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1. 发明公开

US20240345103A1 METHOD OF DIAGNOSING AND TREATING CHRONIC KIDNEY DISEASE 审中-公开
公开(公告)号：US20240345103A1
公开(公告)日：2024-10-17
申请号：US18630041
申请日：2024-04-09
申请人： PrognostX Health Inc.
发明人： Aaron L. CARRITHERS , Stephen L. CARRITHERS , Brennan M. CARRITHERS , Nicholas KEMPER , Luke E. MORRISON
IPC分类号： G01N33/74 , G01N33/70
CPC分类号： G01N33/74 , G01N33/70 , G01N2800/34 , G01N2800/52
摘要： A method of diagnosing and/or treating stage 3 or stage 4 chronic kidney disease (CKD) is provided herein, where a proUGN concentration level of 2.241 ng/ml or higher is indicative of stage 3 or stage 4 CKD. Additionally, a method of diagnosing and/or treating pre-CKD is also provided herein, where a proUGN concentration level of 2.05 ng/ml to and including 2.24 ng/ml in a biological sample is indicative of pre-CKD and that a patient is at risk of developing CKD. The methods may comprise measuring the amount of proUGN in a biological sample of the patient and/or administering a CKD-therapeutic agent and/or providing lifestyle and/or dietary modifications to the patient.

2. 发明授权

US10006921B2 Markers of the male urogenital tract 有权
公开(公告)号：US10006921B2
公开(公告)日：2018-06-26
申请号：US15360240
申请日：2016-11-23
申请人： Sinai Health System
发明人： Keith Jarvi , Eleftherios P. Diamandis , Andrei Drabovich
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N33/689 , G01N2333/705 , G01N2333/78 , G01N2800/34 , G01N2800/342 , G01N2800/367
摘要： Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides, encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.

3. 发明申请

US20160007906A1 METHODS FOR ASSESSING VAGINAL ATROPHY 审中-公开
标题翻译：评估VAGINAL ATROPHY的方法
公开(公告)号：US20160007906A1
公开(公告)日：2016-01-14
申请号：US14796220
申请日：2015-07-10
申请人： The Procter & Gamble Company
发明人： Raphael Warren , Dean Larry DuVal , Miranda Aref Farage , Charles Carson Bascom , Gina Marie Fadayel , Kenneth Robert Wehmeyer , Jay Patrick Tiesman , David Burton Moore , Murray A. Freedman
IPC分类号： A61B5/00 , G01N33/94 , C12Q1/68 , C12Q1/54 , A61B5/01 , A61B10/02
CPC分类号： A61B5/4848 , A61B5/0057 , A61B5/015 , A61B5/14539 , A61B5/4337 , A61B5/4869 , A61B10/02 , A61F13/15 , A61K31/565 , C12Q1/54 , C12Q1/6883 , C12Q2600/158 , G01N33/6869 , G01N33/6893 , G01N33/84 , G01N33/9406 , G01N2570/00 , G01N2800/34 , G01N2800/362 , G01N2800/52
摘要： An array of methods for assessing vaginal atrophy are disclosed. The methods may be used alone or in combination with a treatment or as part of a kit.
摘要翻译：公开了一系列用于评估阴道萎缩的方法。这些方法可以单独使用或与治疗组合使用或作为试剂盒的一部分使用。

4. 发明授权

US09150909B2 Determination of the integrity of RNA 有权
标题翻译：确定RNA的完整性
公开(公告)号：US09150909B2
公开(公告)日：2015-10-06
申请号：US12548226
申请日：2009-08-26
申请人： Vladimir Denisov
发明人： Vladimir Denisov
IPC分类号： G01N27/26 , C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6816 , C12Q1/6806 , C12Q2545/113 , C12Q2563/107 , C12Q2565/125 , G01N2333/4728 , G01N2800/34 , C12Q2561/12 , C12Q2539/101
摘要： Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determination of integrity of an RNA sample is performed by comparing a size profile to reference size profiles (degradation standards) obtained from degradation over different lengths of times. As the reference scale of the level of integrity is derived from the actual degradation that occurs in a sample, high accuracy, reproducibility, and efficiency is provided.
摘要翻译：方法，系统和装置确定生物分子样品的完整性水平。例如，样品中RNA的完整性的确定可以以快速和可再现的方式进行，使得用户可以确保样品的测试准确性（例如定量聚合酶链式反应qPCR）并比较结果不同样品。 RNA样品的完整性的确定通过将尺寸分布与不同长度的降解获得的参考尺寸分布（降解标准）进行比较来进行。由于完整性水平的参考比例来源于样品中发生的实际降解，因此提供了高精度，重复性和效率。

5. 发明授权

US09075045B2 Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis 有权
公开(公告)号：US09075045B2
公开(公告)日：2015-07-07
申请号：US13911242
申请日：2013-06-06
申请人： THE COMMONWEALTH MEDICAL COLLEGE , UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： David Alan Zacharias , Sonia Lobo Planey
IPC分类号： C07K14/705 , G01N33/50 , C07K9/00 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/5091 , C07K9/005 , C07K14/705 , C12Q1/6897 , G01N33/6893 , G01N2333/4728 , G01N2800/34 , Y10T436/110833 , Y10T436/112499
摘要： An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.

6. 发明授权

US09040464B2 Markers of the male urogenital tract 有权
标题翻译：男性泌尿生殖道的标记
公开(公告)号：US09040464B2
公开(公告)日：2015-05-26
申请号：US13814959
申请日：2011-08-16
申请人： Keith Jarvi , Eleftherios P. Diamandis , Andrei Drabovich
发明人： Keith Jarvi , Eleftherios P. Diamandis , Andrei Drabovich
IPC分类号： G01N33/68 , C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N33/689 , G01N2333/705 , G01N2333/78 , G01N2800/34 , G01N2800/342 , G01N2800/367
摘要： Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.
摘要翻译：描述了用于检测受试者中泌尿生殖器官状态或泌尿生殖状态的方法，包括测量来自受试者的样品中的编码标志物的泌尿生殖标志物或多核苷酸。本发明还提供泌尿生殖条件的定位或成像方法，以及用于实施本发明方法的试剂盒。本发明还考虑了使用泌尿生殖标志物，编码标记物的多核苷酸和/或标记物的结合剂的泌尿生殖条件的治疗应用。

7. 发明申请

US20130059318A1 ANTI-IGA1 ANTIBODY 审中-公开
标题翻译： ANTI-IGA1抗体
公开(公告)号：US20130059318A1
公开(公告)日：2013-03-07
申请号：US13519696
申请日：2010-12-28
申请人： Etsuji Kaneko , Yuka Sasaki , Katsuhiro Mori , Yutaka Kanda , Mitsuo Satoh
发明人： Etsuji Kaneko , Yuka Sasaki , Katsuhiro Mori , Yutaka Kanda , Mitsuo Satoh
IPC分类号： C07K16/42 , C12N5/12 , C12N15/63 , G01N33/577 , C12N1/19 , C12N5/10 , C12P21/08 , C12N15/13 , C12N1/21
CPC分类号： C07K16/4283 , C07K2317/34 , C07K2317/92 , G01N2800/34
摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.
摘要翻译：本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区半乳糖不结合。根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。

8. 发明申请

US20120135886A1 METHOD FOR DETECTION OF, OR THE RISK OF, BLADDER CANCER 有权
标题翻译：检测乳腺癌或风险的方法
公开(公告)号：US20120135886A1
公开(公告)日：2012-05-31
申请号：US13386228
申请日：2010-07-29
申请人： Mark W. Ruddock , Cherith N. Reid , Kathleen Williamson , John V. Lamont , Stephen P. Fitzgerald
发明人： Mark W. Ruddock , Cherith N. Reid , Kathleen Williamson , John V. Lamont , Stephen P. Fitzgerald
IPC分类号： C40B30/04 , G01N33/566 , C12Q1/68
CPC分类号： G01N33/57407 , G01N2800/34
摘要： The present invention provides a method for the detection of or the risk of bladder cancer in a patient, comprising the step of detecting the presence of a combination of at least two biomarkers selected from CEA, VEGF, IL-8, NGAL, NSE, IL-2, EGF, TM, d-Dimer, MMP-9, IL-6, IL-4, MMP-9/NGAL, FAS, CRP, TUP and NMP22 in one or more samples isolated from a patient wherein the presence of a combination of at least two biomarkers in the one or more samples indicates the presence or risk of bladder cancer.
摘要翻译：本发明提供了一种用于检测患者膀胱癌或其风险的方法，包括检测选自CEA，VEGF，IL-8，NGAL，NSE，IL的至少两种生物标志物的组合的存在的步骤 -2，EGF，TM，d-二聚体，MMP-9，IL-6，IL-4，MMP-9 / NGAL，FAS，CRP，TUP和NMP22在从患者分离的一个或多个样品中一个或多个样品中至少两个生物标志物的组合指示膀胱癌的存在或风险。

9. 发明申请

US20110177613A1 Use of periostin as a novel biomarker 审中-公开
标题翻译：使用骨膜素作为新生物标志物
公开(公告)号：US20110177613A1
公开(公告)日：2011-07-21
申请号：US12924608
申请日：2010-09-29
申请人： Sharon Adler , Bancha Satirapoj , Ying Wang , Janine LaPage , Cynthia C. Nast
发明人： Sharon Adler , Bancha Satirapoj , Ying Wang , Janine LaPage , Cynthia C. Nast
IPC分类号： G01N33/53 , G01N30/02 , H01J49/26
CPC分类号： G01N33/566 , G01N33/6893 , G01N2030/8831 , G01N2800/34
摘要： The invention provides, in certain embodiments, a method of detecting an indicator of renal injury or renal disease. The method entails assaying a urine sample for periostin, wherein the presence of periostin at an elevated level indicates the presence and/or degree of renal injury or renal disease. Also provided, are methods of determining progression of these conditions, as well as methods of determining subjects' response to treatment.
摘要翻译：在某些实施方案中，本发明提供了检测肾损伤或肾脏疾病指标的方法。该方法需要测定尿样用于骨膜素，其中在升高的水平的骨膜素的存在表示肾损伤或肾脏疾病的存在和/或程度。还提供了确定这些病症进展的方法，以及确定受试者对治疗反应的方法。

10. 发明申请

US20110136917A1 TETRAHYDRO-ISOALPHA ACID COMPOSITIONS AND METHODS FOR WEIGHT MANAGEMENT 审中-公开
标题翻译：四氢异丙醇酸组合物和重量管理方法
公开(公告)号：US20110136917A1
公开(公告)日：2011-06-09
申请号：US12856089
申请日：2010-08-13
申请人： Matthew L. Tripp , Gary Darland , Veera Konda
发明人： Matthew L. Tripp , Gary Darland , Veera Konda
IPC分类号： A61K31/12 , A61P3/00 , A61P9/00 , A61P19/10
CPC分类号： G01N33/6893 , G01N2800/02 , G01N2800/042 , G01N2800/321 , G01N2800/34 , G01N2800/36
摘要： Compositions and methods to promote or maintain weight loss utilizing tetrahydro-isoalpha acid compounds are disclosed. Methods to increase synthesis of GLP-1 are disclosed.
摘要翻译：公开了使用四氢异α酸化合物促进或维持减肥的组合物和方法。公开了增加GLP-1合成的方法。

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