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1. 发明授权

US07492535B2 Multimodal miniature microscope 有权
标题翻译：多模微型显微镜
公开(公告)号：US07492535B2
公开(公告)日：2009-02-17
申请号：US11108616
申请日：2005-04-18
申请人： Michael Descour , Russell Dupuis , Eric Anslyn , Rebecca Richards-Kortum
发明人： Michael Descour , Russell Dupuis , Eric Anslyn , Rebecca Richards-Kortum
IPC分类号： B02B7/02
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , G02B7/003 , G02B21/0024 , G02B21/34 , G02B21/362
摘要： Apparatus for receiving and positioning optical components. The apparatus includes a substrate, one or more mounting slots, and one or more springs. The one or more mounting slots are formed in the substrate, and each mounting slot includes a mounting slot wall. At least one of the mounting slots is adapted to receive an optical component. At least one of the mounting slots is coupled to one of the springs.
摘要翻译：用于接收和定位光学部件的设备。该装置包括基板，一个或多个安装槽和一个或多个弹簧。一个或多个安装槽形成在基板中，并且每个安装槽包括安装槽壁。至少一个安装槽适于接收光学部件。至少一个安装槽与其中一个弹簧连接。

2. 发明申请

US20060058611A1 Multimodal miniature microscope 有权
公开(公告)号：US20060058611A1
公开(公告)日：2006-03-16
申请号：US11108616
申请日：2005-04-18
申请人： Michael Descour , Russell Dupuis , Eric Anslyn , Rebecca Richards-Kortum
发明人： Michael Descour , Russell Dupuis , Eric Anslyn , Rebecca Richards-Kortum
IPC分类号： A61B5/05
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , G02B7/003 , G02B21/0024 , G02B21/34 , G02B21/362
摘要： Apparatus for receiving and positioning optical components. The apparatus includes a substrate, one or more mounting slots, and one or more springs. The one or more mounting slots are formed in the substrate, and each mounting slot includes a mounting slot wall. At least one of the mounting slots is adapted to receive an optical component. At least one of the mounting slots is coupled to one of the springs.

3. 发明申请

US20140349860A1 IDENTIFYING PEPTIDES AT THE SINGLE MOLECULE LEVEL 有权
标题翻译：识别单分子水平的肽
公开(公告)号：US20140349860A1
公开(公告)日：2014-11-27
申请号：US14128247
申请日：2012-06-22
申请人： Edward Marcotte , Jagannath Swaminathan , Andrew Wllington , Eric Anslyn
发明人： Edward Marcotte , Jagannath Swaminathan , Andrew Wllington , Eric Anslyn
IPC分类号： G01N33/68
CPC分类号： G01N33/6824 , G01N2570/00
摘要： The present invention relates to methods for identifying amino acids in peptides. In one embodiment, the present invention contemplates labeling the N-terminal amino acid with a first label and labeling an internal amino acid with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level.
摘要翻译：本发明涉及鉴定肽中氨基酸的方法。在一个实施方案中，本发明考虑用第一标记物标记N-末端氨基酸并用第二标记物标记内部氨基酸。在一些实施方案中，标记是荧光标记。在其它实施方案中，内部氨基酸是赖氨酸。在其它实施方案中，肽中的氨基酸基于每个肽在单分子水平的荧光特征来鉴定。

4. 发明申请

US20060228256A1 Multi-shell microspheres with integrated chomatographic and detection layers for use in array sensors 审中-公开
标题翻译：具有集成的色谱和检测层的多壳微球用于阵列传感器
公开(公告)号：US20060228256A1
公开(公告)日：2006-10-12
申请号：US10544954
申请日：2004-02-09
申请人： John McDevitt , Adrain Goodey , Jason Shear , Eric Anslyn , Dean Neikirk
发明人： John McDevitt , Adrain Goodey , Jason Shear , Eric Anslyn , Dean Neikirk
IPC分类号： G01N21/00
CPC分类号： G01N21/6458 , B01J19/0046 , B01J2219/00317 , B01J2219/00423 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00576 , B01J2219/00648 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2300/021 , B01L2300/0816 , B01L2400/0638 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1463 , G01N21/05 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N33/5432 , G01N33/545 , G01N2021/0346
摘要： The development of miniaturized chromatographic systems localized within individual polymer microspheres and their incorporation into a bead-based cross-reactive sensor array platform is described herein. The integrated chromatographic and detection concept is based on the creation of distinct functional layers within the microspheres. In this first example of the new methodology, complexing ligands have been selectively immobilized to create “separation” layers harboring an affinity for various analytes. Information concerning the identities and concentrations of analytes may be drawn from the temporal properties of the beads' optical responses. Varying the nature of the ligand in the separation shell yields a collection of cross-reactive sensing elements well suited for use in array-based micro-total-analysis systems.
摘要翻译：本文描述了位于单个聚合物微球体内的小型化色谱系统的发展及其掺入到基于珠的交叉反应性传感器阵列平台中。集成的色谱和检测概念是基于在微球内产生不同的功能层。在新方法的第一个例子中，已经选择性地固定络合配体以产生对各种分析物具有亲和性的“分离”层。关于分析物的身份和浓度的信息可以从珠的光学响应的时间特性中得出。改变分离壳中配体的性质产生了非常适合用于基于阵列的微全分析系统的交叉反应感测元件的集合。

5. 发明授权

US08101431B2 Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems 有权
标题翻译：将流体和试剂集成到包含传感器元件和试剂输送系统的独立盒中
公开(公告)号：US08101431B2
公开(公告)日：2012-01-24
申请号：US11020443
申请日：2004-12-22
申请人： John T. McDevitt , Karri L. Ballard , Pierre N. Floriano , Nick J. Christodoulides , Dean Neikirk , Eric Anslyn , Jason Shear
发明人： John T. McDevitt , Karri L. Ballard , Pierre N. Floriano , Nick J. Christodoulides , Dean Neikirk , Eric Anslyn , Jason Shear
IPC分类号： G01N33/53
CPC分类号： G01N21/251 , B01L3/502715 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6441 , Y10S436/809
摘要： Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
摘要翻译：本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。

6. 发明申请

US20050214863A1 Method and system for the analysis of saliva using a sensor array 有权
标题翻译：使用传感器阵列分析唾液的方法和系统
公开(公告)号：US20050214863A1
公开(公告)日：2005-09-29
申请号：US11010816
申请日：2004-12-13
申请人： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk , Nick Christodoulides
发明人： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk , Nick Christodoulides
IPC分类号： B01J19/00 , B01L3/00 , C40B40/10 , C40B60/14 , G01N21/64 , G01N21/77 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/552 , G01N33/68 , G01N33/92
CPC分类号： G01N33/5304 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , C40B40/10 , C40B60/14 , G01N21/6428 , G01N21/6454 , G01N21/77 , G01N33/54313 , G01N33/544 , G01N33/552 , G01N33/6887 , G01N33/92 , G01N2021/7783 , G01N2021/7786 , G01N2201/024 , G01N2800/32 , Y10S436/807 , Y10S436/809
摘要： A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
摘要翻译：用于快速表征唾液中分析物的系统。在一个实施例中，用于检测分析物的系统包括光源，传感器阵列和检测器。传感器阵列由可以形成多个空腔的支撑构件形成。在一个实施方案中，一系列化学敏感性颗粒位于空腔内。当与颗粒偶联的受体与心血管危险因子分析物相互作用并且使用可视化试剂显现颗粒 - 分析物复合物时，颗粒可产生信号。使用模式识别技术，可以对多分析物流体中的分析物进行表征。在一个实施例中，多个空腔的每个空腔被设计成捕获并容纳特定尺寸的颗粒。可以将柔性突出部定位在每个空腔上，以提供颗粒在空腔中的保持。

7. 发明申请

US20050164320A1 Fluid based analysis of multiple analytes by a sensor array 失效
公开(公告)号：US20050164320A1
公开(公告)日：2005-07-28
申请号：US11039054
申请日：2005-01-20
申请人： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk
发明人： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk
IPC分类号： C40B60/14 , G01N21/77 , G01N33/53 , C12M1/34 , G01N33/537 , G01N33/543
CPC分类号： G01N21/77 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , Y10S435/808 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10T436/25
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

8. 发明申请

US20050136548A1 System and method for the analysis of bodily fluids 审中-公开
标题翻译：用于分析体液的系统和方法
公开(公告)号：US20050136548A1
公开(公告)日：2005-06-23
申请号：US10924285
申请日：2004-08-23
申请人： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk
发明人： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk
IPC分类号： B01L3/00 , B81B1/00 , B81B3/00 , C07B61/00 , G01N1/02 , G01N21/25 , G01N21/64 , G01N21/77 , G01N33/48 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/554 , G01N33/569 , G01N35/00 , G06F19/00 , H01L21/00 , G01N1/10
CPC分类号： G01N21/6452 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01L3/0289 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0657 , B01L2200/0668 , B01L2200/12 , B01L2300/0636 , B01L2400/0415 , B01L2400/049 , B01L2400/0633 , B01L2400/0638 , C07B2200/11 , C12Q1/34 , C12Q1/37 , C40B40/00 , G01N21/253 , G01N21/6428 , G01N21/6454 , G01N21/6458 , G01N21/6486 , G01N21/77 , G01N33/54313 , G01N33/54366 , G01N33/54373 , G01N2001/021 , G01N2021/6417 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00564 , G01N2201/062 , G01N2201/0627 , Y02A90/26 , Y10S977/924 , Y10T436/2575
摘要： A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
摘要翻译：在一个实施例中，用于快速表征多分析物流体的系统包括光源，传感器阵列和检测器。传感器阵列由可以形成多个空腔的支撑构件形成。在一个实施例中，一系列化学敏感的颗粒位于空腔内。当与颗粒偶联的受体与分析物相互作用时，颗粒可被配置成产生信号。使用模式识别技术，可以对多分析物流体中的分析物进行表征。

9. 发明授权

US09625469B2 Identifying peptides at the single molecule level 有权
公开(公告)号：US09625469B2
公开(公告)日：2017-04-18
申请号：US14128247
申请日：2012-06-22
申请人： Edward Marcotte , Jagannath Swaminathan , Andrew Ellington , Eric Anslyn
发明人： Edward Marcotte , Jagannath Swaminathan , Andrew Ellington , Eric Anslyn
IPC分类号： G01N33/68
CPC分类号： G01N33/6824 , G01N2570/00
摘要： The present invention relates to methods for identifying amino acids in peptides. In one embodiment, the present invention contemplates labeling the N-terminal amino acid with a first label and labeling an internal amino acid with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level.

10. 发明申请

US20070292968A1 Determining Enantiomeric Excess Using Indicator-Displacement Assays 失效
标题翻译：使用指示剂位移测定法确定对映异构体过量
公开(公告)号：US20070292968A1
公开(公告)日：2007-12-20
申请号：US11839085
申请日：2007-08-15
申请人： Eric Anslyn , J. Frantz-Folmer-Andersen , Lei Zhu
发明人： Eric Anslyn , J. Frantz-Folmer-Andersen , Lei Zhu
IPC分类号： G01N21/00 , G01N33/00
CPC分类号： G01N33/542
摘要： The invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of color with the naked eye, spectrographic measurement, or mathematical calculation. Concentration may also be determined. The assay may involve two independent absorption measurements. On suitable group of enantiomeric molecules to be assayed include α-hydroxyacids. The inherent relationship between the absorbance of the indicator-displacement ensemble and the overall concentration and ee of the analyte is established through solution equilibria. The invention also includes use of the assay in drug screening and manufacturing, high throughput screening of catalysts and kits for use in conducting assays of the invention.
摘要翻译：本发明包括用于量热测定对映体过量（ee）对映异构体样品的对映选择性指示剂置换测定法。确定可以通过肉眼检查颜色，光谱测量或数学计算。也可以确定浓度。该测定可以涉及两次独立的吸收测量。待分析的对映异构体分子的合适组包括α-羟基酸。通过溶液平衡建立指示剂置换组合的吸光度与分析物的总浓度和ee之间的固有关系。本发明还包括在药物筛选和制造中使用该测定法，用于进行本发明测定的催化剂和试剂盒的高通量筛选。

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