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1. 发明授权

US08945856B2 Affinity-based detection of biological targets 有权
标题翻译：基于亲和力的生物靶标检测
公开(公告)号：US08945856B2
公开(公告)日：2015-02-03
申请号：US14188784
申请日：2014-02-25
申请人： Nadezhda V. Kulagina , Chris Rowe Taitt , George P. Anderson , Frances S. Ligler
发明人： Nadezhda V. Kulagina , Chris Rowe Taitt , George P. Anderson , Frances S. Ligler
IPC分类号： G01N33/53 , G01N33/569 , G01N33/554 , G01N33/543
CPC分类号： G01N33/56916 , G01N33/5308 , G01N33/54366 , G01N33/554 , G01N33/56911 , G01N33/56983
摘要： A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.
摘要翻译：生物化学鉴定的方法是：提供与一种或多种底物结合的多种捕获物质，并怀疑具有与至少一种捕获物质结合的一种或多种生物靶标; 检测哪些捕获物种含有结合的生物靶标以产生结合模式; 以及基于所述结合模式识别所述生物学目标。捕获物种独立地选自抗微生物肽，细胞毒性肽，抗生素及其组合。具有捕获物质与基底结合的装置。至少两种捕获物质能够与一种或多种生物靶标进行多特异性结合，并且可以具有重叠但不相同的亲和性质。

2. 发明申请

US20140187446A1 AFFINITY-BASED DETECTION OF BIOLOGICAL TARGETS 有权
标题翻译：基于生物目标的基于亲属的检测
公开(公告)号：US20140187446A1
公开(公告)日：2014-07-03
申请号：US14188784
申请日：2014-02-25
申请人： Nadezhda V. Kulagina , Chris Rowe Taitt , George P. Anderson , Frances S. Ligler
发明人： Nadezhda V. Kulagina , Chris Rowe Taitt , George P. Anderson , Frances S. Ligler
IPC分类号： G01N33/569 , G01N33/543
CPC分类号： G01N33/56916 , G01N33/5308 , G01N33/54366 , G01N33/554 , G01N33/56911 , G01N33/56983
摘要： A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.
摘要翻译：生物化学鉴定的方法是：提供与一种或多种底物结合的多种捕获物质，并怀疑具有与至少一种捕获物质结合的一种或多种生物靶标; 检测哪些捕获物种含有结合的生物靶标以产生结合模式; 以及基于所述结合模式识别所述生物学目标。捕获物种独立地选自抗微生物肽，细胞毒性肽，抗生素及其组合。具有捕获物质与基底结合的装置。至少两种捕获物质能够与一种或多种生物靶标进行多特异性结合，并且可以具有重叠但不相同的亲和性质。

3. 发明申请

US20150203548A1 Single-Domain Antibodies with Improved Thermal Stability Under Cytoplasmic Expression 审中-公开
标题翻译：具有改善细胞质表达下热稳定性的单域抗体
公开(公告)号：US20150203548A1
公开(公告)日：2015-07-23
申请号：US14158208
申请日：2014-01-17
申请人： Daniel Zabetakis , George P. Anderson , Ellen R. Goldman , Kendrick Turner , P. Audrey Brozozog Lee
发明人： Daniel Zabetakis , George P. Anderson , Ellen R. Goldman , Kendrick Turner , P. Audrey Brozozog Lee
IPC分类号： C07K14/47 , C07K16/12
CPC分类号： C07K14/47 , C07K16/1271 , C07K16/1278 , C07K16/16 , C07K2317/569 , C07K2317/94 , C07K2319/00
摘要： Methods of producing a single-domain antibody (sdAb) include causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of α-synuclein; and then purifying the sdAb, wherein the fusion protein is expressed free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
摘要翻译：产生单结构域抗体（sdAb）的方法包括使细菌将细胞表达为细菌的细胞质，其中sdAb与α-突触核蛋白的酸性尾端一起表达为融合蛋白; 然后纯化sdAb，其中融合蛋白被表达为没有周质位置标签。这种抗体在热变性后具有突然的重折叠能力。

4. 发明申请

US20100308275A1 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US20100308275A1
公开(公告)日：2010-12-09
申请号：US12318028
申请日：2008-12-19
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/02
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

5. 发明授权

US07470379B2 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US07470379B2
公开(公告)日：2008-12-30
申请号：US11080946
申请日：2005-03-16
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

6. 发明申请

US20150268214A1 Antibody and Recombinant Derivative for the Detection of Trinitrotoluene 有权
标题翻译：用于检测三硝基甲苯的抗体和重组衍生物
公开(公告)号：US20150268214A1
公开(公告)日：2015-09-24
申请号：US13653474
申请日：2012-10-17
申请人： Jinny Lin Liu , Daniel Zabetakis , Ellen R. Goldman , George P. Anderson
发明人： Jinny Lin Liu , Daniel Zabetakis , Ellen R. Goldman , George P. Anderson
IPC分类号： G01N33/22 , G01N33/53 , C07K16/44
CPC分类号： G01N33/227 , C07K16/44 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , G01N33/5308
摘要： Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
摘要翻译：本文描述了有效结合三硝基甲苯（TNT）的新的识别元件（抗体或其功能片段）。还公开了单链片段识别元件。

7. 发明授权

US07435386B2 Reagentless and reusable biosensors with tunable differential binding affinities and methods of making 有权
标题翻译：具有可调节差异结合亲和力和制备方法的无菌和可重复使用的生物传感器
公开(公告)号：US07435386B2
公开(公告)日：2008-10-14
申请号：US11094540
申请日：2005-03-25
申请人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
发明人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
IPC分类号： G01N21/00 , G01N21/01 , G01N21/64 , G01N33/53 , G01N33/553
CPC分类号： C12Q1/6818 , B82Y5/00 , B82Y10/00 , C12Q1/6825 , G01N21/6428 , G01N2021/6441 , C12Q2565/607 , C12Q2565/101
摘要： The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor-operates without additional development reagents, requiring only the presence of analyte or target for function.
摘要翻译：生物传感器包括模块化生物识别元件和模块化柔性臂元件。生物识别元件和柔性臂元件各自用信号元件标记。柔性臂包含与生物识别元件结合的感兴趣分析物的类似物，使得两个信号元件紧密相邻，这建立了基线荧光共振能量转移（FRET）。当感兴趣的分析物被提供给生物传感器时，分析物将置换分析物类似物，并且借助于该模块化柔性臂的信号模块，以分析物浓度依赖的方式引起FRET信号的可测量的变化。生物传感器的不同部分的模块化允许功能灵活性。生物传感器无需额外的开发试剂即可进行操作，仅需要分析物或靶标的功能。

8. 发明授权

US4228419A Emergency vehicle traffic control system 失效
标题翻译：应急车辆交通管制系统
公开(公告)号：US4228419A
公开(公告)日：1980-10-14
申请号：US932264
申请日：1978-08-09
申请人： George P. Anderson
发明人： George P. Anderson
IPC分类号： G08G1/087 , G08G1/07
CPC分类号： G08G1/087
摘要： The present system provides a traffic signal control system which will allow moving emergency vehicles to remotely take control of the traffic signals at an intersection. The transmitter part of the system utilizes a microwave transmitter that is mounted on each emergency vehicle, which transmitter emits a pulse coded message which is received by a permanently fixed receiver at each intersection to be controlled. The receiver includes decoding logic to verify that a valid code request has been transmitted by the vehicle. The receiver includes a directional antenna that faces each direction to be controlled which therefore automatically discriminates against signals being received from other directions, and if the appropriate code is received during a predetermined interval of time, the receiver will cause the traffic signals to cycle so that a green or go phase will be directed to the oncoming emergency vehicle and cross traffic will be warned by red signals facing it. After the emergency vehicle has entered the intersection, lack of direct transmission from it will conclude the control after a fixed delay to allow the vehicle time to clear the intersection. The same fixed delay will enable the vehicle to maintain control of the intersection even if it should momentarily lose direct microwave contact because of an intervening large truck or bus.
摘要翻译：本系统提供了一种交通信号控制系统，该系统将允许移动的紧急车辆在交叉路口远程控制交通信号。系统的发射机部分使用安装在每个紧急车辆上的微波发射机，该发射机发射脉冲编码消息，该脉冲编码消息由被控制的每个交叉路口处的永久固定的接收机接收。接收机包括解码逻辑以验证车辆已发送有效的代码请求。接收机包括定向天线，其面向要控制的每个方向，因此自动识别从其它方向接收的信号，并且如果在预定的时间间隔期间接收到适当的代码，则接收机将使交通信号循环，使得一个绿色或进入阶段将被引导到即将到来的应急车辆，交叉路口将被面临的红色信号警告。紧急车辆进入十字路口后，由于缺少直接传输，在一段固定的延时之后可以结束控制，让车辆时间清除十字路口。相同的固定延迟将使得车辆能够保持交叉路口的控制，即使由于中间大型卡车或公共汽车，它也应该暂时失去直接的微波接触。

9. 发明授权

US08192646B2 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US08192646B2
公开(公告)日：2012-06-05
申请号：US13229177
申请日：2011-09-09
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

10. 发明申请

US20090272913A1 FLUORESCENT ORGANIC NANOPARTICLES 有权
标题翻译：荧光有机纳米粒子
公开(公告)号：US20090272913A1
公开(公告)日：2009-11-05
申请号：US12431784
申请日：2009-04-29
申请人： Jawad Naciri , Christopher M. Spillmann , George P. Anderson , Banahalli R. Ratna
发明人： Jawad Naciri , Christopher M. Spillmann , George P. Anderson , Banahalli R. Ratna
IPC分类号： G01N21/64 , C09K11/02 , C07D471/06
CPC分类号： G01N21/6428 , B82Y20/00 , B82Y30/00 , C07D471/06 , C09K11/06 , C09K2211/1416 , C09K2211/1433 , C09K2211/1466 , G01N2021/6439 , G01N2021/6441 , H05B33/14
摘要： A nanoparticle having a surfactant shell with a hydrophilic outer surface and a hydrophobic inner surface and an organic chromophore and a polymer having aromatic groups within the surfactant shell. A method of making nanoparticles by: emulsifying an aqueous composition of a surfactant and an organic solution of a monomer and an organic chromophore to form micelles of the monomer and the chromophore inside a surfactant shell; and polymerizing the monomer. A method of: reacting a ω-bromoalkyl acid with acryloyl acid lithium salt, and reacting the product with sodium hydride to produce an acryloyloxyalkyl carboxylic acid sodium salt. The compound shown below.
摘要翻译：具有亲水外表面和疏水性内表面的表面活性剂外壳和有机发色团的纳米颗粒和在表面活性剂外壳内具有芳族基团的聚合物。一种通过以下方法制备纳米颗粒：将表面活性剂的水性组合物和单体和有机发色团的有机溶液乳化，以在表面活性剂壳内形成单体和发色团的胶束; 并使单体聚合。一种使ω-溴烷基酸与丙烯酰基锂盐反应并使产物与氢化钠反应产生丙烯酰氧基烷基羧酸钠盐的方法。化合物如下所示。

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