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1. 发明授权

US07754487B2 Hematology linearity control composition, system and method of use 有权
标题翻译：血液学线性控制组成，系统和使用方法
公开(公告)号：US07754487B2
公开(公告)日：2010-07-13
申请号：US11938853
申请日：2007-11-13
申请人： Nery Ortiz , Theodore J. Gerula
发明人： Nery Ortiz , Theodore J. Gerula
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.
摘要翻译：线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。一系列对照组合物中白细胞类似物的浓度从0.2×103增加到800×103类似物/微升，并且至少一种对照组合物中白细胞类似物的浓度大于每个对照组合物的120×103个类似物微升。稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

2. 发明申请

US20080113438A1 Hematology Linearity Control Composition, System and Method of Use 有权
标题翻译：血液学线性控制组成，系统和使用方法
公开(公告)号：US20080113438A1
公开(公告)日：2008-05-15
申请号：US11938853
申请日：2007-11-13
申请人： Nery Ortiz , Theodore J. Gerula
发明人： Nery Ortiz , Theodore J. Gerula
IPC分类号： G01N33/48 , G01N37/00
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.
摘要翻译：线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。一系列对照组合物中白细胞类似物的浓度从每微升升至0.2×10 3至800×10 3个类似物，并且白细胞类似物的浓度在至少一种对照组合物每微升大于120×10 3个类似物。稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

3. 发明授权

US07354767B2 Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells 有权
标题翻译：含有由无核血细胞制成的有核红细胞成分的参照对照组合物
公开(公告)号：US07354767B2
公开(公告)日：2008-04-08
申请号：US11377171
申请日：2006-03-16
申请人： Nery Ortiz , Theodore J. Gerula , Sandra Socarras
发明人： Nery Ortiz , Theodore J. Gerula , Sandra Socarras
IPC分类号： G01N33/48 , G01N31/00
CPC分类号： G01N33/96 , G01N15/1012 , G01N15/12 , G01N15/147 , G01N2015/1037 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/2525
摘要： A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：公开了含有有核红细胞成分的参照对照组合物及其制造方法。参考对照组合物包含由固定的无核血细胞和悬浮介质制成的有核红细胞成分。非成核血细胞具有与所述血液样品的所述有核红细胞的核的大小基本相似的天然细胞大小。有核红细胞成分可以由马，羊，牛，猫，犬或猪红细胞组成; 并且其基本上不含核酸。参考对照组合物还可包含白细胞成分，红细胞成分，血小板成分，网状细胞成分或其组合。还公开了使用参考对照组合物测量血液分析仪上的有核红细胞的方法。

4. 发明授权

US07393688B2 Method of using a hematology reference control for measurement of immature granulocytes 有权
标题翻译：使用血液学参考对照测量未成熟粒细胞的方法
公开(公告)号：US07393688B2
公开(公告)日：2008-07-01
申请号：US11495056
申请日：2006-07-28
申请人： Nery Ortiz , Theodore J. Gerula , Yi Li
发明人： Nery Ortiz , Theodore J. Gerula , Yi Li
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , Y10S435/967 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A method of using a reference control for measurement of immature granulocytes on a blood analyzer is disclosed. The method includes analyzing a reference control that contains an immature granulocyte component made of processed red blood cells for simulating immature granulocytes and a mature white blood cell component for simulating white blood cells of a blood sample on a blood analyzer adapted for measurement of immature granulocytes, and reporting the immature granulocyte component and the mature white blood cell component of the reference control.
摘要翻译：公开了一种在血液分析仪上使用参考对照测量未成熟粒细胞的方法。该方法包括分析包含由用于模拟未成熟粒细胞的加工红细胞制成的未成熟粒细胞成分的参照对照和用于模拟适于测量未成熟粒细胞的血液分析仪上的血液样品的白细胞的成熟白细胞成分，并报告参考对照的未成熟粒细胞成分和成熟白细胞成分。

5. 发明授权

US07195919B2 Hematology controls for reticulocytes and nucleated red blood cells 有权
标题翻译：网织红细胞和有核红细胞的血液学控制
公开(公告)号：US07195919B2
公开(公告)日：2007-03-27
申请号：US10741390
申请日：2003-12-19
申请人： Dana B. Jacobs , Paul W. Price , Nery Ortiz , Theodore J. Gerula
发明人： Dana B. Jacobs , Paul W. Price , Nery Ortiz , Theodore J. Gerula
IPC分类号： G01N33/554 , G01N31/00
CPC分类号： C12N5/0641 , C12N5/0006 , G01N33/96 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a blood cell sample in a flow cytometer or hematology analysis instrument. The present invention is further drawn to methods of making and using the hematology control.
摘要翻译：本发明涉及由具有附着于颗粒表面的生物聚合物的颗粒的颗粒制成的血液学控制。颗粒模拟流式细胞仪或血液学分析仪器中的血液样品的组分，例如血细胞样品的网织红细胞或有核红细胞成分。本发明进一步涉及制造和使用血液学控制的方法。

6. 发明授权

US07109036B2 Hematology reference control containing an immature granulocyte component 有权
标题翻译：包含未成熟粒细胞成分的血液学参考对照
公开(公告)号：US07109036B2
公开(公告)日：2006-09-19
申请号：US10845557
申请日：2004-05-13
申请人： Nery Ortiz , Theodore J. Gerula , Yi Li
发明人： Nery Ortiz , Theodore J. Gerula , Yi Li
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , Y10S435/967 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of immature granulocytes. The immature granulocyte component can be made of processed avian, reptile or fish red blood cells, or human immature granulocytes produced in vitro. The reference control further includes a white blood cell component which includes white blood cell sub-components for simulating white blood subpopulations. Further disclosed is the method of using the reference control for measurement of immature granulocytes on a blood analyzer.
摘要翻译：公开了含有未成熟粒细胞成分的血液学参考对照和制备方法。参考对照包括由用于模拟人类未成熟粒细胞的加工血细胞制成的未成熟粒细胞组分和适于将组分输送到用于测量未成熟粒细胞的血液分析仪的悬浮培养基。未成熟的粒细胞组分可以由加工的禽，爬行动物或鱼红细胞或体外产生的人类未成熟粒细胞制成。参考对照还包括白血球成分，其包括用于模拟白血球亚群的白细胞亚组分。进一步公开了使用参考对照在血液分析仪上测量未成熟粒细胞的方法。

7. 发明授权

US06569682B2 Hematology control product with increased closed vial stability 有权
标题翻译：血液学控制产品具有增加的封闭瓶子稳定性
公开(公告)号：US06569682B2
公开(公告)日：2003-05-27
申请号：US09917452
申请日：2001-07-27
申请人： Michael Elliott , Dana B. Jacobs , Nery Ortiz , Wayne Goldson , Penny Whitley , Theodore J. Gerula
发明人： Michael Elliott , Dana B. Jacobs , Nery Ortiz , Wayne Goldson , Penny Whitley , Theodore J. Gerula
IPC分类号： G01N3100
CPC分类号： G01N33/96 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/105831 , Y10T436/106664 , Y10T436/108331
摘要： An improved blood suspension media for hematological compositions, having particular utility with a red blood cell component for devices using electronic and optical means for blood determinations, and processes for using the suspension media. The suspension media finds particular utility in providing the hematology control product with a stable and consistent MCV and RDW for an extended product shelf life.
摘要翻译：用于血液学组合物的改进的血液悬浮培养基，其具有用于使用电子和光学手段用于血液测定的装置的红细胞组分的特别用途，以及使用悬浮介质的方法。悬浮介质特别适用于为血液控制产品提供稳定和一致的MCV和RDW以延长产品保质期。

8. 发明授权

US06962817B2 Reference control for optical measurement of nucleated red blood cells of a blood sample 有权
公开(公告)号：US06962817B2
公开(公告)日：2005-11-08
申请号：US10955104
申请日：2004-09-30
申请人： Yi Li , Nery Ortiz , Carole J. Young , Santiago Galvez
发明人： Yi Li , Nery Ortiz , Carole J. Young , Santiago Galvez
IPC分类号： G01N21/00 , G01N31/00 , G01N33/48 , G01N33/569 , G01N33/80
CPC分类号： G01N15/1459 , G01N33/56972 , G01N33/80 , G01N33/96 , G01N2015/0073 , G01N2015/1062 , G01N2015/1486 , G01N2015/1493 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity.

9. 发明申请

US20050255447A1 Hematology reference control containing an immature granulocyte component 有权
标题翻译：包含未成熟粒细胞成分的血液学参考对照
公开(公告)号：US20050255447A1
公开(公告)日：2005-11-17
申请号：US10845557
申请日：2004-05-13
申请人： Nery Ortiz , Theodore Gerula , Yi Li
发明人： Nery Ortiz , Theodore Gerula , Yi Li
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/56 , G01N33/96
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , Y10S435/967 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of immature granulocytes. The immature granulocyte component can be made of processed avian, reptile or fish red blood cells, or human immature granulocytes produced in vitro. The reference control further includes a white blood cell component which includes white blood cell sub-components for simulating white blood subpopulations. Further disclosed is the method of using the reference control for measurement of immature granulocytes on a blood analyzer.
摘要翻译：公开了含有未成熟粒细胞成分的血液学参考对照和制备方法。参考对照包括由用于模拟人类未成熟粒细胞的加工血细胞制成的未成熟粒细胞组分和适于将组分输送到用于测量未成熟粒细胞的血液分析仪的悬浮培养基。未成熟的粒细胞组分可以由加工的禽，爬行动物或鱼红细胞或体外产生的人类未成熟粒细胞制成。参考对照还包括白血球成分，其包括用于模拟白血球亚群的白细胞亚组分。进一步公开了使用参考对照在血液分析仪上测量未成熟粒细胞的方法。

10. 发明申请

US20050074894A1 Reference control for optical measurement of nucleated red blood cells of a blood sample 有权
公开(公告)号：US20050074894A1
公开(公告)日：2005-04-07
申请号：US10955104
申请日：2004-09-30
申请人： Yi Li , Nery Ortiz , Carole Young , Santiago Galvez
发明人： Yi Li , Nery Ortiz , Carole Young , Santiago Galvez
IPC分类号： G01N21/00 , G01N31/00 , G01N33/48 , G01N33/569 , G01N33/80
CPC分类号： G01N15/1459 , G01N33/56972 , G01N33/80 , G01N33/96 , G01N2015/0073 , G01N2015/1062 , G01N2015/1486 , G01N2015/1493 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity.

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