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    • 3. 发明授权
    • Instruments for measuring nanoparticle exposure
    • 用于测量纳米颗粒暴露的仪器
    • US07812306B2
    • 2010-10-12
    • US11439451
    • 2006-05-23
    • Heinz FissanAndreas TrampeDavid Y. H. PuiStanley L. Kaufman
    • Heinz FissanAndreas TrampeDavid Y. H. PuiStanley L. Kaufman
    • H01J49/00
    • G01N27/622B03C3/017B03C3/09B03C3/12B03C3/38B03C3/41B03C3/47G01N15/0266G01N23/00G01N2015/0038
    • An instrument for non-invasively measuring nanoparticle exposure includes a corona discharge element generating ions to effect unipolar diffusion charging of an aerosol, followed by an ion trap for removing excess ions and a portion of the charged particles with electrical mobilities above a threshold. Downstream, an electrically conductive HEPA filter or other collecting element accumulates the charged particles and provides the resultant current to an electrometer amplifier. The instrument is tunable to alter the electrometer amplifier output toward closer correspondence with a selected function describing particle behavior, e.g. nanoparticle deposition in a selected region of the respiratory system. Tuning entails adjusting voltages applied to one or more of the ion trap, the corona discharge element and the collecting element. Alternatively, tuning involves adjusting the aerosol flow rate, either directly or in comparison to the flow rate of a gas conducting the ions toward merger with the aerosol.
    • 用于非侵入性地测量纳米颗粒暴露的仪器包括产生离子以实现气溶胶的单极扩散充电的电晕放电元件,随后是用于去除过量离子的离子阱和一部分电荷迁移率高于阈值的带电粒子。 下游,导电HEPA过滤器或其他收集元件累积带电粒子并将合成电流提供给静电计放大器。 该仪器是可调谐的,以改变静电计放大器输出,使其与所选择的描述粒子行为的函数更接近地对应,例如。 在呼吸系统的选定区域中的纳米颗粒沉积。 调谐需要调整施加到一个或多个离子阱,电晕放电元件和收集元件的电压。 或者,调整包括直接或与将离子导向与气溶胶合并的气体的流速相比调节气溶胶流速。
    • 4. 发明授权
    • Instrument for measuring and classifying nanometer aerosols
    • 用于测量和分类纳米气溶胶的仪器
    • US06230572B1
    • 2001-05-15
    • US09249723
    • 1999-02-12
    • David Y. H. PuiDa-Ren ChenFrederick R. QuantGilmore J. SemHeinz FissanDetlef HummesFrank Dorman
    • David Y. H. PuiDa-Ren ChenFrederick R. QuantGilmore J. SemHeinz FissanDetlef HummesFrank Dorman
    • G01N100
    • B82Y15/00G01N15/0266Y10S977/88Y10S977/881Y10S977/958
    • An apparatus for classifying polydisperse aerosols includes aerosol and sheath gas conduits for conducting a sample aerosol and a sheath gas toward a merger area. At the merger area the sheath gas and about ten percent of the sample aerosol merge, then travel through a differential mobility analyzer (DMA) and along a tubular electrode of the DMA. Selected particles, i.e. particles having electrical mobilities within a narrow range, pass through a collection aperture of the electrode. The DMA output, an aerosol consisting of the selected particles, is provided to a condensation particle counter or other device for determining the aerosol concentration. The remainder of the sample aerosol is conducted away from the merger area along a bypass flow conduit. The bypass flow and an improved aerodynamic design provide for a slit at the merger area that is sufficiently narrow to minimize unwanted electric field penetration at the slit and DMA entrance. An annular flow restriction feature in the bypass conduit promotes and maintains laminar, uniform-velocity flow near the slit. The collection aperture is located medially along the tubular electrode, to prevent electrical field fringing near the aperture.
    • 用于分类多分散气溶胶的装置包括用于将样品气溶胶和护套气体导向合并区域的气溶胶和鞘气导管。 在合并区域,护套气体和约10%的样品气溶胶合并,然后通过差示迁移率分析仪(DMA)和DMA的管状电极行进。 所选择的粒子,即具有窄范围内的电迁移率的粒子通过电极的收集孔。 将DMA输出(由所选颗粒组成的气溶胶)提供给冷凝颗粒计数器或用于确定气溶胶浓度的其它装置。 样品气溶胶的其余部分沿旁路流动导管远离合并区域。 旁路流动和改进的空气动力学设计为合并区域的狭缝提供足够窄的狭缝,以最小化狭缝和DMA入口处的不需要的电场穿透。 旁通管道中的环形流动限制特征促进并维持狭缝附近的层流均匀的流速。 收集孔沿着管状电极向内定位,以防止孔附近的电场边缘。
    • 7. 发明申请
    • Instruments for measuring nanoparticle exposure
    • 用于测量纳米颗粒暴露的仪器
    • US20060284077A1
    • 2006-12-21
    • US11439451
    • 2006-05-23
    • Heinz FissanAndreas TrampeDavid PuiStanley Kaufman
    • Heinz FissanAndreas TrampeDavid PuiStanley Kaufman
    • H01J49/00
    • G01N27/622B03C3/017B03C3/09B03C3/12B03C3/38B03C3/41B03C3/47G01N15/0266G01N23/00G01N2015/0038
    • An instrument for non-invasively measuring nanoparticle exposure includes a corona discharge element generating ions to effect unipolar diffusion charging of an aerosol, followed by an ion trap for removing excess ions and a portion of the charged particles with electrical mobilities above a threshold. Downstream, an electrically conductive HEPA filter or other collecting element accumulates the charged particles and provides the resultant current to an electrometer amplifier. The instrument is tunable to alter the electrometer amplifier output toward closer correspondence with a selected function describing particle behavior, e.g. nanoparticle deposition in a selected region of the respiratory system. Tuning entails adjusting voltages applied to one or more of the ion trap, the corona discharge element and the collecting element. Alternatively, tuning involves adjusting the aerosol flow rate, either directly or in comparison to the flow rate of a gas conducting the ions toward merger with the aerosol.
    • 用于非侵入性地测量纳米颗粒暴露的仪器包括产生离子以实现气溶胶的单极扩散充电的电晕放电元件,随后是用于去除过量离子的离子阱和一部分电荷迁移率高于阈值的带电粒子。 下游,导电HEPA过滤器或其他收集元件累积带电粒子并将合成电流提供给静电计放大器。 该仪器是可调谐的,以改变静电计放大器输出,使其与所选择的描述粒子行为的函数更接近地对应,例如。 在呼吸系统的选定区域中的纳米颗粒沉积。 调谐需要调整施加到一个或多个离子阱,电晕放电元件和收集元件的电压。 或者,调整包括直接或与将离子导向与气溶胶合并的气体的流速相比调节气溶胶流速。