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1. 发明授权

US5817902A Process for preparing .alpha.-olefins 失效
标题翻译：制备α-烯烃的方法
公开(公告)号：US5817902A
公开(公告)日：1998-10-06
申请号：US747517
申请日：1996-11-12
申请人： Minghe Xie , Anshun Sun , Daohua Jiang , Jiabo Qu , Qian Chen , Weibin Li , Zongsheng Yuan , Chunmei Yu , Xixia Song , Shubao Wan , Zhengnian Luo , Fengrong Wang , Qun Xu , Shulan Wang , Yingjie Feng , Yongchen Sun
发明人： Minghe Xie , Anshun Sun , Daohua Jiang , Jiabo Qu , Qian Chen , Weibin Li , Zongsheng Yuan , Chunmei Yu , Xixia Song , Shubao Wan , Zhengnian Luo , Fengrong Wang , Qun Xu , Shulan Wang , Yingjie Feng , Yongchen Sun
IPC分类号： B01J10/00 , B01J19/00 , B01J19/24 , B01J19/26 , C07C2/88
CPC分类号： B01J19/26 , B01J10/002 , B01J19/006 , B01J19/246 , B01J19/2465 , C07C2/88 , B01J2219/0011
摘要： The invention provides a process for making .alpha.-olefins. In the chain growth reaction step of the process a jet loop reactor is used to fully use high pressure ethylene, and two or more stages of the chain growth reaction is used to raise the selectivity of C.sub.6-10 olefins.
摘要翻译：本发明提供了制备α-烯烃的方法。在该方法的链生长反应步骤中，使用喷射环流反应器来完全使用高压乙烯，并且使用两个或更多个链生长反应阶段来提高C6-10烯烃的选择性。

2. 发明申请

US20100120031A1 SYNTHESIS OF TRANS-TERT-BUTYL-2-AMINOCYCLOPENTYLCARBAMATE 审中-公开
标题翻译：转化叔丁基-2-氨基环戊二烯酸的合成
公开(公告)号：US20100120031A1
公开(公告)日：2010-05-13
申请号：US12441925
申请日：2007-09-21
申请人： Daniel H. Appella , Qun Xu , Ning Zhang
发明人： Daniel H. Appella , Qun Xu , Ning Zhang
IPC分类号： C12Q1/68 , C07C271/06 , C07C233/01 , C07C247/02 , C07K1/00 , G01N33/48 , C07K9/00
CPC分类号： C07C271/24 , C07B2200/07 , C07C303/40 , C07C2601/08 , C07K14/003 , Y10T436/143333 , C07C311/20
摘要： The present invention concerns methods of synthesis of trans-tert-butyl-2-aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN3 and TBAF to produce 2-azido-N-tosylcyclopentananiine; reducing the 2-azido-N-tosylcyclopentanamine to produce 2-amino-N-tosylcyclopentanamine; contacting the 2-amino-N-tosylcyclopentanamine with di-tert/-butyl dicarbonate to produce tert-butyl-2-(tosylamino)cyclopentylcarbamate; and detosylation of tert-butyl O(tosylamino) cyclopentylcarbamate to produce trans-tert-butyl-2-aminocyclopentylcarbamate. The invention also concerns PNAs comprising residues of the monomers of the invention in the backbone and uses of such PNAs. The PNAs of the invention can be used to detect DNAs of infectious agents or to suppress expression of protein associated with cancer.
摘要翻译：本发明涉及合成反式 - 叔丁基-2-氨基十八烷基戊基氨基甲酸酯的方法，其包括使6-甲苯磺酰基-6-氮杂双环[3.1.0]己烷与TMSN3和TBAF接触以产生2-叠氮基-N-甲苯磺酰基大环内酯; 还原2-叠氮-N-甲苯磺酰基环戊胺以制备2-氨基-N-甲苯磺酰基环戊胺; 使2-氨基-N-甲苯磺酰基环戊胺与二碳酸二叔丁酯接触以产生叔丁基-2-（甲苯磺酰氨基）环戊基氨基甲酸酯; 和叔丁基O（甲苯磺酰氨基）环戊基氨基甲酸酯的去甲苯基化，得到反式 - 叔丁基-2-氨基环戊基氨基甲酸酯。本发明还涉及包含骨架中本发明的单体的残基的这些PNA的用途和这种PNA的用途。本发明的PNA可用于检测感染因子的DNA或抑制与癌症相关的蛋白质的表达。

3. 发明申请

US20100256098A1 COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS 审中-公开
标题翻译：用于抑制WIP1，PRODRUGS及其组合物的化合物及相关方法
公开(公告)号：US20100256098A1
公开(公告)日：2010-10-07
申请号：US12675167
申请日：2008-08-29
申请人： Ettore Appella , Daniel Appella , Stewart R. Durell , Jeong Bang , Hiroshi Yamaguchi , Qun Xu
发明人： Ettore Appella , Daniel Appella , Stewart R. Durell , Jeong Bang , Hiroshi Yamaguchi , Qun Xu
IPC分类号： A61K31/675 , C07F9/06 , A61P35/00 , C12N5/071 , C12N5/09
CPC分类号： A61K31/675 , A61K31/6615 , C07F9/572
摘要： The invention provides compounds useful in inhibiting the activity of a Wip1 protein in a cell as well as prodrugs thereof, related methods of use and compositions which include the aforesaid compounds and prodrugs thereof. The compounds comprise a ring structure having at least five functional groups bonded thereto, wherein each functional group is bonded to a different ring atom, and wherein the at least five functional groups comprise: (a) first (R1) and second (R3) moieties each comprising a phosphate group wherein these first and second moieties are separated by at least one ring atom; (b) first (R2) and second (R4) hydrophobic groups, wherein the first and second hydrophobic groups are separated by at least one ring atom, and wherein the first hydrophobic group is bonded to a ring atom located between the ring atoms to which the first (R1) and second (R2) moieties are bonded; and an amide or carboxylic acid (R5).
摘要翻译：本发明提供了可用于抑制细胞中Wip1蛋白的活性的化合物及其前药，相关使用方法和包含上述化合物及其前药的组合物。化合物包括具有键合至少五个官能团的环结构，其中每个官能团键合到不同的环原子上，其中至少五个官能团包括：（a）第一（R1）和第二（R3）部分每个包含磷酸基团，其中这些第一和第二部分被至少一个环原子分开; （b）第一（R2）和第二（R4）疏水基团，其中所述第一和第二疏水基团被至少一个环原子隔开，并且其中所述第一疏水基团与位于所述环原子之间的环原子键合，第一（R1）和第二（R2）部分键合; 和酰胺或羧酸（R5）。

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