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1. 发明授权

US09095503B2 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 有权
标题翻译：用于治疗剂的双相透皮离子电渗递送的系统和方法
公开(公告)号：US09095503B2
公开(公告)日：2015-08-04
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/32
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

2. 发明申请

US20130023815A1 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHREOTIC DELIVERY OF THERAPEUTIC AGENTS 有权
公开(公告)号：US20130023815A1
公开(公告)日：2013-01-24
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

3. 发明申请

US20120177700A1 Nanonized Iron Compositions and Methods of Use Thereof 审中-公开
标题翻译：纳米铁组合物及其使用方法
公开(公告)号：US20120177700A1
公开(公告)日：2012-07-12
申请号：US13338210
申请日：2011-12-27
申请人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
发明人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
IPC分类号： A61K9/00 , A61K33/42 , B82Y5/00
CPC分类号： A61K9/14 , A61K33/26
摘要： Embodiments of the invention provide nanonized iron compositions for treatment of iron deficiency such as iron deficiency anemia. Many embodiments provide nanonized iron compositions which are sized to minimize adverse reaction such as immune response, adverse GI reaction and allergic reaction to iron compound included in the composition. The nanonized iron compositions can be used in a variety of drug delivery forms, including an oral dosage form, a transdermal patch, in an intravenous solution or in a dialysate for treatment of a patient with chronic kidney disease (CKD). Embodiments of the invention also provide methods of using the nanonized iron compositions for the treatment of iron deficiency in a patient in need thereof including patients with iron deficiency anemia and CKD.
摘要翻译：本发明的实施方案提供了用于治疗铁缺乏症（例如缺铁性贫血）的纳米铁组合物。许多实施方案提供纳米级铁组合物，其尺寸设定成使包括在组合物中的铁化合物的不良反应如免疫应答，不良GI反应和过敏反应最小化。纳米铁组合物可以以各种药物递送形式使用，包括口服剂型，透皮贴剂，静脉内溶液或用于治疗慢性肾脏病（CKD）患者的透析液。本发明的实施方案还提供了使用纳米铁组合物治疗需要其的患者缺铁的方法，包括缺铁性贫血和CKD患者。

4. 发明申请

US20100191305A1 METHOD AND APPARATUS FOR THE DETECTION OF ABERRANT NEURAL-ELECTRIC ACTIVITY 有权
标题翻译：用于检测ABERRANT神经电活动的方法和装置
公开(公告)号：US20100191305A1
公开(公告)日：2010-07-29
申请号：US12359830
申请日：2009-01-26
申请人： Mir Imran , Lu Wang , Paren Shah , Joel Harris
发明人： Mir Imran , Lu Wang , Paren Shah , Joel Harris
IPC分类号： A61N1/36 , A61B5/0478 , A61M5/00
CPC分类号： A61B5/04001 , A61B5/04004 , A61B5/0478 , A61B5/0531 , A61B5/4094 , A61N1/0529 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36064 , A61N1/36082
摘要： Embodiments provide an apparatus and method for detection of aberrant neural-electric activity (ANEA) in the brain causing an epileptic seizure or other neurologic condition. One embodiment provides an apparatus for detection of ANEA comprising an introducer having at least one lumen. The introducer is introduced into brain tissue through an opening in the skull. A reference electrode is positioned at an introducer distal portion. A plurality of electrode members are advanceable within the at least one lumen with each member having an insulated portion and an exposed distal portion. The members have a non-deployed state in the introducer and a deployed state when outwardly advanced out of the introducer. In the deployed state, the members are substantially orthogonal to each other with the exposed distal portions defining a detection volume capable of determining an electric field vector produced by the ANEA and the direction of a foci of the ANEA.
摘要翻译：实施例提供了用于检测脑中异常神经电活动（ANEA）的装置和方法，其引起癫痫发作或其他神经病症。一个实施例提供了一种用于检测ANEA的装置，包括具有至少一个内腔的导引器。导引器通过头骨中的开口引入脑组织。参考电极位于导引器远端部分。多个电极构件可在至少一个内腔内前进，每个构件具有绝缘部分和暴露的远端部分。这些构件在导引器中具有非展开状态，并且当向外推进导引器时处于展开状态。在展开状态下，构件基本上彼此正交，暴露的远侧部分限定能够确定由ANEA产生的电场矢量和ANEA焦点方向的检测体积。

5. 发明申请

US20090069288A1 Novel therapeutic compounds 审中-公开
标题翻译：新型治疗化合物
公开(公告)号：US20090069288A1
公开(公告)日：2009-03-12
申请号：US12218364
申请日：2008-07-15
申请人： Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Bin Li , Thomas D. Gordon , Robert H. Stoffel , Grier A. Wallace , Pintipa Grongsaard , Lu Wang , Lu Wang
发明人： Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Bin Li , Thomas D. Gordon , Robert H. Stoffel , Grier A. Wallace , Pintipa Grongsaard , Lu Wang , Lu Wang
IPC分类号： A61K31/4196 , C07D249/10 , C07D403/12 , C07D261/14 , A61K31/42 , A61K31/415 , C07D231/14 , A61P35/00
CPC分类号： C07D249/10 , C07D231/14 , C07D249/06 , C07D261/14 , C07D261/18 , C07D273/02 , C07D333/36 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.
摘要翻译：本文公开了式（I）的新化合物，其中变量如本文所定义。式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性疾病和疾病以及增殖性疾病如癌症。

6. 发明申请

US20140315883A1 6H-IMIDAZO[1,5-a]PYRROLO[2,3-e]PYRAZINE COMPOUNDS 审中-公开
标题翻译： 6H-咪唑并[1,5-a]吡咯并[2,3-e]吡嗪化合物
公开(公告)号：US20140315883A1
公开(公告)日：2014-10-23
申请号：US14256224
申请日：2014-04-18
申请人： Eric Breinlinger , Heather Davis , Michael Hoemann , Bin Li , Biqin Li , Gagandeep Somal , Stacy Van Epps , Lu Wang , Lu Wang
发明人： Eric Breinlinger , Heather Davis , Michael Hoemann , Bin Li , Biqin Li , Gagandeep Somal , Stacy Van Epps , Lu Wang , Lu Wang
IPC分类号： C07D487/16
CPC分类号： C07D487/16 , C07D487/14
摘要： The invention provides a compound of Formula (I as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供了本文定义的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫学和肿瘤学病症。

7. 发明授权

US09235879B2 Apparatus, system, and method for temporal domain hole filling based on background modeling for view synthesis 有权
标题翻译：基于视图合成的背景建模的时域填充的装置，系统和方法
公开(公告)号：US09235879B2
公开(公告)日：2016-01-12
申请号：US13538966
申请日：2012-06-29
申请人： Sun Wenxiu , Oscar C. Au , Lingfeng Xu , Yujun Li , Wei Hu , Lu Wang
发明人： Sun Wenxiu , Oscar C. Au , Lingfeng Xu , Yujun Li , Wei Hu , Lu Wang
IPC分类号： G06T5/00 , H04N13/02
CPC分类号： G06T5/005 , G06T2207/10021 , G06T2207/20182 , H04N13/261
摘要： Embodiments of apparatuses, systems, and methods for a temporal hole filling are described. Specifically, an embodiment of the present invention may include a depth-based hole filling process that includes a background modeling technique (SGM). Beneficially, in such an embodiment, holes in the synthesized view may be filled effectively and efficiently.
摘要翻译：描述了用于时空填充的装置，系统和方法的实施例。具体地，本发明的实施例可以包括基于深度的孔填充过程，其包括背景建模技术（SGM）。有利地，在这样的实施例中，可以有效且有效地填充合成视图中的孔。

8. 发明授权

US09183669B2 Method and apparatus for virtual viewpoint synthesis in multi-viewpoint video 有权
标题翻译：多视点视频中虚拟视点综合的方法和装置
公开(公告)号：US09183669B2
公开(公告)日：2015-11-10
申请号：US14342366
申请日：2012-09-07
申请人： Ju Liu , Lu Wang , Jiande Sun , Wei Liu
发明人： Ju Liu , Lu Wang , Jiande Sun , Wei Liu
IPC分类号： G06K9/36 , G06T15/20 , G06T7/00 , G06T3/00
CPC分类号： G06T15/20 , G06T3/00 , G06T7/55
摘要： Disclosed are a virtual viewpoint combination method and device in a multi-viewpoint video, improving the quality of the virtual viewpoint images and improving the display effects of the virtual viewpoint images under the premise of not introducing geometrical distortion. The method includes: taking two viewpoint images provided by a first camera and a second camera as reference viewpoint images, and respectively performing 3D image conversion, pinhole filling, image compensation and image convergence processing on the two viewpoint images to obtain a main virtual viewpoint image; then respectively performing depth-image processing, 3D image conversion, pinhole filling, image compensation and image convergence processing on the two viewpoint images to obtain a subordinate virtual viewpoint image; and performing filling the remaining holes in the main virtual viewpoint image on the basis of the subordinate virtual viewpoint image to obtain a final virtual viewpoint image to be combine.
摘要翻译：公开了一种多视点视频中的虚拟视点组合方法和装置，在不引入几何失真的前提下，提高虚拟视点图像的质量并提高虚拟视点图像的显示效果。该方法包括：将由第一相机和第二相机提供的两个视点图像作为参考视点图像，分别对两个视点图像执行3D图像转换，针孔填充，图像补偿和图像收敛处理，以获得主虚拟视点图像 ; 然后分别对两个视点图像执行深度图像处理，3D图像转换，针孔填充，图像补偿和图像融合处理，以获得下级虚拟视点图像; 并且根据下级虚拟视点图像执行填充主虚拟视点图像中的剩余孔，以获得要组合的最终虚拟视点图像。

9. 发明授权

US09106600B2 Platform-independent method and system for electronically engaging customers 有权
标题翻译：平台独立的方法和系统，用于电子吸引客户
公开(公告)号：US09106600B2
公开(公告)日：2015-08-11
申请号：US13787323
申请日：2013-03-06
申请人： Lu Wang , Jinsheng Wang
发明人： Lu Wang , Jinsheng Wang
IPC分类号： G06F15/16 , H04L12/58
CPC分类号： H04L51/22 , H04L51/04 , H04L51/066 , H04L51/16 , H04W4/14
摘要： Techniques for electronically engaging customers across all different platforms are disclosed. Based on unique device identifiers captured together with interactions by users with one or more applications provided by a business, a message prepared in a first format is automatically converted to a corresponding message in a second format according to what the devices the user have been interacting with can support. Depending on implementation, the message may be a response by the business to an inquiry from a user or a promotion by the business to be distributed to a group of selected users maintained by the business. The interactions include activities a user has had with one or more of the applications provided by the business and provide the statistical or actual data for the business to determine the group of users to receive the message.
摘要翻译：披露了在所有不同平台上电子吸引客户的技术。基于与由企业提供的一个或多个应用的用户交互捕获的唯一设备标识符，根据用户已经与...进行交互的设备将第一格式准备的消息自动转换为第二格式的相应消息可以支持取决于实现，消息可以是业务对来自用户的询问或由业务分发给由业务维护的所选择的用户组的促销的响应。交互包括用户与业务提供的一个或多个应用程序的活动，并为业务提供统计或实际数据，以确定接收消息的用户组。

10. 发明授权

US09031809B1 Method and apparatus for generating three-dimensional pose using multi-modal sensor fusion 有权
标题翻译：使用多模式传感器融合产生三维姿势的方法和装置
公开(公告)号：US09031809B1
公开(公告)日：2015-05-12
申请号：US13182987
申请日：2011-07-14
申请人： Rakesh Kumar , Supun Samarasekera , Han-Pang Chiu , Zhiwei Zhu , Taragay Oskiper , Lu Wang , Raia Hadsell
发明人： Rakesh Kumar , Supun Samarasekera , Han-Pang Chiu , Zhiwei Zhu , Taragay Oskiper , Lu Wang , Raia Hadsell
IPC分类号： G01C21/16 , G06T7/00 , G06F3/01 , G01C21/00 , G06K9/00 , G01S1/00
CPC分类号： G01C21/165 , G01C21/005 , G01S1/00 , G01S5/163 , G06F3/012 , G06F3/017 , G06F3/0304 , G06K9/00671 , G06T7/246 , G06T7/277 , G06T7/285 , G06T2207/10021 , G06T2207/30244
摘要： A method and apparatus for providing three-dimensional navigation for a node comprising an inertial measurement unit for providing gyroscope, acceleration and velocity information (collectively IMU information); a ranging unit for providing distance information relative to at least one reference node; at least one visual sensor for providing images of an environment surrounding the node; a preprocessor, coupled to the inertial measurement unit, the ranging unit and the plurality of visual sensors, for generating error states for the IMU information, the distance information and the images; and an error-state predictive filter, coupled to the preprocessor, for processing the error states to produce a three-dimensional pose of the node.
摘要翻译：一种用于为节点提供三维导航的方法和装置，包括用于提供陀螺仪，加速度和速度信息（统称IMU信息）的惯性测量单元; 测距单元，用于相对于至少一个参考节点提供距离信息; 至少一个视觉传感器，用于提供围绕该节点的环境的图像; 耦合到惯性测量单元，测距单元和多个视觉传感器的预处理器，用于产生IMU信息，距离信息和图像的误差状态; 以及耦合到所述预处理器的错误状态预测滤波器，用于处理所述错误状态以产生所述节点的三维姿态。

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