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1. 发明授权

US5576341A 2-[[2-(N-isobutyl-N-methyl)amino]benzylsulfinyl]-benzimidazole as antimicrobial agent 失效
标题翻译： 2 - [[2-（N-异丁基-N-甲基）氨基]苄基亚磺酰基] - 苯并咪唑作为抗微生物剂
公开(公告)号：US5576341A
公开(公告)日：1996-11-19
申请号：US228750
申请日：1994-04-18
申请人： Mitsuo Masaki , Tomio Yamakawa , Yutaka Nomura , Hitoshi Matsukura
发明人： Mitsuo Masaki , Tomio Yamakawa , Yutaka Nomura , Hitoshi Matsukura
IPC分类号： A01N43/50 , A01N43/52 , A61K31/415
CPC分类号： A61K31/415
摘要： 2-[[2-(N-Isobutyl-N-methyl)amino]benzylsulfinyl]benzimidazole is effective for treating or preventing Helicobacter infections by administration to patients suffering from the infection.
摘要翻译： 2 - [[2-（N-异丁基-N-甲基）氨基]苄基亚磺酰基]苯并咪唑通过给患者感染而治疗或预防幽门螺杆菌感染是有效的。

2. 发明授权

US5091403A Sulfinyl imidazole derivatives and antiulcer agents containing the same 失效
标题翻译：磺酰胺咪唑衍生物和含有其的抗体药剂
公开(公告)号：US5091403A
公开(公告)日：1992-02-25
申请号：US565975
申请日：1990-08-10
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： F16J15/32 , A61K31/415 , A61K31/4164 , A61P1/04 , A61P35/00 , C07D233/84 , F16C33/78
CPC分类号： C07D233/84
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 is hydrogen or an alkyl group having 1-6 carbon atoms, R.sup.2 is an alkyl group having 2-6 carbon atoms substituted with an alkoxy group having 1-4 carbon atoms, each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently is hydrogen, a halogen, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, a fluorine-substituted alkyl group having 1-6 carbon atoms, or a fluorine-substituted alkoxy group having 1-6 carbon atoms. The new imidazole derivatives are effective particularly as anti-ulcer agents.

3. 发明授权

US5180836A Imidazole derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US5180836A
公开(公告)日：1993-01-19
申请号：US786392
申请日：1991-11-01
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： C07D233/84 , C07D235/28
CPC分类号： C07D233/84 , C07D235/28
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.
摘要翻译：公开了具有下式的新的咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或者R 1和R 2结合形成杂环; R3，R4，R5和R6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基或氟取代的 - 烷氧基，或R3与R2结合形成杂环; R8和R9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基，氟取代的 - 烷氧基或芳基，或R8和R9组合形成脂环 ; R 7是，其中R 8和R 9不组合，其中R 8和R 9结合，可以具有取代基的烷基，可以具有取代基的芳基，可以具有取代基的芳基或含硫杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

4. 发明授权

US5082943A Novel imidazole derivatives 失效
标题翻译：新咪唑衍生物
公开(公告)号：US5082943A
公开(公告)日：1992-01-21
申请号：US658424
申请日：1991-02-20
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/47 , A61P1/04 , C07D233/84 , C07D233/86 , C07D233/88 , C07D233/90 , C07D233/92 , C07D235/28 , C07D401/12
CPC分类号： C07D235/28 , C07D233/84
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

5. 发明授权

US4824856A Method of protecting gastrointestinal tract 失效
标题翻译：保护胃肠道的方法
公开(公告)号：US4824856A
公开(公告)日：1989-04-25
申请号：US896154
申请日：1986-08-13
申请人： Susumu Okabe , Masaru Satoh , Tomio Yamakawa , Yutaka Nomura , Masatoshi Hayashi
发明人： Susumu Okabe , Masaru Satoh , Tomio Yamakawa , Yutaka Nomura , Masatoshi Hayashi
IPC分类号： A61K31/445 , C07D235/28 , A61K31/415
CPC分类号： C07D235/28 , A61K31/445
摘要： A method of protecting gastrointestinal tract in a mammal from the untoward, non-gastric-acid-induced effects of exposure to gastrointestinally injuruous agents, which comprises administering orally to said mammal a non-antisecretory amount of a benzimidazole derivative having the formula (I): ##STR1## wherein R.sup.1 is the hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group, phenyl group or aralkyl group, R.sup.2 is the hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom forms a ring, and each of R.sup.3 and R.sup.4 independently is the hydrogen atom, a halogen atom, the trifluoromethyl group, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group.
摘要翻译：一种保护哺乳动物胃肠道免受暴露于胃肠损伤药物的非胃酸，非胃酸诱导作用的方法，其包括向所述哺乳动物口服给予非抗分泌量的式（I）的苯并咪唑衍生物，：其中R 1为氢原子，碳原子数为1〜8的烷基，环烷基，苯基或芳烷基，R 2为氢原子或低级烷基，或者R 1和R 2为一体与相邻的氮原子形成环，R3和R4各自独立地为氢原子，卤素原子，三氟甲基，低级烷基，低级烷氧基，低级烷氧基羰基或氨基。

6. 发明授权

US5106976A Fused pyrazine sulfoxide derivatives for use as antiulcer agents 失效
标题翻译：用作抗菌剂的熔融吡咯烷酮衍生物
公开(公告)号：US5106976A
公开(公告)日：1992-04-21
申请号：US506171
申请日：1990-04-09
申请人： Susumu Okabe , Masaru Satoh , Tomio Yamakawa , Yutaka Nomura , Masatoshi Hayashi
发明人： Susumu Okabe , Masaru Satoh , Tomio Yamakawa , Yutaka Nomura , Masatoshi Hayashi
IPC分类号： C07D241/44 , C07D401/12 , C07D471/04
CPC分类号： C07D401/12 , C07D241/44 , C07D471/04
摘要： Novel sulfoxide derivatives having the formula (I) 5 or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R.sup.1 and R.sup.2 may form together with the adjacent N atom a heterocyclic group; each of R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, and R.sup.7 is hydrogen, halogen, lower alkoxy, lower alkyl, trifluoromethyl, or fluorine atom-containing lower alkoxy; Y is CH or N; and Z is unsubstituted or substituted 2-pyridine or 2-aminophenyl.

7. 发明授权

US4933458A Certain gastric acid secretion inhibiting sulfoxides 失效
标题翻译：某些胃酸分泌抑制亚砜
公开(公告)号：US4933458A
公开(公告)日：1990-06-12
申请号：US198086
申请日：1988-05-24
申请人： Susumu Okabe , Masaru Satoh , Tomio Yamakawa , Yutaka Nomura , Masatoshi Hayashi
发明人： Susumu Okabe , Masaru Satoh , Tomio Yamakawa , Yutaka Nomura , Masatoshi Hayashi
IPC分类号： C07D241/44 , C07D401/12 , C07D471/04
CPC分类号： C07D401/12 , C07D241/44 , C07D471/04
摘要： Sulfoxide derivatives having the formula (I) or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R.sup.1 and R.sup.2 may form together with the adjacent N atom a heterocyclic group; each of R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, and R.sup.7 is hydrogen, halogen, lower alkoxy, lower alkyl, trifluoromethyl, or fluorine atom-containing lower alkoxy; Y is CH or N; and Z is unsubstituted or substituted 2-pyridine or 2-aminophenyl.
摘要翻译：具有式（I）或（V）的亚砜衍生物显示出胃酸分泌抑制作用：其中R1和R2各自为氢，低级烷基，羟烷基，苯基，苯基烷基或环烷基，R 1和R 2可以与相邻的N原子一起形成杂环基; R3，R4，R4a，R4b，R5，R6和R7各自为氢，卤素，低级烷氧基，低级烷基，三氟甲基或含氟原子的低级烷氧基; Y是CH或N; Z是未取代的或取代的2-吡啶或2-氨基苯基。

8. 发明授权

US5773437A Alkylenediamine derivatives 失效
标题翻译：烷二胺衍生物
公开(公告)号：US5773437A
公开(公告)日：1998-06-30
申请号：US722112
申请日：1996-09-30
申请人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Michiko Ishida , Haruhiko Shinozaki , Yutaka Nomura , Yasunori Goto
发明人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Michiko Ishida , Haruhiko Shinozaki , Yutaka Nomura , Yasunori Goto
IPC分类号： C07D275/06 , C07D279/02 , C07D417/06 , A61K31/54
CPC分类号： C07D275/06 , C07D279/02 , C07D279/08 , C07D417/06
摘要： The present invention relates to alkylenediamine derivatives which relieve urinating contraction and therefore are of value as active ingredients of therapeutic agents for treating dysuria.
摘要翻译： PCT No.PCT / JP95 / 00632 Sec。 371日期1996年9月30日 102（e）日期1996年9月30日PCT提交1995年3月31日PCT公布。第WO95 / 26959号公报日期1995年10月12日本发明涉及缓解小便收缩的亚烷基二胺衍生物，因此具有治疗排尿困难的治疗剂的有效成分的价值。

9. 发明授权

US5843992A Epoxysuccinic acid derivatives 失效
标题翻译：环氧琥珀酸衍生物
公开(公告)号：US5843992A
公开(公告)日：1998-12-01
申请号：US930509
申请日：1997-09-29
申请人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
发明人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
IPC分类号： C07D303/48 , A61K31/335
CPC分类号： C07D303/48
摘要： An epoxysuccinic acid derivative having the following formula: ##STR1## �wherein R.sup.1 is hydrogen, alkyl, aryl, or aralkyl; each of R.sup.2 and R.sup.3 independently is aryl, aralkyl or alkyl; X is --O-- or --NR.sup.4 --; and R.sup.4 is hydrogen, alkyl, or aralkyl! is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.
摘要翻译： PCT No.PCT / JP96 / 00889 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1996年4月1日PCT公布。出版物WO96 / 30354 日期：1996年10月3日具有下式的环氧琥珀酸衍生物：其中R 1是氢，烷基，芳基或芳烷基; R2和R3各自独立地为芳基，芳烷基或烷基; X是-O-或-NR4-; 和R4是氢，烷基或芳烷基]可用于预防和治疗骨质疏松症，恶性高钙血症和佩吉特综合征等骨疾病，并且还可用于治疗组织蛋白酶L活性异常增强的骨关节炎和类风湿性关节炎，并且还可用作治疗组织蛋白酶B和L参与的疾病的药物，例如肌营养不良和肌肉萎缩。

10. 发明授权

US09045848B2 Coordinate computation device and sewing machine 有权
标题翻译：坐标计算装置和缝纫机
公开(公告)号：US09045848B2
公开(公告)日：2015-06-02
申请号：US14223031
申请日：2014-03-24
申请人： Masaru Jimbo , Yutaka Nomura , Kentaro Torii , Kazuki Kojima , Daisuke Honda
发明人： Masaru Jimbo , Yutaka Nomura , Kentaro Torii , Kazuki Kojima , Daisuke Honda
IPC分类号： D05B19/16 , G06F3/00 , D05B19/02
CPC分类号： D05B19/16 , D05B19/02 , G06F3/00
摘要： A coordinate computation device includes a position indication portion, a detection portion, a processor, and a memory. The position indication portion includes an indicating portion, a switch, and a transmitter. The detection portion is configured to detect ultrasonic waves transmitted by the transmitter. The memory is configured to store computer-readable instructions. The computer-readable instructions cause the processor to perform processes that include computing sets of first coordinates, based on times when the detection portion detects the ultrasonic waves, computing a movement direction of the position indication portion on a plane, computing an angle formed between the plane and a direction in which the position indication portion is long, and computing a set of second coordinates, based on the computed movement direction, the computed angle, and a set of third coordinates among the sets of the computed first coordinates.
摘要翻译：坐标计算装置包括位置指示部分，检测部分，处理器和存储器。位置指示部分包括指示部分，开关和发射器。检测部被配置为检测由发送器发送的超声波。存储器被配置为存储计算机可读指令。计算机可读指令使得处理器基于检测部分检测超声波的时间，执行包括第一坐标的计算集的处理，计算平面上的位置指示部分的移动方向，计算在平面以及位置指示部分长的方向，并且基于所计算的运动方向，所计算的角度和所计算的第一坐标的组中的一组第三坐标来计算一组第二坐标。

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