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1. 发明申请

US20100221305A1 Formulations for coated microprojections containing non-volatile counterions 审中-公开
标题翻译：含有非挥发性抗衡离子的涂层微注射剂的配方
公开(公告)号：US20100221305A1
公开(公告)日：2010-09-02
申请号：US12583761
申请日：2009-08-24
申请人： Mahmoud Armeri , Wei-Qi Lin , Michel J.N. Cormier , Yuh-Fun Maa
发明人： Mahmoud Armeri , Wei-Qi Lin , Michel J.N. Cormier , Yuh-Fun Maa
IPC分类号： A61K9/70 , A61K38/20 , A61K31/445 , A61K38/29 , A61K38/50 , A61K38/21 , A61K38/19 , A61K38/48 , A61P31/04 , A61P31/12 , A61P29/00 , A61P3/04 , A61P19/02 , A61P25/24 , A61P3/10 , A61P25/06 , A61P35/00 , A61P25/16 , A61P5/18 , B05D7/00
CPC分类号： A61K9/0021 , A61K9/0014 , A61K47/02 , A61K47/12 , Y02A50/471 , Y02A50/478
摘要： The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.
摘要翻译：本发明提供一种用于涂覆一种或多种微注射剂的制剂，其减少或最小化来自涂层的抗衡离子的损失以达到pH稳定的制剂。

2. 发明申请

US20090186147A1 Transdermal drug delivery devices having coated microprotrusions 审中-公开
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US20090186147A1
公开(公告)日：2009-07-23
申请号：US12290678
申请日：2008-10-31
申请人： Michel J.N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona , Mahmoud Armeri
发明人： Michel J.N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona , Mahmoud Armeri
IPC分类号： B05D3/10
CPC分类号： A61M37/0015 , A61K9/0021 , A61K47/20 , A61K47/26 , A61K47/38 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent.
摘要翻译：提供了使用润湿剂作为微喷射表面的预处理或与活性剂一起掺入涂层制剂中的一个或多个微喷射体阵列的一个或多个微喷射体上制备涂层的方法。

3. 发明申请

US20100152649A1 Apparatus and method for transdermal delivery of parathyroid hormone agents 有权
标题翻译：用于甲状旁腺激素试剂透皮递送的装置和方法
公开(公告)号：US20100152649A1
公开(公告)日：2010-06-17
申请号：US12459499
申请日：2009-07-01
申请人： Mahmoud Ameri , Michel J.N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberl
发明人： Mahmoud Ameri , Michel J.N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberl
IPC分类号： A61M37/00
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译：一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。

4. 发明申请

US20090143724A1 Microprojection Array Immunization Patch and Method 审中-公开
标题翻译：微喷射阵列免疫贴片和方法
公开(公告)号：US20090143724A1
公开(公告)日：2009-06-04
申请号：US12367318
申请日：2009-02-06
申请人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
发明人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0046 , A61M2037/0061 , Y02A50/401
摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.
摘要翻译：公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥并施用于使用冲击施加器接种疫苗的皮肤。微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。可以控制抗原剂量和穿透深度。该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

5. 发明授权

US5865792A Reduction of skin irritation during electrotransport delivery 失效
标题翻译：电运输期间减少皮肤刺激
公开(公告)号：US5865792A
公开(公告)日：1999-02-02
申请号：US895096
申请日：1997-07-16
申请人： Philip W. Ledger , Michel J.N. Cormier , Patricia S. Campbell
发明人： Philip W. Ledger , Michel J.N. Cormier , Patricia S. Campbell
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/325 , A61N1/0436 , A61N1/0444
摘要： The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant or mixtures thereof. The composition preferably further includes a gel matrix that is a swellable, hydrophilic polymer, a water soluble hydrophilic polymer or a solid polymer. A hydrophobic polymer and/or additives may also be included.
摘要翻译：本发明涉及一种用于电输送装置的组合物和产品。组合物包括电离药物，抗炎剂和溶剂。优选地，抗炎剂是氢化可的松或其酯，溶剂是醇，二醇，甘油，环糊精，非离子表面活性剂或其混合物。组合物优选还包括可溶胀亲水性聚合物，水溶性亲水聚合物或固体聚合物的凝胶基质。还可以包括疏水性聚合物和/或添加剂。

6. 发明申请

US20100160895A1 Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents 有权
标题翻译：甲状旁腺激素试剂透皮递送装置及方法
公开(公告)号：US20100160895A1
公开(公告)日：2010-06-24
申请号：US12716184
申请日：2010-03-02
申请人： Mahmoud Ameri , Michel J.N. Cormier , Yuh-Fun Maa , Marika Kamberi , Peter E. Daddona
发明人： Mahmoud Ameri , Michel J.N. Cormier , Yuh-Fun Maa , Marika Kamberi , Peter E. Daddona
IPC分类号： A61M5/00
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译：一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。

7. 发明申请

US20100152242A1 Transdermal Electrotransport Delivery Device Including an Antimicrobial Compatible Reservoir Composition 审中-公开
标题翻译：透皮电传递装置，包括抗微生物兼容的储层组成
公开(公告)号：US20100152242A1
公开(公告)日：2010-06-17
申请号：US12711608
申请日：2010-02-24
申请人： Wendy A. Young , Michel J.N. Cormier
发明人： Wendy A. Young , Michel J.N. Cormier
IPC分类号： A61K31/4468 , A61P25/04
CPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
摘要翻译：具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。还提供了一种制备透皮电转运药物递送装置的方法。

8. 发明申请

US20100119568A1 Apparatus and method for transdermal delivery of parathyroid hormone agents 有权
公开(公告)号：US20100119568A1
公开(公告)日：2010-05-13
申请号：US12455830
申请日：2009-06-08
申请人： Mahmoud Ameri , Michel J.N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberi
发明人： Mahmoud Ameri , Michel J.N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberi
IPC分类号： A61K9/00 , A61K38/16
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

9. 发明授权

US07435299B2 Method and apparatus for coating skin piercing microprojections 有权
标题翻译：皮肤穿刺微粒涂层的方法和装置
公开(公告)号：US07435299B2
公开(公告)日：2008-10-14
申请号：US10984510
申请日：2004-11-09
申请人： Joseph C. Trautman , Cedric T. Wright , Michel J.N. Cormier
发明人： Joseph C. Trautman , Cedric T. Wright , Michel J.N. Cormier
IPC分类号： B05C1/08 , B05C1/00
CPC分类号： A61K9/0021 , A61B17/205 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B05D1/18 , B05D1/28
摘要： An apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only the skin piercing microprojections (10) and not the substrate (12) from which the microprojections (10) extend, and then dried. The coating method includes providing an agent-containing coating liquid and conveying the liquid to a liquid holding surface having a coating transfer region. The depth of the coating liquid at the coating transfer region is precisely controlled. The microprojections are then immersed to a predetermined level in the coating liquid. The liquid that coats the microprojections (10) is then dried to form a solid agent-containing coating on the microprojections (10).
摘要翻译：提供了一种用于选择性地将含药剂的液体涂层施加到极微小的皮肤刺穿微突出物（10）上的装置和方法。使用涂覆技术将涂布溶液施加到皮肤刺穿微突出物（10）上，涂覆技术仅选择性地涂覆皮肤刺穿微突出物（10）而不是微突出物（10）延伸的基底（12），然后干燥。涂布方法包括提供含药剂的涂布液体并将液体输送到具有涂覆转移区域的液体保持表面。涂层转移区域的涂布液的深度被精确地控制。然后将微注入物浸入涂布液中的预定水平。然后将涂覆微喷射体（10）的液体干燥，以在微喷射体（10）上形成含固体剂的涂层。

10. 发明申请

US20080058703A1 Drug electrotransport with hydration measurement of hydratable reservoir 审中-公开
标题翻译：药物电传输与水合储层的水合测量
公开(公告)号：US20080058703A1
公开(公告)日：2008-03-06
申请号：US11893732
申请日：2007-08-17
申请人： Janardhanan A. Subramony , Michel J.N. Cormier , Rama V. Padmanabhan
发明人： Janardhanan A. Subramony , Michel J.N. Cormier , Rama V. Padmanabhan
IPC分类号： A61N1/30
CPC分类号： A61K9/0009 , A61K47/32 , A61K47/34 , A61N1/0424 , A61N1/044 , A61N1/30 , A61N1/327
摘要： A transdermal electrotransport drug delivery system with hydratable reservoir and method for drug delivery to an individual. The system has a hydratable reservoir with impedance measurement means for determining level of hydration in the reservoir.
摘要翻译：具有可水合储存器的透皮电运输药物递送系统和用于向个体递送药物的方法。该系统具有用于确定储层中水合水平的阻抗测量装置的可水合储存器。

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