专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050054083A1 Automated laboratory for high-throughput biological assays and RNA interference 有权
标题翻译：用于高通量生物测定和RNA干扰的自动化实验室
公开(公告)号：US20050054083A1
公开(公告)日：2005-03-10
申请号：US10837218
申请日：2004-04-30
申请人： Minh Vuong , Todd Bennett , Javier Flores , Brian Grot , Daniel Hale , Huy Nguyen , Walter Niles , Tuong Phan , Steve Rodems , Jeff Stack , Peter Coassin
发明人： Minh Vuong , Todd Bennett , Javier Flores , Brian Grot , Daniel Hale , Huy Nguyen , Walter Niles , Tuong Phan , Steve Rodems , Jeff Stack , Peter Coassin
IPC分类号： B23B27/04 , C12M1/34 , C12N20060101
CPC分类号： G01N35/1074 , G01N35/028
摘要： The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling. Liquid transfer to and from multiwell platforms, necessary for assay construction or for the initiation of physiological events in cells, is partitioned among different modules specialized for transferring nanoliter or smaller volume quantities of chemical concentrates, or microliter quantities of assay reagents, cells, media and other assay constituents. Applications of this invention include the quantitation and analysis of the expression of multiple genes in cells, measurement of multi-gene expression kinetics, analysis of activation or suppression of multiple signal transduction pathways, screening chemical compounds for modulatory effects on multi-gene expression or on signal transduction pathways or on other biochemical networks of cells, or other analytical biological or biochemical assays.
摘要翻译：本发明是一种自动多功能综合实验室系统，包括用于构建和测量生物测定的可互换模块化元件。模块化元件的功能可以包括多井平台处理，化学试剂或细胞管理，用于测定构建的液体的体积转移或用于回收用于分析的反应产物，在受控环境条件下孵育，来自测定的光谱信号的测量，处理并对所得光谱数据进行分析等功能。模块化元件围绕若干机器人元件布置，其将板递送到不同的模块元件，将板传递到由不同的机器人元件服务的模块组或板处理中所需的其他动作。液体转移至多孔平台，用于测定结构或细胞中生理事件发生所必需的多孔平台，在专门用于转移纳升或更小体积量的化学浓缩物或微量的测定试剂，细胞，培养基和其他检测成分。本发明的应用包括细胞中多个基因的表达的定量和分析，多基因表达动力学的测定，多重信号转导途径的激活或抑制分析，筛选化合物对多基因表达的调节作用或信号转导途径或细胞的其他生物化学网络或其他分析生物或生物化学测定。

2. 发明申请

US20050048575A1 Multi-well plate providing a high-density storage and assay platform 有权
标题翻译：多孔板提供高密度存储和测定平台
公开(公告)号：US20050048575A1
公开(公告)日：2005-03-03
申请号：US10837219
申请日：2004-04-30
申请人： Peter Coassin , Todd Bennett , Brian Grot , David Nicol
发明人： Peter Coassin , Todd Bennett , Brian Grot , David Nicol
IPC分类号： B01L3/00 , B01L9/00 , C12M1/34 , G01N33/53 , G01N33/567
CPC分类号： B01L3/50851 , B01L9/523 , B01L2200/025 , B01L2200/142 , B01L2300/0829 , B01L2300/12
摘要： A dual-use, high density plate for storage and assays includes a frame including a matrix of wells. The matrix includes preferably 3456 wells with top portions being arranged preferably approximately flush with a plane of the frame. A solvent-resistant material such as cyclo-olefin polymer forms at least the bottom portions of the wells, and preferably the same solvent resistant material forms the frame, although varying from the bottoms of the wells by being rendered opaque. Evaporation control wells are preferably included at the periphery of the matrix for reducing effects of evaporation on edge wells.
摘要翻译：用于储存和测定的双重用途的高密度板包括包括孔的矩阵的框架。该基质优选包括3456个孔，顶部优选地与框架的平面大致齐平。耐溶剂材料如环烯烃聚合物至少形成孔的底部，并且优选地，相同的耐溶剂材料形成框架，尽管通过变得不透明而从孔的底部变化。蒸发控制孔优选包含在基质的周边，以减少边缘孔蒸发的影响。

3. 发明申请

US20060139624A1 Detector and screening device for ion channels 有权
公开(公告)号：US20060139624A1
公开(公告)日：2006-06-29
申请号：US11355396
申请日：2006-02-15
申请人： Roger Tsien , Peter Coassin , Andrew Pham , Alec Harootunian , Minh Vuong
发明人： Roger Tsien , Peter Coassin , Andrew Pham , Alec Harootunian , Minh Vuong
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/48728 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.

4. 发明申请

US20070139639A1 Detector and screening device for ion channels 审中-公开
标题翻译：用于离子通道的检测器和筛选装置
公开(公告)号：US20070139639A1
公开(公告)日：2007-06-21
申请号：US11544408
申请日：2006-10-05
申请人： Roger Tsien , Peter Coassin , Andrew Pham , Alec Harootunian , Minh Vuong
发明人： Roger Tsien , Peter Coassin , Andrew Pham , Alec Harootunian , Minh Vuong
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/48728 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.
摘要翻译：本发明提供了用于光学测量的检测器组件，光纤组件和屏蔽系统。

5. 发明申请

US20050032241A1 Reagent dispenser and dispensing method 审中-公开
标题翻译：试剂分配器和分配方法
公开(公告)号：US20050032241A1
公开(公告)日：2005-02-10
申请号：US10789183
申请日：2004-02-26
申请人： Peter Coassin , Javier Flores , David Nicol , Troy Peterson , Philip Salzmann , T. Vuong
发明人： Peter Coassin , Javier Flores , David Nicol , Troy Peterson , Philip Salzmann , T. Vuong
IPC分类号： B01D20060101 , B01J4/00 , B01L3/02 , G01N35/10
CPC分类号： B01L3/0241 , B01J4/001 , G01N35/1002 , G01N35/1009 , G01N35/1074 , Y10T436/2575
摘要： A method and apparatus is disclosed for automated on-the-fly dispensing of reagents. The apparatus includes a detachable reagent dispensing module supported by a support frame. The dispensing module includes a self-contained pressurized fluid delivery subsystem that facilitates efficient attachment and detachment of the module, including pressurized reagent containers and associated accessories arranged such that each reagent container has a discrete fluid path terminating at a corresponding discrete reagent dispensing tip. The dispensing tips are supported in a common dispensing head, and are arranged geometrically such that the centers of the dispensing tips are separated by distances corresponding to relevant dimensions of particular assay plates to be used therewith. Such a geometric arrangement allows for dispensing of multiple reagents substantially simultaneously into multiple corresponding target wells of the assay plate, efficiently and precisely.
摘要翻译：公开了用于自动化的试剂分配的方法和装置。该装置包括由支撑框架支撑的可拆卸的试剂分配模块。分配模块包括独立的加压流体递送子系统，其有助于模块的有效附接和分离，包括加压的试剂容器和相关联的附件，其布置成使得每个试剂容器具有终止于相应的分立的试剂分配尖端的离散流体路径。分配尖端被支撑在共同的分配头中，并且几何地布置成使得分配尖端的中心与对应于要与其一起使用的特定测定板的相关尺寸相对应的距离分开。这种几何布置允许基本上同时将多个试剂分配到分析板的多个相应的目标孔中，并且被有效和准确地分配。

6. 发明申请

US20070289992A1 Method and system for precise dispensation of a liquid 审中-公开
公开(公告)号：US20070289992A1
公开(公告)日：2007-12-20
申请号：US11542754
申请日：2006-10-02
申请人： David Nicol , Binh Nguyen , Peter Coassin , Walter Niles
发明人： David Nicol , Binh Nguyen , Peter Coassin , Walter Niles
IPC分类号： B65D47/18 , B67D5/08 , G01F11/00
CPC分类号： B01L3/0241 , B01L3/0275 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487
摘要： Devices, systems, and methods for the precise dispensation of small volumes of liquids are presented. A fluid microdispenser comprises a liquid-filled tube, an actuator coupled to the tube, and a tip at one end of the tube. When the actuator applies an actuation pressure, a precise volume of liquid is ejected from the orifice of the tip. The orifice is manufactured to control the volume of liquid ejected by each actuation and, therefore, may have a diameter smaller than that of the liquid-filled tube. The invention comprises systems, methods, and devices so that the inner diameter of the liquid-filled tube is decreased (tapered) to that of the orifice so as to maximize transmission to the orifice of the pressure generated by the actuation stimulus. This enables the volume of liquid ejected by each stimulus to be reproducibly controlled by the amplitude of the actuation stimulus.

7. 发明申请

US20070009883A1 Low fluorescence assay platforms and related methods for drug discovery 审中-公开
标题翻译：低荧光测定平台及药物发现的相关方法
公开(公告)号：US20070009883A1
公开(公告)日：2007-01-11
申请号：US11520869
申请日：2006-09-13
申请人： Peter Coassin , Alec Harootunian , Andrew Pham , Harry Stylli , Roger Tsien
发明人： Peter Coassin , Alec Harootunian , Andrew Pham , Harry Stylli , Roger Tsien
IPC分类号： C12M1/34 , C12Q1/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/021 , B01L2300/0829 , B01L2300/12 , C12M23/12 , C12Q1/00 , C40B60/14 , G01N1/30 , G01N21/03 , G01N21/6428 , G01N21/6452 , G01N33/5308 , G01N33/542 , G01N2021/0346
摘要： One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
摘要翻译：本发明的一个方面是用于荧光测量的多孔平台，其包括框架内的多个孔，其中所述多孔平台具有低荧光背景。本发明的另一方面是用于光谱测量的系统，其包括用于测定的试剂和用于荧光测量的多孔平台。本发明的另一方面是通过检测从样品发射的光来检测多孔平台中包含的样品中分析物的存在的方法。本发明的另一方面是通过检测从样品发射的光来识别多孔平台中包含的样品中生物过程或靶的调节剂的方法。本发明的另一方面是通过该方法鉴定的组合物。本发明的另一方面是鉴定治疗剂的方法。本发明的另一方面是通过使用本发明的方法鉴定治疗剂并监测治疗剂在体内模型中的毒理学和功效来测试治疗活性和毒理学治疗剂的方法。

8. 发明申请

US20060057029A1 Analytical biochemistry system with robotically carried bioarray 审中-公开
标题翻译：分析生物化学系统与机器人携带的生物阵列
公开(公告)号：US20060057029A1
公开(公告)日：2006-03-16
申请号：US11073288
申请日：2005-03-04
申请人： Peter Coassin , Jack McNeal , David Helphrey
发明人： Peter Coassin , Jack McNeal , David Helphrey
IPC分类号： G01N33/53 , B01L3/02
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/00292 , B01J2219/00315 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00657 , B01J2219/00659 , B01J2219/00691 , B01J2219/00711 , B01J2219/00722 , B01L3/0275 , B01L3/508 , B01L3/5085 , B01L2300/0636 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/6452 , G01N35/00029 , G01N2035/00118 , G01N2035/00158 , G01N2035/1055 , G01N2035/1062 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate.
摘要翻译：一种分析生物化学系统，其特征在于在固定的已知位置处固定有反应物的基底，支撑基底的保持器和用于将保持器运送到固定样品的操纵器和检查站。反应物是样品中靶生物分子的结合剂，其形成具有可检测特征的结合物质。保持器可以是标准移液器，可选地由机器人手臂或手携带作为操纵器以接触样品以检测样品内目标生物分子的存在。在一个实施例中，保持器是其中容纳衬底的移液管尖端，或者其可以是承载衬底并且配合在标准微量滴定板的样品孔内的移液管适配器。

9. 发明申请

US20050006417A1 Method and system for precise dispensation of a liquid 有权
标题翻译：精确分配液体的方法和系统
公开(公告)号：US20050006417A1
公开(公告)日：2005-01-13
申请号：US10837221
申请日：2004-04-30
申请人： David Nicol , Binh Nguyen , Peter Coassin
发明人： David Nicol , Binh Nguyen , Peter Coassin
IPC分类号： B01L3/02 , B67D7/08 , B67D7/30 , B67D5/08
CPC分类号： B01L3/0241 , B01L3/0275 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487
摘要： Devices, systems, and methods for the precise dispensation of small volumes of liquids are presented. A fluid microdispenser comprises a liquid-filled tube, an actuator coupled to the tube, and a tip at one end of the tube. When the actuator applies an actuation pressure, a precise volume of liquid is ejected from the orifice of the tip. The orifice is manufactured to control the volume of liquid ejected by each actuation and, therefore, may have a diameter smaller than that of the liquid-filled tube. The invention comprises systems, methods, and devices so that the inner diameter of the liquid-filled tube is decreased (tapered) to that of the orifice so as to maximize transmission to the orifice of the pressure generated by the actuation stimulus. This enables the volume of liquid ejected by each stimulus to be reproducibly controlled by the amplitude of the actuation stimulus.
摘要翻译：提出了用于精确分配少量液体的装置，系统和方法。流体微分配器包括充满液体的管，耦合到管的致动器和管的一端的尖端。当致动器施加致动压力时，精确体积的液体从尖端的孔喷出。制造孔口以控制由每次致动喷射的液体的体积，因此可以具有比液体填充管的直径更小的直径。本发明包括系统，方法和装置，使得充满液体的管的内径减小（锥形）到孔口的内径，从而最大程度地使通过致动刺激产生的压力对孔的传递。这使得可以通过致动刺激的振幅可再现地控制由每个刺激喷射的液体的体积。

10. 发明申请

US20060045812A1 Analytical biochemistry system with robotically carried bioarray 审中-公开
公开(公告)号：US20060045812A1
公开(公告)日：2006-03-02
申请号：US11258707
申请日：2005-10-26
申请人： Peter Coassin , Jack McNeal , David Helphrey
发明人： Peter Coassin , Jack McNeal , David Helphrey
IPC分类号： B01L3/02 , B01L9/00
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/00292 , B01J2219/00315 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00657 , B01J2219/00659 , B01J2219/00691 , B01J2219/00711 , B01J2219/00722 , B01L3/0275 , B01L3/508 , B01L3/5085 , B01L2300/0636 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/6452 , G01N35/00029 , G01N2035/00118 , G01N2035/00158 , G01N2035/1055 , G01N2035/1062 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate. After appropriate incubation, the substrate and holder may be moved from contact with the sample, and the substrate may be exposed to any necessary development steps before being moved by the manipulator to a location for probing, such as by a beam. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式