地对准患者并将其与辐射束对准。对准系统可以作为放射治疗系统的组成部分提供，或者可以作为现有放射治疗系统的升级来添加。

2. 发明授权

US07446328B2 Patient alignment system with external measurement and object coordination for radiation therapy system 有权
标题翻译：患者对准系统与外部测量和放射治疗系统的对象协调
公开(公告)号：US07446328B2
公开(公告)日：2008-11-04
申请号：US11695532
申请日：2007-04-02
申请人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
发明人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
IPC分类号： A61N5/00 , G21G5/00
CPC分类号： A61N5/1049 , A61B6/0442 , A61B6/4092 , A61B2090/3937 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.
摘要翻译：用于放射治疗系统的患者对准系统。对准系统包括多个外部测量装置，其获得可移动和/或经受弯曲或其它位置变化的辐射治疗系统的部件的位置测量。对准系统采用外部测量来提供校正定位反馈，以更精确地对准患者并将其与辐射束对准。对准系统可以作为放射治疗系统的组成部分提供，或者可以作为现有放射治疗系统的升级来添加。

3. 发明申请

US20120323516A1 PATIENT ALIGNMENT SYSTEM WITH EXTERNAL MEASUREMENT AND OBJECT COORDINATION FOR RADIATION THERAPY SYSTEM 失效
标题翻译：具有外部测量和放射治疗系统对象协调的患者对齐系统
公开(公告)号：US20120323516A1
公开(公告)日：2012-12-20
申请号：US13594630
申请日：2012-08-24
申请人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
发明人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
IPC分类号： G06F15/00 , G01C9/00 , G01N23/04
CPC分类号： A61N5/107 , A61B6/0442 , A61B6/4092 , A61B6/547 , A61B2090/3937 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.
摘要翻译：用于放射治疗系统的患者对准系统。对准系统包括多个外部测量装置，其获得可移动和/或经受弯曲或其它位置变化的辐射治疗系统的部件的位置测量。对准系统采用外部测量来提供校正定位反馈，以更精确地对准患者并将其与辐射束对准。对准系统可以作为放射治疗系统的组成部分提供，或者可以作为现有放射治疗系统的升级来添加。

4. 发明授权

US08569720B2 Patient alignment system with external measurement and object coordination for radiation therapy system 失效
公开(公告)号：US08569720B2
公开(公告)日：2013-10-29
申请号：US13594630
申请日：2012-08-24
申请人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
发明人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
IPC分类号： A61N5/00 , G21G5/00
CPC分类号： A61N5/107 , A61B6/0442 , A61B6/4092 , A61B6/547 , A61B2090/3937 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.

5. 发明申请

US20090067577A1 PATIENT ALIGNMENT SYSTEM WITH EXTERNAL MEASUREMENT AND OBJECT COORDINATION FOR RADIATION THERAPY SYSTEM 有权
标题翻译：具有外部测量和放射治疗系统对象协调的患者对齐系统
公开(公告)号：US20090067577A1
公开(公告)日：2009-03-12
申请号：US12264854
申请日：2008-11-04
申请人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
发明人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
IPC分类号： A61N5/10 , H05G1/00
CPC分类号： A61N5/107 , A61B6/0442 , A61B6/4092 , A61B6/547 , A61B2090/3937 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.
摘要翻译：用于放射治疗系统的患者对准系统。对准系统包括多个外部测量装置，其获得可移动和/或经受弯曲或其它位置变化的辐射治疗系统的部件的位置测量。对准系统采用外部测量来提供校正定位反馈，以更精确地对准患者并将其与辐射束对准。对准系统可以作为放射治疗系统的组成部分提供，或者可以作为现有放射治疗系统的升级来添加。

6. 发明授权

US07199382B2 Patient alignment system with external measurement and object coordination for radiation therapy system 有权
标题翻译：患者对准系统与外部测量和放射治疗系统的对象协调
公开(公告)号：US07199382B2
公开(公告)日：2007-04-03
申请号：US10917023
申请日：2004-08-12
申请人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
发明人： Nickolas S. Rigney , Daniel C. Anderson , David A. Lesyna , Daniel W. Miller , Michael F. Moyers , Chieh C. Cheng , Michael A. Baumann
IPC分类号： G21F5/02
CPC分类号： A61N5/1049 , A61B6/0442 , A61B6/4092 , A61B2090/3937 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.
摘要翻译：用于放射治疗系统的患者对准系统。对准系统包括多个外部测量装置，其获得可移动和/或经受弯曲或其它位置变化的辐射治疗系统的部件的位置测量。对准系统采用外部测量来提供校正定位反馈，以更精确地对准患者并将其与辐射束对准。对准系统可以作为放射治疗系统的组成部分提供，或者可以作为现有放射治疗系统的升级来添加。

7. 发明授权

US5932483A Synthetic peptide and its uses 失效
标题翻译：合成肽及其用途
公开(公告)号：US5932483A
公开(公告)日：1999-08-03
申请号：US628383
申请日：1996-04-05
申请人： Michael A. Baumann , Byron E. Anderson , Jonathan P. Fryer
发明人： Michael A. Baumann , Byron E. Anderson , Jonathan P. Fryer
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , C07K14/31 , C07K14/47 , G01N33/564
CPC分类号： G01N33/564 , A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence:Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr 1 5 10 �SEQ ID NO 2!or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides methods of treating an inflammatory response and prolonging the survival of transplanted tissue.
摘要翻译：本发明提供C1q的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。本发明还提供了包含以下序列的合成肽：-Glu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr-15×10- [SEQ ID NO 2] - 或其能够结合免疫球蛋白的变体。与C1q片段一样，多个肽可以在单体免疫球蛋白存在下选择性地结合免疫复合物或聚集的免疫球蛋白。作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这些流体中的免疫复合物。本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。本发明还提供了治疗炎症反应并延长移植组织存活的方法。

8. 发明授权

US5364930A Synthetic C1q peptide fragments 失效
标题翻译：合成C1q肽片段
公开(公告)号：US5364930A
公开(公告)日：1994-11-15
申请号：US598416
申请日：1990-10-16
申请人： Michael A. Baumann , Byron E. Anderson
发明人： Michael A. Baumann , Byron E. Anderson
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , C07K14/31 , C07K14/47 , G01N33/564 , A61K37/02 , C07K7/06 , C07K7/08
CPC分类号： A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472 , G01N33/564 , Y10S435/962 , Y10S435/975 , Y10S436/807 , Y10S436/808
摘要： The invention provides a fragment of Clq which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: ##STR1## or variants thereof capable of binding immunoglobulin. Like the Clq fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin.
摘要翻译：本发明提供Clq的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。本发明还提供了包含能够结合免疫球蛋白的序列的合成肽： [SEQ ID NO 2]或其变体。与Clq片段一样，多个肽可以在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这种流体中的免疫复合物。本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。

9. 发明申请

US20080270517A1 PROTON BEAM THERAPY CONTROL SYSTEM 有权
标题翻译：原子束治疗控制系统
公开(公告)号：US20080270517A1
公开(公告)日：2008-10-30
申请号：US12167893
申请日：2008-07-03
申请人： Michael A. Baumann , Alexandre V. Beloussov , Julide Bakir , Deganit Armon , Howard B. Olsen , Dana Salem
发明人： Michael A. Baumann , Alexandre V. Beloussov , Julide Bakir , Deganit Armon , Howard B. Olsen , Dana Salem
IPC分类号： G06F15/16
CPC分类号： A61N5/1079 , A61N5/10 , A61N2005/1074 , A61N2005/1087 , G06F19/00 , G16H40/63 , H04L67/12 , H04L67/32 , H04L69/329
摘要： A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.
摘要翻译：用于管理分布式系统中的网络流量的分层通信架构。客户机或控制计算机与多个硬件设备之间的通信由其协调活动的代理和监视设备来管理以减少开放的通道或插座的数量。通信架构还通过减少网络映射依赖性来提高分布式系统的透明度和可扩展性。该架构理想地在质子束治疗系统中实现，以提供灵活的安全策略，其改善患者的安全性并促进系统维护和开发。

10. 发明授权

US5698449A Synthetic peptide and its uses 失效
标题翻译：合成肽及其用途
公开(公告)号：US5698449A
公开(公告)日：1997-12-16
申请号：US335049
申请日：1994-11-07
申请人： Michael A. Baumann , Byron E. Anderson
发明人： Michael A. Baumann , Byron E. Anderson
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , C07K14/31 , C07K14/47 , G01N33/564
CPC分类号： A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472 , G01N33/564 , Y10S435/962 , Y10S435/975 , Y10S436/807 , Y10S436/808
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: ##STR1## or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin.
摘要翻译：本发明提供C1q的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。本发明还提供了包含能够结合免疫球蛋白的序列的合成肽： [SEQ ID NO 2]或其变体。与C1q片段一样，多个肽可以在单体免疫球蛋白存在下选择性地结合免疫复合物或聚集的免疫球蛋白。作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这些流体中的免疫复合物。本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。

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