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1. 发明申请

US20060273049A1 Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles 有权
标题翻译：用于从包括大颗粒的多组分材料分离和浓缩组分的方法和装置
公开(公告)号：US20060273049A1
公开(公告)日：2006-12-07
申请号：US11441275
申请日：2006-05-25
申请人： Michael Leach , Joel Higgins , Matthew Swift , Nathan Gordon
发明人： Michael Leach , Joel Higgins , Matthew Swift , Nathan Gordon
IPC分类号： C02F1/38
CPC分类号： A61K35/12 , A61M1/3693 , B01L3/502 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2300/0681 , B01L2400/0409 , B01L2400/0478 , B01L2400/0605 , G01N33/491
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：允许分离和收集一部分样品的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了一种从全骨样细胞和骨髓间充质干细胞中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

2. 发明申请

US20060273050A1 Apparatus and method for separating and concentrating fluids containing multiple components 有权
公开(公告)号：US20060273050A1
公开(公告)日：2006-12-07
申请号：US11441276
申请日：2006-05-25
申请人： Joel Higgins , Matthew Swift , Nathan Gordon , Barry Hecker
发明人： Joel Higgins , Matthew Swift , Nathan Gordon , Barry Hecker
IPC分类号： C02F1/38
CPC分类号： B01D17/12 , B01D17/0217 , B01D21/262 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478 , G01N33/491
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

3. 发明申请

US20060051865A1 Systems and methods for isolating stromal cells from adipose tissue and uses thereof 审中-公开
标题翻译：用于从脂肪组织分离基质细胞的系统和方法及其用途
公开(公告)号：US20060051865A1
公开(公告)日：2006-03-09
申请号：US11217087
申请日：2005-08-31
申请人： Joel Higgins , Michael Leach , Felipe Palacios , Nicolaas Vermeulen
发明人： Joel Higgins , Michael Leach , Felipe Palacios , Nicolaas Vermeulen
IPC分类号： C12N5/08
CPC分类号： C12M45/07 , A61K35/28 , A61L27/3834 , C12M45/05 , C12M47/04 , C12N5/0667
摘要： Methods of isolating cells from adipose tissue that have potential to differentiate into cells of mesenchymal origin, including cells of chondrogenic, osteogenic, adipogenic, and/or myogenic origin, comprising: (a) subjecting adipose tissue to an electromagnetic, sonic, or other wave energy source; and (b) centrifuging the tissue to form a pellet comprising stem cells. In various embodiments, the method is carried out without any enzymatic digestion of the adipose tissue. In other embodiments, the method additionally comprises enzymatically digesting the tissue. In various embodiments, methods comprise subjecting the tissue to ultrasonic energy. In some embodiments, the method does not comprise enzymatic digestion of the adipose tissue. In other embodiments, the method additionally comprises enzymatically digesting the tissue. Methods are also provided for intraoperative harvest and delivery of autologous stem cells to the site of acute or chronic wounds. In one embodiment, an autologous supply of stem cells is provided for operative use.
摘要翻译：从具有潜在分化成间充质来源的细胞的脂肪组织分离细胞的方法，包括软骨形成，成骨，脂肪形成和/或肌原性来源的细胞，包括：（a）使脂肪组织进行电磁，声波或其它波能量源; 和（b）离心组织以形成包含干细胞的丸粒。在各种实施方案中，该方法不进行任何酶消化的脂肪组织。在其它实施方案中，该方法还包括酶促消化组织。在各种实施例中，方法包括使组织经受超声能量。在一些实施方案中，该方法不包括脂肪组织的酶消化。在其它实施方案中，该方法还包括酶促消化组织。还提供了用于术中收获和将自体干细胞递送至急性或慢性伤口部位的方法。在一个实施例中，提供干细胞的自体供应用于操作使用。

4. 发明申请

US20050109716A1 Apparatus and method for separating and concentrating fluids containing multiple components 有权
标题翻译：用于分离和浓缩含有多种组分的流体的装置和方法
公开(公告)号：US20050109716A1
公开(公告)日：2005-05-26
申请号：US10932882
申请日：2004-09-02
申请人： Michael Leach , Jennifer Woodell-May , Joel Higgins , Brandon Miller
发明人： Michael Leach , Jennifer Woodell-May , Joel Higgins , Brandon Miller
IPC分类号： B01D21/26 , B01L3/00 , B01L3/14 , B01L99/00 , C02F1/38
CPC分类号： B01L3/502 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：允许分离和收集一部分样品的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

5. 发明授权

US07179391B2 Apparatus and method for separating and concentrating fluids containing multiple components 有权
标题翻译：用于分离和浓缩含有多种组分的流体的装置和方法
公开(公告)号：US07179391B2
公开(公告)日：2007-02-20
申请号：US10445381
申请日：2003-05-23
申请人： Michael Leach , Jennifer E. Woodell-May , Joel Higgins
发明人： Michael Leach , Jennifer E. Woodell-May , Joel Higgins
IPC分类号： B01D17/038 , B01D21/26 , B04B1/02
CPC分类号： B01L3/502 , B01D17/0217 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478 , G01N33/491 , Y10T436/25375
摘要： An apparatus that allows for separating and collecting a concentrated fraction of a fluid, such as a whole blood sample, adipose tissue, or a bone marrow sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. The apparatus includes a container to be placed to a centrifuge after being filled with a whole blood sample. A buoy or fraction separator, which has a density less than that of red blood cells of a whole blood sample, is disposed in the container. During the centrifuge process the buoy separates the red blood cells from another fraction of the whole blood. After the centrifuge process is finished a plunger is used to produce at least two other fractions, including a plasma fraction and a buffy coat. Then, the buffy coat may be removed from the container without commingling the fractions of the sample.
摘要翻译：允许分离和收集流体（例如全血样品，脂肪组织或骨髓样品）的浓缩级分的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。该装置包括在填充全血样品之后放置到离心机上的容器。将具有小于全血样品的红细胞密度的浮标或级分分离器设置在容器中。在离心机过程中，浮标将红细胞与全血的另一部分分开。离心机过程完成后，使用柱塞产生至少两个其它部分，包括血浆部分和血沉棕黄层。然后，可以将血沉棕黄层从容器中取出，而不会混合样品的部分。

6. 发明申请

US20070258956A1 Methods and apparatus for promoting hair growth using adipose cell based therapies 审中-公开
标题翻译：使用基于脂肪细胞的疗法促进头发生长的方法和装置
公开(公告)号：US20070258956A1
公开(公告)日：2007-11-08
申请号：US11417302
申请日：2006-05-02
申请人： Joel Higgins , Felipe Palacios , Nicolaas Vermeulen
发明人： Joel Higgins , Felipe Palacios , Nicolaas Vermeulen
IPC分类号： A61K35/12 , C12N5/08
CPC分类号： A61K35/28 , A61K35/35 , A61K35/36 , A61K2300/00
摘要： Methods and compositions for use in the treatment of androgenetic alopecia and other forms of hair loss by inducing and expediting the growth of hair in the scalp of a patient. Methods comprise the steps of isolating adipose-derived cells and hair follicles from the patient and implanting the combined cells and follicles into the scalp in areas requiring new growth of hair. Use of differentiated and undifferentiated adipose-derived cells with processed and grafted hair follicles for the therapeutic and cosmetic treatment of hair loss in vivo is disclosed.
摘要翻译：用于治疗雄激素性脱发和其它形式脱发的方法和组合物，其通过诱导和加速患者头皮中毛发的生长。方法包括从患者中分离脂肪来源的细胞和毛囊并将合并的细胞和卵泡植入需要头发新生长的区域中的头皮中的步骤。公开了分化和未分化脂肪来源的细胞与加工的和接种的毛囊用于体内脱发的治疗和美容治疗的用途。

7. 发明授权

US5753182A Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components 失效
标题翻译：减少超高分子量聚乙烯骨科组分中存在的自由基数量的方法
公开(公告)号：US5753182A
公开(公告)日：1998-05-19
申请号：US601080
申请日：1996-02-14
申请人： Joel Higgins
发明人： Joel Higgins
IPC分类号： A61L2/08 , A61L27/16
CPC分类号： A61L2/08 , A61L27/16 , C08L2207/068
摘要： A method for reducing the number of free radicals in an implantable medical component requiring sterilization includes the steps of packaging the component in an oxygen-resistant container, sterilizing the packaged component, and exposing the packaged and sterilized component to a gas capable of combining with free radicals. The step of packaging includes vacuum sealing the component in an oxygen barrier bag. The step of sterilizing includes exposing the packaged component to radiation such as gamma radiation. The step of exposing the packaged and sterilized component to a gas capable of combining with free radicals includes placing the packaged and sterilized component in a pressure vessel and introducing pressurized hydrogen gas into the vessel for a period of time.
摘要翻译：减少需要灭菌的可植入医疗部件中的自由基数量的方法包括以下步骤：将组分包装在耐氧容器中，对包装的组分进行灭菌，并将包装和灭菌的组分暴露于能够与自由基组合的气体激进分子包装步骤包括将部件真空密封在氧气阻隔袋中。消毒步骤包括将包装的组分暴露于诸如γ辐射的辐射。将包装和灭菌的组分暴露于能够与自由基组合的气体的步骤包括将包装和灭菌的组分放置在压力容器中并将加压的氢气引入容器中一段时间。

8. 发明申请

US20070092494A1 Composition for wound healing using lyophilized skin or skin-derived collagen 审中-公开
标题翻译：使用冻干皮肤或皮肤衍生胶原的伤口愈合组合物
公开(公告)号：US20070092494A1
公开(公告)日：2007-04-26
申请号：US11259216
申请日：2005-10-26
申请人： Joel Higgins , Jennifer Woodell-May
发明人： Joel Higgins , Jennifer Woodell-May
IPC分类号： A61K35/36
CPC分类号： A61K35/36 , A61K38/17
摘要： A wound healing composition for repairing a wound in a human or animal subject, comprising a first skin tissue material and a carrier comprising collagen derived from a second skin tissue material. Methods of making the wound healing composition and methods of augmenting a wound site with the composition are also provided.
摘要翻译：一种用于修复人或动物受试者中的伤口的伤口愈合组合物，其包含第一皮肤组织材料和包含衍生自第二皮肤组织材料的胶原的载体。还提供了制备伤口愈合组合物的方法和增加伤口部位的组合物的方法。

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