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1. 发明授权

US08263771B2 Method for manufacturing dispersion of quinoline derivative 有权
标题翻译：制备喹啉衍生物分散体的方法
公开(公告)号：US08263771B2
公开(公告)日：2012-09-11
申请号：US12174052
申请日：2008-07-16
申请人： Takayuki Teshima , Kazumichi Nakahama , Akira Kuriyama
发明人： Takayuki Teshima , Kazumichi Nakahama , Akira Kuriyama
IPC分类号： C07D515/00
CPC分类号： C09B48/00 , C09B67/0096
摘要： A method for manufacturing a dispersion of a quinoline derivative that is dispersed at a high concentration and has a small particle size. The method includes the steps of preparing a solution by dissolving an N-arylanthranilic acid derivative in an organosulfonic acid, heating the solution and obtaining a reaction liquid in which a quinoline derivative has been produced by a condensation ring-closing reaction, and obtaining a dispersion of the quinoline derivative by mixing the reaction liquid with an aqueous solution. The step of mixing the reaction liquid with an aqueous solution may be performed in a mixing field having a micro-channel.
摘要翻译：制造分散在高浓度且粒径小的喹啉衍生物的分散体的方法。该方法包括以下步骤：通过将N-芳基邻氨基苯甲酸衍生物溶解在有机磺酸中，加热该溶液并获得通过缩合闭环反应产生喹啉衍生物的反应液，得到分散体的喹啉衍生物通过将反应液与水溶液混合。将反应液与水溶液混合的步骤可以在具有微通道的混合场中进行。

2. 发明授权

US08262790B2 Colored particles 失效
标题翻译：有色颗粒
公开(公告)号：US08262790B2
公开(公告)日：2012-09-11
申请号：US12842920
申请日：2010-07-23
申请人： Kazumichi Nakahama , Shoji Koike
发明人： Kazumichi Nakahama , Shoji Koike
IPC分类号： C09D11/00 , C09B63/00
CPC分类号： C09D11/328 , C09B1/325 , C09B1/5145 , C09B31/14 , C09B67/0086 , C09D11/32
摘要： The present invention relates to colored particles containing a dye and a dispersant, wherein the average particle diameter of the colored particles is 10 nm or more, and 80 nm or less, the solubility index represented by Formula (1) of the dye is 9.20 or more, and the dye content and the dispersant content in the colored particles satisfy the relationship represented by Formula (2).
摘要翻译：本发明涉及含有染料和分散剂的着色颗粒，其中着色颗粒的平均粒径为10nm以上且80nm以下，染料的式（1）表示的溶解度指数为9.20或并且着色颗粒中的染料含量和分散剂含量满足式（2）所示的关系。

3. 发明授权

US08177902B2 Method for producing liquid composition and pigment particles and ink composition for ink jet recording 有权
标题翻译：用于生产液体组合物和颜料颗粒的方法和用于喷墨记录的油墨组合物
公开(公告)号：US08177902B2
公开(公告)日：2012-05-15
申请号：US13036115
申请日：2011-02-28
申请人： Kazumichi Nakahama , Takayuki Teshima , Yukio Hanyu , Ryuji Higashi
发明人： Kazumichi Nakahama , Takayuki Teshima , Yukio Hanyu , Ryuji Higashi
IPC分类号： C08K5/00
CPC分类号： C09B67/0035 , C09D11/322 , C09D11/54
摘要： A method for producing a liquid composition containing pigment particles is provided including (1) maintaining a mixture of a solvent and pigments of at least two types including a pigment A insoluble in the solvent at a normal temperature and a normal pressure, and a pigment B soluble in the solvent at the normal temperature and the normal pressure, at a temperature exceeding the normal temperature and a pressure exceeding the normal pressure, thereby obtaining a pigment solution in which the pigment A and the pigment B are dissolved; and (2) cooling the pigment solution to a temperature precipitating a deposition of the pigment A or lower, thereby precipitating pigment particles containing the pigment A and the pigment B.
摘要翻译：提供一种含有颜料颗粒的液体组合物的制造方法，其包括：（1）在常温常压下，将不溶于溶剂的颜料A至少2种的溶剂和颜料的混合物和颜料B 在正常温度和常压下，超过正常温度和超过常压的压力下溶解在溶剂中，从而得到颜料A和颜料B溶解的颜料溶液; 和（2）将颜料溶液冷却至析出颜料A沉积的温度以下，从而析出含有颜料A和颜料B的颜料粒子。

4. 发明申请

US20110239901A1 COLORING PARTICLES 有权
标题翻译：着色颗粒
公开(公告)号：US20110239901A1
公开(公告)日：2011-10-06
申请号：US13075084
申请日：2011-03-29
申请人： Shinnosuke Koji , Kazumichi Nakahama , Shoji Koike
发明人： Shinnosuke Koji , Kazumichi Nakahama , Shoji Koike
IPC分类号： C09D11/02
CPC分类号： C09B67/0086 , B82Y30/00 , C09B67/0005 , C09B67/0096 , C09D11/023 , C09D11/328
摘要： The present invention provides coloring particles containing a dye and a water-insoluble low-molecular-weight dispersant, wherein the average particle size of the coloring particles is 10 nm or more and 80 nm or less; the solubility parameter of the dye in water with a pH of 6.0 to 10.0 is 9.20 or more, the solubility parameter being represented by formula (1); and the content of the dye and the content of the water-insoluble low-molecular-weight dispersant satisfy a relationship of formula (2).
摘要翻译：本发明提供了含有染料和水不溶性低分子量分散剂的着色颗粒，其中着色颗粒的平均粒径为10nm以上且80nm以下，该染料在pH为6.0〜10.0的水中的溶解度参数为9.20以上，溶解度参数由式（1）表示; 并且染料的含量和水不溶性低分子量分散剂的含量满足式（2）的关系。

5. 发明授权

US07914616B2 Method for producing liquid composition and pigment particles and ink composition for ink jet recording 有权
标题翻译：用于生产液体组合物和颜料颗粒的方法和用于喷墨记录的油墨组合物
公开(公告)号：US07914616B2
公开(公告)日：2011-03-29
申请号：US11680208
申请日：2007-02-28
申请人： Kazumichi Nakahama , Takayuki Teshima , Yukio Hanyu , Ryuji Higashi
发明人： Kazumichi Nakahama , Takayuki Teshima , Yukio Hanyu , Ryuji Higashi
IPC分类号： C09D11/02 , C08K5/00
CPC分类号： C09B67/0035 , C09D11/322 , C09D11/54
摘要： A method for producing a liquid composition containing pigment particles is provided including (1) maintaining a mixture of a solvent and pigments of at least two types including a pigment A insoluble in the solvent at a normal temperature and a normal pressure, and a pigment B soluble in the solvent at the normal temperature and the normal pressure, at a temperature exceeding the normal temperature and a pressure exceeding the normal pressure, thereby obtaining a pigment solution in which the pigment A and the pigment B are dissolved; and (2) cooling the pigment solution to a temperature precipitating a deposition of the pigment A or lower, thereby precipitating pigment particles containing the pigment A and the pigment B.
摘要翻译：提供一种含有颜料颗粒的液体组合物的制造方法，其包括：（1）在常温常压下，将不溶于溶剂的颜料A至少2种的溶剂和颜料的混合物和颜料B 在正常温度和常压下，超过正常温度和超过常压的压力下溶解在溶剂中，从而得到颜料A和颜料B溶解的颜料溶液; 和（2）将颜料溶液冷却至析出颜料A沉积的温度以下，从而析出含有颜料A和颜料B的颜料粒子。

6. 发明申请

US20110033947A1 METHOD OF DETECTING TARGET SUBSTANCE AND TARGET-SUBSTANCE DETECTION KIT 失效
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：US20110033947A1
公开(公告)日：2011-02-10
申请号：US12517053
申请日：2009-02-04
申请人： Kazumichi Nakahama
发明人： Kazumichi Nakahama
IPC分类号： G01N27/72
CPC分类号： G01N33/54333
摘要： Provided is a detection method for a target substance capable of enhancing detection sensitivity and quantitative property of a magnetic biosensor, while keeping monodispersity and dispersion stability of magnetic markers, including the steps of: reacting the target substance in a sample solution with a first target substance trapping member immobilized on a sensing element and with a second target substance trapping member immobilized on a gel particle to hold the gel particle on the sensing element; adjusting a magnetic marker precursor including the gel particle and a magnetic material precursor existing in the gel particle by bringing the magnetic material precursor into contact with the gel particle; synthesizing a magnetic material from the magnetic material precursor held on the gel particle, thereby adjusting the magnetic markers; and detecting the magnetic markers with the sensing element.
摘要翻译：本发明提供能够提高磁性生物传感器的检测灵敏度和定量性能的目标物质的检测方法，同时保持磁性标记物的单分散性和分散稳定性，包括以下步骤：将样品溶液中的目标物质与第一目标物质固定在感测元件上的捕获构件和固定在凝胶颗粒上的第二目标物质捕获构件，以将凝胶颗粒保持在感测元件上; 通过使磁性材料前体与凝胶颗粒接触来调节包含凝胶颗粒的磁性标记前体和存在于凝胶颗粒中的磁性材料前体; 从保持在凝胶粒子上的磁性材料前体合成磁性材料，从而调整磁性标记; 并用感测元件检测磁标记。

7. 发明申请

US20090296515A1 FLUID MIXING APPARATUS, INTEGRATED FLUID MIXING APPARATUS, AND FLUID MIXING SYSTEM 审中-公开
标题翻译：流体混合装置，集成流体混合装置和流体混合系统
公开(公告)号：US20090296515A1
公开(公告)日：2009-12-03
申请号：US11722938
申请日：2006-12-27
申请人： Takahiro Ezaki , Susumu Yasuda , Mamoru Tsukada , Takayuki Teshima , Kazumichi Nakahama , Chienliu Chang
发明人： Takahiro Ezaki , Susumu Yasuda , Mamoru Tsukada , Takayuki Teshima , Kazumichi Nakahama , Chienliu Chang
IPC分类号： B01F15/02 , B01F15/06 , H01L21/306
CPC分类号： B01F13/0059 , B01F5/0256 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01J2219/0095 , B01J2219/00952
摘要： A fluid mixing apparatus is constituted by a plurality of flow passageways for conveying fluids, respectively, and jet outlets, corresponding to and communicating with the flow passageways, respectively, for jetting the fluids therefrom so that movement directions of the fluids intersect each other to mix the fluids. The jet outlets are provided at a surface of a substrate in which the flow passageways are provided. At least one of the flow passageways communicating with at least one of the jet outlets has a center axis partially shifted from a center axis of at least one of the jet outlets so as to incline a movement direction of a fluid jetted from at least one of the jet outlets with respect to the surface of the substrate.
摘要翻译：流体混合装置由分别用于输送流体的多个流动通道和分别对应于流动通道并与流动通道连通的喷射出口构成，用于从其中喷射流体，使得流体的移动方向彼此相交以混合流体。喷射出口设置在设置有流路的基板的表面。与至少一个喷射出口连通的至少一个流动通道具有一个中心轴线，该中心轴线从至少一个喷射出口的中心轴线部分地移动，以便使流体从至少一个喷射出口喷射的流体的运动方向倾斜喷射出口相对于基底的表面。

8. 发明授权

US07625066B2 Mixing apparatus, dispersion manufacturing apparatus and dispersion manufacturing method 失效
标题翻译：混合装置，分散体制造装置和分散体制造方法
公开(公告)号：US07625066B2
公开(公告)日：2009-12-01
申请号：US11855466
申请日：2007-09-14
申请人： Takayuki Teshima , Kazumichi Nakahama , Yukio Hanyu
发明人： Takayuki Teshima , Kazumichi Nakahama , Yukio Hanyu
IPC分类号： B41J2/155
CPC分类号： B01F5/0256 , B01F3/12 , B01F13/1013 , B01F13/1022 , B01F2003/125 , B01F2215/005 , C09B41/008
摘要： A mixing apparatus including a plurality of nozzle groups each formed of nozzles for ejecting the same fluid arranged in group, the nozzles being provided with openings for ejecting fluid, to cause the plurality of nozzle groups to separately eject a plurality of fluids to mix the fluids in areas on the extending lines of the nozzles, wherein the openings of the nozzles forming the nozzle groups are arranged along annular loci and the plurality of nozzle groups are arranged coaxially to each other, a plurality of supplying channels for supplying the plurality of fluids to the nozzle groups corresponding to the plurality of nozzle groups are annular in cross section in the direction perpendicular to the direction in which fluid supplied to the supplying channels flows and arranged coaxially to each other.
摘要翻译：一种混合装置，包括多个喷嘴组，每个喷嘴组由用于喷射组合排列的相同流体的喷嘴形成，喷嘴设置有用于喷射流体的开口，以使多个喷嘴组分别喷射多个流体以混合流体在喷嘴的延伸线上的区域中，形成喷嘴组的喷嘴的开口沿着环状轨迹布置，并且多个喷嘴组彼此同轴布置，多个供应通道用于将多个流体供应到对应于多个喷嘴组的喷嘴组在垂直于供应到供应通道的流体流动并且彼此同轴布置的方向的方向上是横截面的环形。

9. 发明申请

US20080241964A1 MATERIAL FOR IMPROVING SENSITIVITY OF MAGNETIC SENSOR AND METHOD THEREOF 审中-公开
标题翻译：用于提高磁传感器灵敏度的材料及其方法
公开(公告)号：US20080241964A1
公开(公告)日：2008-10-02
申请号：US12054231
申请日：2008-03-24
申请人： Masaru Kaieda , Takashi Ikeda , Kazumichi Nakahama
发明人： Masaru Kaieda , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N33/553 , G01N27/00
CPC分类号： G01N33/54333
摘要： The present invention relates to a capture agent member being used in a magnetic sensor to detect the presence or concentration of a target substance in a test solution by detecting the presence or number of the magnetic marker, wherein the capture agent member contains a capture agent for capturing the target substance and a labeling agent serving as a nucleus for the magnetic marker to agglutinate, and wherein the capture agent is labeled with the labeling agent. The present invention relates to a material which improves detection sensitivity of a biosensor using a magnetic sensor while maintaining reactivity and dispersibility. In particular, according to the present invention, there can be provided a material which enables realization of high sensitivity by using a simple magnetic biosensor such as a semiconductor Hall element and a magnetoresistance effect element.
摘要翻译：本发明涉及一种用于磁传感器中的捕获剂部件，用于通过检测磁性标记物的存在或数量来检测测试溶液中目标物质的存在或浓度，其中捕获剂成分含有捕获剂捕获目标物质和用作磁性标记物的核的标记试剂凝集，其中捕获剂用标记试剂标记。本发明涉及一种能够在保持反应性和分散性的同时提高使用磁传感器的生物传感器的检测灵敏度的材料。特别地，根据本发明，可以提供通过使用诸如半导体霍尔元件和磁阻效应元件的简单的磁生物传感器来实现高灵敏度的材料。

10. 发明申请

US20070248987A1 TARGET SUBSTANCE DETECTION MATERIAL AND METHOD AND KIT FOR DETECTING TARGET SUBSTANCE 失效
标题翻译：目标物质检测材料和检测目标物质的方法和工具包
公开(公告)号：US20070248987A1
公开(公告)日：2007-10-25
申请号：US11697856
申请日：2007-04-09
申请人： Takeshi Imamura , Tetsunori Ojima , Kazumichi Nakahama
发明人： Takeshi Imamura , Tetsunori Ojima , Kazumichi Nakahama
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/54353 , G01N33/544 , G01N33/553
摘要： In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a result, the volume of the polymer matrix is changed. Such a change in the volume of the polymer matrix is measured as a change in the optical properties of the metal structure, and the target is detected. Thereby, the present invention provides a target substance detection material having good operability and high performance, which includes a metal structure as a labeled form, and a target substance detection method for detecting the presence or absence of a target substance in a specimen and/or the concentration thereof, using the material.
摘要翻译：在本发明中，包含金属结构的靶物质检测材料，靶物质捕获单元和保持金属结构的聚合物基质和目标物质捕获单元捕获目标物质，结果，体积的聚合物基体改变了。测量聚合物基体的体积的这种变化，作为金属结构的光学特性的变化，并检测靶。因此，本发明提供了具有良好的可操作性和高性能的目标物质检测材料，其包括作为标记形式的金属结构和用于检测样品中目标物质的存在或不存在的目标物质检测方法和/或其浓度，使用该材料。

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