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1. 发明授权

US07963935B2 Microprojection array having a beneficial agent containing coating 有权
标题翻译：具有含有有益剂的涂层的微型投影阵列
公开(公告)号：US07963935B2
公开(公告)日：2011-06-21
申请号：US10127108
申请日：2002-04-20
申请人： Michel J. N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona
发明人： Michel J. N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61K9/0014 , A61K9/0021 , A61K47/42 , A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/0046
摘要： The device including a plurality of stratum corneum-piercing microprojections, and a solid coating disposed upon the microprojections, wherein the solid coating includes at least one beneficial agent and a biocompatible carrier is provided. The device is applied to the skin of a living animal (e.g., a human), causing the microprojections to pierce the stratum corneum and deliver an effective dose of the agent to the animal.
摘要翻译：所述装置包括多个角质层刺穿的微突出物，以及设置在所述微喷射体上的固体涂层，其中所述固体涂层包括至少一种有益试剂和生物相容性载体。该装置应用于活动物（例如人）的皮肤，导致微突出物刺穿角质层并将有效剂量的药剂递送至动物。

2. 发明授权

US06203817B1 Reduction of skin reactions caused by transdermal drug delivery 失效
标题翻译：减少透皮给药引起的皮肤反应
公开(公告)号：US06203817B1
公开(公告)日：2001-03-20
申请号：US09092606
申请日：1998-06-05
申请人： Michel J. N. Cormier , Peter E. Daddona , Juanita A. Johnson
发明人： Michel J. N. Cormier , Peter E. Daddona , Juanita A. Johnson
IPC分类号： A61F1302
CPC分类号： A61K9/7053 , A61K9/7084
摘要： Transdermal compositions, devices, and methods for the administration of a drug at reduced skin irritation levels are disclosed. More particularly, this invention relates to novel methods, compositions, and devices for the reduction or elimination of irritation or sensitization caused by an irritating or sensitizing drug when it is delivered transdermally. According to a preferred embodiment, transdermal administration of a drug salt of a non-zwitterionic drug is disclosed wherein the drug salt comprises a combination of surface activity and a low octanol-water partition coefficient. Such drug salts have been found to reduce irritation or sensitization to the drug being delivered while achieving therapeutically effective transdermal fluxes.
摘要翻译：公开了用于在皮肤刺激水平降低的药物给药的透皮组合物，装置和方法。更具体地说，本发明涉及当通过皮肤递送时由刺激性或致敏性药物引起的刺激或致敏的减少或消除的新方法，组合物和装置。根据优选的实施方案，公开了非两性离子药物的药物盐的透皮给药，其中所述药物盐包含表面活性和低辛醇 - 水分配系数的组合。已经发现，这些药物盐可以减少对所递送药物的刺激或致敏，同时实现治疗有效的经皮通气。

3. 发明授权

US08663155B2 Transdermal drug delivery devices having coated microprotrusions 有权
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US08663155B2
公开(公告)日：2014-03-04
申请号：US11347779
申请日：2006-02-02
申请人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona , Wei-Qi Lin
发明人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona , Wei-Qi Lin
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.
摘要翻译：提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

4. 发明授权

US07537795B2 Transdermal drug delivery devices having coated microprotrusions 有权
公开(公告)号：US07537795B2
公开(公告)日：2009-05-26
申请号：US10045842
申请日：2001-10-26
申请人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona
发明人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona
IPC分类号： B05D3/02
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

5. 发明申请

US20090186147A1 Transdermal drug delivery devices having coated microprotrusions 审中-公开
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US20090186147A1
公开(公告)日：2009-07-23
申请号：US12290678
申请日：2008-10-31
申请人： Michel J.N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona , Mahmoud Armeri
发明人： Michel J.N. Cormier , Wendy A. Young , Juanita A. Johnson , Peter E. Daddona , Mahmoud Armeri
IPC分类号： B05D3/10
CPC分类号： A61M37/0015 , A61K9/0021 , A61K47/20 , A61K47/26 , A61K47/38 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent.
摘要翻译：提供了使用润湿剂作为微喷射表面的预处理或与活性剂一起掺入涂层制剂中的一个或多个微喷射体阵列的一个或多个微喷射体上制备涂层的方法。

6. 发明申请

US20090143724A1 Microprojection Array Immunization Patch and Method 审中-公开
标题翻译：微喷射阵列免疫贴片和方法
公开(公告)号：US20090143724A1
公开(公告)日：2009-06-04
申请号：US12367318
申请日：2009-02-06
申请人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
发明人： Michel J.N. Cormier , James A. Matriano , Peter E. Daddona , Juanita A. Johnson , Wendy A. Young
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0046 , A61M2037/0061 , Y02A50/401
摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.
摘要翻译：公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥并施用于使用冲击施加器接种疫苗的皮肤。微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。可以控制抗原剂量和穿透深度。该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

7. 发明授权

US08633159B2 Apparatus and method for transdermal delivery of parathyroid hormone agents 有权
标题翻译：用于甲状旁腺激素试剂透皮递送的装置和方法
公开(公告)号：US08633159B2
公开(公告)日：2014-01-21
申请号：US12716184
申请日：2010-03-02
申请人： Mahmoud Ameri , Michel J. N. Cormier , Yuh-Fun Maa , Marika Kamberi , Peter E. Daddona
发明人： Mahmoud Ameri , Michel J. N. Cormier , Yuh-Fun Maa , Marika Kamberi , Peter E. Daddona
IPC分类号： A61P5/18 , A61M5/30 , C07K14/635 , A61K38/16
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译：一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。

8. 发明授权

US07131960B2 Apparatus and method for piercing skin with microprotrusions 有权
标题翻译：用微刺穿皮肤的装置和方法
公开(公告)号：US07131960B2
公开(公告)日：2006-11-07
申请号：US09976798
申请日：2001-10-12
申请人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人： Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150824 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/1519 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046
摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译：描述了一种方法和装置，用于将包括多个微突出物（90）的微量挤压构件（44）施加到角质层上。该方法和装置用于改善药剂在皮肤上的运输，用于药剂递送或取样。施加器（10,60,80）导致微推进构件（44）以确定的一定量的冲击力冲击角质层，以有效地用微突起（90）刺穿皮肤。优选的施用器（10,60,80）在微滴注构件（44）中以10毫秒或更小的速度冲击至少0.05焦耳/微米/ 2微米输注构件（44）的冲击角减。

9. 发明授权

US09295714B2 Apparatus and method for transdermal delivery of parathyroid hormone agents 有权
公开(公告)号：US09295714B2
公开(公告)日：2016-03-29
申请号：US12455830
申请日：2009-06-08
申请人： Mahmoud Ameri , Michel J. N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberi
发明人： Mahmoud Ameri , Michel J. N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberi
IPC分类号： A61K38/29 , C07K14/635 , A61M31/00 , A61M37/00 , A61K9/00 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

10. 发明授权

US5995869A Reduction of skin sensitization in electrotransport drug delivery 失效
标题翻译：减少电转运药物中的皮肤过敏
公开(公告)号：US5995869A
公开(公告)日：1999-11-30
申请号：US872723
申请日：1997-06-11
申请人： Michel J. N. Cormier , James A. Matriano , Ronald P. Haak , Peter E. Daddona
发明人： Michel J. N. Cormier , James A. Matriano , Ronald P. Haak , Peter E. Daddona
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A device and method are provided for reducing or preventing skin sensitization in electrotransport drug delivery. The method involves co-administration of a countersensitizing agent, comprising cis-urocanic acid or an analog thereof, with the drug delivered via electrotransport. Novel drug reservoirs and electrotransport drug delivery systems, formulated with a countersensitizing agent as described herein, are provided as well.
摘要翻译：提供了用于减少或预防电转运药物递送中的皮肤致敏的装置和方法。该方法包括将包含顺式尿刊或其类似物的致敏剂与经由电转运递送的药物共同给药。还提供了用本文所述的增敏剂配制的新型药物储库和电转运药物递送系统。

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