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1. 发明授权

US06921496B2 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US06921496B2
公开(公告)日：2005-07-26
申请号：US09811824
申请日：2001-03-20
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： G01N33/566 , G01N33/53 , G01N33/551 , G01N33/58 , C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

2. 发明申请

US20110319601A1 Inorganic Particle Conjugates 有权
标题翻译：无机粒子共轭体
公开(公告)号：US20110319601A1
公开(公告)日：2011-12-29
申请号：US13229177
申请日：2011-09-09
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C07K17/14 , C07H21/00 , C07K14/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

3. 发明授权

US08034259B2 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US08034259B2
公开(公告)日：2011-10-11
申请号：US12318028
申请日：2008-12-19
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

4. 发明申请

US20100308275A1 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US20100308275A1
公开(公告)日：2010-12-09
申请号：US12318028
申请日：2008-12-19
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/02
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

5. 发明授权

US07470379B2 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US07470379B2
公开(公告)日：2008-12-30
申请号：US11080946
申请日：2005-03-16
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

6. 发明授权

US08192646B2 Inorganic particle conjugates 有权
标题翻译：无机颗粒共轭物
公开(公告)号：US08192646B2
公开(公告)日：2012-06-05
申请号：US13229177
申请日：2011-09-09
申请人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
发明人： George P. Anderson , Hedi Mattoussi , J. Matthew Mauro , Moungi G. Bawendi , Vikram C. Sundar
IPC分类号： C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译：离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。

7. 发明授权

US07361516B2 Field of modular multifunctional ligands 失效
标题翻译：模块化多功能配体领域
公开(公告)号：US07361516B2
公开(公告)日：2008-04-22
申请号：US10956586
申请日：2004-09-24
申请人： Harry T. Uyeda , Hedi Mattoussi , Igor L. Medintz
发明人： Harry T. Uyeda , Hedi Mattoussi , Igor L. Medintz
IPC分类号： G01N33/544 , G01N33/551 , C07C321/112 , C07C321/116
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/588 , Y10T436/182
摘要： This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof. Colloidal nanoparticle is characterized by an inorganic surface having attached to it one or more of the ligands, The colloidal bioconjugate is characterized by an inorganic surface having attached thereto one or more of the ligand wherein at least some of the ligand have a biomolecule conjugated thereto.
摘要翻译：本发明涉及表面配体; 配体的制备; 胶体纳米颗粒，例如带有一个或多个配体的量子点; 其特征在于具有一个或多个与生物分子缀合的配体的纳米颗粒。该配体的特征在于存在可以附着到无机表面上的原子的第一模块; 赋予配体和附着于配体的无机表面的水溶性的第二模块; 以及包含可以直接或间接缀合到生物分子的官能团的第三模块。模块的顺序可以不同，其他模块和组可以在配体上。配体的制备包括以下步骤：将具有可附着于无机表面的原子的化合物与赋予其可配位的无机表面和赋予其水溶性的水溶性化合物反应。胶体纳米颗粒的特征在于其上附着有一个或多个配体的无机表面。胶体生物缀合物的特征在于具有与一个或多个配体连接的无机表面，其中至少一些配体具有与其结合的生物分子。

8. 发明申请

US20070269904A1 FIELD OF MODULAR MULTIFUNCTIONAL LIGANDS 有权
标题翻译：模块化多功能配置领域
公开(公告)号：US20070269904A1
公开(公告)日：2007-11-22
申请号：US11775255
申请日：2007-07-10
申请人： Harry Uyeda , Hedi Mattoussi , Igor Medintz
发明人： Harry Uyeda , Hedi Mattoussi , Igor Medintz
IPC分类号： G01N33/553
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/588 , Y10T436/182
摘要： This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof. Colloidal nanoparticle is characterized by an inorganic surface having attached to it one or more of the ligands. The colloidal bioconjugate is characterized by an inorganic surface having attached thereto one or more of the ligand wherein at least some of the ligand have a biomolecule conjugated thereto.
摘要翻译：本发明涉及表面配体; 配体的制备; 胶体纳米颗粒，例如带有一个或多个配体的量子点; 其特征在于具有一个或多个与生物分子缀合的配体的纳米颗粒。该配体的特征在于存在可以附着到无机表面上的原子的第一模块; 赋予配体和附着于配体的无机表面的水溶性的第二模块; 以及包含可以直接或间接缀合到生物分子的官能团的第三模块。模块的顺序可以不同，其他模块和组可以在配体上。配体的制备包括以下步骤：将具有可附着于无机表面的原子的化合物与赋予其可配位的无机表面和赋予其水溶性的水溶性化合物反应。胶体纳米颗粒的特征在于其上连接有一个或多个配体的无机表面。胶体生物缀合物的特征在于其上附着有一种或多种配体的无机表面，其中至少一些配体具有与其缀合的生物分子。

9. 发明申请

US20060068506A1 Field of modular multifunctional ligands 失效
标题翻译：模块化多功能配体领域
公开(公告)号：US20060068506A1
公开(公告)日：2006-03-30
申请号：US10956586
申请日：2004-09-24
申请人： Harry Uyeda , Hedi Mattoussi , Igor Medintz
发明人： Harry Uyeda , Hedi Mattoussi , Igor Medintz
IPC分类号： G01N33/553
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/588 , Y10T436/182
摘要： This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof. Colloidal nanoparticle is characterized by an inorganic surface having attached to it one or more of the ligands, The colloidal bioconjugate is characterized by an inorganic surface having attached thereto one or more of the ligand wherein at least some of the ligand have a biomolecule conjugated thereto.
摘要翻译：本发明涉及表面配体; 配体的制备; 胶体纳米颗粒，例如带有一个或多个配体的量子点; 其特征在于具有一个或多个与生物分子缀合的配体的纳米颗粒。该配体的特征在于存在可以附着到无机表面上的原子的第一模块; 赋予配体和附着于配体的无机表面的水溶性的第二模块; 以及包含可以直接或间接缀合到生物分子的官能团的第三模块。模块的顺序可以不同，其他模块和组可以在配体上。配体的制备包括以下步骤：将具有可附着于无机表面的原子的化合物与赋予其可配位的无机表面和赋予其水溶性的水溶性化合物反应。胶体纳米颗粒的特征在于其上附着有一个或多个配体的无机表面。胶体生物缀合物的特征在于具有与一个或多个配体连接的无机表面，其中至少一些配体具有与其结合的生物分子。

10. 发明申请

US20080087843A1 METHOD OF CONTROLLING QUANTUM DOT PHOTOLUMINESCENCE AND OTHER INTRINSIC PROPERTIES THROUGH BIOLOGICAL SPECIFICITY 失效
标题翻译：通过生物学特性控制量子点光致发光和其他内在特性的方法
公开(公告)号：US20080087843A1
公开(公告)日：2008-04-17
申请号：US11683226
申请日：2007-03-07
申请人： Igor Medintz , Hedi Mattoussi , Moungi Bawendi , J. Mauro , George Anderson , Thomas Pons
发明人： Igor Medintz , Hedi Mattoussi , Moungi Bawendi , J. Mauro , George Anderson , Thomas Pons
IPC分类号： H05B33/02 , C07H21/00 , H05B39/04 , C12N9/76
CPC分类号： G01N33/588 , B82Y15/00 , C12Q1/6825 , G01N33/542 , Y10T436/143333
摘要： A method of controllably changing an intrinsic property of a quantum dot by using a biological entity, either attached or in close proximity to the quantum dot, and changing the state of biological entity with a controllable mechanism. The change in state of the biological entity controllably changes the intrinsic property of the quantum dot. The photoluminescence emission of quantum dots can be controlled by the present method. The methods disclosed include controlling the magnitude of QD photoluminescence as well as turning the photoluminescence on/off. The methods disclosed include using the same biological control architecture to control other intrinsic QD properties such as charge state, magnetic or other property.
摘要翻译：通过使用附着或非常接近量子点的生物实体可控地改变量子点的固有特性的方法，并以可控机制改变生物实体的状态。生物体的状态变化可以控制地改变量子点的固有特性。量子点的光致发光可通过本方法进行控制。所公开的方法包括控制QD光致发光的大小以及打开/关闭光致发光。所公开的方法包括使用相同的生物学控制结构来控制其它固有QD特性，例如电荷状态，磁性或其他性质。

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