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    • 1. 发明授权
    • Pressure flow system and method for treating a fluid permeable workpiece
such as a bone
    • 压力流动系统和用于处理流体可渗透的工件(例如骨)的方法
    • US5846484A
    • 1998-12-08
    • US821603
    • 1997-03-20
    • Nelson L. ScarboroughJohn W. MorrisJames L. RussellMichael Dowd
    • Nelson L. ScarboroughJohn W. MorrisJames L. RussellMichael Dowd
    • B08B5/02A61L2/00A61L27/00A61L27/36B08B3/02A61M31/00
    • A61F2/4644A61L2/0088A61L27/3608A61L27/3683A61F2002/4646Y10S623/923
    • A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.
    • 提供了一种压力流动系统及其使用方法,用于使流体可渗透的例如多孔的工件的内部接触。 该系统包括流体压力室,其具有形成在其中一个室壁中的入口和开口。 能够在具有不均匀表面的工件的外部提供流体密封的可调节密封件定位在开口内。 在压力下的流体被供应到压力室以迫使流体流过工件的内部基体。 在优选实施例中,工件是骨或其部分,并且迫使流体通过骨的脉管系统和多孔结构从骨的内膜部分流动到骨的骨膜部分,以去除血液,骨髓和 /或来自骨的其它非骨组分。 或者,可以选择流体以对骨进行去污和/或去矿物质,染色骨以改善骨微血管的可视化或用药物(抗生素,骨生长因子等)浸渍,使得骨可以作为 输送系统。