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1. 发明授权

US07963935B2 Microprojection array having a beneficial agent containing coating 有权
标题翻译：具有含有有益剂的涂层的微型投影阵列
公开(公告)号：US07963935B2
公开(公告)日：2011-06-21
申请号：US10127108
申请日：2002-04-20
申请人： Michel J. N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona
发明人： Michel J. N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61K9/0014 , A61K9/0021 , A61K47/42 , A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/0046
摘要： The device including a plurality of stratum corneum-piercing microprojections, and a solid coating disposed upon the microprojections, wherein the solid coating includes at least one beneficial agent and a biocompatible carrier is provided. The device is applied to the skin of a living animal (e.g., a human), causing the microprojections to pierce the stratum corneum and deliver an effective dose of the agent to the animal.
摘要翻译：所述装置包括多个角质层刺穿的微突出物，以及设置在所述微喷射体上的固体涂层，其中所述固体涂层包括至少一种有益试剂和生物相容性载体。该装置应用于活动物（例如人）的皮肤，导致微突出物刺穿角质层并将有效剂量的药剂递送至动物。

2. 发明授权

US08663155B2 Transdermal drug delivery devices having coated microprotrusions 有权
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US08663155B2
公开(公告)日：2014-03-04
申请号：US11347779
申请日：2006-02-02
申请人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona , Wei-Qi Lin
发明人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona , Wei-Qi Lin
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.
摘要翻译：提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

3. 发明授权

US07537795B2 Transdermal drug delivery devices having coated microprotrusions 有权
公开(公告)号：US07537795B2
公开(公告)日：2009-05-26
申请号：US10045842
申请日：2001-10-26
申请人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona
发明人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona
IPC分类号： B05D3/02
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

4. 发明申请

US20090186147A1 Transdermal drug delivery devices having coated microprotrusions 审中-公开
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US20090186147A1
公开(公告)日：2009-07-23
申请号：US12290678
申请日：2008-10-31
申请人： Michel J.N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona , Mahmoud Armeri
发明人： Michel J.N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona , Mahmoud Armeri
IPC分类号： B05D3/10
CPC分类号： A61M37/0015 , A61K9/0021 , A61K47/20 , A61K47/26 , A61K47/38 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent.
摘要翻译：提供了使用润湿剂作为微喷射表面的预处理或与活性剂一起掺入涂层制剂中的一个或多个微喷射体阵列的一个或多个微喷射体上制备涂层的方法。

5. 发明申请

US20090143724A1 Microprojection Array Immunization Patch and Method 审中-公开
标题翻译：微喷射阵列免疫贴片和方法
公开(公告)号：US20090143724A1
公开(公告)日：2009-06-04
申请号：US12367318
申请日：2009-02-06
申请人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
发明人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0046 , A61M2037/0061 , Y02A50/401
摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.
摘要翻译：公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥并施用于使用冲击施加器接种疫苗的皮肤。微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。可以控制抗原剂量和穿透深度。该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

6. 发明授权

US07761147B2 Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权
公开(公告)号：US07761147B2
公开(公告)日：2010-07-20
申请号：US11084628
申请日：2005-03-18
申请人： Wendy A. Young , Michel J. N. Cormier
发明人： Wendy A. Young , Michel J. N. Cormier
IPC分类号： A61N1/30 , A61K9/22
CPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

7. 发明授权

US07054682B2 Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权
公开(公告)号：US07054682B2
公开(公告)日：2006-05-30
申请号：US10117024
申请日：2002-04-04
申请人： Wendy A. Young , Michel J. N. Cormier
发明人： Wendy A. Young , Michel J. N. Cormier
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

8. 发明授权

US07287319B2 Method of making a housing for drug delivery 有权
标题翻译：制作住房用于药物输送的方法
公开(公告)号：US07287319B2
公开(公告)日：2007-10-30
申请号：US11101844
申请日：2005-04-07
申请人： Wendy A. Young , Lothar W. Kleiner
发明人： Wendy A. Young , Lothar W. Kleiner
IPC分类号： H01R43/00
CPC分类号： A61N1/0448 , Y10T29/49082 , Y10T29/49117 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49204
摘要： An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same time providing a means for conducting an electric current therethrough.
摘要翻译：电输送储存器壳体，其一体地形成在其中，至少一个导电材料区域，其允许液体和湿气屏障，同时提供用于传导电流的装置。

9. 发明授权

US07024762B2 Method of making a housing for drug delivery 有权
标题翻译：制作住房用于药物输送的方法
公开(公告)号：US07024762B2
公开(公告)日：2006-04-11
申请号：US10324279
申请日：2002-12-19
申请人： Wendy A. Young , Lothar W. Kleiner
发明人： Wendy A. Young , Lothar W. Kleiner
IPC分类号： H05R43/00
CPC分类号： A61N1/0448 , Y10T29/49082 , Y10T29/49117 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49204
摘要： An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same time providing a means for conducting an electric current therethrough.
摘要翻译：电输送储存器壳体，其一体地形成在其中，至少一个导电材料区域，其允许液体和湿气屏障，同时提供用于传导电流的装置。

10. 发明授权

US07801599B2 Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权
标题翻译：透皮电运输装置包括抗微生物相容的储存器组合物
公开(公告)号：US07801599B2
公开(公告)日：2010-09-21
申请号：US11556413
申请日：2006-11-03
申请人： Wendy A. Young , Michel J. Cormier
发明人： Wendy A. Young , Michel J. Cormier
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
摘要翻译：具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。还提供了一种制备透皮电转运药物递送装置的方法。

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