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1. 发明申请

US20110053148A1 COCCIDIOSIS VACCINES 审中-公开
标题翻译： COCCIDOOSIS VACCINES
公开(公告)号：US20110053148A1
公开(公告)日：2011-03-03
申请号：US12633426
申请日：2009-12-08
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/00
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

2. 发明授权

US07150873B2 Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US07150873B2
公开(公告)日：2006-12-19
申请号：US10723123
申请日：2003-11-26
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： A61K39/00 , A61K39/012 , C07H21/04 , C12P21/06
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

3. 发明申请

US20060051865A1 Systems and methods for isolating stromal cells from adipose tissue and uses thereof 审中-公开
标题翻译：用于从脂肪组织分离基质细胞的系统和方法及其用途
公开(公告)号：US20060051865A1
公开(公告)日：2006-03-09
申请号：US11217087
申请日：2005-08-31
申请人： Joel Higgins , Michael Leach , Felipe Palacios , Nicolaas Vermeulen
发明人： Joel Higgins , Michael Leach , Felipe Palacios , Nicolaas Vermeulen
IPC分类号： C12N5/08
CPC分类号： C12M45/07 , A61K35/28 , A61L27/3834 , C12M45/05 , C12M47/04 , C12N5/0667
摘要： Methods of isolating cells from adipose tissue that have potential to differentiate into cells of mesenchymal origin, including cells of chondrogenic, osteogenic, adipogenic, and/or myogenic origin, comprising: (a) subjecting adipose tissue to an electromagnetic, sonic, or other wave energy source; and (b) centrifuging the tissue to form a pellet comprising stem cells. In various embodiments, the method is carried out without any enzymatic digestion of the adipose tissue. In other embodiments, the method additionally comprises enzymatically digesting the tissue. In various embodiments, methods comprise subjecting the tissue to ultrasonic energy. In some embodiments, the method does not comprise enzymatic digestion of the adipose tissue. In other embodiments, the method additionally comprises enzymatically digesting the tissue. Methods are also provided for intraoperative harvest and delivery of autologous stem cells to the site of acute or chronic wounds. In one embodiment, an autologous supply of stem cells is provided for operative use.
摘要翻译：从具有潜在分化成间充质来源的细胞的脂肪组织分离细胞的方法，包括软骨形成，成骨，脂肪形成和/或肌原性来源的细胞，包括：（a）使脂肪组织进行电磁，声波或其它波能量源; 和（b）离心组织以形成包含干细胞的丸粒。在各种实施方案中，该方法不进行任何酶消化的脂肪组织。在其它实施方案中，该方法还包括酶促消化组织。在各种实施例中，方法包括使组织经受超声能量。在一些实施方案中，该方法不包括脂肪组织的酶消化。在其它实施方案中，该方法还包括酶促消化组织。还提供了用于术中收获和将自体干细胞递送至急性或慢性伤口部位的方法。在一个实施例中，提供干细胞的自体供应用于操作使用。

4. 发明申请

US20060003349A1 Tm leveling compositions 有权
标题翻译： Tm匀染组合物
公开(公告)号：US20060003349A1
公开(公告)日：2006-01-05
申请号：US11109923
申请日：2005-04-19
申请人： Robert Dempcy , Alexander Gall , Sergey Lokhov , Irina Afonina , Michael Singer , Igor Kutyavin , Nicolaas Vermeulen
发明人： Robert Dempcy , Alexander Gall , Sergey Lokhov , Irina Afonina , Michael Singer , Igor Kutyavin , Nicolaas Vermeulen
IPC分类号： C12Q1/68 , C07H21/02 , C07K14/00
CPC分类号： C07H19/06 , C07B2200/11 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , C07H21/00 , C12Q1/6832 , C40B40/00 , G06F19/22 , C12Q2525/117
摘要： Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
摘要翻译：提供了修饰的寡核苷酸，其含有选自未取代的和3-取代的吡唑并[3,4-d]嘧啶和5-取代的嘧啶的碱，并且任选具有连接的小沟结合剂和报道基团。

5. 发明申请

US20050277144A1 Compounds and methods for fluorescent labeling 有权
公开(公告)号：US20050277144A1
公开(公告)日：2005-12-15
申请号：US11127040
申请日：2005-05-10
申请人： Eugeny Lukhtanov , Alexei Vorobiev , Michael Reed , Nicolaas Vermeulen
发明人： Eugeny Lukhtanov , Alexei Vorobiev , Michael Reed , Nicolaas Vermeulen
IPC分类号： C09B11/08 , C09B19/00 , C09B57/02 , C09B57/14 , G01N33/533 , C12Q1/68 , C07D311/78 , C07K14/47
CPC分类号： C09B57/14 , C09B11/08 , C09B19/00 , C09B57/02 , G01N33/533
摘要： Dye reagents useful in labeling biological materials are provided along with methods for their use.

6. 发明授权

US06680061B1 Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US06680061B1
公开(公告)日：2004-01-20
申请号：US09749233
申请日：2000-12-27
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： A61K39012
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

7. 发明授权

US5789233A DNA encoding an Eimekia 50 KD antigen 失效
标题翻译：编码Eimekia 50 KD抗原的DNA
公开(公告)号：US5789233A
公开(公告)日：1998-08-04
申请号：US310357
申请日：1994-09-21
申请人： Arnoldus Nicolaas Vermeulen , Paul van den Boogaart , Jacobus Johannus Kok
发明人： Arnoldus Nicolaas Vermeulen , Paul van den Boogaart , Jacobus Johannus Kok
IPC分类号： C12N15/09 , A61K20060101 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/395 , A61P33/02 , C07D20060101 , C07K20060101 , C07K14/455 , C07K16/20 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/30 , C12N15/63 , C12N15/83 , C12P20060101 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K14/455 , C07K16/20 , A61K39/00
摘要： The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby protecting the chickens against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
摘要翻译：本发明涉及具有免疫原性的新颖艾美球虫蛋白以及编码这些蛋白质的DNA序列。这些蛋白质可以施用于鸡，从而保护鸡免于球虫病。此外，编码这些蛋白质的DNA可用于制备针对球虫病的载体疫苗。

8. 发明申请

US20070166723A1 Hybridization-triggered fluorescent detection of nucleic acids 失效
标题翻译：杂交荧光检测核酸
公开(公告)号：US20070166723A1
公开(公告)日：2007-07-19
申请号：US11242977
申请日：2005-10-03
申请人： Robert Dempcy , Irina Afonina , Nicolaas Vermeulen
发明人： Robert Dempcy , Irina Afonina , Nicolaas Vermeulen
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07H21/00 , C12Q1/6816 , C12Q2563/107 , C12Q2565/107 , C12Q2563/173
摘要： Compositions and methods for fluorescent detection of nucleic acids are provided. The compositions can be detected by fluorescence when hybridized to a nucleic acid containing a target sequence, but are non-fluorescent in the non-hybridized state. Alternatively, the fluorescence properties of the compositions change in a detectable manner upon hybridization to a nucleic acid containing a target sequence. Methods for synthesis and methods of use of the compositions are also provided.
摘要翻译：提供了核酸荧光检测的组合物和方法。当与含有靶序列的核酸杂交时，可以通过荧光检测组合物，但是在非杂交状态下是非荧光的。或者，当与含有靶序列的核酸杂交时，组合物的荧光特性以可检测的方式变化。还提供了合成方法和组合物的使用方法。

9. 发明授权

US07230075B1 Coccidiosis poultry vaccine 失效
标题翻译：球虫病家禽疫苗
公开(公告)号：US07230075B1
公开(公告)日：2007-06-12
申请号：US09390846
申请日：1999-09-14
申请人： Jacobus Johannes Kok , Paul van den Boogaart , Arnodus Nicolaas Vermeulen
发明人： Jacobus Johannes Kok , Paul van den Boogaart , Arnodus Nicolaas Vermeulen
IPC分类号： C07K1/00 , C07K14/00 , A01N37/18 , A61K39/00 , A61K39/38 , A61K38/00 , A61K39/012
CPC分类号： A61K39/012 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/53 , C07K14/455 , C07K16/20 , C12N9/0006
摘要： This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
摘要翻译：本发明涉及具有免疫原性的新颖艾美球虫蛋白质以及编码这些蛋白质的DNA序列。这些蛋白质可以施用于家禽，从而保护鸟类免于球虫病。此外，编码这些蛋白质的DNA可用于制备针对球虫病的载体疫苗。

10. 发明申请

US20050239121A1 Non-aggregating non-quenching oligomers comprising nucleotide analogs; methods of synthesis and use thereof 审中-公开
标题翻译：包含核苷酸类似物的非聚集性非猝灭寡聚体; 合成和使用方法
公开(公告)号：US20050239121A1
公开(公告)日：2005-10-27
申请号：US11129003
申请日：2005-05-13
申请人： Alexander Gall , Igor Kutyavin , Nicolaas Vermeulen , Robert Dempcy
发明人： Alexander Gall , Igor Kutyavin , Nicolaas Vermeulen , Robert Dempcy
IPC分类号： G01N33/53 , A61K31/519 , A61K48/00 , C07D487/04 , C07H21/00 , C07H21/04 , C07K5/06 , C07K5/078 , C07K14/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/50 , G01N33/58
CPC分类号： C07D487/04 , A61K31/519 , C07H21/00 , C07K5/06026 , C07K5/06139 , C07K14/003 , C12Q1/6818 , C12Q1/6832 , C12Q2525/107 , C12Q2525/101
摘要： The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.
摘要翻译：本发明提供使用DNA，RNA，PNA和嵌合寡聚物改进杂交分析的组合物和方法，其中一个或多个嘌呤碱基被吡唑并[5,4-d]嘧啶或7-脱氮嘌呤嘌呤类似物取代。当寡聚物以涉及杂交的各种方法使用时，获得了减少的自聚集和减少的荧光猝灭。还提供了合成方法，以及新型合成前体。

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