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1. 发明申请

US20160199430A1 A Purified Extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma 有权
标题翻译：从Pseudolysimachion rotundum var。中分离的纯化提取物含有大量活性成分的亚结构，其制备方法和包含其作为预防或治疗炎症，过敏和哮喘的活性成分的组合物
公开(公告)号：US20160199430A1
公开(公告)日：2016-07-14
申请号：US14653852
申请日：2013-12-23
申请人： YUNGJIN PHARMACEUTICAL CO., LTD. , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人： Yongnam LEE , Ji-seok YOO , Dae-hee SHIN , Byung-hwan RYOO , Sei-ryang OH , Kyung-seop AHN , Hyeongkyu LEE , Ok-kyoung KWON , Doo-young KIM , Jung-hee KIM , Hyuk-hwan SONG
IPC分类号： A61K36/68 , A61K31/192 , A61K31/7048
CPC分类号： A61K36/68 , A23L1/296 , A23L27/10 , A23L33/105 , A23V2002/00 , A61K9/0056 , A61K31/192 , A61K31/7048 , A61K36/80 , A61K2236/15 , A61K2236/33 , A61K2236/331 , A61K2236/333 , A61K2236/39 , A61K2236/51 , A61K2236/55
摘要： A method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of Pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.
摘要翻译：一种制备纯化提取物的方法，该纯化提取物含有比现有技术中公开的常规制备方法制备的含有更丰富活性成分如萜类衍生物的提取物，其含有纯化的提取物，其用于治疗和/ 预防炎症，过敏性或哮喘性疾病。纯化的提取物比通过各种体内试验例如现有技术公开的常规制备方法制备的抗炎，抗过敏和抗哮喘活性更强，如嗜酸性粒细胞的再生抑制试验，免疫球蛋白的释放和血浆和支气管肺泡液中的炎性趋化因子以及在OVA致敏/攻击小鼠模型中抑制气道高反应性和杯状细胞增生。

2. 发明授权

US09226521B2 Infant formula with probiotics and milk fat globule membrane components 有权
标题翻译：婴幼儿配方配有益生菌和乳脂肪球膜组分
公开(公告)号：US09226521B2
公开(公告)日：2016-01-05
申请号：US13514513
申请日：2010-12-07
申请人： Jalil Benyacoub , Stephanie Blum-Sperisen , Mohamed Nabil Bosco , Lionel Jean Rene Bovetto , Isabelle Bureau-Franz , Anne Donnet-Hughes , Eduardo Schiffrin , Laurent Favre
发明人： Jalil Benyacoub , Stephanie Blum-Sperisen , Mohamed Nabil Bosco , Lionel Jean Rene Bovetto , Isabelle Bureau-Franz , Anne Donnet-Hughes , Eduardo Schiffrin , Laurent Favre
IPC分类号： A61K35/74 , A23L1/29 , A23L1/30 , A23L1/305 , A61K35/20
CPC分类号： A23L1/296 , A23C2240/05 , A23L33/115 , A23L33/135 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K35/20 , A61K35/74 , A61K2300/00 , A23V2200/3202 , A23V2200/3204 , A23V2200/324 , A23V2200/32 , A23V2250/18
摘要： A nutritional composition is proposed comprising a probiotic and milk fat globule membrane (MFGM) wherein the MFGM and the probiotics mutually potentiate their respective effects and promote complementary beneficial protective mechanisms that reflect physiological synergy. The nutritional composition can be an infant formula, infant cereals, baby food or health care nutritional product. The synergistic effect can include promoting immune maturation and/or immune education and/or reducing inflammation and/or treating or preventing disease or infections.
摘要翻译：提出了一种营养组合物，其包括益生菌和乳脂肪球膜（MFGM），其中MFGM和益生菌相互增强其各自的作用并促进反映生理协同作用的互补有益的保护机制。营养成分可以是婴儿配方食品，婴儿谷物，婴儿食品或保健营养品。协同效应可以包括促进免疫成熟和/或免疫教育和/或减少炎症和/或治疗或预防疾病或感染。

3. 发明授权

US08889617B2 Liquid food composition 有权
标题翻译：液体食物组成
公开(公告)号：US08889617B2
公开(公告)日：2014-11-18
申请号：US13516536
申请日：2010-12-17
申请人： Hiroaki Inoue , Yui Kawashima , Kazuya Hamada , Shinichi Yokota , Hiromi Maeda , Tatsumasa Mae , Jun Tomono
发明人： Hiroaki Inoue , Yui Kawashima , Kazuya Hamada , Shinichi Yokota , Hiromi Maeda , Tatsumasa Mae , Jun Tomono
IPC分类号： A23L1/29 , A61K9/00 , A23L1/308 , A23L1/304 , A23L1/305 , A61K9/10
CPC分类号： A23L1/296 , A23L33/16 , A23L33/17 , A23L33/185 , A23L33/21 , A23L33/40 , A61K9/0065 , A61K9/10
摘要： Provided is a liquid food composition capable of semi-solidifying in the stomach, which is a one-pack type product containing a water-soluble dietary fiber preliminarily added thereto and in the form of a liquid that can be easily taken, and stably sustains the liquid nature thereof during distribution and storage. The liquid food composition, which is capable of semi-solidifying in an acidic region, comprises a water-soluble dietary fiber (a), a specific metal compound (b), a protein (c) and an emulsifier (d), and the particle size distribution of particles contained in said liquid food composition shows two or more peaks in a neutral region.
摘要翻译：本发明提供一种能够在胃中半固化的液体食品组合物，其为预先添加有水溶性膳食纤维的单组分产品，并且可以容易地摄取并且稳定地维持在分配和储存期间的液体性质。能够在酸性区域半固化的液体食品组合物包含水溶性膳食纤维（a），特定金属化合物（b），蛋白质（c）和乳化剂（d），并且包含在所述液体食品组合物中的颗粒的粒度分布在中性区域中显示两个或多个峰。

4. 发明授权

US08834941B2 Method of treatment and prevention of metabolic and digestion disorders and of pathological states associated therewith and products used therein 有权
标题翻译：治疗和预防代谢和消化障碍及其相关病理状态的方法及其中使用的产品
公开(公告)号：US08834941B2
公开(公告)日：2014-09-16
申请号：US12627590
申请日：2009-11-30
申请人： Gela Sulaberidze
发明人： Gela Sulaberidze
IPC分类号： A61K36/00 , A23L1/29 , A23L1/10 , A23L1/164 , A23L1/314 , A61K36/889 , A61K36/899 , A23L1/308
CPC分类号： A23L1/296 , A23L7/115 , A23L7/139 , A23L7/198 , A23L13/426 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K36/889 , A61K36/899 , A61K2300/00 , A23V2200/332 , A23V2200/32 , A23V2250/5106 , A23V2250/022
摘要： This invention relates to methods for the treatment and prevention of metabolic disorders, digestive disorders, and pathological conditions related thereto whereby a patient is given a nutrient food combination comprising 1) mechanically processed bran and 2) meat or a dried product comprising fruit, vegetables, berries, or any combination thereof. Diluted vinegar may be included.
摘要翻译：本发明涉及用于治疗和预防代谢紊乱，消化系统疾病以及与之有关的病理状况的方法，由此给予患者营养食品组合，其包括1）机械加工的麸皮和2）包含水果，蔬菜，浆果或其任何组合。可能包括稀释的醋。

5. 发明授权

US08815279B2 Baby feeding formula and system 有权
标题翻译：婴儿喂养配方和系统
公开(公告)号：US08815279B2
公开(公告)日：2014-08-26
申请号：US12318678
申请日：2009-01-06
申请人： Atul Singhal , Alan Lucas
发明人： Atul Singhal , Alan Lucas
IPC分类号： A61K47/00 , A23L1/29 , A23L1/305 , A23L1/302 , A23L1/304
CPC分类号： A23L1/296 , A23L33/15 , A23L33/16 , A23L33/17 , A23L33/40 , Y10S426/801
摘要： A method is provided for reducing the extent of or occurrence of long-term adverse health effects in human infants, comprising feeding to said infants when newborn a nutrient-containing-formula providing not more than 1 gram of protein per 100 ml of formula and/or not more than 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of obesity or atherosclerosis in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.
摘要翻译：提供了一种减少人类婴儿长期不良健康影响的程度或发生的方法，包括在新生儿时向所述婴儿喂养含营养素的配方，每100ml配方提供不超过1克的蛋白质和/ 或不超过50kcal / 100ml配方。还公开了施用婴儿配方以降低生命后期个体中胰岛素抵抗的发生或程度的方法，以通过喂养新生儿来减少生命中以后的个体或其组合中的肥胖或动脉粥样硬化的发生或程度本文所述的新生儿婴儿配方奶粉。

6. 发明申请

US20140065259A1 NUTRITIONAL COMPOSITIONS HAVING REDUCED SODIUM CONTENT AND METHODS FOR MAKING SAME 有权
标题翻译：具有减少的钠含量的营养组合物及其制备方法
公开(公告)号：US20140065259A1
公开(公告)日：2014-03-06
申请号：US14008345
申请日：2012-03-26
申请人： Elizabeth Ann-Clubbs Koenig , Jill Dean Wegner , Karen Wink Barnes
发明人： Elizabeth Ann-Clubbs Koenig , Jill Dean Wegner , Karen Wink Barnes
IPC分类号： A23L1/29
CPC分类号： A23L1/296 , A23L7/109 , A23L11/01 , A23L19/00 , A23L27/40 , A23L33/16 , A23L33/40
摘要： Nutritional compositions with targeted sodium levels for young children (e.g., ages 1-4 years) are provided. In a general embodiment, the present disclosure provides nutritional compositions having a targeted level of sodium, made from wholesome foods that provide macronutrients and micronutrients needed in a child's daily diet and are developmentally appropriate for this age group. The sodium levels of the nutritional compositions may be less than or equal to about 200 mg per 100 g nutritional composition. Methods of making nutritional compositions with targeted sodium levels while also achieving acceptable product flavors at both pilot and factory levels are also provided. The batching methods may include adding a slurry of ice, cold water and KCl to a batched product after an initial cooling step and before packaging.
摘要翻译：提供了针对幼儿（例如，1-4岁）的目标钠水平的营养组合物。在一般实施方案中，本公开提供了具有目标水平的钠的营养组合物，其由在儿童日常饮食中提供大量营养素和微量营养素的健康食品制成，并且适合于该年龄组。营养组合物的钠水平可以小于或等于约200mg / 100g营养组合物。还提供了制备具有目标钠含量的营养组合物同时在试验和工厂水平实现可接受的产品香料的方法。配料方法可以包括在初始冷却步骤之后和在包装之前将冰，冷水和KCl的浆料加入到批次产品中。

7. 发明授权

US08652563B2 Nutrient composition 有权
标题翻译：营养成分
公开(公告)号：US08652563B2
公开(公告)日：2014-02-18
申请号：US12038290
申请日：2008-02-27
申请人： Itaru Kon , Naoki Hayashi , Tatsuro Tanaka , Hisayuki Uneyama , Shinji Somekawa
发明人： Itaru Kon , Naoki Hayashi , Tatsuro Tanaka , Hisayuki Uneyama , Shinji Somekawa
IPC分类号： A23G3/00
CPC分类号： A23L1/296 , A23L33/40 , A61K35/20
摘要： The present invention relates to a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that the volume-based median size (d50) of particles in the nutrient composition is 5 to 100 μm and water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition, or a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition and the mass of the protein with respect to the total moles of divalent ions forming the water-insoluble particles is 1.5 to 3 g/mmol.
摘要翻译：本发明涉及至少含有碳水化合物，脂质，蛋白质和矿物质，并且是液体或半固体的营养组合物，其特征在于，营养组合物中颗粒的基于体积的中值大小（d50）为作为营养组合物的主要成分，含有至少含有碳水化合物，脂质，蛋白质和矿物质的营养成分，含有5〜100μm的具有不溶于二价阳离子的蛋白质的水不溶性粒子，以及是液体或半固体，其特征在于含有不溶于二价阳离子的蛋白质的水不溶性颗粒作为营养组合物的主要组分，并且蛋白质的质量相对于形成水不溶性的二价离子的总摩尔数颗粒为1.5〜3g / mmol。

8. 发明申请

US20130224331A1 NUTRITIONAL COMPOSITION CONTAINING OLIGOSACCHARIDE MIXTURE 有权
标题翻译：含有低聚糖混合物的营养组合物
公开(公告)号：US20130224331A1
公开(公告)日：2013-08-29
申请号：US13860229
申请日：2013-04-10
申请人： Nestec S.A.
发明人： Marie-Claire Fichot , Norbert Sprenger , Francois-Pierre Martin , Sunil Kochhar , Serge Rezzi
IPC分类号： A23L1/29
CPC分类号： A23L1/296 , A23L2/52 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/135 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , A23V2250/28 , A23V2250/704 , A23V2250/70 , A23V2250/156 , A23V2200/332
摘要： A nutritional composition for administration to an infant which composition comprises, on a dry matter basis, from 2.5 to 15.0 wt % of an oligosaccharide mixture consisting of N-acetylated oligosaccharide(s), galacto-oligasaccharide(s) and sialylated oligosaccharide(s) with the proviso that the composition comprises at least 0.02 wt % of an N-acetylated oligosaccharide, at least 2.0 wt % of a galacto-oligosaccharide and at least 0.04 wt % of a sialylated oligosaccharide and that the N-acetylated oligosaccharide(s) comprise 0.5 to 4.0% of the oligosaccharide mixture, the galacto- oligosaccharide(s) comprise 92.0 to 98.5% of the oligosaccharide mixture and the sialylated oligosacchardide(s) comprise 1.0 to 4.0% of the oligosaccharide mixture. The composition is useful for administration to an infant in the first six months of life to reduce the risk of obesity later in life.
摘要翻译：一种用于给予婴儿的营养组合物，其组合物以干物质为基础，包含2.5至15.0重量％的由N-乙酰化寡糖，半乳寡糖和唾液酸化寡糖组成的寡糖混合物，条件是组合物包含至少0.02重量％的N-乙酰化寡糖，至少2.0重量％的低聚半乳糖和至少0.04重量％的唾液酸化寡糖，并且所述N-乙酰化寡糖包含 0.5至4.0％的寡糖混合物中，寡聚半乳糖包含92.0至98.5％的寡糖混合物，唾液酸化的寡糖包含寡糖混合物的1.0-4.0％。该组合物可用于在生命的头六个月对婴儿的施用以降低生命后期的肥胖风险。

9. 发明授权

US08425955B2 Nutritional composition with prebiotic component 有权
标题翻译：营养成分与益生元组分
公开(公告)号：US08425955B2
公开(公告)日：2013-04-23
申请号：US12843610
申请日：2010-07-26
申请人： Anja Wittke
发明人： Anja Wittke
IPC分类号： A23D7/00 , A61K31/715 , A61K31/202
CPC分类号： A23L1/296 , A23L33/10 , A23L33/115 , A23L33/17 , A23L33/26 , A23L33/40
摘要： The present disclosure relates to nutritional compositions comprising a prebiotic component for inhibiting adherence of pathogens in the gastrointestinal tract of a subject and to the prebiotic component, which comprises galactooligosaccharide, polydextrose or any mixture thereof. The nutritional compositions of the present disclosure comprise a fat or lipid source, a protein source, and a carbohydrate source comprising an effective amount of the prebiotic component.
摘要翻译：本公开涉及营养组合物，其包含用于抑制受试者的胃肠道中的病原体的粘附的益生元组分和包含低聚半乳糖，聚右旋糖或其任何混合物的益生元组分。本公开的营养组合物包含脂肪或脂质来源，蛋白质来源和包含有效量的益生元组分的碳水化合物源。

10. 发明申请

US20120321600A1 INFANT FORMULA WITH PROBIOTICS AND MILK FAT GLOBULE MEMBRANE COMPONENTS 有权
标题翻译：婴儿配方奶粉与乳糖全球薄膜组件
公开(公告)号：US20120321600A1
公开(公告)日：2012-12-20
申请号：US13514513
申请日：2010-12-07
申请人： Jalil Benyacoub , Stephanie Blum-Sperisen , Mohamed Nabil Bosco , Lionel Jean Rene Bovetto , Isabelle Bureau-Franz , Anne Donnet-Hughes , Eduardo Schiffrin , Laurent Favre
发明人： Jalil Benyacoub , Stephanie Blum-Sperisen , Mohamed Nabil Bosco , Lionel Jean Rene Bovetto , Isabelle Bureau-Franz , Anne Donnet-Hughes , Eduardo Schiffrin , Laurent Favre
IPC分类号： A61K35/74 , A61P1/00 , A61P29/00 , A61P31/00 , A61P3/02 , A61P37/00
CPC分类号： A23L1/296 , A23C2240/05 , A23L33/115 , A23L33/135 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K35/20 , A61K35/74 , A61K2300/00 , A23V2200/3202 , A23V2200/3204 , A23V2200/324 , A23V2200/32 , A23V2250/18
摘要： A nutritional composition is proposed comprising a probiotic and milk fat globule membrane (MFGM) wherein the MFGM and the probiotics mutually potentiate their respective effects and promote complementary beneficial protective mechanisms that reflect physiological synergy. The nutritional composition can be an infant formula, infant cereals, baby food or health care nutritional product. The synergistic effect can include promoting immune maturation and/or immune education and/or reducing inflammation and/or treating or preventing disease or infections.
摘要翻译：提出了一种营养组合物，其包括益生菌和乳脂肪球膜（MFGM），其中MFGM和益生菌相互增强其各自的作用并促进反映生理协同作用的互补有益的保护机制。营养成分可以是婴儿配方食品，婴儿谷物，婴儿食品或保健营养品。协同效应可以包括促进免疫成熟和/或免疫教育和/或减少炎症和/或治疗或预防疾病或感染。

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