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1. 发明授权

US06575933B1 Mechanical support for an expandable membrane 有权
标题翻译：可膨胀膜的机械支撑
公开(公告)号：US06575933B1
公开(公告)日：2003-06-10
申请号：US09491239
申请日：2000-01-25
申请人： Dan Wittenberger , Claudia Lueckge , Robert Martin , Sean Carroll , Leonilda Capuano , Margaret Yoklavich
发明人： Dan Wittenberger , Claudia Lueckge , Robert Martin , Sean Carroll , Leonilda Capuano , Margaret Yoklavich
IPC分类号： A61M2900
CPC分类号： A61B18/02 , A61B2017/00867 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/00404 , A61B2018/00422 , A61B2018/0212 , A61B2018/025 , A61B2018/0262 , A61B2018/0281 , A61F2007/126 , A61M25/10 , A61M2025/1084 , A61M2205/3606
摘要： A medical implement that employs a mechanically supported expandable element. In one embodiment, the mechanically supported expandable element is a balloon. In another embodiment, the mechanically supported expandable membrane is a balloon disposed within a cryogenic catheter usable to treat tissue. A variety of illustrative mechanical support schemes are possible.
摘要翻译：一种采用机械支撑的可扩张元件的医疗器具。在一个实施例中，机械支撑的可膨胀元件是气球。在另一个实施方案中，机械支撑的可膨胀膜是设置在可用于治疗组织的低温导管内的球囊。各种说明性的机械支持方案是可能的。

2. 发明授权

US06270493B1 Cryoablation structure 有权
标题翻译：冷冻消融结构
公开(公告)号：US06270493B1
公开(公告)日：2001-08-07
申请号：US09356433
申请日：1999-07-19
申请人： Jean-Pierre Lalonde , Cristian Petre , Robert Martin , Claudia Lueckge , Sean Carroll , Dan Wittenberger , George Klein
发明人： Jean-Pierre Lalonde , Cristian Petre , Robert Martin , Claudia Lueckge , Sean Carroll , Dan Wittenberger , George Klein
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2017/00084 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0268
摘要： A cryocatheter for treatment of tissue includes a coolant line communicating with a cryochamber having a coolant receiving interior and a thermally conductive wall for contacting and conductively treating tissue. A return line returns spent coolant, and an insert or partition in the cryochamber conditions flow or channels fluid from the coolant line to the return line to enhance the rate or uniformity of cooling. The partition may extend axially to define an elongated sub-chamber which is preferentially cooled, or it may isolate one side to define an uncooled side of the cryochamber. The partition may extend axially to define a sub-chamber extending along a segmented length around a partial circumference of the catheter tip, or may channel the coolant from a central region outwardly against the peripheral wall of the cryochamber. The return line may be a vacuum return line. The catheter may include a means for warming the catheter tip to warm up or accelerate thawing of treated tissue, and the heating may be implemented by a heater in thermal contact with a fluid supply line, which may, moreover, be the coolant supply line. Alternatively, the warming fluid supply line may be distinct from the coolant line. In one embodiment, the device may connect the warming line as an additional coolant return line during cryotreatment, and switch its connection to supply warming fluid after the tissue has been cooled. The catheter may further include sensors such as thermal or impedance sensors for sensing contact orientation of the catheter against adjacent tissue. Electrodes may apply signals of two different frequencies to the two sides, and a processor may determine frequency, impedance or a differential temperature to indicate the tip contact orientation.
摘要翻译：用于治疗组织的低温灭菌器包括与具有冷却剂接收内部的冷冻箱和用于接触和导电地处理组织的导热壁连通的冷却剂管线。返回管路返回耗尽的冷却剂，冷冻箱条件中的插入物或分隔件将流体从冷却剂管路流向或返回管路，以提高冷却速度或均匀性。分隔件可以轴向延伸以限定优选冷却的细长子室，或者可以隔离一侧以限定冷冻箱的未冷却侧。分隔件可以轴向延伸以限定围绕导管尖端的部分圆周的分段长度延伸的子室，或者可以将冷却剂从中心区域向外引导抵靠冷冻箱的周壁。返回管线可以是真空回流管线。导管可以包括用于加温导管尖端以加热或加速经处理的组织的解冻的装置，并且加热可以通过与流体供应管线热接触的加热器来实现，流体供应管线还可以是冷却剂供应管线。或者，加温流体供应管线可以不同于冷却剂管线。在一个实施例中，该装置可以在冷冻处理期间将加热管线作为另外的冷却剂返回管线连接，并且在组织冷却之后将其连接切换到供应加热流体。导管还可以包括传感器，例如用于感测导管相对于相邻组织的接触取向的热传感器或阻抗传感器。电极可以将两个不同频率的信号施加到两侧，并且处理器可以确定频率，阻抗或差分温度以指示尖端接触取向。

3. 发明授权

US09314588B2 Systems and methods for variable injection flow 有权
标题翻译：可变注射流量的系统和方法
公开(公告)号：US09314588B2
公开(公告)日：2016-04-19
申请号：US13300931
申请日：2011-11-21
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.
摘要翻译：公开了用于可控地变化的流体流动的系统和方法，其提供修改可用于流体流动的流体输送导管的有效横截面面积的能力。因此，选择性地控制这些构造允许在流体输送压力保持相同时根据需要调节流体流动。本文提供的其它配置允许选择性地操纵在单个过程期间用医疗装置实现的足迹或治疗模式，否定了去除和插入多个装置以实现治疗几何形状或特征的相同变化的需要。

4. 发明授权

US09320871B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09320871B2
公开(公告)日：2016-04-26
申请号：US13409875
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

5. 发明授权

US5899899A Cryosurgical linear ablation structure 失效
标题翻译：冷冻线性消融结构
公开(公告)号：US5899899A
公开(公告)日：1999-05-04
申请号：US893825
申请日：1997-07-11
申请人： Steven G. Arless , Fredric L. Milder , Kenneth A. Spector , Dan Wittenberger , Domenic N. Santoianni , Claudia Lueckge
发明人： Steven G. Arless , Fredric L. Milder , Kenneth A. Spector , Dan Wittenberger , Domenic N. Santoianni , Claudia Lueckge
IPC分类号： A61B17/00 , A61B18/00 , A61B18/02 , A61F7/02 , A61M25/00 , A61B17/36
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00292 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61F2007/0298 , A61M2025/0039 , A61M25/0029
摘要： A cryogenic catheter includes a flexible member having an elongate, thermally-transmissive region and a cryogenic fluid path through the flexible member to the thermally-transmissive region. The thermally-transmissive region can be deformable from a linear configuration to an arcuate configuration and can include multiple thermally-transmissive elements having a first side exposed to the cryogenic fluid path and a second side exposed to points exterior to the flexible member. The thermally-transmissive elements can be rigid or flexible longitudinal strips. Alternatively, annular, cylindrical, or wedge-shaped metallic structures disposed in a spaced-apart relationship can define the thermally-transmissive region. In other embodiments the thermally-transmissive region is defined by a helical coil that is at least partially embedded in the flexible member. The helical coil can also define at least a portion of the cryogenic fluid path through the flexible member and include a gas expansion or boiling chamber.
摘要翻译：低温导管包括具有细长的热透射区域的柔性构件和通过柔性构件到达热传导区域的低温流体路径。热传导区域可以从线性构造变形到弓形构造，并且可以包括具有暴露于低温流体路径的第一侧的多个热传递元件和暴露于柔性构件外部的点的第二侧。透光元件可以是刚性或柔性的纵向条。或者，以间隔开的关系设置的环形，圆柱形或楔形金属结构可以限定热传导区域。在其它实施例中，热传导区域由至少部分地嵌入在柔性构件中的螺旋线圈限定。螺旋线圈还可以限定通过柔性构件的低温流体路径的至少一部分，并且包括气体膨胀或沸腾室。

6. 发明授权

US09168080B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US09168080B2
公开(公告)日：2015-10-27
申请号：US13360092
申请日：2012-01-27
申请人： Dan Wittenberger , Claudia Lueckge , Réal Ste-Marie
发明人： Dan Wittenberger , Claudia Lueckge , Réal Ste-Marie
IPC分类号： A61B18/02 , A61B18/14 , A61B18/00
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0016 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device including a catheter body defining a proximal portion and a distal portion. An expandable element is included defining a proximal end and a distal end, the proximal end being coupled to the distal portion of the catheter body. A tip element coupled to the distal end of the expandable element is included, the tip element including a shaft slideably receivable within a portion of the catheter body. A tensioning element coupled to the shaft and disposed within the expandable element is included, the tensioning element being engageable with the distal end of the catheter body and biasing the expandable element toward a pre-determined longitudinal position. An electrode array defining a substantially closed loop affixed to and extending from the tip element is also included.
摘要翻译：一种医疗装置，包括限定近端部分和远端部分的导管主体。包括可扩张元件，其限定近端和远端，近端联接到导管主体的远端部分。包括联接到可扩张元件的远端的尖端元件，末端元件包括可滑动地容纳在导管主体的一部分内的轴。包括联接到轴并且设置在可扩张元件内的张紧元件，张紧元件可与导管主体的远端接合并且朝向预定的纵向位置偏压可扩张元件。还包括限定固定到尖端元件并从尖端元件延伸的基本上闭合回路的电极阵列。

7. 发明授权

US09931152B2 Dual injection tube cryocatheter and method for using same 有权
公开(公告)号：US09931152B2
公开(公告)日：2018-04-03
申请号：US12844388
申请日：2010-07-27
申请人： Dan Wittenberger , Claudia Lueckge , Miriam Lane
发明人： Dan Wittenberger , Claudia Lueckge , Miriam Lane
IPC分类号： A61B18/02 , A61B18/00 , A61B90/00
CPC分类号： A61B18/02 , A61B2018/00166 , A61B2018/0022 , A61B2018/00642 , A61B2018/0212 , A61B2090/064
摘要： A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.

8. 发明授权

US09352121B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09352121B2
公开(公告)日：2016-05-31
申请号：US13409646
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

9. 发明授权

US5899898A Cryosurgical linear ablation 失效
标题翻译：冷冻外科线性消融
公开(公告)号：US5899898A
公开(公告)日：1999-05-04
申请号：US807382
申请日：1997-02-27
申请人： Steven G. Arless , Fredric L. Milder , Kenneth A. Spector , Dan Wittenberger , Domenic N. Santoianni , Claudia Lueckge
发明人： Steven G. Arless , Fredric L. Milder , Kenneth A. Spector , Dan Wittenberger , Domenic N. Santoianni , Claudia Lueckge
IPC分类号： A61B17/00 , A61B18/00 , A61B18/02 , A61F7/02 , A61M25/00 , A61B17/36
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00292 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61F2007/0298 , A61M2025/0039 , A61M25/0029
摘要： A cryogenic catheter includes a flexible member having an elongate, thermally-transmissive region and a cryogenic fluid path through the flexible member to the thermally-transmissive region. The thermally-transmissive region can be deformable from a linear configuration to an arcuate configuration and can include multiple thermally-transmissive elements having a first side exposed to the cryogenic fluid path and a second side exposed to points exterior to the flexible member. The thermally-transmissive elements can be rigid or flexible longitudinal strips. Alternatively, annular, cylidrical, or wedge-shaped metallic structures disposed in a spaced-apart relationship can define the thermally-transmissive region. In other embodiments the thermally-transmissive region is defined by a helical coil that is at least partially embedded in the flexible member. The helical coil can also define at least a portion of the cryogenic fluid path through the flexible member and include a gas expansion or boiling chamber.
摘要翻译：低温导管包括具有细长的热透射区域的柔性构件和通过柔性构件到达热传导区域的低温流体路径。热传导区域可以从线性构造变形到弓形构造，并且可以包括具有暴露于低温流体路径的第一侧的多个热传递元件和暴露于柔性构件外部的点的第二侧。透光元件可以是刚性或柔性的纵向条。或者，以间隔开的关系设置的环形，圆形或楔形金属结构可以限定热传导区域。在其它实施例中，热传导区域由至少部分地嵌入在柔性构件中的螺旋线圈限定。螺旋线圈还可以限定通过柔性构件的低温流体路径的至少一部分，并且包括气体膨胀或沸腾室。

10. 发明授权

US07955298B2 Defined deflection structure 有权
标题翻译：定义偏转结构
公开(公告)号：US07955298B2
公开(公告)日：2011-06-07
申请号：US11112100
申请日：2005-05-09
申请人： Sean Carroll , Domenic Santoianni , Benoit Thibault , Dan Wittenberger , Mathieu-Philippe Aubert , Marc-André Marcotte
发明人： Sean Carroll , Domenic Santoianni , Benoit Thibault , Dan Wittenberger , Mathieu-Philippe Aubert , Marc-André Marcotte
IPC分类号： A61M31/00
CPC分类号： A61M25/0105 , A61B1/0051 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , A61M25/0041 , A61M25/0043 , A61M25/005 , A61M25/0054 , A61M25/0116 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0662 , A61M25/10 , A61M2025/0161 , A61M2025/0163 , A61M2025/09141
摘要： Deflection mechanisms are disclosed that are positionable to deflecting portions of a flexible body, such as a catheter, in more than one direction in a single plane, as well as in more than one plane. The invention allows a distal portion of a catheter to be deflected more than 360 degrees to provide a loop.
摘要翻译：公开了一种偏转机构，其可定位成在单个平面中以及多于一个平面中在多于一个方向上偏转诸如导管的柔性体的部分。本发明允许导管的远端部分被偏转超过360度以提供环路。

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