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1. 发明申请

US20120052042A1 AMPHIPHILIC COMPOUNDS AND SELF-ASSEMBLING COMPOSITIONS MADE THEREFROM 有权
标题翻译：大分子化合物和自组装组合物
公开(公告)号：US20120052042A1
公开(公告)日：2012-03-01
申请号：US13202376
申请日：2010-02-22
申请人： Sébastien Ladet , Philippe Gravagna
发明人： Sébastien Ladet , Philippe Gravagna
IPC分类号： A61K31/765 , A61K38/39 , C07K17/10 , A61K31/79 , A61K31/785 , A61K31/78 , C08B37/02 , A61K31/721 , C08B37/00 , A61K31/715 , C08B37/08 , A61K31/722 , A61K31/728 , C08B37/04 , A61K31/734 , A61K31/726 , C07C57/18 , C07C247/02 , A61K31/655 , A61K38/21 , A61K39/395 , A61K38/28 , A61K38/22 , A61K38/26 , A61K39/385 , C08G65/34 , C08G18/00 , C08G63/08 , C08G73/10 , C08G69/14 , C08F26/10 , C08F116/06 , C08F120/06 , C08F120/14 , C08G69/00 , C08G64/02 , C08K5/05 , C08K5/06 , C08K5/053 , C07K17/02
CPC分类号： A61K47/34 , C08L5/00
摘要： The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.
摘要翻译：本公开涉及两亲化合物，由两亲性化合物形成的自组装组合物和制备这种组合物的方法。

2. 发明申请

US20100120031A1 SYNTHESIS OF TRANS-TERT-BUTYL-2-AMINOCYCLOPENTYLCARBAMATE 审中-公开
标题翻译：转化叔丁基-2-氨基环戊二烯酸的合成
公开(公告)号：US20100120031A1
公开(公告)日：2010-05-13
申请号：US12441925
申请日：2007-09-21
申请人： Daniel H. Appella , Qun Xu , Ning Zhang
发明人： Daniel H. Appella , Qun Xu , Ning Zhang
IPC分类号： C12Q1/68 , C07C271/06 , C07C233/01 , C07C247/02 , C07K1/00 , G01N33/48 , C07K9/00
CPC分类号： C07C271/24 , C07B2200/07 , C07C303/40 , C07C2601/08 , C07K14/003 , Y10T436/143333 , C07C311/20
摘要： The present invention concerns methods of synthesis of trans-tert-butyl-2-aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN3 and TBAF to produce 2-azido-N-tosylcyclopentananiine; reducing the 2-azido-N-tosylcyclopentanamine to produce 2-amino-N-tosylcyclopentanamine; contacting the 2-amino-N-tosylcyclopentanamine with di-tert/-butyl dicarbonate to produce tert-butyl-2-(tosylamino)cyclopentylcarbamate; and detosylation of tert-butyl O(tosylamino) cyclopentylcarbamate to produce trans-tert-butyl-2-aminocyclopentylcarbamate. The invention also concerns PNAs comprising residues of the monomers of the invention in the backbone and uses of such PNAs. The PNAs of the invention can be used to detect DNAs of infectious agents or to suppress expression of protein associated with cancer.
摘要翻译：本发明涉及合成反式 - 叔丁基-2-氨基十八烷基戊基氨基甲酸酯的方法，其包括使6-甲苯磺酰基-6-氮杂双环[3.1.0]己烷与TMSN3和TBAF接触以产生2-叠氮基-N-甲苯磺酰基大环内酯; 还原2-叠氮-N-甲苯磺酰基环戊胺以制备2-氨基-N-甲苯磺酰基环戊胺; 使2-氨基-N-甲苯磺酰基环戊胺与二碳酸二叔丁酯接触以产生叔丁基-2-（甲苯磺酰氨基）环戊基氨基甲酸酯; 和叔丁基O（甲苯磺酰氨基）环戊基氨基甲酸酯的去甲苯基化，得到反式 - 叔丁基-2-氨基环戊基氨基甲酸酯。本发明还涉及包含骨架中本发明的单体的残基的这些PNA的用途和这种PNA的用途。本发明的PNA可用于检测感染因子的DNA或抑制与癌症相关的蛋白质的表达。

3. 发明授权

US5539005A Polymeric foaming agents and their application to the preparatiion of synthetic foams 失效
标题翻译：聚合物发泡剂及其在制备合成泡沫中的应用
公开(公告)号：US5539005A
公开(公告)日：1996-07-23
申请号：US430463
申请日：1995-04-28
申请人： Didier Bedel , Chantal Crozat
发明人： Didier Bedel , Chantal Crozat
IPC分类号： C07C247/04 , C07C247/02 , C07C247/10 , C08J9/06 , C08J9/10 , C08K5/00 , C08L61/10 , C08L75/00 , C09K3/00
CPC分类号： C07C247/02 , C08J9/106
摘要： Foamable composition comprising a mixture based on polymer resin and a effective quantity, in relation to the said resin, of blowing agent. The blowing agent comprises at least one .alpha.,.beta.-hydroxolated hydrocarbon azide.Application to the production of articles made of synthetic foam.
摘要翻译：可发泡组合物包含基于聚合物树脂的混合物和相对于所述树脂的有效量的发泡剂。发泡剂包含至少一种α，β-羟基化的烃叠氮化物。适用于生产由合成泡沫制成的物品。

4. 发明授权

US07772358B2 Polytriazoles constructed by 1,3-dipolar cycloaddition 有权
标题翻译：由1,3-偶极环加成构成的三叉唑
公开(公告)号：US07772358B2
公开(公告)日：2010-08-10
申请号：US11896675
申请日：2007-09-05
申请人： Benzhong Tang , Anjun Qin , Matthias Haeussler
发明人： Benzhong Tang , Anjun Qin , Matthias Haeussler
IPC分类号： C08G73/08 , C07C247/02 , C07C247/16
CPC分类号： C08F24/00 , C08F26/06 , C08F30/04
摘要： A process of synthesizing hyperbranched polytriazoles, linear and hyperbranched poly(aroyltriazoles) by Huisgen 1,3-dipolar cycloaddition. The polytriazoles were prepared by A2+B3 method to avoid self-polymerization during monomer preparation and storage. The polymers are light emissive and can be crosslinked to generate well-resolution photopatterns upon UV irradiation. White light emission patterns were observed with fluorescence microscopy. The high molecular weight poly(aroyltriazoles) (up to 26000 Da) are prepared in high yields (up to 92.0%) and with high regioselectivity (the ratio of 1,4- and 1,5-disubstituted 1,2,3-triazole is equal or larger than 9:1). The polycyclomerization is not moisture or oxygen sensitive and therefore, no special precautions are necessary before and during the reaction. All the polymers are processible, easily film-forming, and curable into thermosets by heat or irradiation. The hyperbranched polymers can act as fluorescent adhesive materials with large tensile strength.
摘要翻译：通过Huisgen 1,3-偶极环加成合成超支化聚三唑，线性和超支化聚（芳酰基三唑）的方法。通过A2 + B3方法制备聚三唑，以避免单体制备和储存过程中的自聚合。聚合物是发光的并且可以交联以在UV照射时产生良好分辨率的光图案。用荧光显微镜观察白光发射模式。高分子量聚（芳基三唑）（高达26000Da）以高产率（高达92.0％）和高分辨率选择性（1,4和1,5-二取代的1,2,3-三唑的比例等于或大于9：1）。多重环化不是水分或氧气敏感的，因此在反应之前和期间都不需要特别的预防措施。所有的聚合物都是可加工的，易成膜的，并且通过热或照射可固化成热固性材料。超支化聚合物可以作为具有大拉伸强度的荧光粘合剂材料。

5. 发明授权

US5665890A Stereoselective ring opening reactions 失效
标题翻译：立体选择性开环反应
公开(公告)号：US5665890A
公开(公告)日：1997-09-09
申请号：US403374
申请日：1995-03-14
申请人： Eric N. Jacobsen , James L. Leighton , Luis E. Martinez
发明人： Eric N. Jacobsen , James L. Leighton , Luis E. Martinez
IPC分类号： B01J31/22 , C07B53/00 , C07B57/00 , C07B61/00 , C07C213/02 , C07C247/02 , C07C247/14 , C07C251/24 , C07D207/12 , C07D317/36 , C07F7/08 , C07F7/10 , C07F7/18 , C07C247/00
CPC分类号： C07F7/083 , C07B53/00 , C07B57/00 , C07C213/02 , C07C247/14 , C07D317/36 , C07F7/188 , C07F7/1892 , C07C2101/10 , C07C2101/14 , C07C2101/16
摘要： The present invention relates a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a steroisomerically or regioselectively enriched product.
摘要翻译：本发明涉及用于立体选择性或区域选择性化学合成的方法，其通常包括在非外消旋手性催化剂存在下使亲核体和手性或前手性环状底物反应以产生立体异构或区域选择性富集的产物。

6. 发明授权

US5329025A 3-azido compound 失效
标题翻译： 3-叠氮基化合物
公开(公告)号：US5329025A
公开(公告)日：1994-07-12
申请号：US862157
申请日：1992-04-02
申请人： Chi-Huey Wong , Richard L. Pederson , Yi-Fong Wang
发明人： Chi-Huey Wong , Richard L. Pederson , Yi-Fong Wang
IPC分类号： C07C45/89 , C07C247/04 , C07C247/02 , C07C205/05 , C07C207/00 , C07C247/00
CPC分类号： C07C247/04 , C07C45/89
摘要： A new and practical method for synthesizing heterocyclic polyhydroxylated alkaloids using enzymatic aldol condensation and catalytic intramolecular reductive amination is disclosed.
摘要翻译：公开了一种使用酶促醛缩醇缩合和催化分子内还原胺化合成杂环多羟基化生物碱的新型实用方法。

7. 发明申请

US20230095750A1 FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES 有权
公开(公告)号：US20230095750A1
公开(公告)日：2023-03-30
申请号：US17783511
申请日：2020-12-14
申请人： The Regents of the University of California
发明人： Michael D. Burkart , Thien An Phung Hai
IPC分类号： C07C263/12 , C07C243/14 , C07C247/02
摘要： The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.

8. 发明申请

US20100292084A1 NOVEL DIARYLPHOSPHINE- AND DIALKYLPHOSPHINE-CONTAINING COMPOUNDS, PROCESSES OF PREPARING SAME AND USES THEREOF AS TRIDENTATE LIGANDS 有权
标题翻译：新型二硫代磷酸和含二氢吡啶鎓的化合物，其制备方法及其作为三氯乙烯配位体的用途
公开(公告)号：US20100292084A1
公开(公告)日：2010-11-18
申请号：US12779093
申请日：2010-05-13
申请人： Mark GANDELMAN , Elaine Melissa Schuster , Gennady Nisnevich
发明人： Mark GANDELMAN , Elaine Melissa Schuster , Gennady Nisnevich
IPC分类号： C40B20/00 , C07F9/28 , C07D249/04 , C40B40/04 , C07F15/00 , C40B40/16 , C07C247/02 , C07F9/53
CPC分类号： C07D249/04 , B01J31/189 , B01J31/226 , B01J2231/4261 , B01J2531/0244 , B01J2531/824 , B01J2531/828 , C07F9/5013 , C07F9/5304 , C07F9/6518 , C07F9/65583 , C07F15/006 , C40B30/08 , C40B40/04 , C40B40/16
摘要： A novel process of preparing tridentate ligands containing one or more of a diarylphosphine and/or dialkylphosphine electron donating groups are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing and dialkylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed. Novel precursor molecules useful for preparing the tridentate ligands and processes of preparing same are also disclosed.
摘要翻译：公开了一种制备含有一个或多个二芳基膦和/或二烷基膦给电子基团的三齿配体的新方法。还公开了该方法用于制备这种三齿配体的组合文库和含有它们的有机金属络合物的用途。还公开了可以用作三齿配体（例如夹心配体）的新型含二芳基膦和含二烷基膦的化合物，这种三齿配体的组合文库，含有这些配体的有机金属配合物（例如夹心络合物）和这种配合物的组合文库。还公开了利用这些文库筛选候选有机金属催化剂的方法。还公开了可用于制备三齿配体的新型前体分子及其制备方法。

9. 发明申请

US20090311177A1 Radiolabelling Methods 有权
标题翻译：放射性标记方法
公开(公告)号：US20090311177A1
公开(公告)日：2009-12-17
申请号：US11721694
申请日：2005-12-09
申请人： Erik Arstad , Matthias Eberhard Glaser
发明人： Erik Arstad , Matthias Eberhard Glaser
IPC分类号： A61K51/08 , C07K1/13 , C07C247/02 , C07C19/08 , C07K2/00 , C07K5/08 , C07K7/64
CPC分类号： A61K51/088 , A61K51/082 , A61K51/1051
摘要： The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-N3 (II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
摘要翻译：本发明涉及放射性诊断和放射治疗剂，包括用放射性核素标记的生物活性载体。它还涉及标记载体的方法和试剂，例如肽，其包括式（I）化合物与式（II）化合物的反应：R * -L2-N3（II）或式（III）化合物）与式（IV）的化合物在Cu（I）催化剂的存在下反应。所得到的标记的缀合物可用作诊断剂，例如作为放射性药物更具体地用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）或放射治疗。

10. 发明授权

US09279817B2 Carbofluorescein lactone ion indicators and their applications 有权
公开(公告)号：US09279817B2
公开(公告)日：2016-03-08
申请号：US14450658
申请日：2014-08-04
申请人： AAT Bioquest, Inc.
发明人： Zhenjun Diwu , Haitao Guo , Ruogu Peng , Qin Zhao , Jixiang Liu , Jinfang Liao
IPC分类号： C07C229/60 , C07C247/02 , G01N33/84 , C09B5/00 , G01N33/50 , C07D311/90 , C07D219/06 , C07D493/10 , G01N33/533 , C07D307/94 , C07C247/04
CPC分类号： C07D307/94 , C07C229/60 , C07C247/04 , C07C2603/24 , C07D219/06 , C07D311/90 , C07D493/10 , C09B5/00 , G01N33/5041 , G01N33/533 , G01N33/84
摘要： Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.

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