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1. 发明申请

US20100248998A1 PROCESS FOR THE PRODUCTION OF A GRANULE OF A COATED OXIDIZING COMPOUND SUCH GRANULE AND USES OF THE GRANULE 有权
标题翻译：用于生产涂覆氧化化合物这种颗粒的颗粒的方法和颗粒的用途
公开(公告)号：US20100248998A1
公开(公告)日：2010-09-30
申请号：US12738120
申请日：2008-10-15
申请人： Mona Ezzelarab , Carl Aften , Carolina Andersson , Cecilia Johansson , Richard Lalama , Geoffrey Monteith , Lars-Inge Olsson , Ajse Sandqvist , Frank Schinkel , Markus Svensson , Walter Watson , Caroline Wegner
发明人： Mona Ezzelarab , Carl Aften , Carolina Andersson , Cecilia Johansson , Richard Lalama , Geoffrey Monteith , Lars-Inge Olsson , Ajse Sandqvist , Frank Schinkel , Markus Svensson , Walter Watson , Caroline Wegner
IPC分类号： C09K8/90 , B05D7/00 , B32B5/16 , C09K8/60 , C09K8/80 , C09K8/88
CPC分类号： C09K8/685 , C01B15/103 , C01B15/106 , C02F1/722 , C02F2103/10 , C02F2209/09 , C02F2305/14 , C09K8/68 , C09K8/706 , C09K8/80 , C09K8/92 , C09K2208/26 , Y10T428/2991 , Y10T428/2993
摘要： The invention provides a process for the production of a granule of a coated oxidizing compound which granule has good delayed release properties, said process comprising a) providing cores of an oxidizing compound produced by fluidized bed spray granulation, b) spraying on the oxidizing compound cores an aqueous solution of metal sili-cate in a fluidized bed, said aqueous solution comprising at least 15% by weight metal silicate, and c) drying to form a metal silicate coating layer on the oxidizing compound core, provided that the amount of metal silicate coating layer is at least 8%, preferably at least 10% by weight based on the total weight of the granule. The invention also provides such granule and well treatment fluids including such granule, and processes for use.
摘要翻译：本发明提供一种制备包覆氧化剂颗粒的方法，该颗粒具有良好的延迟释放性质，所述方法包括a）提供通过流化床喷雾造粒产生的氧化化合物的核心，b）喷洒在氧化复合物芯在流化床中的金属硅酸盐水溶液，所述水溶液包含至少15重量％的金属硅酸盐，以及c）干燥以在氧化化合物芯上形成金属硅酸盐涂层，条件是金属硅酸盐的量涂层相对于颗粒的总重量为至少8重量％，优选至少10重量％。本发明还提供了包括这种颗粒的颗粒和井处理流体，以及使用的方法。

2. 发明授权

US08338341B2 Process for the production of a granule of a coated oxidizing compound such granule and uses of the granule 有权
标题翻译：用于生产颗粒的包衣氧化剂颗粒的颗粒和颗粒的用途的方法
公开(公告)号：US08338341B2
公开(公告)日：2012-12-25
申请号：US12738120
申请日：2008-10-15
申请人： Mona Ezzelarab , Carl Aften , Carolina Andersson , Cecilia Johansson , Richard Lalama , Geoffrey Monteith , Lars-Inge Olsson , Ajse Sandqvist , Frank Schinkel , Markus Svensson , Walter Watson , Caroline Wegner
发明人： Mona Ezzelarab , Carl Aften , Carolina Andersson , Cecilia Johansson , Richard Lalama , Geoffrey Monteith , Lars-Inge Olsson , Ajse Sandqvist , Frank Schinkel , Markus Svensson , Walter Watson , Caroline Wegner
IPC分类号： E21B21/00 , E21B43/00 , E21B43/26 , C09K8/68 , C09K8/60 , C09K8/74 , C09K8/504 , B05D7/00 , B32B5/16
CPC分类号： C09K8/685 , C01B15/103 , C01B15/106 , C02F1/722 , C02F2103/10 , C02F2209/09 , C02F2305/14 , C09K8/68 , C09K8/706 , C09K8/80 , C09K8/92 , C09K2208/26 , Y10T428/2991 , Y10T428/2993
摘要： The invention provides a process for the production of a granule of a coated oxidizing compound which granule has good delayed release properties, said process comprising a) providing cores of an oxidizing compound produced by fluidized bed spray granulation, b) spraying on the oxidizing compound cores an aqueous solution of metal sili-cate in a fluidized bed, said aqueous solution comprising at least 15% by weight metal silicate, and c) drying to form a metal silicate coating layer on the oxidizing compound core, provided that the amount of metal silicate coating layer is at least 8%, preferably at least 10% by weight based on the total weight of the granule. The invention also provides such granule and well treatment fluids including such granule, and processes for use.
摘要翻译：本发明提供一种制备包覆氧化剂颗粒的方法，该颗粒具有良好的延迟释放性质，所述方法包括a）提供通过流化床喷雾造粒产生的氧化化合物的核心，b）喷洒在氧化复合物芯在流化床中的金属硅酸盐水溶液，所述水溶液包含至少15重量％的金属硅酸盐，以及c）干燥以在氧化化合物芯上形成金属硅酸盐涂层，条件是金属硅酸盐的量涂层相对于颗粒的总重量为至少8重量％，优选至少10重量％。本发明还提供了包括这种颗粒的颗粒和井处理流体，以及使用的方法。

3. 发明申请

US20090227539A1 Boron compounds useful in bnct 有权
标题翻译：硼化合物可用于bnct
公开(公告)号：US20090227539A1
公开(公告)日：2009-09-10
申请号：US11990634
申请日：2006-08-17
申请人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
发明人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
IPC分类号： A61K31/69 , C07D475/00 , C07F5/02 , C07F15/00 , A61K31/555 , A61K31/4985
CPC分类号： C07F5/027 , C07D475/04
摘要： The present invention relates to novel boron comprising compounds, to pharmaceutical compositions comprising said compounds, to the therapeutic use of said compounds, and to a process for preparation of said compounds. The compounds are useful in boron neutron capture therapy (BNCT).
摘要翻译：本发明涉及包含新化合物的化合物，包含所述化合物的药物组合物，所述化合物的治疗用途以及所述化合物的制备方法。这些化合物可用于硼中子俘获治疗（BNCT）。

4. 发明授权

US5403930A Substituted salicylic acids 失效
标题翻译：取代水杨酸
公开(公告)号：US5403930A
公开(公告)日：1995-04-04
申请号：US132874
申请日：1993-10-07
申请人： Hubert Agback , Leif Ahrgren , Thomas Berglindh , Martin Haraldsson , Goran Smedeg.ang.rd , Lars-Inge Olsson
发明人： Hubert Agback , Leif Ahrgren , Thomas Berglindh , Martin Haraldsson , Goran Smedeg.ang.rd , Lars-Inge Olsson
IPC分类号： A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/603 , A61P1/00 , A61P29/00 , A61P37/02 , A61P37/06 , C07D213/75 , C07D213/76 , C07D213/78 , C07D233/88 , C07D233/90 , C07D237/20 , C07D239/42 , C07D239/69 , C07D241/20 , C07D249/12 , C07D249/14 , C07D261/14 , C07D261/16 , C07D263/28 , C07D277/20 , C07D277/22 , C07D277/32 , C07D277/38 , C07D277/82 , C07D237/26 , C07D211/56
CPC分类号： C07D213/76 , C07D237/20 , C07D239/42 , C07D261/16 , C07D277/82
摘要： A compound of the formula Het--NR--SO.sub.2 --Ph.sup.2 --A--Ph.sup.1 (COOH)(OH) and tautomic form, salts, solvates, C.sub.1-6 alkyl esters and pharmaceutical compositions of the compound. Ph.sup.1 and Ph.sup.2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl.The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.
摘要翻译：式Het-NR-SO2-Ph2-A-Ph1（COOH）（OH）和互变异构形式的化合物，盐，溶剂合物，C 1-6烷基酯和该化合物的药物组合物。 Ph1和Ph2是苯环，条件是羧基和羟基彼此邻接。 Het包括任选取代的杂环，其包括共轭双键并与NR结合。该化合物的特征在于A是不是偶氮还原反应稳定的桥，其中R是氢或低级烷基。本发明还包括该化合物的制备及其作为药物的用途，特别是用于治疗自身免疫性疾病。

5. 发明授权

US5968953A Compounds with analgesic and local anaesthetic effect 失效
标题翻译：化合物具有止痛和局部麻醉作用
公开(公告)号：US5968953A
公开(公告)日：1999-10-19
申请号：US64187
申请日：1998-04-22
申请人： Anna-Lena Ask , Lars-Inge Olsson , Rune Sandberg
发明人： Anna-Lena Ask , Lars-Inge Olsson , Rune Sandberg
IPC分类号： C07D211/64 , A61K20060101 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/45 , A61K31/451 , A61K31/535 , A61K31/5355 , A61P23/02 , A61P25/02 , A61P25/04 , A61P29/00 , C07D20060101 , C07D211/32 , C07D401/06 , C07D413/06
CPC分类号： C07D211/64
摘要： New compounds of the formula (A) ##STR1## a process for their preparation and their use in the manufacture of pharmaceutical preparations. The new compounds have both local anaesthetic and analgesic effect.
摘要翻译：式（A）的新化合物是其制备方法及其在制备药物制剂中的用途。新化合物具有局部麻醉和镇痛作用。

6. 发明授权

US5756520A Compounds with analgesic and local anaesthetic effect 失效
标题翻译：化合物具有止痛和局部麻醉作用
公开(公告)号：US5756520A
公开(公告)日：1998-05-26
申请号：US403767
申请日：1995-03-24
申请人： Anna-Lena Ask , Lars-Inge Olsson , Rune Sandberg
发明人： Anna-Lena Ask , Lars-Inge Olsson , Rune Sandberg
IPC分类号： C07D211/64 , A61K20060101 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/45 , A61K31/451 , A61K31/535 , A61K31/5355 , A61P23/02 , A61P25/02 , A61P25/04 , A61P29/00 , C07D20060101 , C07D211/32 , C07D401/06 , C07D413/06
CPC分类号： C07D211/64
摘要： New compounds of the formula (A) ##STR1## a process for their preparation and their use in the manufacture of pharmaceutical preparations. The new compounds have both local anaesthetic and analgesic effect.
摘要翻译： PCT No.PCT / SE95 / 00106 Sec。 371日期：1995年3月24日 102（e）1995年3月24日PCT PCT 1995年2月3日提交PCT公布。公开号WO95 / 21821 日期1995年8月17日新化合物（A）（A）其制备方法及其在制备药物制剂中的用途。新化合物具有局部麻醉和镇痛作用。

7. 发明授权

US5556855A N-heterocyclic substituted salicylic acids 失效
标题翻译： N-杂环取代的水杨酸
公开(公告)号：US5556855A
公开(公告)日：1996-09-17
申请号：US365869
申请日：1994-12-29
申请人： Hubert Agback , Leif Ahrgren , Thomas Berglindh , Martin Haraldsson , G oran Smedeg.ang.rd , Lars-Inge Olsson
发明人： Hubert Agback , Leif Ahrgren , Thomas Berglindh , Martin Haraldsson , G oran Smedeg.ang.rd , Lars-Inge Olsson
IPC分类号： A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/603 , A61P1/00 , A61P29/00 , A61P37/02 , A61P37/06 , C07D213/75 , C07D213/76 , C07D213/78 , C07D233/88 , C07D233/90 , C07D237/20 , C07D239/42 , C07D239/69 , C07D241/20 , C07D249/12 , C07D249/14 , C07D261/14 , C07D261/16 , C07D263/28 , C07D277/20 , C07D277/22 , C07D277/32 , C07D277/38 , C07D277/82
CPC分类号： C07D213/76 , C07D237/20 , C07D239/42 , C07D261/16 , C07D277/82
摘要： A compound of the formula Het--NR--SO.sub.2 --Ph.sup.2 --A--Ph.sup.1 (COOH)(OH) and tautomic form, salts, solvates, C.sub.1-6 alkyl esters and pharmaceutical compositions of the compound. Ph.sup.1 and Ph.sup.2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl.The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.
摘要翻译：式Het-NR-SO2-Ph2-A-Ph1（COOH）（OH）和互变异构形式的化合物，盐，溶剂合物，C 1-6烷基酯和该化合物的药物组合物。 Ph1和Ph2是苯环，条件是羧基和羟基彼此邻接。 Het包括任选取代的杂环，其包括共轭双键并与NR结合。该化合物的特征在于A是不是偶氮还原反应稳定的桥，其中R是氢或低级烷基。本发明还包括该化合物的制备及其作为药物的用途，特别是用于治疗自身免疫性疾病。

8. 发明授权

US08183247B2 Boron compounds useful in BNCT 有权
标题翻译：硼化合物可用于BNCT
公开(公告)号：US08183247B2
公开(公告)日：2012-05-22
申请号：US11990634
申请日：2006-08-17
申请人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
发明人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07F5/027 , C07D475/04
摘要： The present invention relates to novel boron comprising compounds, to pharmaceutical compositions comprising said compounds, to the therapeutic use of said compounds, and to a process for preparation of said compounds. The compounds are useful in boron neutron capture therapy (BNCT).
摘要翻译：本发明涉及包含新化合物的化合物，包含所述化合物的药物组合物，所述化合物的治疗用途以及所述化合物的制备方法。这些化合物可用于硼中子俘获治疗（BNCT）。

9. 发明授权

US5354792A Flowability improving agent, a process for the production thereof and a use thereof 失效
标题翻译：流动性改进剂，其制备方法及其用途
公开(公告)号：US5354792A
公开(公告)日：1994-10-11
申请号：US917092
申请日：1992-08-06
申请人： Lars-Inge Olsson , Kent Hamacek
发明人： Lars-Inge Olsson , Kent Hamacek
IPC分类号： C04B24/02 , C04B24/00 , C04B24/06 , C04B24/22 , C04B24/30 , C04B24/32 , C04B28/02 , C08K3/00 , C08K5/05 , C08K5/55
CPC分类号： C04B40/0039 , C04B24/003 , C04B24/006 , C04B24/32 , C04B28/02 , C04B2103/30
摘要： The invention relates to a flowability improving agent comprising a combination, calculated on a dry product, of: A) 60-99% by weight of a sulphonated melamine-formaldehyde resin, a sulphonated melamine-urea-formaldehyde resin or a sulphonated naphthalene-formaldehyde resin; C) 0.5-40% by weight of a boron containing polyhydroxycarboxylic acid or a water-soluble salt of such an acid and optionally D) 0.5-30% by weight of a compound with formulaAr O--(R.sub.1).sub.n --R.sub.2where Ar is unsubstituted or substituted benzene moiety or naphthalene moiety, R.sub.1 is an oxyethylene group; --CH.sub.2 CH.sub.2 O--or an oxypropylene group; ##STR1## an oxyethylene chain or an oxypropylene chain with up to fifteen oxyethylene groups or oxypropylene groups or a combination of oxyethylene groups and oxypropylene groups to a chain where the sum of these groups is at most fifteen; the mean value n for n is 1-15 and R.sub.2 is hydrogen or a phosphonate group with the formula ##STR2## where M.sub.1 and M.sub.2 are hydrogen ion or alkali metal ion or where R.sub.2 is a group with the formula ##STR3## where M.sub.2 has the above meaning and M.sub.3 is --(R.sub.1).sub.n --O Ar where R.sub.1, n and Ar have the above meaning; a process for the production of the agent and the use of the agent in a cement containing composition.
摘要翻译： PCT No.PCT / SE91 / 00096 Sec。 371日期：1992年8月6日 102（e）日期1992年8月6日PCT 1991年2月12日提交PCT公布。出版物WO91 / 12214 PCT 日本1991年8月22日。本发明涉及一种流动性改进剂，其包含以干产物计算的组合，其为：A）60-99重量％的磺化三聚氰胺 - 甲醛树脂，磺化三聚氰胺 - 脲 - 甲醛树脂或磺化萘甲醛树脂; C）0.5-40重量％的含硼聚羟基羧酸或这种酸的水溶性盐，任选地D）0.5-30重量％的具有式Ar O-（R1）n -R2的化合物，其中Ar 是未取代或取代的苯部分或萘部分，R1是氧化乙烯基团; -CH 2 CH 2 O-或氧亚丙基; 具有至多十五个氧化乙烯基团或氧化丙烯基团的氧化乙烯链或氧化丙烯链或氧化乙烯基团和氧化丙烯基团的组合连接到这些基团的总数至多为十五个的链上; n的平均值＆upbar＆n为1-15，R2为氢或具有式“IMAGE”的膦酸酯基，其中M1和M2为氢离子或碱金属离子，或其中R2为具有式“IMAGE”的基团，其中M2 具有上述含义，M3为 - （R1）nO Ar，其中R1，n和Ar具有上述含义; 用于生产该试剂的方法和该试剂在含水泥组合物中的用途。

10. 发明授权

US06673819B2 Compounds useful as antibacterial agents 失效
标题翻译：可用作抗菌剂的化合物
公开(公告)号：US06673819B2
公开(公告)日：2004-01-06
申请号：US10028399
申请日：2001-12-20
申请人： Rolf Bergman , Arne Eek , Lars-Inge Olsson , Per Lindberg
发明人： Rolf Bergman , Arne Eek , Lars-Inge Olsson , Per Lindberg
IPC分类号： A61K314439
CPC分类号： C07D401/12
摘要： The present invention relates to novel compounds of Formula I, and pharmaceutically acceptable salts thereof, as antibacterial agents. The compounds of the present invention are nitric oxide releasing derivatives of proton pump inhibitors (NO-releasing PPIs). In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above. The invention also relates to new intermediates for use in the preparation of the novel compounds. Additionally the present invention relates to co-administration of NO-releasing PPIs with other known medicaments.
摘要翻译：本发明涉及新颖的式I化合物及其药学上可接受的盐作为抗菌剂。本发明的化合物是释放质子泵抑制剂（NO释放PPI）的一氧化氮释放衍生物。在另外的方面，本发明涉及用于治疗的本发明化合物; 制备这些新化合物的方法; 含有至少一种本发明化合物或其药学上可接受的盐作为活性成分的药物组合物; 以及使用活性化合物制造上述用于医疗用途的药物。本发明还涉及用于制备新化合物的新中间体。此外，本发明涉及将NO释放的PPI与其它已知药物共同给药。

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