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1. 发明授权

US09095503B2 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 有权
标题翻译：用于治疗剂的双相透皮离子电渗递送的系统和方法
公开(公告)号：US09095503B2
公开(公告)日：2015-08-04
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/32
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

2. 发明申请

US20130023815A1 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHREOTIC DELIVERY OF THERAPEUTIC AGENTS 有权
公开(公告)号：US20130023815A1
公开(公告)日：2013-01-24
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

3. 发明授权

US08821945B2 Method for transdermal iontophoretic delivery of chelated agents 有权
标题翻译：螯合剂透皮离子电渗递送方法
公开(公告)号：US08821945B2
公开(公告)日：2014-09-02
申请号：US12459862
申请日：2009-07-07
申请人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
发明人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
IPC分类号： A01N59/16 , A01N59/26 , A61N1/30
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/703 , A61K9/7084 , A61K33/26 , A61K33/42 , A61K41/00 , A61N1/0496 , A61N1/30 , A61N1/325
摘要： Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
摘要翻译：实施方案提供用于经皮递送螯合化合物的装置，系统和方法。一个实施方案提供了用于治疗贫血的螯合铁络合物的离子电渗疗法透皮递送的方法。将包含活性电极和螯合铁络合物的第一贴片施加到皮肤上; 还应用了包含电极的第二贴片。然后从活性电极将电流输送到皮肤。螯合络合物通过电流从电流传递穿过皮肤，铁在运输过程中与皮肤基本上不发生色素反应，因此由于不溶性氧化产物的形成，皮肤几乎或没有纹身。然后通过吞噬作用或相关过程解离复合物以释放铁，其中它可被转铁蛋白或铁蛋白结合并携带到其它部位用于储存或代谢使用。

4. 发明申请

US20100272827A1 Method for transdermal iontophoretic delivery of chelated agents 有权
标题翻译：螯合剂透皮离子电渗递送方法
公开(公告)号：US20100272827A1
公开(公告)日：2010-10-28
申请号：US12459862
申请日：2009-07-07
申请人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
发明人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
IPC分类号： A61K33/42 , A61K33/26 , A61P7/06
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/703 , A61K9/7084 , A61K33/26 , A61K33/42 , A61K41/00 , A61N1/0496 , A61N1/30 , A61N1/325
摘要： Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
摘要翻译：实施方案提供用于经皮递送螯合化合物的装置，系统和方法。一个实施方案提供了用于治疗贫血的螯合铁络合物的离子电渗疗法透皮递送的方法。将包含活性电极和螯合铁络合物的第一贴片施加到皮肤上; 还应用了包含电极的第二贴片。然后从活性电极将电流输送到皮肤。螯合络合物通过电流从电流传递穿过皮肤，铁在运输过程中与皮肤基本上不发生色素反应，因此由于不溶性氧化产物的形成，皮肤几乎或没有纹身。然后通过吞噬作用或相关过程解离复合物以释放铁，其中它可被转铁蛋白或铁蛋白结合并携带到其它部位用于储存或代谢使用。

5. 发明申请

US20130325108A1 BIODEGRADABLE MEDICAL IMPLANTS, POLYMER COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：生物可降解医用植入物，聚合物组合物和使用方法
公开(公告)号：US20130325108A1
公开(公告)日：2013-12-05
申请号：US13261054
申请日：2010-06-01
申请人： Mir Imran , Sanjay Patel , Joel Harris
发明人： Mir Imran , Sanjay Patel , Joel Harris
IPC分类号： A61L27/14 , A61F2/04 , A61F2/82
CPC分类号： A61L27/14 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2210/0004 , A61L27/26 , A61L27/58 , A61L31/041 , A61L31/148
摘要： Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.
摘要翻译：本发明的实施方案提供了包含生物可降解聚合物，由这些组合物制造的医疗植入物和使用这种植入物的方法的组合物。许多实施方案提供医学植入物，其包含具有第一生物降解速率的第一聚合物主链和具有比第一速率快的第二生物降解速率的第二聚合物主链。在一些实施例中，第二主干被配置为由天然组织层代替。第一个骨架提供植入物的支架，而第二个骨架降解。该支架可以增强植入物的机械性能，包括机械强度的各个方面，例如拉伸，弯曲，箍和屈服强度; 和弹性。支架还用于在第二主骨架的退化期间或植入物的整个寿命期间保持植入物的最小结构支撑水平，使得植入物不会机械地失效。

6. 发明申请

US20120177700A1 Nanonized Iron Compositions and Methods of Use Thereof 审中-公开
标题翻译：纳米铁组合物及其使用方法
公开(公告)号：US20120177700A1
公开(公告)日：2012-07-12
申请号：US13338210
申请日：2011-12-27
申请人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
发明人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
IPC分类号： A61K9/00 , A61K33/42 , B82Y5/00
CPC分类号： A61K9/14 , A61K33/26
摘要： Embodiments of the invention provide nanonized iron compositions for treatment of iron deficiency such as iron deficiency anemia. Many embodiments provide nanonized iron compositions which are sized to minimize adverse reaction such as immune response, adverse GI reaction and allergic reaction to iron compound included in the composition. The nanonized iron compositions can be used in a variety of drug delivery forms, including an oral dosage form, a transdermal patch, in an intravenous solution or in a dialysate for treatment of a patient with chronic kidney disease (CKD). Embodiments of the invention also provide methods of using the nanonized iron compositions for the treatment of iron deficiency in a patient in need thereof including patients with iron deficiency anemia and CKD.
摘要翻译：本发明的实施方案提供了用于治疗铁缺乏症（例如缺铁性贫血）的纳米铁组合物。许多实施方案提供纳米级铁组合物，其尺寸设定成使包括在组合物中的铁化合物的不良反应如免疫应答，不良GI反应和过敏反应最小化。纳米铁组合物可以以各种药物递送形式使用，包括口服剂型，透皮贴剂，静脉内溶液或用于治疗慢性肾脏病（CKD）患者的透析液。本发明的实施方案还提供了使用纳米铁组合物治疗需要其的患者缺铁的方法，包括缺铁性贫血和CKD患者。

7. 发明授权

US10046085B2 Biodegradable medical implants, polymer compositions and methods of use 有权
公开(公告)号：US10046085B2
公开(公告)日：2018-08-14
申请号：US13261054
申请日：2010-06-01
申请人： Mir Imran , Sanjay Patel , Joel Harris
发明人： Mir Imran , Sanjay Patel , Joel Harris
IPC分类号： A61L27/14 , A61F2/82 , A61L27/26 , A61L27/58 , A61L31/04 , A61L31/14 , A61F2/04 , A61F2/06 , A61F2/07
摘要： Embodiments of the invention provide compositions include bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants including a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.

8. 发明授权

US08639885B2 Reducing implementation costs of communicating cache invalidation information in a multicore processor 有权
标题翻译：降低在多核处理器中传送缓存无效信息的实施成本
公开(公告)号：US08639885B2
公开(公告)日：2014-01-28
申请号：US12643238
申请日：2009-12-21
申请人： Prashant Jain , Sandip Das , Sanjay Patel
发明人： Prashant Jain , Sandip Das , Sanjay Patel
IPC分类号： G06F12/00
CPC分类号： G06F12/0897 , Y02D10/13
摘要： A processor may include several processor cores, each including a respective higher-level cache, wherein each higher-level cache includes higher-level cache lines; and a lower-level cache including lower-level cache lines, where each of the lower-level cache lines may be configured to store data that corresponds to multiple higher-level cache lines. In response to invalidating a given lower-level cache line, the lower-level cache may be configured to convey a sequence including several invalidation packets to the processor cores via an interface, where each member of the sequence of invalidation packets corresponds to a respective higher-level cache line to be invalidated, and where the interface is narrower than an interface capable of concurrently conveying all invalidation information corresponding to the given lower-level cache line. Each invalidation packet may include invalidation information indicative of a location of the respective higher-level cache line within different ones of the processor cores.
摘要翻译：处理器可以包括几个处理器核心，每个处理器核心包括相应的更高级别的高速缓存，其中每个更高级别的高速缓存包括更高级别的高速缓存行; 以及包括较低级别高速缓存行的下级缓存，其中每个下级高速缓存行可以被配置为存储对应于多个更高级别的高速缓存行的数据。响应于使给定的低级高速缓存行无效，低级缓存可以被配置为经由接口将包括若干无效分组的序列传送到处理器核，其中无效分组序列中的每个成员对应于相应较高的高级缓存行将被无效，并且其中接口比能够同时传送对应于给定下级高速缓存行的所有无效信息的接口更窄。每个无效分组可以包括指示相应的较高级别高速缓存行在不同处理器核心内的位置的无效信息。

9. 发明申请

US20130263124A1 Apparatus and Method for Guest and Root Register Sharing in a Virtual Machine 有权
标题翻译：虚拟机中访客和根注册器共享的装置和方法
公开(公告)号：US20130263124A1
公开(公告)日：2013-10-03
申请号：US13436654
申请日：2012-03-30
申请人： Sanjay Patel , Ranjit Joseph Rozario
发明人： Sanjay Patel , Ranjit Joseph Rozario
IPC分类号： G06F9/455
CPC分类号： G06F9/4555
摘要： A computer readable storage medium includes executable instructions to define a processor with guest mode control registers supporting guest mode operating behavior defined by guest context specified in the guest mode control registers. The guest mode control registers include a control bit to specify a guest access blocked register state and a shared register state. Root mode control registers support root mode operating behavior defined by root context specified in the root mode control registers. The root mode control registers include control bits to enable replicated register state access and shared register state access. The guest context and the root context support virtualization of hardware resources such that multiple operating systems supporting multiple applications are executed by the hardware resources.
摘要翻译：计算机可读存储介质包括可执行指令，以定义具有访客模式控制寄存器的处理器，所述访客模式控制寄存器支持由访客模式控制寄存器中指定的访客上下文定访客模式控制寄存器包括一个控制位，用于指定访客阻止寄存器状态和共享寄存器状态。根模式控制寄存器支持在根模式控制寄存器中指定的根上下文定义的根模式操作行为。根模式控制寄存器包括用于启用复制寄存器状态访问和共享寄存器状态访问的控制位。访客环境和根本环境支持硬件资源的虚拟化，使得支持多个应用的多个操作系统由硬件资源执行。

10. 发明授权

US08510752B2 System and method for data management of embedded systems 有权
标题翻译：嵌入式系统的数据管理系统和方法
公开(公告)号：US08510752B2
公开(公告)日：2013-08-13
申请号：US11848957
申请日：2007-08-31
申请人： Sanjay Patel , Phanindranath Vedula , William Allen Hinton , Sunayana Bhan , Ashok Sivaram , Tanweer Khan
发明人： Sanjay Patel , Phanindranath Vedula , William Allen Hinton , Sunayana Bhan , Ashok Sivaram , Tanweer Khan
IPC分类号： G06F3/00
CPC分类号： G06Q10/00 , G06F9/542
摘要： A system, method, and computer program manage embedded component information for a product design in a product lifecycle management (PLM) environment. The method includes displaying at least one message object and associating the at least one message object with a signal object.
摘要翻译：系统，方法和计算机程序在产品生命周期管理（PLM）环境中管理产品设计的嵌入式组件信息。该方法包括显示至少一个消息对象并将至少一个消息对象与信号对象相关联。

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