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1. 发明授权

US08221783B2 Medical devices with triggerable bioadhesive material 有权
标题翻译：具有可触发生物粘附材料的医疗设备
公开(公告)号：US08221783B2
公开(公告)日：2012-07-17
申请号：US12207839
申请日：2008-09-10
申请人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
IPC分类号： C08B37/08 , C08L71/02 , A61K47/36 , A61K47/42 , A61K9/70 , A61K9/00 , A61K31/337 , A61K31/436 , A61K47/38 , A61F2/02 , C07K14/78 , C08F210/00 , C08G63/06 , C08G67/00 , C08G73/00 , C08G73/10
CPC分类号： A61L31/145 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416
摘要： Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
摘要翻译：本文描述的是可植入医疗装置，其包括生物相容性聚合物，其包含可触发的生物粘合性质，其允许该装置粘附于身体组织。可以通过暴露于刺激物来触发或激活聚合物的可触发生物粘合性质。此外，本发明涉及制造包括生物相容性聚合物的可植入医疗装置的方法，所述生物相容性聚合物包含允许装置粘附于身体组织的可触发的生物粘合性质。

2. 发明申请

US20110014264A1 Medical Devices Having Nanostructured Regions For Controlled Tissue Biocompatibility And Drug Delivery 审中-公开
标题翻译：具有控制组织生物相容性和药物递送的纳米结构区域的医疗器械
公开(公告)号：US20110014264A1
公开(公告)日：2011-01-20
申请号：US12888864
申请日：2010-09-23
申请人： Michael N. Helmus , Yixin Xu , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Shrirang V. Ranade
IPC分类号： A61F2/82 , A61M31/00 , A61K38/02 , A61K31/726 , A61P43/00 , A61P35/00
CPC分类号： B82Y30/00 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/252 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/624 , A61N1/05 , B82Y5/00
摘要： According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions.
摘要翻译：根据本发明的某些方面，提供了可植入或可插入的医疗装置，其包含一个或多个纳米多孔区域，其可以进一步包括互连的纳米孔。本发明的其它方面涉及含有一个或多个纳米结构区域的可植入或可插入的医疗装置，其通过多种方法形成。本发明的另外其它方面涉及具有纳米纹理表面区域的可植入或可插入的医疗装置，其中提供细胞粘附促进生物分子（例如，糖胺聚糖，蛋白聚糖，细胞粘附肽和粘合蛋白），其中，纳米纹理表面区域。

3. 发明申请

US20090098176A1 MEDICAL DEVICES WITH TRIGGERABLE BIOADHESIVE MATERIAL 有权
标题翻译：具有可触发生物材料的医疗器械
公开(公告)号：US20090098176A1
公开(公告)日：2009-04-16
申请号：US12207839
申请日：2008-09-10
申请人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
IPC分类号： A61K47/30 , C08G73/02 , C08F226/08 , C08B1/00 , C08B37/04 , C08B37/08 , C08L71/02 , A61K47/36 , A61K47/42 , A61F2/02 , A61K9/70 , A61K9/00 , A61K31/337 , A61K31/436 , A61K47/38 , C07K14/78 , C08F210/00 , C08G63/06 , C08G67/00 , C08G73/00 , C08G73/10
CPC分类号： A61L31/145 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416
摘要： Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
摘要翻译：本文描述的是可植入医疗装置，其包括生物相容性聚合物，其包含可触发的生物粘合性质，其允许该装置粘附于身体组织。可以通过暴露于刺激物来触发或激活聚合物的可触发生物粘附性质。此外，本发明涉及制造包括生物相容性聚合物的可植入医疗装置的方法，所述生物相容性聚合物包含允许装置粘附于身体组织的可触发的生物粘合性质。

4. 发明授权

US08535702B2 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
标题翻译：具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置
公开(公告)号：US08535702B2
公开(公告)日：2013-09-17
申请号：US11048616
申请日：2005-02-01
申请人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
发明人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

5. 发明授权

US07767220B2 Implantable or insertable medical articles having covalently modified, biocompatible surfaces 有权
标题翻译：具有共价修饰的生物相容表面的可植入或可插入的医疗制品
公开(公告)号：US07767220B2
公开(公告)日：2010-08-03
申请号：US10830772
申请日：2004-04-23
申请人： Shrirang V. Ranade , Michael N. Helmus
发明人： Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/02 , A61F2/00 , A61K47/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2400/18
摘要： Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between 20 and 30 dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced thromboresistance, relative to other surfaces.
摘要翻译：可植入或可插入的医疗装置包括通过共价地将分子种类（或分子种类的组合）共价连接到其上的表面区域。选择分子种类，使得所得到的改性表面区域具有20至30达因/厘米的临界表面能。在某些实施方案中，共价偶联的分子种类包含一个或多个甲基。本发明的一个优点是提供了新的医疗装置，其具有表面具有临界表面能值，该表面已显示出相对于其它表面显示增强的生物相容性，包括增强的血栓阻力。

6. 发明授权

US08067026B2 Drug release regions for medical devices, which include polycyclic-structure-containing polymers 有权
标题翻译：用于医疗器械的药物释放区域，其包括含多环结构的聚合物
公开(公告)号：US08067026B2
公开(公告)日：2011-11-29
申请号：US11079621
申请日：2005-03-14
申请人： Shrirang V. Ranade , Michael N. Helmus , Robert E. Richard
发明人： Shrirang V. Ranade , Michael N. Helmus , Robert E. Richard
IPC分类号： A61F2/02 , A61F13/00 , A61F2/00 , A61F2/01 , A61F2/24
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

7. 发明授权

US07625552B2 Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces 有权
标题翻译：用于向疏水性医疗用品表面赋予生物活性的生物活性聚合物
公开(公告)号：US07625552B2
公开(公告)日：2009-12-01
申请号：US11442773
申请日：2006-05-30
申请人： Michael N. Helmus , Paul Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Paul Valint , Shrirang V. Ranade
IPC分类号： A61K38/05 , A61K38/06 , A61K38/08 , A61K38/16 , A61K31/727 , A61K31/785 , C08G63/91
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/236 , A61L2300/25
摘要： According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.
摘要翻译：根据本发明的一个方面，提供了生物活性聚合物，其具有（a）亲水性生物活性部分和（b）通过含有链转移剂的共价键与亲水生物活性部分连接的至少一个疏水性聚合物基团残留物根据本发明的另一方面，通过用包含这种生物活性聚合物的涂层材料涂覆医疗制品来提供生物活性表面。

8. 发明申请

US20090068271A1 EMBOLIZATION PARTICLES 审中-公开
标题翻译：嵌合颗粒
公开(公告)号：US20090068271A1
公开(公告)日：2009-03-12
申请号：US12179115
申请日：2008-07-24
申请人： Paul DiCarlo , Barron W. Tenney , Yixin Xu , Michael N. Helmus
发明人： Paul DiCarlo , Barron W. Tenney , Yixin Xu , Michael N. Helmus
IPC分类号： A61K9/14 , B32B15/02 , B32B27/02
CPC分类号： A61K9/1635 , A61K9/146 , Y10T428/2933 , Y10T428/2935 , Y10T428/2936 , Y10T428/294 , Y10T428/298
摘要： Embolic particles, embolic particle chains, and methods for making embolic particles and embolic particle chains are described.
摘要翻译：描述了栓塞颗粒，栓塞颗粒链和制备栓塞颗粒和栓塞颗粒链的方法。

9. 发明授权

US08574615B2 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 有权
标题翻译：具有用于受控治疗剂递送的纳米多孔涂层的医疗装置
公开(公告)号：US08574615B2
公开(公告)日：2013-11-05
申请号：US12787209
申请日：2010-05-25
申请人： Barron Tenney , Yixin Xu , Michael N. Helmus
发明人： Barron Tenney , Yixin Xu , Michael N. Helmus
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/30767 , A61F2/82 , A61F2/91 , A61F2002/30677 , A61F2002/3068 , A61F2002/3084 , A61F2210/0076 , A61F2250/0068 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/375 , B82Y30/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含（a）含有至少一种治疗剂的一种或多种凹陷，和（b）在含治疗剂的凹陷上设置的纳米多孔涂层，其调节物质在含治疗剂的凹陷和装置的外部之间的运输。可植入或可插入的装置被配置为预防仅仅药物递送的作用，例如在体内提供机械和/或电功能等功能。本发明的一个优点是可以提供医疗装置，其释放的量远远超过纳米多孔涂层内的空隙体积，同时提供延伸超出药物递送的功能。这种释放可以进一步接近或实现零级动力学药物释放曲线。

10. 发明申请

US20080102194A1 METHOD AND APPARATUS FOR COATING A MEDICAL DEVICE BY ELECTROLESS PLATING 审中-公开
标题翻译：通过电镀法涂敷医疗器械的方法和装置
公开(公告)号：US20080102194A1
公开(公告)日：2008-05-01
申请号：US11860866
申请日：2007-09-25
申请人： Michael N. Helmus , Yixin Xu , John Benco
发明人： Michael N. Helmus , Yixin Xu , John Benco
IPC分类号： B05D1/18 , A61F2/06
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/606 , A61L2420/02 , C23C18/1644 , C23C18/1662 , C23C18/44
摘要： Methods and apparatus for coating surfaces of medical devices by electroless plating are disclosed. In one embodiment, the invention includes a coating method in which a therapeutic agent and a plating material are plated onto the surface of the medical device by an electroless plating chemical reaction. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in a soluble plating solution and plating a plating material onto the medical device by electroless plating wherein the plated material contains the suspended therapeutic agent. In another embodiment, a coating method is provided wherein the coating is formed by initially bonding a therapeutic agent to a plating material, and then plating the bonded therapeutic agent/plating material onto the medical device by electroless plating. In another embodiment, an additive is introduced to the soluble plating solution to regulate the chemical reaction of electroless plating. In another embodiment, a coating method is provided wherein the surface of the medical device is treated, e.g. creating a porous surface layer, to increase the amount of the therapeutic agent that may be plated onto the medical device by electroless plating. The coating is formed by plating a therapeutic agent into and/or onto the porous surface layer. These methods and apparatus are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.
摘要翻译：公开了通过化学镀涂覆医疗器械表面的方法和装置。在一个实施方案中，本发明包括通过化学镀化学反应将治疗剂和电镀材料镀在医疗装置的表面上的涂布方法。在另一个实施方案中，公开了一种涂覆方法，其中通过将治疗剂悬浮在可溶性电镀溶液中并通过化学镀将电镀材料镀覆到医疗装置上而形成涂层，其中电镀材料含有悬浮治疗剂。在另一个实施方案中，提供了涂覆方法，其中通过首先将治疗剂粘合到电镀材料上形成所述涂层，然后通过无电镀将所述结合的治疗剂/电镀材料电镀到所述医疗装置上。在另一个实施方案中，将添加剂引入到可溶性电镀溶液中以调节化学镀的化学反应。在另一个实施例中，提供一种涂覆方法，其中治疗医疗装置的表面，例如，产生多孔表面层，以通过无电镀来增加可镀在医疗装置上的治疗剂的量。通过将治疗剂镀在多孔表面层中和/或之上而形成涂层。这些方法和装置用于同时或按顺序施加一种或多种涂层材料。在本发明的某些实施方案中，涂层材料包括治疗剂和阳离子药物。

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