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1. 发明申请

US20110136264A1 METHOD FOR DETECTING TARGET SUBSTANCE AND TARGET-SUBSTANCE DETECTION KIT 审中-公开
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：US20110136264A1
公开(公告)日：2011-06-09
申请号：US13030089
申请日：2011-02-17
申请人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
发明人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting part, and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ1ψ3>0 and ψ2=0, i) ψ1ψ2 0, and |ψ2|>|ψ3|, and iii) ψ1ψ2
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。样品溶液中的磁性标记的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系式i）至iv）中的任何一个：ψ1ψ3> 0和 ψ2= 0，i）ψ1ψ2<0和ψ3= 0，ii）ψ1ψ2<0，ψ2ψ3> 0和|ψ2|> |ψ3|，以及iii）ψ1ψ2<0和ψ2ψ3<0; iv）并且由磁性标签承载的目标物质被由检测部分承载的主要捕获体捕获，或者由被检测部分承载的主捕获体捕获的目标物质被由磁体承载的二次捕获体捕获标签。

2. 发明申请

US20090000360A1 Method for Detecting Target Substance and Target-Substance Detection Kit 有权
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：US20090000360A1
公开(公告)日：2009-01-01
申请号：US12162789
申请日：2007-03-30
申请人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
发明人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N30/62 , G06K7/08
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting parts and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ1ψ3>0 and ψ2=0, i) ψ1ψ2 0, and |ψ2|>|ψ3|, and iii) ψ1ψ2
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。样品溶液中的磁性标记的表面电位psi1，检测部分的表面电位psi2和非检测部分的表面电位psi3满足以下关系式i）至iv）中的任何一个：<？in-line -formulae description =“In-line Formulas”end =“lead”？> psi1psi3> 0 and psi2 = 0，i）<？in-line-formula description =“In-line Formulas”end =“tail”？> ？in-line-formula description =“In-line Formulas”end =“lead”？> psi1psi2 <0 and psi3 = 0，ii）<？in-line-formula description =“In-line Formulas”end =“tail “？> <？in-line-formula description =”在线公式“end =”lead“？> psi1psi2 <0，psi2psi3> 0和| psi2 |> | psi3 |，以及iii） -formulae description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line formula”end =“lead”？> psi1psi2 <0 and psi2psi3 <0; iv）<？in-line-formula description =“In-line Formulas”end =“tail”？>，由磁性标签承载的目标物质由检测部分所承载的主捕获体或目标物质由被检测部分承载的主要捕获体捕获的捕获体被由磁性标签承载的次级捕获体俘获。

3. 发明授权

US07932100B2 Method for detecting target substance and target-substance detection kit 有权
标题翻译：检测目标物质和靶物检测试剂盒的方法
公开(公告)号：US07932100B2
公开(公告)日：2011-04-26
申请号：US12162789
申请日：2007-03-30
申请人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
发明人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N33/553
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting parts and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): i) ψ1ψ3>0 and ψ2=0, ii) ψ1ψ2 0, and |ψ2|>|ψ3|, and iv) ψ1ψ2
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。样品溶液中的磁性标记的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系式i）至iv）中的任何一个：i）ψ1ψ3> 0 ψ2= 0，ii）ψ1ψ2<0和ψ3= 0，iii）ψ1ψ2<0，ψ2ψ3> 0和ψ2|> |ψ3|，以及iv）ψ1ψ2<0和ψ2ψ3<0; 并且由磁性标签承载的目标物质由被检测部分承载的主要捕获体俘获，或者由被检测部分承载的主要捕获体捕获的目标物质被由磁性标签承载的二次捕获体俘获。

4. 发明申请

US20090148346A1 SUBSTRATE WITH BINDING FUNCTIONAL GROUP 审中-公开
标题翻译：基座与绑定功能组
公开(公告)号：US20090148346A1
公开(公告)日：2009-06-11
申请号：US12065720
申请日：2006-10-03
申请人： Kazuhiro Ban , Kazumichi Nakahama , Miki Ogawa
发明人： Kazuhiro Ban , Kazumichi Nakahama , Miki Ogawa
IPC分类号： G01N21/00 , C08L33/02
CPC分类号： B82Y30/00 , B82Y15/00 , G01N33/54393
摘要： A structural member having a binding functional group on a substrate for binding a capturing molecule capable of capturing a target substance, characterized in that the substrate binds to one end of a polymer which includes at the other end those to which the binding functional group is bound and those to which a suppressing functional group for suppressing adsorption of biological molecules to the structural member and that the suppressing functional group is also bound to a side chain of the polymer.
摘要翻译：一种在底物上具有结合能捕获靶物质的捕获分子的结合官能团的结构部件，其特征在于，所述底物与聚合物的一端结合，所述聚合物的另一端包含结合官能团所结合的那些以及抑制生物分子吸附到结构构件上的抑制官能团，抑制官能团也与聚合物的侧链结合的那些。

5. 发明申请

US20070248987A1 TARGET SUBSTANCE DETECTION MATERIAL AND METHOD AND KIT FOR DETECTING TARGET SUBSTANCE 失效
标题翻译：目标物质检测材料和检测目标物质的方法和工具包
公开(公告)号：US20070248987A1
公开(公告)日：2007-10-25
申请号：US11697856
申请日：2007-04-09
申请人： Takeshi Imamura , Tetsunori Ojima , Kazumichi Nakahama
发明人： Takeshi Imamura , Tetsunori Ojima , Kazumichi Nakahama
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/54353 , G01N33/544 , G01N33/553
摘要： In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a result, the volume of the polymer matrix is changed. Such a change in the volume of the polymer matrix is measured as a change in the optical properties of the metal structure, and the target is detected. Thereby, the present invention provides a target substance detection material having good operability and high performance, which includes a metal structure as a labeled form, and a target substance detection method for detecting the presence or absence of a target substance in a specimen and/or the concentration thereof, using the material.
摘要翻译：在本发明中，包含金属结构的靶物质检测材料，靶物质捕获单元和保持金属结构的聚合物基质和目标物质捕获单元捕获目标物质，结果，体积的聚合物基体改变了。测量聚合物基体的体积的这种变化，作为金属结构的光学特性的变化，并检测靶。因此，本发明提供了具有良好的可操作性和高性能的目标物质检测材料，其包括作为标记形式的金属结构和用于检测样品中目标物质的存在或不存在的目标物质检测方法和/或其浓度，使用该材料。

6. 发明授权

US08080430B2 Target substance detection material and method and kit for detecting target substance 失效
标题翻译：靶物质检测材料及检测目标物质的方法和试剂盒
公开(公告)号：US08080430B2
公开(公告)日：2011-12-20
申请号：US11697856
申请日：2007-04-09
申请人： Takeshi Imamura , Tetsunori Ojima , Kazumichi Nakahama
发明人： Takeshi Imamura , Tetsunori Ojima , Kazumichi Nakahama
IPC分类号： G01N33/553
CPC分类号： G01N33/54353 , G01N33/544 , G01N33/553
摘要： In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a result, the volume of the polymer matrix is changed. Such a change in the volume of the polymer matrix is measured as a change in the optical properties of the metal structure, and the target is detected. Thereby, the present invention provides a target substance detection material having good operability and high performance, which includes a metal structure as a labeled form, and a target substance detection method for detecting the presence or absence of a target substance in a specimen and/or the concentration thereof, using the material.
摘要翻译：在本发明中，包含金属结构的靶物质检测材料，靶物质捕获单元和保持金属结构的聚合物基质和目标物质捕获单元捕获目标物质，结果，体积的聚合物基体改变了。测量聚合物基体的体积的这种变化，作为金属结构的光学特性的变化，并检测靶。因此，本发明提供了具有良好的可操作性和高性能的目标物质检测材料，其包括作为标记形式的金属结构和用于检测样品中目标物质的存在或不存在的目标物质检测方法和/或其浓度，使用该材料。

7. 发明申请

US20080241964A1 MATERIAL FOR IMPROVING SENSITIVITY OF MAGNETIC SENSOR AND METHOD THEREOF 审中-公开
标题翻译：用于提高磁传感器灵敏度的材料及其方法
公开(公告)号：US20080241964A1
公开(公告)日：2008-10-02
申请号：US12054231
申请日：2008-03-24
申请人： Masaru Kaieda , Takashi Ikeda , Kazumichi Nakahama
发明人： Masaru Kaieda , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N33/553 , G01N27/00
CPC分类号： G01N33/54333
摘要： The present invention relates to a capture agent member being used in a magnetic sensor to detect the presence or concentration of a target substance in a test solution by detecting the presence or number of the magnetic marker, wherein the capture agent member contains a capture agent for capturing the target substance and a labeling agent serving as a nucleus for the magnetic marker to agglutinate, and wherein the capture agent is labeled with the labeling agent. The present invention relates to a material which improves detection sensitivity of a biosensor using a magnetic sensor while maintaining reactivity and dispersibility. In particular, according to the present invention, there can be provided a material which enables realization of high sensitivity by using a simple magnetic biosensor such as a semiconductor Hall element and a magnetoresistance effect element.
摘要翻译：本发明涉及一种用于磁传感器中的捕获剂部件，用于通过检测磁性标记物的存在或数量来检测测试溶液中目标物质的存在或浓度，其中捕获剂成分含有捕获剂捕获目标物质和用作磁性标记物的核的标记试剂凝集，其中捕获剂用标记试剂标记。本发明涉及一种能够在保持反应性和分散性的同时提高使用磁传感器的生物传感器的检测灵敏度的材料。特别地，根据本发明，可以提供通过使用诸如半导体霍尔元件和磁阻效应元件的简单的磁生物传感器来实现高灵敏度的材料。

8. 发明申请

US20120252974A1 METHOD FOR PRODUCING POLYMER PARTICLES 有权
标题翻译：生产聚合物颗粒的方法
公开(公告)号：US20120252974A1
公开(公告)日：2012-10-04
申请号：US13432155
申请日：2012-03-28
申请人： Takayuki Hiratani , Shinnosuke Koji , Kazumichi Nakahama
发明人： Takayuki Hiratani , Shinnosuke Koji , Kazumichi Nakahama
IPC分类号： C08G63/91
CPC分类号： C08F2/18
摘要： A method for producing polymer particles includes a preparation step for preparing a first oily liquid containing an oily olefin monomer, a radical polymerization initiator, and an iodine molecule, a synthesis step for obtaining a second oily liquid containing at least an iodine compound produced by a reaction between a radical generated by cleavage of the radical polymerization initiator and the iodine molecule in the first oily liquid, a suspension step for obtaining an oil droplet of the second oily liquid by suspending the second oily liquid in water, and a polymerization step for polymerizing the oily olefin monomer in the oil droplet.
摘要翻译：制备聚合物颗粒的方法包括制备含有油性烯烃单体，自由基聚合引发剂和碘分子的第一油性液体的制备步骤，用于获得至少含有碘化合物的第二油性液体的合成步骤通过自由基聚合引发剂的裂解和第一油性液体中的碘分子产生的自由基之间的反应，通过将第二油性液体悬浮在水中获得第二油性液体的油滴的悬浮液步骤和聚合步骤油滴中的油状烯烃单体。

9. 发明申请

US20120048721A1 MICROWAVE REACTOR AND METHOD OF PRODUCING POLYMER COMPOUND USING THE SAME 有权
标题翻译：微波反应器及使用该聚合物的聚合物化合物的制造方法
公开(公告)号：US20120048721A1
公开(公告)日：2012-03-01
申请号：US13214539
申请日：2011-08-22
申请人： Shinnosuke Koji , Takayuki Hiratani , Kazumichi Nakahama
发明人： Shinnosuke Koji , Takayuki Hiratani , Kazumichi Nakahama
IPC分类号： B01J19/12
CPC分类号： B01J19/126 , B01J19/18 , B01J2219/00063 , B01J2219/00078 , B01J2219/1215 , B01J2219/123 , B01J2219/1242 , B01J2219/1245 , B01J2219/126 , B01J2219/1293 , C08F2/46 , C08F12/08 , C08F120/06
摘要： Provided is a microwave reactor including a reaction container for receiving a reaction solution, a microwave radiator for irradiating the reaction solution received in the reaction container with microwaves, and a cooler for cooling the reaction solution received in the reaction container, wherein a heat-generating medium generating heat by absorbing the microwaves is arranged on a surface of the cooler or in the vicinity of the surface at a position receiving the microwaves from the microwave radiator through the reaction solution.
摘要翻译：本发明提供一种微波反应器，其包括用于接收反应溶液的反应容器，用微波照射容纳在反应容器中的反应溶液的微波辐射器，以及用于冷却接收在反应容器中的反应溶液的冷却器，其中发热通过吸收微波产生热量的介质通过反应溶液布置在冷却器的表面或表面附近，通过微波辐射器接收微波的位置。

10. 发明授权

US07737270B2 Method for producing a pigment 失效
标题翻译：颜料的制造方法
公开(公告)号：US07737270B2
公开(公告)日：2010-06-15
申请号：US12019209
申请日：2008-01-24
申请人： Kazumichi Nakahama , Yukio Hanyu , Takayuki Teshima , Akira Kuriyama , Toshihiko Hiaki , Kiwamu Sue , Hayato Hattori , Hironori Yamamoto
发明人： Kazumichi Nakahama , Yukio Hanyu , Takayuki Teshima , Akira Kuriyama , Toshihiko Hiaki , Kiwamu Sue , Hayato Hattori , Hironori Yamamoto
IPC分类号： C04B14/00 , C07B47/00 , C07D487/22
CPC分类号： C09B47/06 , Y02P20/544
摘要： Provided is a method for producing a pigment, in particular, a metal phthalocyanine, in high yield and in a green process. The method has (1) a step of obtaining a solution mixture by mixing at least one type of compound serving as a raw material for a pigment with a solvent, and (2) a step of obtaining the pigment by reacting the compound while holding the solution mixture at not less than a temperature where a subcritical state or a supercritical state of the solvent occurs.
摘要翻译：提供了以高产率和绿色方法制备颜料，特别是金属酞菁的方法。该方法具有（1）通过将至少一种用作颜料的原料的化合物与溶剂混合来获得溶液混合物的步骤，和（2）通过使化合物同时保持而获得颜料的步骤溶液混合物在不低于溶剂的亚临界状态或超临界状态的温度下进行。

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