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1. 发明授权

US07419481B2 Apparatus and method for piercing skin with microprotrusions 有权
标题翻译：用微刺穿皮肤的装置和方法
公开(公告)号：US07419481B2
公开(公告)日：2008-09-02
申请号：US11092800
申请日：2005-03-28
申请人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150908 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译：描述了一种方法和装置，用于将包括多个微突出物（90）的微量挤压构件（44）施加到角质层上。该方法和装置用于改善药剂在皮肤上的运输，用于药剂递送或取样。施加器（10,60,80）导致微推进构件（44）以确定的一定量的冲击力冲击角质层，以有效地用微突起（90）刺穿皮肤。优选的施用器（10,60,80）在微滴注构件（44）中以10毫秒或更小的速度冲击至少0.05焦耳/微米/ 2微米输注构件（44）的冲击角减。

2. 发明授权

US5995869A Reduction of skin sensitization in electrotransport drug delivery 失效
标题翻译：减少电转运药物中的皮肤过敏
公开(公告)号：US5995869A
公开(公告)日：1999-11-30
申请号：US872723
申请日：1997-06-11
申请人： Michel J. N. Cormier , James A. Matriano , Ronald P. Haak , Peter E. Daddona
发明人： Michel J. N. Cormier , James A. Matriano , Ronald P. Haak , Peter E. Daddona
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A device and method are provided for reducing or preventing skin sensitization in electrotransport drug delivery. The method involves co-administration of a countersensitizing agent, comprising cis-urocanic acid or an analog thereof, with the drug delivered via electrotransport. Novel drug reservoirs and electrotransport drug delivery systems, formulated with a countersensitizing agent as described herein, are provided as well.
摘要翻译：提供了用于减少或预防电转运药物递送中的皮肤致敏的装置和方法。该方法包括将包含顺式尿刊或其类似物的致敏剂与经由电转运递送的药物共同给药。还提供了用本文所述的增敏剂配制的新型药物储库和电转运药物递送系统。

3. 发明授权

US07131960B2 Apparatus and method for piercing skin with microprotrusions 有权
标题翻译：用微刺穿皮肤的装置和方法
公开(公告)号：US07131960B2
公开(公告)日：2006-11-07
申请号：US09976798
申请日：2001-10-12
申请人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150824 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/1519 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046
摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译：描述了一种方法和装置，用于将包括多个微突出物（90）的微量挤压构件（44）施加到角质层上。该方法和装置用于改善药剂在皮肤上的运输，用于药剂递送或取样。施加器（10,60,80）导致微推进构件（44）以确定的一定量的冲击力冲击角质层，以有效地用微突起（90）刺穿皮肤。优选的施用器（10,60,80）在微滴注构件（44）中以10毫秒或更小的速度冲击至少0.05焦耳/微米/ 2微米输注构件（44）的冲击角减。

4. 发明授权

US07798987B2 Apparatus and method for piercing skin with microprotrusions 有权
标题翻译：用微刺穿皮肤的装置和方法
公开(公告)号：US07798987B2
公开(公告)日：2010-09-21
申请号：US11092202
申请日：2005-03-28
申请人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150824 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/1519 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046
摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译：描述了一种方法和装置，用于将包括多个微突出物（90）的微量挤压构件（44）施加到角质层上。该方法和装置用于改善药剂在皮肤上的运输，用于药剂递送或取样。施加器（10,60,80）导致微推进构件（44）以确定的一定量的冲击力冲击角质层，以有效地用微突起（90）刺穿皮肤。优选的施加器（10,60,80）在微滴注构件（44）中以10毫秒或更短的冲击速率冲击至少0.05焦耳/ cm2的微推进构件（44）。

5. 发明申请

US20090143724A1 Microprojection Array Immunization Patch and Method 审中-公开
标题翻译：微喷射阵列免疫贴片和方法
公开(公告)号：US20090143724A1
公开(公告)日：2009-06-04
申请号：US12367318
申请日：2009-02-06
申请人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
发明人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0046 , A61M2037/0061 , Y02A50/401
摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.
摘要翻译：公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥并施用于使用冲击施加器接种疫苗的皮肤。微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。可以控制抗原剂量和穿透深度。该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

6. 发明授权

US06749575B2 Method for transdermal nucleic acid sampling 有权
标题翻译：透皮核酸取样方法
公开(公告)号：US06749575B2
公开(公告)日：2004-06-15
申请号：US09933647
申请日：2001-08-20
申请人： James A. Matriano , Michel J. N. Cormier
发明人： James A. Matriano , Michel J. N. Cormier
IPC分类号： A61B1000
CPC分类号： A61B17/205 , A61B10/0045 , A61B2010/008
摘要： A minimally invasive transdermal nucleic acid sampling method comprises piercing through the outermost layer of the skin and into the underlying epidermis with a plurality of microprojections. Living skin cells in the underlying epidermis are disrupted, causing them to release their contents including their nucleic acids (i.e., DNA, RNA, fragments thereof or other polynucleic acid material found in the nucleii and/or mitochondria of cells). The nucleic acid is collected on the surfaces of the microprojections and/or in a separate nucleic acid collection reservoir. The collected nucleic acid is then analyzed using standard polymerase chain reaction (PCR) techniques. Optionally a suction device applies a partial vacuum through openings in the microprojection member to the microcuts in the skin for enhanced efflux of intracellular and extracellular (i.e., body) fluids containing the nucleic acid.
摘要翻译：微创透皮核酸取样方法包括用多个微突出物穿透皮肤的最外层并进入下面的表皮。底层表皮中的活细胞被破坏，导致它们释放出其核酸（即DNA，RNA，其片段或细胞核和/或线粒体中发现的其他多核酸物质）的内容物。将核酸收集在微突出物表面和/或在单独的核酸采集储存器中。然后使用标准聚合酶链反应（PCR）技术分析所收集的核酸。任选地，抽吸装置通过微突出物构件中的开口将局部真空施加到皮肤中的微切口，以增强含有核酸的细胞内和细胞外（即，体）流体的流出。

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