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1. 发明授权

US5006643A Process for preparing isothiocyanato functionalized metal complexes 失效
标题翻译：制备异硫氰酸酯官能化金属络合物的方法
公开(公告)号：US5006643A
公开(公告)日：1991-04-09
申请号：US383103
申请日：1989-07-20
申请人： Michael J. Fazio , Douglas K. Pollock , Nicolas J. Kotite
发明人： Michael J. Fazio , Douglas K. Pollock , Nicolas J. Kotite
IPC分类号： A61K47/48 , A61K49/00 , A61K51/10 , C07C331/28 , C07D257/02 , C07F15/00 , C07F19/00
CPC分类号： C07D257/02 , A61K47/48707 , A61K49/0002 , A61K51/1093 , C07C331/28 , C07F15/008 , C07F19/005 , A61K2123/00
摘要： The present invention is directed to a novel process for preparing isothiocyanate functionalized chelates by reacting amino functionalized chelates with thiophosgene.
摘要翻译：本发明涉及通过使氨基官能化螯合物与硫光气反应制备异硫氰酸酯官能化螯合物的新方法。

2. 发明授权

US5284644A Functionalized polyamine chelants and rhodium complexes thereof for conjugation to antibodies 失效
标题翻译：功能化的多胺螯合剂和铑络合物用于与抗体缀合
公开(公告)号：US5284644A
公开(公告)日：1994-02-08
申请号：US619153
申请日：1990-11-28
申请人： William J. Kruper, Jr. , William A. Fordyce , Douglas K. Pollock , Michael J. Fazio , Muthiah N. Inbaskaran , Ramaiah Muthyala
发明人： William J. Kruper, Jr. , William A. Fordyce , Douglas K. Pollock , Michael J. Fazio , Muthiah N. Inbaskaran , Ramaiah Muthyala
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07C211/14 , C07C211/49 , C07C211/50 , C07D257/02 , C07F15/00 , A61K43/00 , A61K39/00
CPC分类号： C07D257/02 , A61K47/48707 , A61K49/0002 , A61K51/1093 , C07F15/008 , A61K2123/00
摘要： A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.
摘要翻译：公开了一组与铑形成络合物的官能化多胺螯合剂。铑络合物可以连接到抗体或抗体片段上，并用于治疗或诊断目的。

3. 发明授权

US4994560A Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies 失效
标题翻译：功能化的多胺螯合剂和其放射性铑络合物用于与抗体缀合
公开(公告)号：US4994560A
公开(公告)日：1991-02-19
申请号：US65739
申请日：1987-06-24
申请人： William J. Kruper, Jr. , Douglas K. Pollock , William A. Fordyce , Michael J. Fazio , Muthiah N. Inbasekaran
发明人： William J. Kruper, Jr. , Douglas K. Pollock , William A. Fordyce , Michael J. Fazio , Muthiah N. Inbasekaran
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07C211/14 , C07C211/49 , C07C211/50 , C07D257/02 , C07F15/00
CPC分类号： C07D257/02 , A61K47/48707 , A61K49/0002 , A61K51/1093 , C07F15/008 , A61K2123/00
摘要： A group of functionalized polyamine chelants that form complexes with radioactive rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

4. 发明授权

US06177414B1 Starburst conjugates 失效
标题翻译：星爆共轭体
公开(公告)号：US06177414B1
公开(公告)日：2001-01-23
申请号：US09521409
申请日：2000-03-08
申请人： Donald A. Tomalia , William J. Kruper , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson , Donald A. Kaplan
发明人： Donald A. Tomalia , William J. Kruper , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson , Donald A. Kaplan
IPC分类号： A61K3160
CPC分类号： A01N25/10 , A61K47/59 , A61K47/6885 , A61K47/6949 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

5. 发明授权

US5527524A Dense star polymer conjugates 失效
标题翻译：密集聚合物共轭物
公开(公告)号：US5527524A
公开(公告)日：1996-06-18
申请号：US43198
申请日：1993-04-05
申请人： Donald A. Tomalia , Larry R. Wilson , David M. Hedstrand , Ian A. Tomlinson , Michael J. Fazio , William J. Kruper, Jr. , Donald A. Kaplan , Roberta C. Cheng , David S. Edwards , Chu W. Jung
发明人： Donald A. Tomalia , Larry R. Wilson , David M. Hedstrand , Ian A. Tomlinson , Michael J. Fazio , William J. Kruper, Jr. , Donald A. Kaplan , Roberta C. Cheng , David S. Edwards , Chu W. Jung
IPC分类号： A01N25/10 , A61K47/48 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/00 , C08L101/00 , C12N15/87 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/487 , A61K47/48961 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由携带的农业，药物或其它材料的至少一个单元组成的至少一个树枝状大分子组成的密集聚合物共轭物。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

6. 发明授权

US5034536A Process for preparing 2-isopropenyl oxazoline 失效
标题翻译： 2-异丙烯基恶唑啉的制备方法
公开(公告)号：US5034536A
公开(公告)日：1991-07-23
申请号：US542671
申请日：1990-06-22
申请人： Michael J. Fazio
发明人： Michael J. Fazio
IPC分类号： C07C231/02 , C07C233/20 , C07D263/12
CPC分类号： C07D263/12 , C07C231/02 , C07C233/20
摘要： Unsaturated esters with an alkyl group at the 2 carbon, such as methyl methacrylate, react with .beta.-aminoalkanols, such as 2-aminoethanol, in the presence of an alkali metal alkoxide or hydroxide such as sodium methoxide, under moderate temperatures to form an amide such as N-(2-hydroxyethyl)methacrylamide. The amide may be cyclized by a weak Lewis acid, such as ferric chloride, at about 220.degree. C. to form a 2-alkenyl oxazoline, such as isopropenyl oxazoline.
摘要翻译：在中等温度下，在碱金属醇盐或氢氧化物如甲醇钠的存在下，在2-碳上具有烷基的不饱和酯如甲基丙烯酸甲酯与β-氨基链烷醇如2-氨基乙醇反应形成酰胺例如N-（2-羟乙基）甲基丙烯酰胺。酰胺可以在约220℃下由弱路易斯酸如氯化铁环化，形成2-烯基恶唑啉，如异丙烯基恶唑啉。

7. 发明授权

US4826588A Pyrite depressants useful in the separation of pyrite from coal 失效
标题翻译：用于将黄铁矿从煤中分离的黄铁矿抑制剂
公开(公告)号：US4826588A
公开(公告)日：1989-05-02
申请号：US187115
申请日：1988-04-28
申请人： Richard R. Klimpel , Robert D. Hansen , Michael J. Fazio
发明人： Richard R. Klimpel , Robert D. Hansen , Michael J. Fazio
IPC分类号： B03D1/01 , B03D1/012 , B03D1/02
CPC分类号： B03D1/012 , B03D1/006 , B03D1/02 , B03D2201/007 , B03D2201/02 , B03D2201/06 , B03D2203/02
摘要： The separation of coal from pyrite during a froth flotation process is enhanced by the use of an effective amount of a pyrite depressant. The depressant is a hydrophilic nitrogen-sulfur-containing compound.
摘要翻译：通过使用有效量的黄铁矿抑制剂，可提高泡沫浮选过程中煤与黄铁矿的分离。抑制剂是亲水性含硫的化合物。

8. 发明授权

US4595704A Preparation of ion-exchange catalysts 失效
标题翻译：离子交换催化剂的制备
公开(公告)号：US4595704A
公开(公告)日：1986-06-17
申请号：US639980
申请日：1984-08-13
申请人： Michael J. Fazio
发明人： Michael J. Fazio
IPC分类号： C08F8/00 , B01J31/08 , B01J31/10 , B01J39/08 , B01J39/18 , B01J39/20 , B01J47/00 , C07C27/00 , C07C37/20 , C07C39/16 , C07C67/00 , C08F8/26 , C08F8/28 , C08F8/32 , C08F8/34 , C08C19/00
CPC分类号： B01J47/006 , B01J31/10 , B01J2231/347
摘要： Partially neutralize a strong-acid cation-exchange resin in acid form using an N-(2-mercaptoalkyl)amide in the presence of water.
摘要翻译：在水存在下使用N-（2-巯基烷基）酰胺部分中和酸性阳离子交换树脂。

9. 发明申请

US20110092741A1 PROCESS FOR PREPARING A 1,2-ETHYLENEDIAMINE OR 1,2-PROPYLENEDIAMINE 审中-公开
标题翻译：制备1,2-乙烯二胺或1,2-丙烯二胺的方法
公开(公告)号：US20110092741A1
公开(公告)日：2011-04-21
申请号：US12850894
申请日：2010-08-05
申请人： Michael J. Fazio , Erich J. Molitor
发明人： Michael J. Fazio , Erich J. Molitor
IPC分类号： C07C209/16
CPC分类号： C07C209/16 , C07C211/10 , C07C211/11
摘要： The present invention generally relates to a process for preparing a 1,2-ethylenediamine; 1,2-propylenediamine; or a mixture thereof by way of a catalyzed reductive amination reaction employing hydrogen, a reductive amination catalyst, (C3-C40)polyhydric alcohol having at least three hydroxy groups on consecutive carbon atoms thereof, and primary amine, the catalyzed reductive amination reaction employing reaction conditions that are effective for reductively aminating at least two of the hydroxy groups of the (C3-C40)polyhydric alcohol and reductively eliminating at least one other of the hydroxy groups of the (C3-C40)polyhydric alcohol in such a way so as to give a 1,2-ethylenediamine; 1,2-propylenediamine; or a mixture thereof.
摘要翻译：本发明一般涉及一种制备1,2-乙二胺的方法; 1,2-丙二胺; 或其混合物，通过使用氢的催化还原胺化反应，还原胺化催化剂，在其连续碳原子上具有至少三个羟基的（C 3 -C 40）多元醇和伯胺，使用反应的催化还原胺化反应有效地还原性胺化（C 3 -C 40）多元醇的至少两个羟基并且还原性地除去（C 3 -C 40）多元醇的至少一个其它羟基的条件，使得得到1,2-乙二胺; 1,2-丙二胺; 或其混合物。

10. 发明申请

US20090221808A1 Process for the Preparation of Nucleic Acid Duplexes 审中-公开
标题翻译：制备核酸复合物的方法
公开(公告)号：US20090221808A1
公开(公告)日：2009-09-03
申请号：US12092942
申请日：2006-11-03
申请人： Michael J. Fazio
发明人： Michael J. Fazio
IPC分类号： C07H1/00
CPC分类号： C12N15/111 , C07H21/00 , C12N15/10 , C12N2310/14 , C12N2330/30
摘要： The invention is a process for the preparation of at least one nucleic acid duplex by the steps of: (a) synthesizing a first single strand oligonucleotide to produce a crude solution of the first single strand oligonucleotide; (b) purifying the first single strand oligonucleotide from the crude solution by first liquid chromatography to produce a solution of purified first single strand oligonucleotide in a first liquid chromatography eluant; (c) synthesizing a second single strand oligonucleotide to produce a crude solution of the second single strand oligonucleotide; (d) purifying the second single strand oligonucleotide from the crude solution by second liquid chromatography to produce a solution of purified second single strand oligonucleotide in a second liquid chromatography eluant; (e) mixing the solution of purified first single strand oligonucleotide in the first liquid chromatography eluant with the solution of purified second single strand oligonucleotide in the second liquid chromatography eluant so that the first and second single strand oligonucleotides can complex to form a nucleic acid duplex in the mixture of first and second liquid chromatography eluants.
摘要翻译：本发明是通过以下步骤制备至少一种核酸双链体的方法：（a）合成第一单链寡核苷酸以产生第一单链寡核苷酸的粗溶液; （b）通过第一液相色谱法从粗溶液纯化第一单链寡核苷酸，以在第一液相色谱洗脱液中产生纯化的第一单链寡核苷酸溶液; （c）合成第二单链寡核苷酸以产生第二单链寡核苷酸的粗溶液; （d）通过第二液相色谱法从粗溶液中纯化第二单链寡核苷酸以在第二液相色谱洗脱液中产生纯化的第二单链寡核苷酸溶液; （e）将第一液相色谱洗脱液中的纯化的第一单链寡核苷酸的溶液与纯化的第二单链寡核苷酸的溶液混合在第二液相色谱洗脱液中，使得第一和第二单链寡核苷酸可以复合以形成核酸双在第一和第二液相色谱洗脱液的混合物中。

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