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1. 发明授权

US07179299B2 Osteoimplant and method for making same 有权
标题翻译：植骨及其制作方法
公开(公告)号：US07179299B2
公开(公告)日：2007-02-20
申请号：US10285715
申请日：2002-11-01
申请人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
发明人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
IPC分类号： A61F2/28
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
摘要翻译：提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

2. 发明授权

US07662184B2 Osteoimplant and method for making same 有权
标题翻译：植骨及其制作方法
公开(公告)号：US07662184B2
公开(公告)日：2010-02-16
申请号：US11676429
申请日：2007-02-19
申请人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
发明人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
IPC分类号： A61F2/44
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
摘要翻译：提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

3. 发明授权

US09387094B2 Osteoimplant and method of making same 有权
公开(公告)号：US09387094B2
公开(公告)日：2016-07-12
申请号：US10137862
申请日：2002-05-02
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
IPC分类号： A61F2/28 , A61F2/46 , A61L27/36 , A61L31/00 , A61F2/30 , A61B17/86 , A61F2/44
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

4. 发明授权

US08663672B2 Osteoimplant and method of making same 有权
标题翻译：植骨及其制作方法
公开(公告)号：US08663672B2
公开(公告)日：2014-03-04
申请号：US11231954
申请日：2005-09-21
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
IPC分类号： A61K9/00 , C12N5/02
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
摘要翻译：提供了一种骨植入物，其包括细长骨颗粒的相干团聚体，所述骨植入物具有预定的尺寸和形状。骨质植入物具有高吸收性和海绵状。本文还提供了一种制造骨样植入物的方法以及利用骨植入物修复和/或治疗骨缺损的方法。

5. 发明授权

US5899939A Bone-derived implant for load-supporting applications 失效
标题翻译：用于负载支持应用的骨源植入物
公开(公告)号：US5899939A
公开(公告)日：1999-05-04
申请号：US009997
申请日：1998-01-21
申请人： Todd M. Boyce , Albert Manrique , Nelson L. Scarborough , James L. Russell
发明人： Todd M. Boyce , Albert Manrique , Nelson L. Scarborough , James L. Russell
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61L27/36
CPC分类号： A61L27/3683 , A61F2/28 , A61L27/3608 , A61L27/365 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/2882 , A61F2002/30059 , A61F2002/30113 , A61F2002/30125 , A61F2002/30138 , A61F2002/30153 , A61F2002/30154 , A61F2002/30224 , A61F2002/30261 , A61F2002/30448 , A61F2002/30599 , A61F2002/30785 , A61F2002/30789 , A61F2002/30971 , A61F2002/448 , A61F2220/005 , A61F2230/0006 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00293 , A61L2430/02
摘要： A bone-derived implant is provided which is made up of one or more layers of fully mineralized or partially demineralized cortical bone and, optionally, one or more layers of some other material. The layers constituting the implant are assembled into a unitary structure to provide an implant exhibiting good overall load-supporting properties.
摘要翻译：提供骨源植入物，其由一层或多层完全矿化或部分去矿物质的皮质骨和任选的一层或多层一些其它材料构成。构成植入物的层被组装成单一结构以提供具有良好的整体负荷支撑性质的植入物。

6. 发明授权

US5846484A Pressure flow system and method for treating a fluid permeable workpiece such as a bone 失效
标题翻译：压力流动系统和用于处理流体可渗透的工件（例如骨）的方法
公开(公告)号：US5846484A
公开(公告)日：1998-12-08
申请号：US821603
申请日：1997-03-20
申请人： Nelson L. Scarborough , John W. Morris , James L. Russell , Michael Dowd
发明人： Nelson L. Scarborough , John W. Morris , James L. Russell , Michael Dowd
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02 , A61M31/00
CPC分类号： A61F2/4644 , A61L2/0088 , A61L27/3608 , A61L27/3683 , A61F2002/4646 , Y10S623/923
摘要： A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.
摘要翻译：提供了一种压力流动系统及其使用方法，用于使流体可渗透的例如多孔的工件的内部接触。该系统包括流体压力室，其具有形成在其中一个室壁中的入口和开口。能够在具有不均匀表面的工件的外部提供流体密封的可调节密封件定位在开口内。在压力下的流体被供应到压力室以迫使流体流过工件的内部基体。在优选实施例中，工件是骨或其部分，并且迫使流体通过骨的脉管系统和多孔结构从骨的内膜部分流动到骨的骨膜部分，以去除血液，骨髓和 /或来自骨的其它非骨组分。或者，可以选择流体以对骨进行去污和/或去矿物质，染色骨以改善骨微血管的可视化或用药物（抗生素，骨生长因子等）浸渍，使得骨可以作为输送系统。

7. 发明授权

US07662185B2 Intervertebral implants 有权
标题翻译：椎间植入物
公开(公告)号：US07662185B2
公开(公告)日：2010-02-16
申请号：US10651390
申请日：2003-08-28
申请人： Arthur A. Alfaro , Lawrence A. Shimp , James L. Russell , John W. Boyle , Erik O. Martz , Daniel E. Rosenthal , John W. Morris
发明人： Arthur A. Alfaro , Lawrence A. Shimp , James L. Russell , John W. Boyle , Erik O. Martz , Daniel E. Rosenthal , John W. Morris
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30112 , A61F2002/30118 , A61F2002/30156 , A61F2002/30207 , A61F2002/3023 , A61F2002/30233 , A61F2002/30289 , A61F2002/30291 , A61F2002/30324 , A61F2002/30387 , A61F2002/30459 , A61F2002/30492 , A61F2002/30599 , A61F2002/30604 , A61F2002/30772 , A61F2002/30789 , A61F2002/30827 , A61F2002/3085 , A61F2002/30874 , A61F2002/4475 , A61F2220/0025 , A61F2220/0066 , A61F2230/0004 , A61F2230/0006 , A61F2230/0023 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61F2250/0036 , A61F2250/0063 , A61F2310/00131 , A61F2310/00179 , A61F2310/00359
摘要： A multipart intervertebral implant is provided which includes an implant portion and an implant extender portion. The implant portion and the implant extender portion can be fastened together using any known fastening means including pins, interlocking structure (e.g., dovetail, tongue and groove, etc.), adhesives, etc. The size of the implant extender portion can be selected during a surgical procedure to provide an implant suitable for a particular intervertebral receiving bed. An intervertebral implant is also provided which may be formed from a multiplicity of implant sections which are fastened together to provide an implant having a desired length. Implants having surface configurations which more closely correspond to the configuration of vertebral endplates are also provided.
摘要翻译：提供多部分椎间植入物，其包括植入部分和植入物延伸部分。植入物部分和植入物延伸部分可以使用任何已知的紧固装置固定在一起，所述紧固装置包括销钉，互锁结构（例如，燕尾榫，舌部和凹槽等），粘合剂等。可以在植入物延伸部分的尺寸提供适于特定椎间接受床的植入物的外科手术。还提供了一种椎间植入物，其可以由多个植入部分形成，所述多个植入部分紧固在一起以提供具有期望长度的植入物。还提供了具有更接近于椎骨终板的构造的表面构造的植入物。

8. 发明授权

US4477912A Correlation data communications system 失效
标题翻译：相关数据通信系统
公开(公告)号：US4477912A
公开(公告)日：1984-10-16
申请号：US348425
申请日：1982-02-12
申请人： James L. Russell
发明人： James L. Russell
IPC分类号： H04L7/04 , H04L23/02 , H04K1/04
CPC分类号： H04L7/042 , H04L23/02 , H04L7/043
摘要： A digital data communications system employing correlation detection is disclosed as comprising an encoding system which encodes successive k-bit data words from a data source into predetermined start-stop phases of either a 2.sup.k -bit repeating pseudorandom binary code or a 2.sup.k -1 bit repeating pseudorandom binary code and a decoding system which receives the stream of ones and zeros in the pseudorandom binary code from the encoder and reproduces therefrom, using a correlation detector and associated circuitry, a replica of the original k-bit data word from the data source. Undesirable signal variations in the output of the correlation detector caused by a frequency translation error introduced in the transmission and reception of the pseudorandom binary code is eliminated by a feedback system which detects the effects of the frequency translation error at the output of the correlation detector and applies a frequency correction signal component to the pseudorandom binary code which offsets the frequency translation error prior to introduction of the pseudorandom binary code to the correlation detector.
摘要翻译：公开了一种使用相关检测的数字数据通信系统，其包括编码系统，其将来自数据源的连续k比特数据字编码为2k位重复伪随机二进制码或2k-1比特重复的预定起始停止相位伪随机二进制码和解码系统，其从编码器接收伪随机二进制码中的1和0的流，并使用相关检测器和相关联的电路从数据源再现原始k位数据字的副本。通过在相关检测器的输出端检测频率转换误差的影响的反馈系统来消除由在伪随机二进制码的发送和接收中引入的频率转换误差引起的相关检测器的输出中不期望的信号变化，将频率校正信号分量应用于伪随机二进制码，其在将伪随机二进制码引入相关检测器之前抵消频率转换误差。

9. 发明授权

US4527275A Correlation data communications system 失效
标题翻译：相关数据通信系统
公开(公告)号：US4527275A
公开(公告)日：1985-07-02
申请号：US390702
申请日：1982-06-21
申请人： James L. Russell
发明人： James L. Russell
IPC分类号： H04B7/01 , H04L7/04 , H04L23/02 , H04L27/20 , H04L27/227 , H04K1/04 , H04L27/10
CPC分类号： H04L7/042 , H04B7/01 , H04L23/02 , H04L27/2014 , H04L27/2278 , H04L7/043
摘要： A digital data communications system employing correlation detection is disclosed as comprising an encoding system which encodes successive k-bit data words from a data source into predetermined start-stop phases of either a 2.sup.k -bit repeating pseudorandom binary code or a 2.sup.k -l bit repeating pseudorandom binary code and a decoding system which receives the stream of ones and zeros in the pseudorandom binary code from the encoder and reproduces therefrom, using a correlation detector and associated circuitry, a replica of the original k-bit data word from the data source. Undesirable signal variations in the output of the correlation detector caused by a frequency translation error introduced in the transmission and reception of the pseudorandom binary code is eliminated by a feedback system which detects the effects of the frequency translation error at the output of the correlation detector and applies a frequency correction signal component to the pseudorandom binary code which offsets the frequency translation error prior to introduction of the pseudorandom binary code to the correlation detector. In lieu of the feedback system, a frequency translation error can also be minimized through the use of minimum shift keying (MSK) encoding and decoding apparatus respectively provided in the encoding and decoding systems, upstream of the correlation detector.
摘要翻译：公开了一种使用相关检测的数字数据通信系统，其包括将来自数据源的连续k位数据字编码为2k位重复伪随机二进制码或2k-1位重复的预定起始停止相位的编码系统伪随机二进制码和解码系统，其从编码器接收伪随机二进制码中的1和0的流，并使用相关检测器和相关联的电路从数据源再现原始k位数据字的副本。通过在相关检测器的输出端检测频率转换误差的影响的反馈系统来消除由在伪随机二进制码的发送和接收中引入的频率转换误差引起的相关检测器的输出中不期望的信号变化，将频率校正信号分量应用于伪随机二进制码，其在将伪随机二进制码引入相关检测器之前抵消频率转换误差。代替反馈系统，也可以通过使用分别在相关检测器的上游的编码和解码系统中提供的最小移位键控（MSK）编码和解码装置来最小化频率转换误差。

10. 发明授权

US4128835A Method and apparatus for measuring distance between an aircraft and a ground station 失效
标题翻译：用于测量飞机和地面站之间的距离的方法和装置
公开(公告)号：US4128835A
公开(公告)日：1978-12-05
申请号：US874480
申请日：1978-02-02
申请人： James L. Russell
发明人： James L. Russell
IPC分类号： G01S13/79 , G01S13/84 , G01S9/04 , G01S9/56
CPC分类号： G01S13/84 , G01S13/79
摘要： A distance measuring system is provided including a ground station transponder continuously transmitting a repeating pseudorandom coded bit pattern, and at least one aircraft interrogator receiving and locking onto the ground station signal. The aircraft interrogator transmits a coded interrogation signal in precise synchronism with an arbitrarily selected any one of the repetitive code words (bit patterns) that comprise the repeating pseudorandom coded bit pattern which are coded identically with the interrogation signal and waits for a reply. If the ground station receives the coded interrogation signal in synchronism with an identically coded word in its continuous transmission, it transmits a reply signal to the aircraft interrogator optionally encoded with synchronism error or interrogation steering information. If no reply is received by the aircraft interrogator, it transmits its next coded interrogation signal shifted by one or more bits relative to the arbitrarily selected received code word from the ground station. Successive interrogation signals are each shifted an additional predetermined number of bits until synchronism is attained and a reply signal is received. The number of bits of shifting performed by the aircraft needed for synchronization when combined with the number of bits representing the whole code word intervals elapsing between transmission of an interrogation and receipt of a reply represents the distance between the ground station and aircraft. The optionally encoded synchronism error and steering information is respectively utilized by the aircraft to more precisely calculate distance and alter its time of interrogation.
摘要翻译：提供了一种距离测量系统，包括地面站应答器连续地发送重复的伪随机编码比特模式，以及至少一个飞机询问器，接收并锁定到地面站信号上。飞机询问器以与询问信号相同的编码重复码元编码比特模式的任意一个重复码字（比特码型）任意一个进行精确同步发送编码询问信号，并等待回复。如果地面站在其连续传输中与相同编码的字同步地接收到编码的询问信号，则它向飞机询问器发送应答信号，该信号可选地用同步错误或询问指导信息进行编码。如果飞机询问器没有接收到应答，则它发送其相对于来自地面站的任意选择的接收码字移位一个或多个比特的下一个编码询问信号。连续询问信号各自移位额外的预定数量的位，直到获得同步并且接收到应答信号。当与询问的发送和回复的接收之间经过的表示整个码字间隔的位的数量组合时，由同步所需的飞机执行的位移的位数表示地面站和飞行器之间的距离。航空器分别利用可选地编码的同步误差和驾驶信息来更精确地计算距离并改变其询问时间。

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