专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06673819B2 Compounds useful as antibacterial agents 失效
标题翻译：可用作抗菌剂的化合物
公开(公告)号：US06673819B2
公开(公告)日：2004-01-06
申请号：US10028399
申请日：2001-12-20
申请人： Rolf Bergman , Arne Eek , Lars-Inge Olsson , Per Lindberg
发明人： Rolf Bergman , Arne Eek , Lars-Inge Olsson , Per Lindberg
IPC分类号： A61K314439
CPC分类号： C07D401/12
摘要： The present invention relates to novel compounds of Formula I, and pharmaceutically acceptable salts thereof, as antibacterial agents. The compounds of the present invention are nitric oxide releasing derivatives of proton pump inhibitors (NO-releasing PPIs). In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above. The invention also relates to new intermediates for use in the preparation of the novel compounds. Additionally the present invention relates to co-administration of NO-releasing PPIs with other known medicaments.
摘要翻译：本发明涉及新颖的式I化合物及其药学上可接受的盐作为抗菌剂。本发明的化合物是释放质子泵抑制剂（NO释放PPI）的一氧化氮释放衍生物。在另外的方面，本发明涉及用于治疗的本发明化合物; 制备这些新化合物的方法; 含有至少一种本发明化合物或其药学上可接受的盐作为活性成分的药物组合物; 以及使用活性化合物制造上述用于医疗用途的药物。本发明还涉及用于制备新化合物的新中间体。此外，本发明涉及将NO释放的PPI与其它已知药物共同给药。

2. 发明授权

US08183247B2 Boron compounds useful in BNCT 有权
标题翻译：硼化合物可用于BNCT
公开(公告)号：US08183247B2
公开(公告)日：2012-05-22
申请号：US11990634
申请日：2006-08-17
申请人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
发明人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07F5/027 , C07D475/04
摘要： The present invention relates to novel boron comprising compounds, to pharmaceutical compositions comprising said compounds, to the therapeutic use of said compounds, and to a process for preparation of said compounds. The compounds are useful in boron neutron capture therapy (BNCT).
摘要翻译：本发明涉及包含新化合物的化合物，包含所述化合物的药物组合物，所述化合物的治疗用途以及所述化合物的制备方法。这些化合物可用于硼中子俘获治疗（BNCT）。

3. 发明申请

US20090227539A1 Boron compounds useful in bnct 有权
标题翻译：硼化合物可用于bnct
公开(公告)号：US20090227539A1
公开(公告)日：2009-09-10
申请号：US11990634
申请日：2006-08-17
申请人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
发明人： Lars-Inge Olsson , Erwan Arzel , Arne Eek
IPC分类号： A61K31/69 , C07D475/00 , C07F5/02 , C07F15/00 , A61K31/555 , A61K31/4985
CPC分类号： C07F5/027 , C07D475/04
摘要： The present invention relates to novel boron comprising compounds, to pharmaceutical compositions comprising said compounds, to the therapeutic use of said compounds, and to a process for preparation of said compounds. The compounds are useful in boron neutron capture therapy (BNCT).
摘要翻译：本发明涉及包含新化合物的化合物，包含所述化合物的药物组合物，所述化合物的治疗用途以及所述化合物的制备方法。这些化合物可用于硼中子俘获治疗（BNCT）。

4. 发明授权

US06355015B1 Medical device for internal heat treatment and drug delivery 失效
标题翻译：用于内部热处理和药物输送的医疗装置
公开(公告)号：US06355015B1
公开(公告)日：2002-03-12
申请号：US09308584
申请日：1999-05-21
申请人： Arne Eek , Magnus Bolmsjö
发明人： Arne Eek , Magnus Bolmsjö
IPC分类号： A61H2900
CPC分类号： A61F7/12 , A61B2017/4216 , A61M2025/0057
摘要： Medical device (1) for effecting heat treatment and local delivery of a fluid medicament on body tissue presenting a predetermined section of a boundary wall of a passageway in a human or animal body comprising a catheter-like member (12) for insertion into the passageway to a predetermined insertion position, the catheter-like member being provided with an inflatable balloon structure (11) having a boundary wall which is inflatable against the body tissue when the catheter-like member (12) is in the predetermined insertion position and delivery means (2,11,25) for local delivery of the fluid medicament on the body tissue when the catheter-like member (12) is in the predetermined insertion position, and a heating arrangement (10,15) which is adapted to heat the body tissue when the catheter-like member (12) is in the predetermined insertion position. The delivery means (2,11,25) comprises a supply channel (25) for supply of the fluid medicament to the balloon structure (11) and a construction for the boundary wall (2) of the balloon structure (11) which is permeable to the fluid medicament. Supply of the fluid medicament to the balloon structure along the supply channel (25) when the catheter-like member (12) is in the predetermined insertion position thereby causes the balloon structure (11) to inflate and fluid medicament to be delivered locally on the body tissue through the boundary wall (2) of the balloon structure (11).
摘要翻译：用于在身体组织上进行流体药物的热处理和局部输送的医疗装置（1），所述身体组织呈现人体或动物体内通道的边界壁的预定部分，包括用于插入通道的导管状部件（12）导管状构件设置有可膨胀气球结构（11），该气囊结构具有当导管状构件（12）处于预定插入位置时可抵靠身体组织充气的边界壁，并且输送装置（2,11,25），用于当所述导管状构件（12）处于所述预定插入位置时在所述身体组织上局部输送所述流体药物;以及加热装置（10,15），其适于加热所述身体当导管状构件（12）处于预定插入位置时的组织。输送装置（2,11,25）包括用于将流体药物供应到球囊结构（11）的供应通道（25）和用于球囊结构（11）的边界壁（2）的结构，其是可渗透的流体药物。当导管状构件（12）处于预定的插入位置时，将流体药物沿着供应通道（25）供应到球囊结构，从而导致球囊结构（11）膨胀并且流体药物在身体组织穿过球囊结构（11）的边界壁（2）。

5. 外观设计

USD398054S Infusion bag 失效
公开(公告)号：USD398054S
公开(公告)日：1998-09-08
申请号：US60617
申请日：1996-10-02
申请人： Arne Eek
设计人： Arne Eek

6. 发明授权

US5856342A Combination of a .beta.-receptor blocker and a local anaesthetic 失效
标题翻译： β-受体阻滞剂和局部麻醉剂的组合
公开(公告)号：US5856342A
公开(公告)日：1999-01-05
申请号：US428170
申请日：1995-04-28
申请人： Arne Eek
发明人： Arne Eek
IPC分类号： A61K31/135 , A61K31/165 , A61K31/405 , A61K31/445 , A61K45/06 , A61P25/02 , A61P25/04 , A61P43/00
CPC分类号： A61K45/06 , A61K31/135 , A61K31/165 , A61K31/405 , A61K31/445 , Y10S514/817 , Y10S514/818
摘要： New combination of a .beta.-receptor blocker, an enantiomer thereof, and a local anesthetic, administered simultaneously or sequentially, giving excellent pain relief. Also comprised in the invention is the use of a non-selective .beta.-receptor blocker alone, especially a non-selective .beta.-receptor blocker giving pain relief.
摘要翻译： PCT No.PCT / SE95 / 00314 Sec。 371日期：1995年4月28日 102（e）日期1995年4月28日PCT提交1995年4月24日PCT公布。出版物WO95 / 27511 日期1995年10月19日新的β受体阻滞剂，其对映异构体和局部麻醉剂的组合，同时或依次施用，提供极好的疼痛缓解。本发明还包括单独使用非选择性β-受体阻断剂，特别是给予疼痛缓解的非选择性β-受体阻断剂。

7. 发明申请

US20090200335A1 Spray Device, Method for Spraying a Certain Quantity of Fluid and a Process for Manufacturing the Device 审中-公开
标题翻译：喷涂装置，喷涂一定量的流体的方法和制造装置的方法
公开(公告)号：US20090200335A1
公开(公告)日：2009-08-13
申请号：US11988746
申请日：2006-07-05
申请人： Billy Nilson , Arne Eek
发明人： Billy Nilson , Arne Eek
IPC分类号： B67D5/64 , G01F11/00
CPC分类号： A61M15/08 , A61M15/0068 , A61M15/009 , B05B11/0038 , B05B11/3056
摘要： A device and a method for spraying a certain quantity of fluid. The device includes a casing with a cavity for accommodating a liquid reservoir and a pump which delivers a specific quantity fluid upon activation. The device further includes a nozzle through which the flow of fluid passes in the form of spray droplets together with an activating device which acts upon the base of the reservoir due to the application of opposing forces to the casing, basically at right angles to the pumping movement of the device.
摘要翻译：用于喷射一定量流体的装置和方法。该装置包括具有用于容纳液体储存器的空腔的壳体和在启动时输送特定量的流体的泵。该装置还包括一个喷嘴，流体的流动通过该喷嘴与一个启动装置一起通过，该启动装置作用在储存器的底部上，因为基本上与抽吸成直角地施加相反的力设备的移动。

8. 发明申请

US20090170854A1 New Use 审中-公开
标题翻译：新用途
公开(公告)号：US20090170854A1
公开(公告)日：2009-07-02
申请号：US12185514
申请日：2008-08-04
申请人： Arne Eek
发明人： Arne Eek
IPC分类号： A61K31/501 , C07D471/04 , A61K31/437 , C07D401/04 , A61K31/506 , C07D471/14 , A61K31/4375 , C07D487/04 , A61P1/04
CPC分类号： A61K45/06 , A61K31/437 , A61K31/4375 , A61K31/5025 , A61K31/506 , A61K2300/00
摘要： The present invention relates to a new use of certain pharmaceutically active compounds in the treatment and/or prevention of medicament induced gastric ulcer. More particularly the invention is directed to the use of said compounds, and pharmaceutically acceptable salts thereof, for the treatment and/or prevention of NSAID (non-steroidal antiinflammatory drugs) induced gastric ulcer as well as a pharmaceutical composition in the unit dosage form for the prevention of NSAID induced gastric ulcer in a mammal comprising an NSAID together with a 6-carboxamido-imidazo[1,2-a]pyridine compounds. Other pharmaceutically active compounds used in the present invention comprises COX-2 inhibitors, NO-NSAIDs and bisphosphonates.
摘要翻译：本发明涉及某些药物活性化合物在治疗和/或预防药物诱导的胃溃疡中的新用途。更具体地，本发明涉及所述化合物及其药学上可接受的盐在治疗和/或预防NSAID（非甾体抗炎药）诱导的胃溃疡中的用途以及单位剂型中的药物组合物预防包含NSAID的哺乳动物中的NSAID诱导的胃溃疡以及6-甲酰氨基 - 咪唑并[1,2-a]吡啶化合物。本发明中使用的其它药物活性化合物包括COX-2抑制剂，NO-NSAID和双膦酸盐。

9. 发明授权

US06593339B1 Use of compounds as antibacterial agents 失效
标题翻译：使用化合物作为抗菌剂
公开(公告)号：US06593339B1
公开(公告)日：2003-07-15
申请号：US09673007
申请日：2000-09-29
申请人： Arne Eek , Johan Raud
发明人： Arne Eek , Johan Raud
IPC分类号： A61K314439
CPC分类号： A61K45/06 , A61K31/00 , A61K31/21 , A61K31/216 , A61K31/381 , A61K31/403 , A61K31/4035 , A61K31/405 , A61K31/407 , Y10S514/926 , Y10S514/927
摘要： The present invention discloses a new use of NO-releasing NSAIDs, especially NO-releasing NSAIDs of the formula I, or a pharmaceutically acceptable salt or enantiomer thereof, for the manufacture of a medicament for the treatment of bacterial infections, especially caused or mediated by Helicobacter pylon. Disclosed is also the new use of a NO-releasing NSAID in combination with an acid susceptible proton pump inhibitor for the treatment of bacterial infections.
摘要翻译：本发明公开了用于制备用于治疗细菌感染的药物的新的用途，所述NSAID特别是NO释放的NSAID，特别是式I的NO释放的NSAID或其药学上可接受的盐或对映异构体用于治疗特别是由幽门螺杆菌。公开也是释放NSAID与酸敏感质子泵抑制剂联合治疗细菌感染的新用途。

10. 发明授权

US06322542B1 Device for delivering liquid containing medicament 失效
标题翻译：用于输送含药物的液体的装置
公开(公告)号：US06322542B1
公开(公告)日：2001-11-27
申请号：US09254421
申请日：1999-03-08
申请人： Billy Nilson , Arne Eek
发明人： Billy Nilson , Arne Eek
IPC分类号： A61M500
CPC分类号： B05B11/04 , A61M15/0065 , A61M31/00 , A61M2210/0618 , B05B1/14 , B05B11/02 , B05B11/025 , B05B11/3032
摘要： A delivery means for delivering liquid containing medicament to a posterior region of the nasal cavity, comprising an elongate tubular member (35; 151) and a nozzle (37; 153) at the free end thereof, which nozzle (37; 153) includes at least one opening (39; 155) through which liquid is in use delivered.
摘要翻译：一种用于将含有药物的液体输送到鼻腔的后部区域的输送装置，包括一个细长的管状构件（35; 151）和一个在其自由端处的喷嘴（37; 153），该喷嘴（37; 153）至少一个开口（39; 155），通过该开口输送液体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式