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1. 发明授权

US4994560A Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies 失效
标题翻译：功能化的多胺螯合剂和其放射性铑络合物用于与抗体缀合
公开(公告)号：US4994560A
公开(公告)日：1991-02-19
申请号：US65739
申请日：1987-06-24
申请人： William J. Kruper, Jr. , Douglas K. Pollock , William A. Fordyce , Michael J. Fazio , Muthiah N. Inbasekaran
发明人： William J. Kruper, Jr. , Douglas K. Pollock , William A. Fordyce , Michael J. Fazio , Muthiah N. Inbasekaran
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07C211/14 , C07C211/49 , C07C211/50 , C07D257/02 , C07F15/00
CPC分类号： C07D257/02 , A61K47/48707 , A61K49/0002 , A61K51/1093 , C07F15/008 , A61K2123/00
摘要： A group of functionalized polyamine chelants that form complexes with radioactive rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

2. 发明授权

US5489425A Functionalized polyamine chelants 失效
标题翻译：官能化多胺螯合剂
公开(公告)号：US5489425A
公开(公告)日：1996-02-06
申请号：US31416
申请日：1993-03-15
申请人： William J. Kruper, Jr. , Douglas K. Pollock , William A. Fordyce , Machael J. Fazio , Muthiah N. Inbasekaran , Ramaiah Muthyala
发明人： William J. Kruper, Jr. , Douglas K. Pollock , William A. Fordyce , Machael J. Fazio , Muthiah N. Inbasekaran , Ramaiah Muthyala
IPC分类号： A61K47/48 , A61K49/00 , A61K51/10 , C07D257/02 , C07F15/00 , A61K51/00 , C07C211/00
CPC分类号： A61K47/48707 , A61K49/0002 , A61K51/1093 , C07D257/02 , C07F15/008 , A61K2123/00
摘要： A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.
摘要翻译：公开了一组与铑形成络合物的官能化多胺螯合剂。铑络合物可以连接到抗体或抗体片段上，并用于治疗或诊断目的。

3. 发明授权

US5284644A Functionalized polyamine chelants and rhodium complexes thereof for conjugation to antibodies 失效
标题翻译：功能化的多胺螯合剂和铑络合物用于与抗体缀合
公开(公告)号：US5284644A
公开(公告)日：1994-02-08
申请号：US619153
申请日：1990-11-28
申请人： William J. Kruper, Jr. , William A. Fordyce , Douglas K. Pollock , Michael J. Fazio , Muthiah N. Inbaskaran , Ramaiah Muthyala
发明人： William J. Kruper, Jr. , William A. Fordyce , Douglas K. Pollock , Michael J. Fazio , Muthiah N. Inbaskaran , Ramaiah Muthyala
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07C211/14 , C07C211/49 , C07C211/50 , C07D257/02 , C07F15/00 , A61K43/00 , A61K39/00
CPC分类号： C07D257/02 , A61K47/48707 , A61K49/0002 , A61K51/1093 , C07F15/008 , A61K2123/00
摘要： A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.
摘要翻译：公开了一组与铑形成络合物的官能化多胺螯合剂。铑络合物可以连接到抗体或抗体片段上，并用于治疗或诊断目的。

4. 发明授权

US5006643A Process for preparing isothiocyanato functionalized metal complexes 失效
标题翻译：制备异硫氰酸酯官能化金属络合物的方法
公开(公告)号：US5006643A
公开(公告)日：1991-04-09
申请号：US383103
申请日：1989-07-20
申请人： Michael J. Fazio , Douglas K. Pollock , Nicolas J. Kotite
发明人： Michael J. Fazio , Douglas K. Pollock , Nicolas J. Kotite
IPC分类号： A61K47/48 , A61K49/00 , A61K51/10 , C07C331/28 , C07D257/02 , C07F15/00 , C07F19/00
CPC分类号： C07D257/02 , A61K47/48707 , A61K49/0002 , A61K51/1093 , C07C331/28 , C07F15/008 , C07F19/005 , A61K2123/00
摘要： The present invention is directed to a novel process for preparing isothiocyanate functionalized chelates by reacting amino functionalized chelates with thiophosgene.
摘要翻译：本发明涉及通过使氨基官能化螯合物与硫光气反应制备异硫氰酸酯官能化螯合物的新方法。

5. 发明授权

US4962154A Latex-antigen-antibody complexes for immunoassay 失效
标题翻译：用于免疫测定的乳胶抗原 - 抗体复合物
公开(公告)号：US4962154A
公开(公告)日：1990-10-09
申请号：US218782
申请日：1988-07-14
申请人： Douglas K. Pollock , Charles J. McDonald , William E. Cohrs , John M. Reno
发明人： Douglas K. Pollock , Charles J. McDonald , William E. Cohrs , John M. Reno
IPC分类号： C08F8/04 , C08F212/04 , G01N33/543
CPC分类号： G01N33/54313 , C08F212/04 , C08F8/04
摘要： A latex partice comprising a vinyl aromatic monomer and an vinyl acrylate ester monomer which is modified by a protein binding modifying monomer to facilitate the binding of a protein via coupling techniques. These latex particles are useful in diagnostic test applications. The vinyl acrylate ester monomer and a vinyl aromatic monomer are dispersed in a ratio between 1:3 to 3:1 of vinyl acrylate ester monomer to vinyl aromatic monomer in an aqueous phase containing a protein binding modifying monomer. The protein modifying monomer can be a vinyl carboxylic acid, such as a acrylic acid in a concentration of from about 0.5 percent to about 10 percent of the monomers. The dispersion is subjected to emulsion polymerization to provide a latex particle in a size range from 0.1 to 1 micron. The latex particle is sensitized with an antibody or antigen via coupling techniques. The resulting sensitized latex particles combine attributes of each monomer to provide utility in difficult protein systems to form latex antigen/antibody complexes. The products of the invention may be used in a variety of diagnostic applications.
摘要翻译：包含乙烯基芳族单体和丙烯酸乙烯酯单体的胶乳部分，其由蛋白质结合修饰单体修饰以促进通过偶联技术结合蛋白质。这些胶乳颗粒可用于诊断测试应用。乙烯基丙烯酸酯单体和乙烯基芳族单体在含有蛋白质结合改性单体的水相中以1:3至3:1的乙烯基丙烯酸酯单体与乙烯基芳族单体的比例分散。蛋白质修饰单体可以是乙烯基羧酸，例如浓度为单体约0.5％至约10％的丙烯酸。将分散体进行乳液聚合以提供0.1至1微米尺寸范围内的胶乳颗粒。胶乳颗粒通过偶联技术用抗体或抗原致敏。所得到的敏化乳胶颗粒结合各单体的特性，以提供在困难的蛋白质体系中的用途以形成胶乳抗原/抗体复合物。本发明的产品可用于各种诊断应用。

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