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1. 发明授权

US5846484A Pressure flow system and method for treating a fluid permeable workpiece such as a bone 失效
标题翻译：压力流动系统和用于处理流体可渗透的工件（例如骨）的方法
公开(公告)号：US5846484A
公开(公告)日：1998-12-08
申请号：US821603
申请日：1997-03-20
申请人： Nelson L. Scarborough , John W. Morris , James L. Russell , Michael Dowd
发明人： Nelson L. Scarborough , John W. Morris , James L. Russell , Michael Dowd
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02 , A61M31/00
CPC分类号： A61F2/4644 , A61L2/0088 , A61L27/3608 , A61L27/3683 , A61F2002/4646 , Y10S623/923
摘要： A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.
摘要翻译：提供了一种压力流动系统及其使用方法，用于使流体可渗透的例如多孔的工件的内部接触。该系统包括流体压力室，其具有形成在其中一个室壁中的入口和开口。能够在具有不均匀表面的工件的外部提供流体密封的可调节密封件定位在开口内。在压力下的流体被供应到压力室以迫使流体流过工件的内部基体。在优选实施例中，工件是骨或其部分，并且迫使流体通过骨的脉管系统和多孔结构从骨的内膜部分流动到骨的骨膜部分，以去除血液，骨髓和 /或来自骨的其它非骨组分。或者，可以选择流体以对骨进行去污和/或去矿物质，染色骨以改善骨微血管的可视化或用药物（抗生素，骨生长因子等）浸渍，使得骨可以作为输送系统。

2. 发明授权

US06436138B1 Process for producing flexible sheets from demineralized, elongate, bone particles 有权
标题翻译：从软化细长的骨颗粒生产柔性片的方法
公开(公告)号：US06436138B1
公开(公告)日：2002-08-20
申请号：US09155064
申请日：1998-09-18
申请人： Michael Dowd , Nelson L. Scarborough , Mark Daugherty , Jack McMickle
发明人： Michael Dowd , Nelson L. Scarborough , Mark Daugherty , Jack McMickle
IPC分类号： A61F228
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61F2002/30957 , A61F2002/4649 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L2430/40 , Y10S623/901 , Y10S623/919
摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid form the demineralized bone particles to provide a cohering shaped mass of demineralized bone particles, and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period. The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.
摘要翻译：从软化骨粒子制造成形材料的方法包括以下步骤：将软化骨颗粒的液体浆料施加到支撑体上，从脱矿骨粒子中除去多余的液体，以提供凝固成型的脱矿质骨粒子，并加热成形质量的软化骨颗粒在预定温度和预定时间段内。所得骨量在再水化时表现出增强的拉伸强度和最小的骨粒子分离，从而改善在手术部位的产品处理和应用。

3. 发明授权

US07179299B2 Osteoimplant and method for making same 有权
标题翻译：植骨及其制作方法
公开(公告)号：US07179299B2
公开(公告)日：2007-02-20
申请号：US10285715
申请日：2002-11-01
申请人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
发明人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
IPC分类号： A61F2/28
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
摘要翻译：提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

4. 发明授权

US08663672B2 Osteoimplant and method of making same 有权
标题翻译：植骨及其制作方法
公开(公告)号：US08663672B2
公开(公告)日：2014-03-04
申请号：US11231954
申请日：2005-09-21
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
IPC分类号： A61K9/00 , C12N5/02
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
摘要翻译：提供了一种骨植入物，其包括细长骨颗粒的相干团聚体，所述骨植入物具有预定的尺寸和形状。骨质植入物具有高吸收性和海绵状。本文还提供了一种制造骨样植入物的方法以及利用骨植入物修复和/或治疗骨缺损的方法。

5. 发明授权

US07662184B2 Osteoimplant and method for making same 有权
标题翻译：植骨及其制作方法
公开(公告)号：US07662184B2
公开(公告)日：2010-02-16
申请号：US11676429
申请日：2007-02-19
申请人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
发明人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
IPC分类号： A61F2/44
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
摘要翻译：提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

6. 发明授权

US09387094B2 Osteoimplant and method of making same 有权
公开(公告)号：US09387094B2
公开(公告)日：2016-07-12
申请号：US10137862
申请日：2002-05-02
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
IPC分类号： A61F2/28 , A61F2/46 , A61L27/36 , A61L31/00 , A61F2/30 , A61B17/86 , A61F2/44
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

7. 发明授权

US5899939A Bone-derived implant for load-supporting applications 失效
标题翻译：用于负载支持应用的骨源植入物
公开(公告)号：US5899939A
公开(公告)日：1999-05-04
申请号：US009997
申请日：1998-01-21
申请人： Todd M. Boyce , Albert Manrique , Nelson L. Scarborough , James L. Russell
发明人： Todd M. Boyce , Albert Manrique , Nelson L. Scarborough , James L. Russell
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61L27/36
CPC分类号： A61L27/3683 , A61F2/28 , A61L27/3608 , A61L27/365 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/2882 , A61F2002/30059 , A61F2002/30113 , A61F2002/30125 , A61F2002/30138 , A61F2002/30153 , A61F2002/30154 , A61F2002/30224 , A61F2002/30261 , A61F2002/30448 , A61F2002/30599 , A61F2002/30785 , A61F2002/30789 , A61F2002/30971 , A61F2002/448 , A61F2220/005 , A61F2230/0006 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00293 , A61L2430/02
摘要： A bone-derived implant is provided which is made up of one or more layers of fully mineralized or partially demineralized cortical bone and, optionally, one or more layers of some other material. The layers constituting the implant are assembled into a unitary structure to provide an implant exhibiting good overall load-supporting properties.
摘要翻译：提供骨源植入物，其由一层或多层完全矿化或部分去矿物质的皮质骨和任选的一层或多层一些其它材料构成。构成植入物的层被组装成单一结构以提供具有良好的整体负荷支撑性质的植入物。

8. 发明授权

US08197474B2 Volume maintaining osteoinductive/osteoconductive compositions 有权
标题翻译：体积维持骨诱导/骨传导组合物
公开(公告)号：US08197474B2
公开(公告)日：2012-06-12
申请号：US13185553
申请日：2011-07-19
申请人： Nelson L. Scarborough , Sergio J. Gadeleta , David R. Kaes , Albert Manrique
发明人： Nelson L. Scarborough , Sergio J. Gadeleta , David R. Kaes , Albert Manrique
IPC分类号： A61F2/28
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译：由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。还提供了使用该组合物修复骨缺损部位的方法。

9. 发明申请

US20110274668A1 VOLUME MAINTAINING OSTEOINDUCTIVE/OSTEOCONDUCTIVE COMPOSITIONS 有权
标题翻译：体积维持机械/磁性组合物
公开(公告)号：US20110274668A1
公开(公告)日：2011-11-10
申请号：US13185553
申请日：2011-07-19
申请人： Nelson L. Scarborough , Sergio J. Gadaleta , David Kaes , Albert Manrique
发明人： Nelson L. Scarborough , Sergio J. Gadaleta , David Kaes , Albert Manrique
IPC分类号： A61K35/32 , A61P19/00
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译：由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。还提供了使用该组合物修复骨缺损部位的方法。

10. 发明授权

US08002813B2 Volume maintaining osteoinductive/osteoconductive compositions 有权
标题翻译：体积维持骨诱导/骨传导组合物
公开(公告)号：US08002813B2
公开(公告)日：2011-08-23
申请号：US12548029
申请日：2009-08-26
申请人： Nelson L. Scarborough , Sergio J. Gadaleta , David Keas , Albert Manrique
发明人： Nelson L. Scarborough , Sergio J. Gadaleta , David Keas , Albert Manrique
IPC分类号： A61F2/28
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译：由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。还提供了使用该组合物修复骨缺损部位的方法。

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