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    • 2. 发明授权
    • Methods for using indicator compositions
    • 使用指示剂组合物的方法
    • US09289528B2
    • 2016-03-22
    • US13927164
    • 2013-06-26
    • Mridula NairKevin D. LofftusMary Christine Brick
    • Mridula NairKevin D. LofftusMary Christine Brick
    • G01N21/78A61L2/28
    • A61L2/28
    • An indicator composition can be exposed to various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 μm; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change.
    • 指示剂组合物可以暴露于各种环境条件下,例如在灭菌或储存过程中的刺激。 该指示剂组合物具有:a)包含固体连续聚合物相和第一反应物的第一聚合物颗粒,第一聚合物颗粒的模式粒径等于或小于50μm; 和b)在第一聚合物颗粒之外的第二反应物,当暴露于所选择的环境条件刺激时,第二反应物能够与第一反应物反应。 指示剂组合物可以通过将其暴露于环境条件刺激足够的时间来引起指示剂组合物的可检测变化,例如可检测的颜色变化。
    • 3. 发明申请
    • METHODS FOR USING INDICATOR COMPOSITIONS
    • 使用指示剂组合物的方法
    • US20150004707A1
    • 2015-01-01
    • US13927164
    • 2013-06-26
    • Mridula NairKevin D. LofftusMary Christine Brick
    • Mridula NairKevin D. LofftusMary Christine Brick
    • A61L2/28
    • A61L2/28
    • An indicator composition can be exposed to various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 μm; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change.
    • 指示剂组合物可以暴露于各种环境条件下,例如在灭菌或储存过程中的刺激。 该指示剂组合物具有:a)包含固体连续聚合物相和第一反应物的第一聚合物颗粒,第一聚合物颗粒的模式粒径等于或小于50μm; 和b)在第一聚合物颗粒之外的第二反应物,当暴露于所选择的环境条件刺激时,第二反应物能够与第一反应物反应。 指示剂组合物可以通过将其暴露于环境条件刺激足够的时间来引起指示剂组合物的可检测变化,例如可检测的颜色变化。
    • 4. 发明申请
    • REACTIVE INDICATOR COMPOSITIONS AND ARTICLES CONTAINING SAME
    • 反应性指示剂组合物和含有其的制品
    • US20150004706A1
    • 2015-01-01
    • US13927139
    • 2013-06-26
    • Mridula NairKevin D. LofftusMary Christine Brick
    • Mridula NairKevin D. LofftusMary Christine Brick
    • G01N21/78
    • G01N21/78A61L2/28
    • An indicator composition can be used to detect various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 μm; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change.
    • 指示剂组合物可用于检测诸如灭菌或储存过程中的各种环境条件刺激。 该指示剂组合物具有:a)包含固体连续聚合物相和第一反应物的第一聚合物颗粒,第一聚合物颗粒的模式粒径等于或小于50μm; 和b)在第一聚合物颗粒之外的第二反应物,当暴露于所选择的环境条件刺激时,第二反应物能够与第一反应物反应。 指示剂组合物可以通过将其暴露于环境条件刺激足够的时间来引起指示剂组合物的可检测变化,例如可检测的颜色变化。
    • 5. 发明授权
    • Reactive indicator compositions and articles containing same
    • 活性指示剂组合物和含有它们的物品
    • US09291570B2
    • 2016-03-22
    • US13927139
    • 2013-06-26
    • Mridula NairKevin D. LofftusMary Christine Brick
    • Mridula NairKevin D. LofftusMary Christine Brick
    • A61L2/28G01N21/78
    • G01N21/78A61L2/28
    • An indicator composition can be used to detect various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 μm; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change.
    • 指示剂组合物可用于检测诸如灭菌或储存过程中的各种环境条件刺激。 该指示剂组合物具有:a)包含固体连续聚合物相和第一反应物的第一聚合物颗粒,第一聚合物颗粒的模式粒径等于或小于50μm; 和b)在第一聚合物颗粒之外的第二反应物,当暴露于所选择的环境条件刺激时,第二反应物能够与第一反应物反应。 指示剂组合物可以通过将其暴露于环境条件刺激足够的时间以引起指示剂组合物的可检测变化,例如可检测的颜色变化来使用。
    • 6. 发明授权
    • Method of making inorganic porous particles
    • 无机多孔颗粒的制备方法
    • US08394396B2
    • 2013-03-12
    • US13101185
    • 2011-05-05
    • Mary Christine BrickJoseph Salvatore SeditaJoan Kay WilliamsMridula Nair
    • Mary Christine BrickJoseph Salvatore SeditaJoan Kay WilliamsMridula Nair
    • A01N25/26
    • C01B13/328A61K47/02C01B33/18C01F7/36C01G1/02C01G23/053C01G25/02C01P2004/61C01P2006/16C01P2006/17
    • Sol-gel inorganic porous particles are composed of an inorganic compound that provides an inorganic solid phase including an external particle surface. They also have a first set of pores wherein the pores have an average diameter of less than 100 nm and a second set of pores wherein the pores have an average diameter of at least 100 nm, which second set of pores contains stabilizing organic microgel particles. These inorganic porous particles are prepared using a first oil phase comprising a first water-immiscible aprotic solvent having a dielectric constant of less than 10 and having dissolved therein organic microgel particles. An aqueous phase comprising a polar solvent, an inorganic gel precursor, a catalyst, and a dispersing surfactant is neutralized to initiate condensation of the inorganic gel precursor. An oil-in-water emulsion is then formed with the organic microgel particles in the first oil phase, which is dispersed as first oil phase droplets in the aqueous phase. A second oil phase is combined with the oil-in-water emulsion with the second oil phase to form an oil-in-water-in-oil emulsion comprising the first oil phase droplets in the aqueous phase.
    • 溶胶凝胶无机多孔颗粒由提供包含外部颗粒表面的无机固相的无机化合物组成。 它们还具有第一组孔,其中孔具有小于100nm的平均直径和第二组孔,其中孔具有至少100nm的平均直径,该第二组孔含有稳定的有机微粒凝胶颗粒。 这些无机多孔颗粒使用第一油相制备,所述第一油相包含介电常数小于10并且溶解有机微粒凝胶颗粒的第一不溶于水的非质子传递溶剂。 包含极性溶剂,无机凝胶前体,催化剂和分散表面活性剂的水相被中和以引发无机凝胶前体的缩合。 然后与第一油相中的有机微粒凝胶颗粒形成水包油乳液,其作为第一油相液滴分散在水相中。 将第二油相与水包油乳液与第二油相组合以形成包含在水相中的第一油相液滴的油包水包油乳液。
    • 7. 发明申请
    • METHOD OF MAKING INORGANIC POROUS PARTICLES
    • 制造无机多孔颗粒的方法
    • US20120282316A1
    • 2012-11-08
    • US13101185
    • 2011-05-05
    • Mary Christine BrickJoseph Salvatore SeditaJoan Kay WilliamsMridula Nair
    • Mary Christine BrickJoseph Salvatore SeditaJoan Kay WilliamsMridula Nair
    • A01N25/08B01J31/02A01P1/00B01J37/06C01B13/14A61K9/14B01J37/02
    • C01B13/328A61K47/02C01B33/18C01F7/36C01G1/02C01G23/053C01G25/02C01P2004/61C01P2006/16C01P2006/17
    • Sol-gel inorganic porous particles are composed of an inorganic compound that provides an inorganic solid phase including an external particle surface. They also have a first set of pores wherein the pores have an average diameter of less than 100 nm and a second set of pores wherein the pores have an average diameter of at least 100 nm, which second set of pores contains stabilizing organic microgel particles. These inorganic porous particles are prepared using a first oil phase comprising a first water-immiscible aprotic solvent having a dielectric constant of less than 10 and having dissolved therein organic microgel particles. An aqueous phase comprising a polar solvent, an inorganic gel precursor, a catalyst, and a dispersing surfactant is neutralized to initiate condensation of the inorganic gel precursor. An oil-in-water emulsion is then formed with the organic microgel particles in the first oil phase, which is dispersed as first oil phase droplets in the aqueous phase. A second oil phase is combined with the oil-in-water emulsion with the second oil phase to form an oil-in-water-in-oil emulsion comprising the first oil phase droplets in the aqueous phase.
    • 溶胶凝胶无机多孔颗粒由提供包含外部颗粒表面的无机固相的无机化合物组成。 它们还具有第一组孔,其中孔具有小于100nm的平均直径和第二组孔,其中孔具有至少100nm的平均直径,该第二组孔含有稳定的有机微粒凝胶颗粒。 这些无机多孔颗粒使用第一油相制备,所述第一油相包含介电常数小于10并且溶解有机微粒凝胶颗粒的第一不溶于水的非质子传递溶剂。 包含极性溶剂,无机凝胶前体,催化剂和分散表面活性剂的水相被中和以引发无机凝胶前体的缩合。 然后与第一油相中的有机微粒凝胶颗粒形成水包油乳液,其作为第一油相液滴分散在水相中。 将第二油相与水包油乳液与第二油相组合以形成包含在水相中的第一油相液滴的油包水包油乳液。