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1. 发明授权

US08221783B2 Medical devices with triggerable bioadhesive material 有权
标题翻译：具有可触发生物粘附材料的医疗设备
公开(公告)号：US08221783B2
公开(公告)日：2012-07-17
申请号：US12207839
申请日：2008-09-10
申请人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
IPC分类号： C08B37/08 , C08L71/02 , A61K47/36 , A61K47/42 , A61K9/70 , A61K9/00 , A61K31/337 , A61K31/436 , A61K47/38 , A61F2/02 , C07K14/78 , C08F210/00 , C08G63/06 , C08G67/00 , C08G73/00 , C08G73/10
CPC分类号： A61L31/145 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416
摘要： Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
摘要翻译：本文描述的是可植入医疗装置，其包括生物相容性聚合物，其包含可触发的生物粘合性质，其允许该装置粘附于身体组织。可以通过暴露于刺激物来触发或激活聚合物的可触发生物粘合性质。此外，本发明涉及制造包括生物相容性聚合物的可植入医疗装置的方法，所述生物相容性聚合物包含允许装置粘附于身体组织的可触发的生物粘合性质。

2. 发明申请

US20110014264A1 Medical Devices Having Nanostructured Regions For Controlled Tissue Biocompatibility And Drug Delivery 审中-公开
标题翻译：具有控制组织生物相容性和药物递送的纳米结构区域的医疗器械
公开(公告)号：US20110014264A1
公开(公告)日：2011-01-20
申请号：US12888864
申请日：2010-09-23
申请人： Michael N. Helmus , Yixin Xu , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Shrirang V. Ranade
IPC分类号： A61F2/82 , A61M31/00 , A61K38/02 , A61K31/726 , A61P43/00 , A61P35/00
CPC分类号： B82Y30/00 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/252 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/624 , A61N1/05 , B82Y5/00
摘要： According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions.
摘要翻译：根据本发明的某些方面，提供了可植入或可插入的医疗装置，其包含一个或多个纳米多孔区域，其可以进一步包括互连的纳米孔。本发明的其它方面涉及含有一个或多个纳米结构区域的可植入或可插入的医疗装置，其通过多种方法形成。本发明的另外其它方面涉及具有纳米纹理表面区域的可植入或可插入的医疗装置，其中提供细胞粘附促进生物分子（例如，糖胺聚糖，蛋白聚糖，细胞粘附肽和粘合蛋白），其中，纳米纹理表面区域。

3. 发明申请

US20090098176A1 MEDICAL DEVICES WITH TRIGGERABLE BIOADHESIVE MATERIAL 有权
标题翻译：具有可触发生物材料的医疗器械
公开(公告)号：US20090098176A1
公开(公告)日：2009-04-16
申请号：US12207839
申请日：2008-09-10
申请人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
IPC分类号： A61K47/30 , C08G73/02 , C08F226/08 , C08B1/00 , C08B37/04 , C08B37/08 , C08L71/02 , A61K47/36 , A61K47/42 , A61F2/02 , A61K9/70 , A61K9/00 , A61K31/337 , A61K31/436 , A61K47/38 , C07K14/78 , C08F210/00 , C08G63/06 , C08G67/00 , C08G73/00 , C08G73/10
CPC分类号： A61L31/145 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416
摘要： Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
摘要翻译：本文描述的是可植入医疗装置，其包括生物相容性聚合物，其包含可触发的生物粘合性质，其允许该装置粘附于身体组织。可以通过暴露于刺激物来触发或激活聚合物的可触发生物粘附性质。此外，本发明涉及制造包括生物相容性聚合物的可植入医疗装置的方法，所述生物相容性聚合物包含允许装置粘附于身体组织的可触发的生物粘合性质。

4. 发明授权

US08535702B2 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
标题翻译：具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置
公开(公告)号：US08535702B2
公开(公告)日：2013-09-17
申请号：US11048616
申请日：2005-02-01
申请人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
发明人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

5. 发明授权

US07767220B2 Implantable or insertable medical articles having covalently modified, biocompatible surfaces 有权
标题翻译：具有共价修饰的生物相容表面的可植入或可插入的医疗制品
公开(公告)号：US07767220B2
公开(公告)日：2010-08-03
申请号：US10830772
申请日：2004-04-23
申请人： Shrirang V. Ranade , Michael N. Helmus
发明人： Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/02 , A61F2/00 , A61K47/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2400/18
摘要： Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between 20 and 30 dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced thromboresistance, relative to other surfaces.
摘要翻译：可植入或可插入的医疗装置包括通过共价地将分子种类（或分子种类的组合）共价连接到其上的表面区域。选择分子种类，使得所得到的改性表面区域具有20至30达因/厘米的临界表面能。在某些实施方案中，共价偶联的分子种类包含一个或多个甲基。本发明的一个优点是提供了新的医疗装置，其具有表面具有临界表面能值，该表面已显示出相对于其它表面显示增强的生物相容性，包括增强的血栓阻力。

6. 发明授权

US08067026B2 Drug release regions for medical devices, which include polycyclic-structure-containing polymers 有权
标题翻译：用于医疗器械的药物释放区域，其包括含多环结构的聚合物
公开(公告)号：US08067026B2
公开(公告)日：2011-11-29
申请号：US11079621
申请日：2005-03-14
申请人： Shrirang V. Ranade , Michael N. Helmus , Robert E. Richard
发明人： Shrirang V. Ranade , Michael N. Helmus , Robert E. Richard
IPC分类号： A61F2/02 , A61F13/00 , A61F2/00 , A61F2/01 , A61F2/24
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

7. 发明授权

US07625552B2 Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces 有权
标题翻译：用于向疏水性医疗用品表面赋予生物活性的生物活性聚合物
公开(公告)号：US07625552B2
公开(公告)日：2009-12-01
申请号：US11442773
申请日：2006-05-30
申请人： Michael N. Helmus , Paul Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Paul Valint , Shrirang V. Ranade
IPC分类号： A61K38/05 , A61K38/06 , A61K38/08 , A61K38/16 , A61K31/727 , A61K31/785 , C08G63/91
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/236 , A61L2300/25
摘要： According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.
摘要翻译：根据本发明的一个方面，提供了生物活性聚合物，其具有（a）亲水性生物活性部分和（b）通过含有链转移剂的共价键与亲水生物活性部分连接的至少一个疏水性聚合物基团残留物根据本发明的另一方面，通过用包含这种生物活性聚合物的涂层材料涂覆医疗制品来提供生物活性表面。

8. 发明授权

US08052989B2 Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology 失效
标题翻译：将碳纳米管装入医疗器具，碳纳米管医疗器具和使用碳纳米管技术涂覆的医疗器具的方法
公开(公告)号：US08052989B2
公开(公告)日：2011-11-08
申请号：US12644939
申请日：2009-12-22
申请人： Shrirang V. Ranade
发明人： Shrirang V. Ranade
IPC分类号： A61K6/083 , A61F2/00 , A61F2/82 , B05D3/00
CPC分类号： A61L27/303 , A61L27/54 , A61L29/103 , A61L29/16 , A61L31/084 , B82Y30/00 , Y10S977/742 , Y10S977/746 , Y10S977/752
摘要： A method of coating a medical device, such as a stent or balloon. The method comprises assembling an array of vertically-oriented carbon nanotubes on a surface of the medical device and contacting the array of carbon nanotubes with a liquid. The liquid is evaporated to form a cellular foam made of carbon nanotubes. The liquid may contain a bioactive agent. Also described are medical devices having a coating of cellular foam that is made of carbon nanotubes.
摘要翻译：一种涂覆医疗装置（例如支架或气囊）的方法。该方法包括在医疗装置的表面上组装垂直取向的碳纳米管阵列，并使碳纳米管阵列与液体接触。将液体蒸发以形成由碳纳米管制成的多孔泡沫。液体可含有生物活性剂。还描述了具有由碳纳米管制成的细胞泡沫涂层的医疗装置。

9. 发明授权

US07964209B2 Orienting polymer domains for controlled drug delivery 失效
标题翻译：定向聚合物结构域用于受控药物递送
公开(公告)号：US07964209B2
公开(公告)日：2011-06-21
申请号：US11005852
申请日：2004-12-07
申请人： Shrirang V. Ranade , Robert E. Richard , Kinh-Luan (Lenny) D. Dao , Samuel P. Gido , Akinbode Idowu Isaacs-Sodeye
发明人： Shrirang V. Ranade , Robert E. Richard , Kinh-Luan (Lenny) D. Dao , Samuel P. Gido , Akinbode Idowu Isaacs-Sodeye
IPC分类号： A61F13/00 , A61F2/00 , B05D3/02 , A61M31/00
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphase separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices formed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，所述聚合物组合物包含彼此不混溶的两个或更多个微相分离的聚合物区域，并且通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。本发明的其它方面涉及由上述技术形成的医疗装置。

10. 发明授权

US07988987B2 Medical devices containing crazed polymeric release regions for drug delivery 失效
标题翻译：包含用于药物递送的疯狂聚合物释放区域的医疗装置
公开(公告)号：US07988987B2
公开(公告)日：2011-08-02
申请号：US11042038
申请日：2005-01-25
申请人： Shrirang V. Ranade
发明人： Shrirang V. Ranade
IPC分类号： A61F2/02
CPC分类号： A61L31/14 , A61K9/0024 , A61K9/2027 , A61L31/16 , A61L2300/00 , C08J5/00
摘要： A medical device that contains (a) at least one polymeric release region that either contains crazing or which is adapted to undergo crazing as a result of stresses (e.g., mechanical, chemical or thermal) that are applied during the implantation or insertion of the medical device into a patient; and (b) and a therapeutic agent disposed beneath or within the polymeric release region.
摘要翻译：一种医疗装置，其包含（a）至少一个聚合物释放区域，其包含裂纹，或者由于在植入或插入医疗过程中施加的应力（例如机械，化学或热）而适应于经历龟裂装置进入病人; 和（b）和设置在聚合物释放区域下面或内部的治疗剂。

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