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1. 发明申请

US20050255447A1 Hematology reference control containing an immature granulocyte component 有权
标题翻译：包含未成熟粒细胞成分的血液学参考对照
公开(公告)号：US20050255447A1
公开(公告)日：2005-11-17
申请号：US10845557
申请日：2004-05-13
申请人： Nery Ortiz , Theodore Gerula , Yi Li
发明人： Nery Ortiz , Theodore Gerula , Yi Li
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/56 , G01N33/96
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , Y10S435/967 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of immature granulocytes. The immature granulocyte component can be made of processed avian, reptile or fish red blood cells, or human immature granulocytes produced in vitro. The reference control further includes a white blood cell component which includes white blood cell sub-components for simulating white blood subpopulations. Further disclosed is the method of using the reference control for measurement of immature granulocytes on a blood analyzer.
摘要翻译：公开了含有未成熟粒细胞成分的血液学参考对照和制备方法。参考对照包括由用于模拟人类未成熟粒细胞的加工血细胞制成的未成熟粒细胞组分和适于将组分输送到用于测量未成熟粒细胞的血液分析仪的悬浮培养基。未成熟的粒细胞组分可以由加工的禽，爬行动物或鱼红细胞或体外产生的人类未成熟粒细胞制成。参考对照还包括白血球成分，其包括用于模拟白血球亚群的白细胞亚组分。进一步公开了使用参考对照在血液分析仪上测量未成熟粒细胞的方法。

2. 发明申请

US20070218558A1 Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells 有权
标题翻译：含有由无核血细胞制成的有核红细胞成分的参照对照组合物
公开(公告)号：US20070218558A1
公开(公告)日：2007-09-20
申请号：US11377171
申请日：2006-03-16
申请人： Nery Ortiz , Theodore Gerula , Sandra Socarras
发明人： Nery Ortiz , Theodore Gerula , Sandra Socarras
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , G01N15/1012 , G01N15/12 , G01N15/147 , G01N2015/1037 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/2525
摘要： A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：公开了含有有核红细胞成分的参照对照组合物及其制造方法。参考对照组合物包含由固定的无核血细胞和悬浮介质制成的有核红细胞成分。非成核血细胞具有与所述血液样品的所述有核红细胞的核的大小基本相似的天然细胞大小。有核红细胞成分可以由马，羊，牛，猫，犬或猪红细胞组成; 并且其基本上不含核酸。参考对照组合物还可包含白细胞成分，红细胞成分，血小板成分，网状细胞成分或其组合。还公开了使用参考对照组合物测量血液分析仪上的有核红细胞的方法。

3. 发明申请

US20070020611A1 Hematology reference control containing an immature granulocyte component 有权
标题翻译：包含未成熟粒细胞成分的血液学参考对照
公开(公告)号：US20070020611A1
公开(公告)日：2007-01-25
申请号：US11495056
申请日：2006-07-28
申请人： Nery Ortiz , Theodore Gerula , Yi Li
发明人： Nery Ortiz , Theodore Gerula , Yi Li
IPC分类号： C12Q1/00
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , Y10S435/967 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of immature granulocytes. The immature granulocyte component can be made of processed avian, reptile or fish red blood cells, or human immature granulocytes produced in vitro. The reference control further includes a white blood cell component which includes white blood cell sub-components for simulating white blood subpopulations. Further disclosed is the method of using the reference control for measurement of immature granulocytes on a blood analyzer.
摘要翻译：公开了含有未成熟粒细胞成分的血液学参考对照和制备方法。参考对照包括由用于模拟人类未成熟粒细胞的加工血细胞制成的未成熟粒细胞组分和适于将组分输送到用于测量未成熟粒细胞的血液分析仪的悬浮培养基。未成熟的粒细胞组分可以由加工的禽，爬行动物或鱼红细胞或体外产生的人类未成熟粒细胞制成。参考对照还包括白血球成分，其包括用于模拟白血球亚群的白细胞亚组分。进一步公开了使用参考对照在血液分析仪上测量未成熟粒细胞的方法。

4. 发明申请

US20050136409A1 Hematology controls for reticulocytes and nucleated red blood cells 有权
标题翻译：网织红细胞和有核红细胞的血液学控制
公开(公告)号：US20050136409A1
公开(公告)日：2005-06-23
申请号：US10741390
申请日：2003-12-19
申请人： Dana Jacobs , Paul Price , Nery Ortiz , Theodore Gerula
发明人： Dana Jacobs , Paul Price , Nery Ortiz , Theodore Gerula
IPC分类号： G01N33/96 , C12N5/078 , C12N5/10 , C12N15/09 , C12Q1/68 , C12N5/08
CPC分类号： C12N5/0641 , C12N5/0006 , G01N33/96 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a blood cell sample in a flow cytometer or hematology analysis instrument. The present invention is further drawn to methods of making and using the hematology control.
摘要翻译：本发明涉及由具有附着于颗粒表面的生物聚合物的颗粒的颗粒制成的血液学控制。颗粒模拟流式细胞仪或血液学分析仪器中的血液样品的组分，例如血细胞样品的网织红细胞或有核红细胞成分。本发明进一步涉及制造和使用血液学控制的方法。

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