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1. 发明授权

US07754487B2 Hematology linearity control composition, system and method of use 有权
标题翻译：血液学线性控制组成，系统和使用方法
公开(公告)号：US07754487B2
公开(公告)日：2010-07-13
申请号：US11938853
申请日：2007-11-13
申请人： Nery Ortiz , Theodore J. Gerula
发明人： Nery Ortiz , Theodore J. Gerula
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.
摘要翻译：线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。一系列对照组合物中白细胞类似物的浓度从0.2×103增加到800×103类似物/微升，并且至少一种对照组合物中白细胞类似物的浓度大于每个对照组合物的120×103个类似物微升。稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

2. 发明申请

US20100041011A1 Reference Control for Cell by Cell Analysis 有权
标题翻译：细胞分析的参考控制
公开(公告)号：US20100041011A1
公开(公告)日：2010-02-18
申请号：US12190772
申请日：2008-08-13
申请人： Andreas Van Agthoven , Fabrice Malergue
发明人： Andreas Van Agthoven , Fabrice Malergue
IPC分类号： A01N1/02 , G01N33/00 , C12Q1/02
CPC分类号： A61K35/407 , G01N33/721 , G01N33/96 , G01N2333/805 , G01N2496/10 , Y10T436/101666 , Y10T436/107497
摘要： A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed prior to use. The cellular analogs further contain a fluorescence marker therein. Further disclosed are a method of making the reference control and a method using the reference control, as an internal or stand-alone control, for measurements of cellular hemoglobin and cellular hemoglobin variant of a blood sample.
摘要翻译：用于流式细胞分析仪的细胞分析的参考对照包含由其中含有聚集的细胞内蛋白质和其保留的抗原位点的透过血细胞制成的细胞类似物，其具有可抗抗体的细胞膜和悬浮介质。参考对照在使用前准备并解冻后冷冻。细胞类似物还含有荧光标记物。进一步公开的是进行参考控制的方法和使用参考对照作为血液样品的细胞血红蛋白和细胞血红蛋白变体的测量作为内部或独立控制的方法。

3. 发明申请

US20050074894A1 Reference control for optical measurement of nucleated red blood cells of a blood sample 有权
公开(公告)号：US20050074894A1
公开(公告)日：2005-04-07
申请号：US10955104
申请日：2004-09-30
申请人： Yi Li , Nery Ortiz , Carole Young , Santiago Galvez
发明人： Yi Li , Nery Ortiz , Carole Young , Santiago Galvez
IPC分类号： G01N21/00 , G01N31/00 , G01N33/48 , G01N33/569 , G01N33/80
CPC分类号： G01N15/1459 , G01N33/56972 , G01N33/80 , G01N33/96 , G01N2015/0073 , G01N2015/1062 , G01N2015/1486 , G01N2015/1493 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity.

4. 发明授权

US3558522A Hematology control standard comprising washed red blood cells and synthetic latex particles 失效
标题翻译：包含洗涤的红血细胞和合成乳酸杆菌的血液学控制标准
公开(公告)号：US3558522A
公开(公告)日：1971-01-26
申请号：US3558522D
申请日：1969-03-05
申请人： BAXTER LABORATORIES INC
发明人： LOUDERBACK ALLAN L , YOUHNE YOUNG
IPC分类号： G01N33/49 , G01N15/12 , G01N33/543 , G01N33/96 , G01N33/16
CPC分类号： G01N15/12 , G01N33/96 , G01N2333/765 , G01N2496/05 , G01N2496/10 , Y10T436/101666 , Y10T436/105831 , Y10T436/107497 , Y10T436/108331
摘要： A HERMATOLOGY CONTROL STANDARD FOR THE CALIBRATION OF BLOOD CELL COUNTING APPARATUS AND A METHOD FOR THE PREPARATION THEREOF BY ADMIXING PREDETERMINED AMOUNTS OF WASHED RED BLOOD CELLS AND SYNTHETIC LATEX PARTICLES HAVING A 5 TO 15 MICRON PARTICLE SIZE RANGE IN A FLUID SUSPENSION OF A KNOWN AMOUNT OF SERUM ALBUMIN.

5. 发明授权

US07195919B2 Hematology controls for reticulocytes and nucleated red blood cells 有权
标题翻译：网织红细胞和有核红细胞的血液学控制
公开(公告)号：US07195919B2
公开(公告)日：2007-03-27
申请号：US10741390
申请日：2003-12-19
申请人： Dana B. Jacobs , Paul W. Price , Nery Ortiz , Theodore J. Gerula
发明人： Dana B. Jacobs , Paul W. Price , Nery Ortiz , Theodore J. Gerula
IPC分类号： G01N33/554 , G01N31/00
CPC分类号： C12N5/0641 , C12N5/0006 , G01N33/96 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a blood cell sample in a flow cytometer or hematology analysis instrument. The present invention is further drawn to methods of making and using the hematology control.
摘要翻译：本发明涉及由具有附着于颗粒表面的生物聚合物的颗粒的颗粒制成的血液学控制。颗粒模拟流式细胞仪或血液学分析仪器中的血液样品的组分，例如血细胞样品的网织红细胞或有核红细胞成分。本发明进一步涉及制造和使用血液学控制的方法。

6. 发明授权

US07176031B2 Reference control for optical measurement of nucleated red blood cells of a blood sample 有权
标题翻译：用于血液样品的有核红细胞的光学测量的参考控制
公开(公告)号：US07176031B2
公开(公告)日：2007-02-13
申请号：US11194405
申请日：2005-08-01
申请人： Yi Li , Nery Ortiz , Carole J. Young , Santiago Galvez
发明人： Yi Li , Nery Ortiz , Carole J. Young , Santiago Galvez
IPC分类号： G01N33/48
CPC分类号： G01N15/1459 , G01N33/56972 , G01N33/80 , G01N33/96 , G01N2015/0073 , G01N2015/1062 , G01N2015/1486 , G01N2015/1493 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity.
摘要翻译：公开了参考对照组合物和使用方法用于测量有核红细胞，其包括一组平均粒径范围为6.2μm至6.8μm的合成球形颗粒，以及单分散在水性中的1.58至1.62的折射率悬浮介质。合成球形颗粒具有通过光学测量测量的模拟有核红细胞的光学性质的光学性质。参考对照组合物可进一步包括具有模拟白细胞光学性质的光学性质的第二组合成球形颗粒。进一步公开了一种参考控制系统，其包括一系列参考控制组合物，每个参考对照组合物具有一定量的一种类型的合成球形颗粒，其具有模拟具有特定细胞成熟度的有核红细胞的光学性质的光学性质。

7. 发明申请

US20050221497A1 Quality control method 审中-公开
标题翻译：质量控制方法
公开(公告)号：US20050221497A1
公开(公告)日：2005-10-06
申请号：US11137637
申请日：2005-05-25
申请人： Carole Young
发明人： Carole Young
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14 , G01N33/48 , G01N33/50 , G01N33/92 , G01N33/96
CPC分类号： G01N15/1012 , G01N15/12 , G01N33/5094 , G01N33/92 , G01N33/96 , G01N2015/1062 , G01N2015/1087 , G01N2015/1486 , G01N2015/1493 , G01N2496/05 , G01N2496/10 , Y10T436/101666 , Y10T436/102499 , Y10T436/105831 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331
摘要： A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.
摘要翻译：一种用于诊断仪器故障原因的质量控制方法。该方法使用样品的物理性质的测量来诊断仪器故障的原因。分析对照产品样品的空间位置。或者，可以使用统计学上显着数量的患者血液样本的空间位置。该方法能够监测仪器与由红细胞裂解无效率引起的碎片和噪声相关的问题; 仪器试剂泵体积设置; 仪器激光对准仪器增益设置; 和由部分插头，残留插头或其他流量问题引起的流动噪声。该方法提供了与现有技术方法提供的非特定标记相比，仪器故障的类型和原因的更具体的指示。

8. 发明授权

US5288642A Shelf-stable milk calibration standards 失效
标题翻译：保质期牛奶校准标准
公开(公告)号：US5288642A
公开(公告)日：1994-02-22
申请号：US987825
申请日：1992-12-09
申请人： Jeffrey D. Turner
发明人： Jeffrey D. Turner
IPC分类号： G01N15/10 , G01N33/04 , G01N33/50 , G01N33/96 , G01N31/00 , G01N31/22
CPC分类号： G01N21/278 , A01J5/0132 , A01J5/0133 , G01N15/1012 , G01N33/04 , G01N33/5005 , G01N33/96 , G01N2021/6439 , G01N2496/10 , Y10T436/10 , Y10T436/101666 , Y10T436/109163
摘要： A calibration standard for calibrating machines which count the somatic cells in a milk sample, comprises an aqueous dispersion of microbeads bearing a fluorescent dye, a suspending agent, and an electrolyte; the dye has an excitation wavelength below 580 nm and a fluorescence emission wavelength in the range of 550 to 660 nm, with the excitation wavelength being at least 10 nm below the emission wavelength; the microbeads are present in a predetermined number per unit volume of dispersion; typically the standard contains 1.times.10.sup.5 to 9.times.10.sup.5 beads/ml.
摘要翻译：用于校准计算牛奶样品中体细胞的机器的校准标准包括含有荧光染料，悬浮剂和电解质的微珠的水分散体; 该染料具有低于580nm的激发波长和550至660nm范围内的荧光发射波长，其中激发波长比发射波长低至少10nm; 微珠以每单位体积的分散体预定数量存在; 通常标准包含1 * 105至9 * 105珠/ ml。

9. 发明授权

US3436187A Method of estimating thymol turbidity employing polystyrene latex suspensions as standards 失效
标题翻译：使用聚苯乙烯悬浮液作为标准估算THYMOL TURBIDITY的方法
公开(公告)号：US3436187A
公开(公告)日：1969-04-01
申请号：US3436187D
申请日：1965-03-03
申请人： DADE REAGENTS INC
发明人： FERRO PATRICK V , HAM ANNA B
IPC分类号： G01N33/96 , G01N31/00
CPC分类号： G01N33/96 , G01N2496/10 , Y10T436/10 , Y10T436/109163 , Y10T436/203332

10. 发明申请

US20080113438A1 Hematology Linearity Control Composition, System and Method of Use 有权
标题翻译：血液学线性控制组成，系统和使用方法
公开(公告)号：US20080113438A1
公开(公告)日：2008-05-15
申请号：US11938853
申请日：2007-11-13
申请人： Nery Ortiz , Theodore J. Gerula
发明人： Nery Ortiz , Theodore J. Gerula
IPC分类号： G01N33/48 , G01N37/00
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.
摘要翻译：线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。一系列对照组合物中白细胞类似物的浓度从每微升升至0.2×10 3至800×10 3个类似物，并且白细胞类似物的浓度在至少一种对照组合物每微升大于120×10 3个类似物。稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

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