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1. 发明申请

US20070098761A1 Processed fat composition for preventing/ameliorating lifestyle-related diseases 审中-公开
标题翻译：用于预防/改善生活方式相关疾病的加工脂肪组合物
公开(公告)号：US20070098761A1
公开(公告)日：2007-05-03
申请号：US10560900
申请日：2004-07-14
申请人： Naoki Arai , Hideyuki Kishida , Toshinori Ikehara , Tatsumasa Mae
发明人： Naoki Arai , Hideyuki Kishida , Toshinori Ikehara , Tatsumasa Mae
IPC分类号： A61K9/48 , A61K47/00
CPC分类号： A61K36/484 , A23L33/105 , A23L33/115 , A23V2002/00 , A61K9/4858 , A61K31/352 , A61K31/353 , A23V2200/332
摘要： The object of the invention is to provide a composition for prevention and/or amelioration of life-style related disease, and/or a composition for inhibition and/or amelioration of increase in body weight, comprising at least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B as compounds having a PPAR ligand activity effective in amelioration of insulin resistance and in prevention and/or amelioration of life-style related diseases such as visceral fat obesity, type 2 diabetes, hyperlipemia and hypertension, which can be utilized in food and drink such as health food and health functional food (food for specified uses and food with nutrient function), pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. At least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B is dissolved in medium-chain fatty acid triglycerides and/or partial glycerides, whereby the stability of the compound(s) is improved and the processability thereof into food and drink, pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. is also improved.
摘要翻译：本发明的目的是提供一种用于预防和/或改善生命方式相关疾病的组合物和/或用于抑制和/或改善体重增加的组合物，其包含至少一种选自以下的化合物： glabrene，glabridin，glabrol，3'-羟基-4'-O-甲基吡咯啶，4'-O-甲基吡咯啶和嗜麦芽窄食idin宾B作为具有有效改善胰岛素抵抗和预防和/或改善生命的PPAR配体活性的化合物类风湿性关节疾病，如内脏脂肪肥胖，2型糖尿病，高脂血症和高血压，可用于食品和饮料，如保健食品和保健功能食品（特定用途的食品和营养功能食品），药物制剂，药物制剂，化妆品等。至少一种选自由Glabrene，glabridin，glabrol，3'-羟基-4'-O-甲基吡咯啶，4'-O-甲基吡咯烷和hyspaglab ridin B溶解在中链脂肪酸甘油三酯和/或部分甘油酯中，从而提高了化合物的稳定性，并且其加工成食品和饮料，药物制剂，非药物制剂，化妆品等也是改进。

2. 发明申请

US20080312333A1 Agent for Preventing/Ameliorating Life Style-Related Diseases Containing Turmeric Essential Oil Component 审中-公开
标题翻译：用于预防/改善含有姜黄精油成分的生活方式相关疾病的药剂
公开(公告)号：US20080312333A1
公开(公告)日：2008-12-18
申请号：US11569835
申请日：2005-05-30
申请人： Tatsumasa Mae , Tozo Nishiyama , Hideyuki Kishida , Ryoji Takagaki , Masaji Yamamoto
发明人： Tatsumasa Mae , Tozo Nishiyama , Hideyuki Kishida , Ryoji Takagaki , Masaji Yamamoto
IPC分类号： A61K31/12 , A61K31/045 , A61K31/015 , A61P3/04 , A61P3/10
CPC分类号： A61K31/12 , A23L33/105 , A61K31/045 , A61K36/9066
摘要： The present invention has its object to provide an agent for preventing and/or ameliorating life style-related diseases which contains, as an active ingredient, a substance derived from a safe food material having a long history of being eaten as a food and which is capable of being utilized as functional foods such as health foods or functional health foods (specific health foods, functional nutritive foods).The agent for preventing and/or ameliorating life style-related diseases according to the invention contains, as an active ingredient, at least one compound selected from the group consisting of ar-turmerone, α-turmerone, β-turmerone, curlone, bisacumol and β-sesquiphellandrene, or at least one compound selected from among the bisabolane type sesquiterpenoids derived from Curcuma longa L., and therefore is useful for preventing and/or ameliorating diabetes, visceral fat obesity, metabolic syndrome and obesity, among others.
摘要翻译：本发明的目的是提供一种用于预防和/或改善生活方式相关疾病的药剂，其包含作为活性成分的来源于作为食物具有长期食用历史的安全食品的物质，其为能够用作保健食品或功能保健食品（特定健康食品，功能性营养食品）等功能性食品。根据本发明的用于预防和/或改善生活方式相关疾病的药剂含有选自下组的至少一种化合物作为活性成分，所述化合物选自：佐美酮，α-姜黄酮，β-黄酮酮，卷曲酮，双抗坏血酸和 β倍半柔比星，或至少一种选自源自姜黄的双代谢型倍半萜类化合物的化合物，因此可用于预防和/或改善糖尿病，内脏脂肪肥胖，代谢综合征和肥胖症等。

3. 发明申请

US20050287233A1 Compositions for preventing or ameliorating multiple risk factor syndromes 有权
标题翻译：用于预防或改善多种危险因素综合征的组合物
公开(公告)号：US20050287233A1
公开(公告)日：2005-12-29
申请号：US11206073
申请日：2005-08-18
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Hideyuki Kishida , Mitsuaki Kitano , Mikio Kitahara , Kaku Nakagawa
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Hideyuki Kishida , Mitsuaki Kitano , Mikio Kitahara , Kaku Nakagawa
IPC分类号： A21D2/36 , A23K1/16 , A23K1/18 , A23L1/24 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305 , A61K8/97 , A61K33/06 , A61K36/00 , A61K36/48 , A61K36/54 , A61K36/61 , A61K36/9066 , A61P3/06 , A61P3/10 , A61P9/12 , A61Q19/06 , A61K35/78
CPC分类号： A61Q19/06 , A21D2/36 , A23K20/10 , A23K50/40 , A23L27/60 , A23L33/10 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A61K8/97 , A61K36/48 , A61K36/54 , A61K36/61 , A61K36/9066 , Y10S514/909 , A61K2300/00
摘要： The invention aims at a composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.
摘要翻译：本发明旨在预防或改善涉及内脏脂肪型肥胖，糖尿病，高脂血症和高血压的多种危险因素综合征的组合物，其包含选自甘草疏水提取物，姜黄提取物，丁香提取物和肉桂提取物。

4. 发明授权

US07090874B2 Ligand for peroxisome proliferator-activated receptor 有权
公开(公告)号：US07090874B2
公开(公告)日：2006-08-15
申请号：US10752643
申请日：2004-01-08
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Hideyuki Kishida , Mitsuaki Kitano , Mikio Kitahara , Kaku Nakagawa , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Hideyuki Kishida , Mitsuaki Kitano , Mikio Kitahara , Kaku Nakagawa , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
IPC分类号： A61K36/9066
CPC分类号： A61K31/12 , A21D2/14 , A23D7/0056 , A23D9/007 , A23K20/111 , A23K50/40 , A23L7/109 , A23L27/60 , A23L33/105 , A61K31/00
摘要： The object of the present invention is to provide PPARγ ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPARγ ligand as an active agent.The present invention relates to a ligand for peroxisome proliferator-activated receptor which comprises curcumin or its derivatives. The composition according to the present invention, which comprises the PPARγ ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

5. 发明授权

US08071141B2 Compositions for preventing or ameliorating multiple risk factor syndromes 有权
标题翻译：用于预防或改善多种危险因素综合征的组合物
公开(公告)号：US08071141B2
公开(公告)日：2011-12-06
申请号：US11206073
申请日：2005-08-18
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Hideyuki Kishida , Mitsuaki Kitano , Mikio Kitahara , Kaku Nakagawa
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Hideyuki Kishida , Mitsuaki Kitano , Mikio Kitahara , Kaku Nakagawa
IPC分类号： A61K36/236 , A61K36/00
CPC分类号： A61Q19/06 , A21D2/36 , A23K20/10 , A23K50/40 , A23L27/60 , A23L33/10 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A61K8/97 , A61K36/48 , A61K36/54 , A61K36/61 , A61K36/9066 , Y10S514/909 , A61K2300/00
摘要： A composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.
摘要翻译：一种预防或改善涉及内脏脂肪型肥胖，糖尿病，高脂血症和高血压的多发危险因素综合征的组合物，其包含选自甘草疏水提取物，姜黄提取物，丁香提取物和肉桂提取物。

6. 发明授权

US07888388B2 Peroxisome proliferator activated receptor ligand and process for producing the same 有权
标题翻译：过氧化物酶体增殖物激活的受体配体及其制备方法
公开(公告)号：US07888388B2
公开(公告)日：2011-02-15
申请号：US12233069
申请日：2008-09-18
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
IPC分类号： A01N43/16
CPC分类号： C07D311/06 , A23K20/111 , A23K20/121 , A23K50/00 , A23K50/40 , A23L33/10 , A23L33/105 , A61K31/12 , A61K31/353 , A61K31/37 , A61K36/484 , A61K2300/00
摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient.The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.
摘要翻译：本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质，食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

7. 发明申请

US20080188549A1 Composition for Preventing and/or Treating Metabolic Syndrome and Insulin Resistance Syndrome 审中-公开
标题翻译：用于预防和/或治疗代谢综合征和胰岛素抵抗综合征的组合物
公开(公告)号：US20080188549A1
公开(公告)日：2008-08-07
申请号：US11815896
申请日：2006-02-08
申请人： Hozumi Tanaka , Shinichi Yokota , Misuzu Tsukagawa , Tatsumasa Mae , Minpei Kuroda , Yoshihiro Mimaki
发明人： Hozumi Tanaka , Shinichi Yokota , Misuzu Tsukagawa , Tatsumasa Mae , Minpei Kuroda , Yoshihiro Mimaki
IPC分类号： A61K31/352 , C07C49/248 , C07D311/26 , A61P3/00 , A61K31/12 , C07D493/04
CPC分类号： C07D311/28 , A61K31/121 , A61K31/352 , C07C45/78 , C07C49/84
摘要： The present invention has its object to provide a specific compound derived from a naturally occurring substance, and a composition for the prevention and/or treatment of metabolic syndrome and insulin resistance syndrome which comprises that as an active ingredient, easily and efficiently.The present invention relates to a composition for the prevention and/or treatment of metabolic syndrome and a composition for the prevention and/or treatment of insulin resistance syndrome, each of which comprises, as an active ingredient, at least one compound selected from among the compound represented by the formula (1), compounds represented by the formula (4) and compounds represented by the formula (5), or a salt or ester thereof.
摘要翻译：本发明的目的是提供衍生自天然存在物质的特定化合物，以及用于预防和/或治疗代谢综合征和胰岛素抵抗综合征的组合物，其包含作为活性成分，其容易且有效。本发明涉及用于预防和/或治疗代谢综合征的组合物和用于预防和/或治疗胰岛素抵抗综合征的组合物，其中每种组合物包含至少一种选自以下的化合物作为活性成分：由式（1）表示的化合物，由式（4）表示的化合物和由式（5）表示的化合物或其盐或酯。

8. 发明申请

US20080132544A1 Peroxisome Proliferator-Activated Receptor Ligand 审中-公开
标题翻译：过氧化物酶体增殖物激活受体配体
公开(公告)号：US20080132544A1
公开(公告)日：2008-06-05
申请号：US11792695
申请日：2005-12-19
申请人： Mitsuaki Kitano , Misuzu Tsukagawa , Eisaku Konishi , Tatsumasa Mae , Kazunori Hosoe
发明人： Mitsuaki Kitano , Misuzu Tsukagawa , Eisaku Konishi , Tatsumasa Mae , Kazunori Hosoe
IPC分类号： A61K31/445 , C07D221/00 , A61K31/164 , A61P3/04 , C07C235/00
CPC分类号： G11B17/056
摘要： An object of the present invention is to provide a peroxisome proliferator-activated receptor γ (PPARγ) ligand derived from a natural product and to provide a composition for prevention or improvement of insulin resistant syndrome, diabetes mellitus, obesity, or visceral fat obesity, characterized by comprising the ligand as an active ingredient. The present invention provides a PPARγ ligand comprising as an active ingredient, at least one compound selected from the group consisting of coumaperine and derivatives thereof. The present invention also provides a composition for prevention or improvement of insulin resistant syndrome, diabetes mellitus, obesity, or visceral fat obesity comprising the compound as an active ingredient.
摘要翻译：本发明的目的是提供一种由天然产物衍生的过氧化物酶体增殖物激活受体γ（PPARγ）配体，并提供预防或改善胰岛素抵抗综合征，糖尿病，肥胖或内脏脂肪肥胖的组合物，其特征在于通过包含配体作为活性成分。本发明提供了包含作为活性成分的至少一种选自由香豆素及其衍生物组成的组的至少一种化合物的PPARγ配体。本发明还提供了用于预防或改善包含该化合物作为活性成分的胰岛素抵抗综合征，糖尿病，肥胖症或内脏脂肪肥胖症的组合物。

9. 发明申请

US20050014819A1 Peroxisome proliferator activated receptor ligands and process for producing the same 失效
标题翻译：过氧化物酶体增殖物激活受体配体及其制备方法
公开(公告)号：US20050014819A1
公开(公告)日：2005-01-20
申请号：US10490641
申请日：2002-10-11
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
IPC分类号： A23K1/16 , A23K1/18 , A23L1/30 , A61K31/12 , A61K31/353 , A61K31/366 , A61K31/37 , A61K36/00 , A61K36/484 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P37/02 , A61P43/00 , C07D311/06 , C07D311/18 , C07D311/30 , C07D311/36 , C07D311/38 , C07D311/58 , C07D493/04
CPC分类号： C07D311/06 , A23K20/111 , A23K20/121 , A23K50/00 , A23K50/40 , A23L33/10 , A23L33/105 , A61K31/12 , A61K31/353 , A61K31/37 , A61K36/484 , A61K2300/00
摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenyl flavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.
摘要翻译：本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯黄酮，不含异戊烯基类黄酮的查耳酮衍生物，不包含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或酯化物质或食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

10. 发明申请

US20130172245A1 Liquid food composition 有权
标题翻译：液体食物组成
公开(公告)号：US20130172245A1
公开(公告)日：2013-07-04
申请号：US13516536
申请日：2010-12-17
申请人： Hiroaki Inoue , Yui Kawashima , Kazuya Hamada , Shinichi Yokota , Hiromi Maeda , Tatsumasa Mae , Jun Tomono
发明人： Hiroaki Inoue , Yui Kawashima , Kazuya Hamada , Shinichi Yokota , Hiromi Maeda , Tatsumasa Mae , Jun Tomono
IPC分类号： A23L1/29
CPC分类号： A23L1/296 , A23L33/16 , A23L33/17 , A23L33/185 , A23L33/21 , A23L33/40 , A61K9/0065 , A61K9/10
摘要： Provided is a liquid food composition capable of semi-solidifying in the stomach, which is a one-pack type product containing a water-soluble dietary fiber preliminarily added thereto and in the form of a liquid that can be easily taken, and stably sustains the liquid nature thereof during distribution and storage. The liquid food composition, which is capable of semi-solidifying in an acidic region, comprises a water-soluble dietary fiber (a), a specific metal compound (b), a protein (c) and an emulsifier (d), and the particle size distribution of particles contained in said liquid food composition shows two or more peaks in a neutral region.
摘要翻译：本发明提供一种能够在胃中半固化的液体食品组合物，其为预先添加有水溶性膳食纤维的单组分产品，并且可以容易地摄取并且稳定地维持在分配和储存期间的液体性质。能够在酸性区域半固化的液体食品组合物包含水溶性膳食纤维（a），特定金属化合物（b），蛋白质（c）和乳化剂（d），并且包含在所述液体食品组合物中的颗粒的粒度分布在中性区域中显示两个或多个峰。

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