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1. 发明授权

US07683029B2 Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin 有权
标题翻译：含有胰岛素和烟雾发生装置的液体气溶胶制剂和产生气雾化胰岛素的方法
公开(公告)号：US07683029B2
公开(公告)日：2010-03-23
申请号：US10829945
申请日：2004-04-23
申请人： Michael Hindle , Kenneth A. Cox
发明人： Michael Hindle , Kenneth A. Cox
IPC分类号： A61K38/28 , A61M15/00
CPC分类号： A61K9/007 , A61K38/28 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/0065 , A61M15/008 , A61M15/02 , A61M15/025 , A61M2016/0039 , A61M2205/8206 , A61M2205/8237
摘要： Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the liquid aerosol formulation can be propellant free. An aerosol generating device generates the aerosolized insulin by passing the liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor which entrains insulin particles which mix with air to form an aerosol. The insulin particles can be dry insulin particles produced by a hand held inhaler. By controlling the concentration of the insulin in the formulation, the size of the flow passage and/or the amount of heat which heats the flow passage, the aerosol can be provided with a selected mass median aerodynamic diameter of 1 to 3 μm or less than 1 μm so as to be delivered to a targeted portion of the lung using the inhaler.
摘要翻译：用于产生气雾化胰岛素的液体气溶胶制剂包括胰岛素和至少一种高挥发性载体，其保护胰岛素在载体蒸发期间的热降解。载体可以是乙醇和水的混合物，液体气溶胶制剂可以不含推进剂。烟雾发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化成蒸气，该蒸气夹带与空气混合以形成气溶胶的胰岛素颗粒，产生雾化的胰岛素。胰岛素颗粒可以是由手持式吸入器产生的干性胰岛素颗粒。通过控制制剂中胰岛素的浓度，流路的尺寸和/或加热流道的热量，气溶胶可以具有1至3μm或更小的选定质量中值空气动力学直径使用吸入器将其输送到肺的目标部分。

2. 发明授权

US06516796B1 Aerosol generator and methods of making and using an aerosol generator 有权
标题翻译：气溶胶发生器和制造和使用气溶胶发生器的方法
公开(公告)号：US06516796B1
公开(公告)日：2003-02-11
申请号：US09479597
申请日：2000-01-07
申请人： Kenneth A. Cox , Timothy Paul Beane , William R. Sweeney , Walter A. Nichols , F. Murphy Sprinkel, Jr.
发明人： Kenneth A. Cox , Timothy Paul Beane , William R. Sweeney , Walter A. Nichols , F. Murphy Sprinkel, Jr.
IPC分类号： A61M1100
CPC分类号： A61M15/008 , A24F47/008 , A61M11/007 , A61M11/042 , A61M15/0003 , A61M15/0066 , A61M15/0083 , A61M2016/0039 , A61M2205/10 , A61M2205/3561 , A61M2205/3653 , A61M2205/50 , A61M2205/52 , A61M2205/8225
摘要： An aerosol generator includes a flow passage having an inlet and an outlet, a heater arranged relative to the flow passage for heating the flow passage, a source of material to be volatilized in communication with the inlet of the flow passage, a valve to open and close communication between the source of material and the inlet of the flow passage, and a pressurization arrangement for causing material in the source of material to be introduced into the flow passage when the valve is in an open position. The aerosol generator further includes a source of power for operating the heater and the valve, and a control device for controlling supply of power from the source of power to the heater and the valve. A metering device in an inhaler includes a pressurized source of medicated fluid and a metering chamber configured to deliver a predetermined volume of fluid to a heated flow passage in the inhaler. The metering chamber can be part of a rotary valve having a bore and a displacement member moveable within the bore from a first position where the fluid is loaded into the bore to a second position where the predetermined volume is ejected out of the bore. Another metering chamber has an elastic portion of a delivery passage in fluid communication with the pressurized source of liquid and the elastic portion of the delivery passage is deformed to eject the predetermined volume.
摘要翻译：气雾发生器包括具有入口和出口的流动通道，相对于流道设置的加热流道的加热器，与流动通道的入口连通的待挥发的材料源，打开的阀和材料源与流路入口之间的紧密连通，以及用于当阀处于打开位置时将材料源中的材料引入流路的加压装置。气溶胶发生器还包括用于操作加热器和阀的动力源，以及用于控制从动力源到加热器和阀的动力供应的控制装置。吸入器中的计量装置包括加压的药液源和配置成将预定体积的流体输送到吸入器中的加热流动通道的计量腔。计量室可以是具有孔的旋转阀的一部分，以及位于孔内的位移元件，该位移元件从第一位置移动到第二位置，在第一位置，流体被加载到孔中到第二位置，其中预定的体积被排出孔。另一个计量室具有与加压液体流体连通的输送通道的弹性部分，并且输送通道的弹性部分变形以排出预定体积。

3. 发明授权

US5189708A Methods and apparatus for optically determining the acceptability of products 失效
标题翻译：用于光学确定产品可接受性的方法和装置
公开(公告)号：US5189708A
公开(公告)日：1993-02-23
申请号：US634110
申请日：1990-12-17
申请人： Kenneth A. Cox , Robert J. Maher
发明人： Kenneth A. Cox , Robert J. Maher
IPC分类号： G01B11/24 , B07C5/10 , G01N21/88 , G06K9/62 , G06T1/00 , G06T7/00 , G07C3/14
CPC分类号： G06K9/6217 , B07C5/10 , G01N21/88 , G06T7/001 , G07C3/14 , G01N21/8851 , G06T2207/30164
摘要： The appearance of a product is determined to be acceptable or unacceptable by computing a discriminant function or image from a plurality of two-dimensional images of products of the kind to be inspected. A two-dimensional image of the product is then formed and processed using the discriminant image to produce an output value which can be compared to a predetermined value used in computing the discriminant image. If the output value deviates from the predetermined value by more than a predetermined amount, the product has been found to have an unacceptable appearance.
摘要翻译：通过从被检查的产品的多个二维图像计算判别函数或图像，确定产品的外观是可接受的或不可接受的。然后使用判别图像形成并处理产品的二维图像，以产生可与用于计算判别图像的预定值进行比较的输出值。如果输出值偏离预定值超过预定量，则产品已经被发现具有不可接受的外观。

4. 发明授权

US5046111A Methods and apparatus for optically determining the acceptability of products 失效
标题翻译：用于光学确定产品可接受性的方法和装置
公开(公告)号：US5046111A
公开(公告)日：1991-09-03
申请号：US308739
申请日：1989-02-09
申请人： Kenneth A. Cox , Robert J. Maher
发明人： Kenneth A. Cox , Robert J. Maher
IPC分类号： G01B11/24 , B07C5/10 , G01N21/88 , G06K9/62 , G06T1/00 , G06T7/00 , G07C3/14
CPC分类号： G06K9/6217 , B07C5/10 , G01N21/88 , G06T7/001 , G07C3/14 , G01N21/8851 , G06T2207/30164
摘要： The appearance of a product is determined to be acceptable or unacceptable by computing a discriminant function or image from a plurality of two-dimensional images of products of the kind to be inspected. A two-dimensional image of the product is then formed and processed using the discriminant image to produce an output value which can be compared to a predetermined value used in computing the discriminant image. If the output value deviates from the predetermined value by more than a predetermined amount, the product has been found to have an unacceptable appearance.

5. 发明授权

US07743766B2 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 有权
标题翻译：气溶胶产生装置和用于产生具有受控粒度的气溶胶的方法
公开(公告)号：US07743766B2
公开(公告)日：2010-06-29
申请号：US11140984
申请日：2005-06-01
申请人： Rajiv Gupta , Douglas D. McRae , Kenneth A. Cox , Walter A. Nichols
发明人： Rajiv Gupta , Douglas D. McRae , Kenneth A. Cox , Walter A. Nichols
IPC分类号： F24F3/14 , F23D11/00 , H05B3/00 , A61M15/00
CPC分类号： B05B1/24 , A61M11/002 , A61M11/041 , A61M11/042 , A61M15/00 , A61M2205/50 , B05B7/0012
摘要： An aerosol generating device includes a housing, a heater and an optional mouthpiece. The heater volatilizes liquid within a flow passage and forms an aerosol in the mouthpiece. An aerosol confinement sleeve is disposed to control the size distribution of the aerosol.
摘要翻译：烟雾发生装置包括壳体，加热器和可选的接口。加热器在流动通道内挥发液体并在接口管中形成气溶胶。设置气溶胶限制套管以控制气溶胶的尺寸分布。

6. 发明授权

US07173222B2 Aerosol generator having temperature controlled heating zone and method of use thereof 有权
标题翻译：具有温度控制加热区的气溶胶发生器及其使用方法
公开(公告)号：US07173222B2
公开(公告)日：2007-02-06
申请号：US10279035
申请日：2002-10-24
申请人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
发明人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
IPC分类号： A05B1/02
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2205/3372
摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.
摘要翻译：温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。

7. 发明授权

US07040314B2 Aerosol generating devices and methods for generating aerosols suitable for forming propellant-free aerosols 有权
标题翻译：用于产生适于形成不含无推进剂的气溶胶的气溶胶的气溶胶产生装置和方法
公开(公告)号：US07040314B2
公开(公告)日：2006-05-09
申请号：US10653934
申请日：2003-09-04
申请人： Tung T. Nguyen , Christopher L. Irving , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
发明人： Tung T. Nguyen , Christopher L. Irving , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61M16/00
CPC分类号： A61K9/0078 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/02 , A61M15/025 , A61M2016/0027 , A61M2205/8206 , A61M2205/8237
摘要： Liquid aerosol formulations for generating aerosols include at least one high volatility carrier and a second component. In some embodiments, the liquid aerosol formulation is propellant free. An aerosol generating device generates an aerosol by passing liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor, which is mixed with air to form an aerosol. In some embodiments, particles of the aerosol consist essentially of the second component. The aerosol generator can be incorporated in a hand held inhaler. The aerosol can be delivered to a targeted portion of the lung using the inhaler.
摘要翻译：用于产生气溶胶的液体气溶胶制剂包括至少一种高挥发性载体和第二组分。在一些实施方案中，液体气溶胶制剂不含推进剂。气溶胶发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化为蒸汽而产生气溶胶，该蒸汽与空气混合以形成气溶胶。在一些实施方案中，气溶胶的颗粒基本上由第二组分组成。气溶胶发生器可以并入手持式吸入器中。气雾剂可以使用吸入器输送到肺的目标部分。

8. 发明授权

US06766220B2 Method and apparatus for generating a volatilized liquid 有权
标题翻译：用于产生挥发性液体的方法和装置
公开(公告)号：US06766220B2
公开(公告)日：2004-07-20
申请号：US10206320
申请日：2002-07-29
申请人： Douglas D. McRae , John L. Felter , Clinton E. Blake , Mark T. Capps , Kenneth A. Cox , David H. Keeler , Rajiv Gupta
发明人： Douglas D. McRae , John L. Felter , Clinton E. Blake , Mark T. Capps , Kenneth A. Cox , David H. Keeler , Rajiv Gupta
IPC分类号： G05B2100
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025 , A61M16/0093 , A61M16/1065 , A61M16/202 , A61M2205/3317 , A61M2205/3368 , A61M2209/02 , B05B9/002
摘要： A programmable aerosol generator forms a volatilized liquid by supplying a material in liquid form to a flow passage and heating the flow passage, such that the material volatilizes and expands out of an outlet of the channel. The volatilized material, if desired, mixes with ambient air such that volatilized material condenses to form the aerosol. An apparatus and method for generating such a volatilized liquid, as well as the control and methods of heating, are disclosed as an analytical tool useful for experimental use, a tool useful for production of commercial products or an inhaler device.
摘要翻译：可编程气溶胶发生器通过将液体形式的材料供应到流动通道并加热流路而形成挥发液体，使得材料从通道的出口挥发和膨胀。如果需要，挥发的物质与环境空气混合，使得挥发的物质冷凝形成气溶胶。公开了用于产生这种挥发性液体的装置和方法以及加热控制和方法，作为可用于实验用途的分析工具，可用于生产商业产品或吸入器装置的工具。

9. 发明授权

US06501052B2 Aerosol generator having multiple heating zones and methods of use thereof 有权
标题翻译：具有多个加热区域的气溶胶发生器及其使用方法
公开(公告)号：US06501052B2
公开(公告)日：2002-12-31
申请号：US09742322
申请日：2000-12-22
申请人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
发明人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
IPC分类号： H05B102
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2205/3372
摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.
摘要翻译：温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。

10. 发明授权

US07625548B2 Methods and apparatus for producing nanoscale particles 有权
标题翻译：制备纳米级颗粒的方法和装置
公开(公告)号：US07625548B2
公开(公告)日：2009-12-01
申请号：US12149604
申请日：2008-05-05
申请人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
发明人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61K47/06
CPC分类号： A61K31/137 , A61K9/0073 , A61K31/573 , A61K47/08 , A61K47/10 , A61M11/041 , A61M11/042 , A61M15/0025 , A61M15/025 , A61M2016/0021 , A61M2205/8206 , A61M2205/8237
摘要： Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand held inhaler, and can be delivered to a targeted portion of the lung using the inhaler. Composite controlled release particles of micron or nanoscale size can be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.
摘要翻译：用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。颗粒发生器可以并入手持式吸入器中，并且可以使用吸入器输送到肺的目标部分。可以通过使药物，控制释放剂和载液的溶液流过毛细管加热器来生产微米或纳米尺寸的复合控制释放颗粒。

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