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1. 发明授权

US08535702B2 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
标题翻译：具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置
公开(公告)号：US08535702B2
公开(公告)日：2013-09-17
申请号：US11048616
申请日：2005-02-01
申请人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
发明人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

2. 发明授权

US08067026B2 Drug release regions for medical devices, which include polycyclic-structure-containing polymers 有权
标题翻译：用于医疗器械的药物释放区域，其包括含多环结构的聚合物
公开(公告)号：US08067026B2
公开(公告)日：2011-11-29
申请号：US11079621
申请日：2005-03-14
申请人： Shrirang V. Ranade , Michael N. Helmus , Robert E. Richard
发明人： Shrirang V. Ranade , Michael N. Helmus , Robert E. Richard
IPC分类号： A61F2/02 , A61F13/00 , A61F2/00 , A61F2/01 , A61F2/24
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

3. 发明授权

US08870814B2 Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent 有权
标题翻译：可植入或可插入的含有共聚物的硅氧烷共聚物，用于治疗剂的控制递送
公开(公告)号：US08870814B2
公开(公告)日：2014-10-28
申请号：US10632008
申请日：2003-07-31
申请人： Robert E. Richard , Marlene C. Schwarz , Frederick H. Strickler
发明人： Robert E. Richard , Marlene C. Schwarz , Frederick H. Strickler
IPC分类号： A61K9/22 , A61M37/00 , A61L33/00 , A61L31/10 , A61L31/06 , A61L29/06 , A61L29/08 , A61L31/16 , A61L29/16 , A61K9/00
CPC分类号： A61K9/0024 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/602 , C08L83/04
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises a silicone copolymer that contains a plurality of siloxane units and a plurality of non-siloxane units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区域还包含含有多个硅氧烷单元和多个非硅氧烷单元的硅氧烷共聚物。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

4. 发明授权

US08992512B2 Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species 有权
标题翻译：具有聚合物区域的医疗器械具有含有烃和含杂原子的单体物质的共聚物
公开(公告)号：US08992512B2
公开(公告)日：2015-03-31
申请号：US13314726
申请日：2011-12-08
申请人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
发明人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
IPC分类号： A61K9/22 , A61F2/00 , C08F8/00 , C08F297/02 , A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/08 , A61L31/10
CPC分类号： A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/10 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包含以下物质的共聚物：（a）一种或多种不饱和烃单体物质和（b）一种或多种含杂原子的单体物质。

5. 发明授权

US08075906B2 Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species 有权
标题翻译：具有聚合物区域的医疗器械具有含有烃和含杂原子的单体物质的共聚物
公开(公告)号：US08075906B2
公开(公告)日：2011-12-13
申请号：US11048613
申请日：2005-02-01
申请人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
发明人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
IPC分类号： A61F2/24 , A61M1/12
CPC分类号： A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/10 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包含以下物质的共聚物：（a）一种或多种不饱和烃单体物质和（b）一种或多种含杂原子的单体物质。

6. 发明授权

US07964209B2 Orienting polymer domains for controlled drug delivery 失效
标题翻译：定向聚合物结构域用于受控药物递送
公开(公告)号：US07964209B2
公开(公告)日：2011-06-21
申请号：US11005852
申请日：2004-12-07
申请人： Shrirang V. Ranade , Robert E. Richard , Kinh-Luan (Lenny) D. Dao , Samuel P. Gido , Akinbode Idowu Isaacs-Sodeye
发明人： Shrirang V. Ranade , Robert E. Richard , Kinh-Luan (Lenny) D. Dao , Samuel P. Gido , Akinbode Idowu Isaacs-Sodeye
IPC分类号： A61F13/00 , A61F2/00 , B05D3/02 , A61M31/00
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphase separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices formed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，所述聚合物组合物包含彼此不混溶的两个或更多个微相分离的聚合物区域，并且通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。本发明的其它方面涉及由上述技术形成的医疗装置。

7. 发明授权

US09114199B2 Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent 有权
标题翻译：含有丙烯酸共聚物的可植入或可插入的医疗器械用于治疗剂的控制递送
公开(公告)号：US09114199B2
公开(公告)日：2015-08-25
申请号：US10632061
申请日：2003-07-31
申请人： Robert E. Richard , Marlene C. Schwarz
发明人： Robert E. Richard , Marlene C. Schwarz
IPC分类号： A61L31/10 , A61L27/34 , C08L53/02 , A61L31/16 , A61L27/54 , A61L29/08 , A61L29/16
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , C08L53/02
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises an acrylic copolymer, which comprises (i) a plurality of rubbery acrylic units and (ii) a plurality of hard units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区还包括丙烯酸共聚物，其包含（i）多个橡胶状丙烯酸单元和（ii）多个硬单元。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

8. 发明授权

US07727541B2 Medical devices having polymeric regions based on vinyl ether block copolymers 失效
标题翻译：具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置
公开(公告)号：US07727541B2
公开(公告)日：2010-06-01
申请号：US11436813
申请日：2006-05-18
申请人： Robert E. Richard , Marlene C. Schwarz , Mark Boden
发明人： Robert E. Richard , Marlene C. Schwarz , Mark Boden
IPC分类号： A61F2/86 , A61F2/82 , A61K47/32
CPC分类号： A61L27/34 , A61L27/16 , A61L31/10 , C08L53/00 , C08L35/08
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。嵌段共聚物包括（a）含有至少一种高Tg乙烯基醚单体的至少一种高Tg（玻璃化转变温度）聚合物嵌段和（b）含有至少一种低Tg乙烯基醚单体的至少一种低Tg聚合物嵌段。

9. 发明授权

US07939094B2 Multiphase polymeric drug release region 失效
标题翻译：多相聚合物药物释放区
公开(公告)号：US07939094B2
公开(公告)日：2011-05-10
申请号：US10175526
申请日：2002-06-19
申请人： Marlene C. Schwarz , Robert E. Richard
发明人： Marlene C. Schwarz , Robert E. Richard
IPC分类号： A61F2/00 , A61K47/32 , A61K9/14
CPC分类号： A61L31/10 , A61K9/0024 , A61K31/337 , A61L31/16 , A61L2300/602
摘要： A method is provided for modulating the rate of release of a therapeutic agent from a release region, which constitutes at least a portion of an implantable or insertable medical device and which controls the rate at which the therapeutic is released from the medical device. The method comprises: (a) providing a release region that comprises (i) a therapeutic agent and (ii) polymer composition comprising two or more immiscible phases; and (b) modulating the rate of release of the therapeutic agent by changing the volume that is occupied by at least one of the immiscible polymer phases relative to the total volume of the release region that is formed. The release region can be, for example, a carrier layer, which comprises the therapeutic agent, or a barrier layer, which is disposed over a region that contains the therapeutic agent. In preferred embodiments, the release region is formed by a process comprising: (a) providing a solution comprising (i) a solvent and (ii) the polymer composition; and (b) forming the release region from the solution by removing the solvent from the solution.
摘要翻译：提供了一种用于调节治疗剂从释放区域的释放速率的方法，该释放区域构成可植入或可插入的医疗装置的至少一部分并且其控制治疗剂从医疗装置释放的速率。该方法包括：（a）提供释放区，其包含（i）治疗剂和（ii）包含两个或更多个不混溶相的聚合物组合物; 和（b）相对于形成的释放区域的总体积，通过改变至少一个不混溶的聚合物相占据的体积来调节治疗剂的释放速率。释放区域可以是例如包含治疗剂的载体层或设置在含有治疗剂的区域上的阻挡层。在优选的实施方案中，通过包括以下方法形成释放区域：（a）提供包含（i）溶剂和（ii）聚合物组合物的溶液; 和（b）通过从溶液中除去溶剂从溶液中形成释放区。

10. 发明申请

US20080311173A1 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DELIVERY OF A THERAPEUTIC AGENT 审中-公开
标题翻译：用于控制输送治疗药物的可植入或插入式医疗装置
公开(公告)号：US20080311173A1
公开(公告)日：2008-12-18
申请号：US12192879
申请日：2008-08-15
申请人： Marlene C. Schwarz , Robert E. Richard
发明人： Marlene C. Schwarz , Robert E. Richard
IPC分类号： A61K9/22 , A61M1/00 , A61P43/00 , A61F2/06 , A61M25/10 , A61M25/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/56 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602
摘要： The present invention is directed to novel implantable or insertable medical devices that provide release of a therapeutic agent. According to a first aspect of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an implantable or insertable medical device; (b) a release layer disposed over at least a portion of the implantable or insertable medical device, and (c) a therapeutic agent. The release layer regulates the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. The release layer comprises (i) a first polymer comprising one or more polymer chains that form one or more polymer phase domains when the first polymer is in a pure solid-state form; and (ii) a second polymer comprising two or more polymer chains that form two or more phase domains when the second polymer is in a pure solid-state form. The first and second polymers are preferably selected such that at least one polymer chain in the second polymer is compatible with at least one polymer chain in the first polymer. The present invention is also directed to methods of forming the above implantable or insertable medical devices, methods of administering a therapeutic agent to a patient using such devices, and methods of modulating the release of therapeutic agents from implantable or insertable medical devices.
摘要翻译：本发明涉及提供治疗剂释放的新型可植入或可插入的医疗装置。根据本发明的第一方面，提供了一种治疗剂释放医疗装置，其包括：（a）可植入或可插入的医疗装置; （b）设置在所述可植入或可插入医疗装置的至少一部分上的释放层，和（c）治疗剂。释放层调节在将装置植入或插入患者体内治疗剂从医疗装置释放的速率。释放层包含（i）第一聚合物，其包含当第一聚合物处于纯固态形式时形成一个或多个聚合物相域的一个或多个聚合物链; 和（ii）当第二聚合物处于纯固态形式时，包含两个或更多个形成两个或多个相域的聚合物链的第二聚合物。优选选择第一和第二聚合物，使得第二聚合物中的至少一个聚合物链与第一聚合物中的至少一个聚合物链相容。本发明还涉及形成上述可植入或可插入的医疗装置的方法，使用这种装置向患者施用治疗剂的方法，以及调节治疗剂从可植入或可插入医疗装置释放的方法。

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