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1. 发明申请

US20100300437A1 MANUFACTURE OF METERED DOSE VALVE COMPONENTS 审中-公开
标题翻译：计量剂阀组件的制造
公开(公告)号：US20100300437A1
公开(公告)日：2010-12-02
申请号：US12599565
申请日：2008-03-28
申请人： Michael B. Sivigny , Peter D. Hodson
发明人： Michael B. Sivigny , Peter D. Hodson
IPC分类号： A61M15/00 , B22F3/12
CPC分类号： B22F3/1021 , A61M15/0065 , A61M15/009 , A61M2207/00 , B22F3/004 , B22F5/00 , B22F2301/35 , B22F2304/10 , B22F2998/10 , B65D83/48
摘要： Use of metal powder injection molding for the manufacture of a metal valve component, such as a valve stem or a valve body, of a metered dose dispensing valve for use in a medicinal pressurized metered dose dispenser, such as an inhaler.
摘要翻译：使用金属粉末注射成型用于制造用于药用加压计量剂量分配器（例如吸入器）的计量剂量分配阀的金属阀组件（例如阀杆或阀体）。

2. 发明授权

US09067031B2 Metered dose valves and dispensers 有权
标题翻译：计量剂量阀和分配器
公开(公告)号：US09067031B2
公开(公告)日：2015-06-30
申请号：US12444864
申请日：2007-10-19
申请人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
发明人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
IPC分类号： A61M11/00 , A61M15/00 , B65D83/54 , B65D83/14
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译：一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气溶胶制剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种多孔的，可流体渗透的，颗粒状的半渗透体，所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游的计量室。

3. 发明申请

US20120132203A1 DRY POWDER INHALERS 有权
标题翻译：干粉吸入器
公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译：干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内，载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。

4. 发明授权

US6102179A Device for transmission of one-way torque 失效
标题翻译：用于传递单向力矩的装置
公开(公告)号：US6102179A
公开(公告)日：2000-08-15
申请号：US850439
申请日：1997-05-05
申请人： Peter D. Hodson , Stephen J. Howgill , Anthony C. L. Wass
发明人： Peter D. Hodson , Stephen J. Howgill , Anthony C. L. Wass
IPC分类号： A61M15/00 , F16D41/18 , F16D41/12
CPC分类号： F16D41/18
摘要： A device for the transmission of one-way torque comprising an outer annular member having a plurality of radially inwardly projecting teeth each comprising a driving surface and a cam surface, and a shaft concentrically mounted with respect to the outer annular member and comprising a plurality of drive elements each having a driving surface and a cam surface. Rotation of the shaft or outer annular member in its driving direction causes engagement of a driving surface of at least one drive element with a driving surface of at least one tooth thereby resulting in joint rotation of the shaft and outer annular member. Rotation of the shaft or outer annular member in its non-driving direction causes engagement of the cam surface of at least one drive element with the cam surface of at least one tooth resulting in additional relative movement, substantially radially, between the drive element and tooth, thereby preventing rotational movement being transmitted between the shaft and the outer annular member.
摘要翻译：一种用于单向扭矩传递的装置，包括具有多个径向向内突出的齿的外环形构件，每个径向向内突出的齿各自包括驱动表面和凸轮表面，以及相对于外环形构件同心安装的轴，驱动元件各自具有驱动表面和凸轮表面。轴或外环形构件沿其驱动方向的旋转使得至少一个驱动元件的驱动表面与至少一个齿的驱动表面接合，从而导致轴和外环形构件的联合旋转。轴或外环形构件在其非驱动方向上的旋转导致至少一个驱动元件的凸轮表面与至少一个齿的凸轮表面的接合，从而在驱动元件和齿之间基本上径向地进一步相对移动从而防止旋转运动在轴和外环形构件之间传递。

5. 发明授权

US5740793A Dry powder inhalation device with elongate carrier for power 失效
标题翻译：干粉吸入装置，带细长载体供电
公开(公告)号：US5740793A
公开(公告)日：1998-04-21
申请号：US471612
申请日：1995-06-06
申请人： Peter D. Hodson , David K. Smith , David J. Velasquez , Anthony C.L. Wass , Clyde D. Calhoun
发明人： Peter D. Hodson , David K. Smith , David J. Velasquez , Anthony C.L. Wass , Clyde D. Calhoun
IPC分类号： A61K9/14 , A61K45/08 , A61K47/30 , A61M15/00 , A61M15/02 , A61M16/00 , A61P11/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0045 , A61M15/0006 , A61M15/0016 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0066 , A61M15/0078 , A61M15/0085 , A61M15/0091 , A61M15/02 , A61M2016/0024 , A61M2202/064 , A61M2205/8206
摘要： A dry powder inhalation device comprising a housing defining a chamber in communication with a patient port in the form of a mouthpiece or nasal adaptor, and an elongate carrier bearing a powdered medicament, the device being constructed and arranged such that areas of predetermined size of the elongate carrier may sequentially be exposed within the chamber, the device comprising one or more air inlets such that when a patient inhales through the patient port an air flow is established from the air inlet(s) to the patient port through the chamber such that particles of the powdered medicament of respirable size from said exposed area of the elongate carrier are entrained within the air flow.
摘要翻译：一种干粉吸入装置，其特征在于，包括壳体，所述壳体限定与所述口部或鼻部适配器形式的患者端口连通的室，以及承载有粉末状药物的细长载体，所述装置被构造和布置成使得预定尺寸的细长的载体可以顺序地在腔室内暴露，该装置包括一个或多个空气入口，使得当患者通过患者端口吸入时，通过腔室从空气入口到患者端口建立空气流，使得颗粒的来自所述细长载体的所述暴露区域的可吸入尺寸的粉末状药物被夹带在空气流中。

6. 发明授权

US5469843A Inhalation device 失效
标题翻译：吸入装置
公开(公告)号：US5469843A
公开(公告)日：1995-11-28
申请号：US240675
申请日：1994-05-04
申请人： Peter D. Hodson
发明人： Peter D. Hodson
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61M15/0091 , A61M11/002 , A61M15/0045 , A61M15/0051 , A61M2202/064
摘要： The present invention relates to a dry powder inhaler having one or more deaglommeration channels through which an airstream containing entrained medicament particles passes. Each channel has a substantially constant cross-sectional area and a bend having a radius of curvature of no greater than 10 mm.
摘要翻译： PCT No.PCT / US92 / 09505 Sec。 371日期：1994年5月4日 102（e）日期1994年5月4日PCT提交1992年11月6日PCT公布。公开号WO93 / 09832 日本专利日本：1993年5月27日。本发明涉及具有一个或多个脱胶通道的干粉吸入器，通过该通道，含有夹带药物颗粒的气流通过该吸入器。每个通道具有基本恒定的横截面面积和具有不大于10mm的曲率半径的弯曲部。

7. 发明授权

US08814009B2 Metered dose valve 有权
标题翻译：计量剂量阀
公开(公告)号：US08814009B2
公开(公告)日：2014-08-26
申请号：US12681280
申请日：2008-10-02
申请人： Peter D. Hodson , Matthew A. Goring , Stephen J. Howgill , John Fielding , Richard D. Brewer , Rachael V. Shaw , Paul A. Charnock , Stuart A. McGlasson , Stephen D. Helm , Graham V. Jackson , Anthony W. Balkwill , Jason A. Graves
发明人： Peter D. Hodson , Matthew A. Goring , Stephen J. Howgill , John Fielding , Richard D. Brewer , Rachael V. Shaw , Paul A. Charnock , Stuart A. McGlasson , Stephen D. Helm , Graham V. Jackson , Anthony W. Balkwill , Jason A. Graves
IPC分类号： B65D83/00
CPC分类号： A61M15/009 , B65D83/54
摘要： An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gasket to deflect while maintaining the seal with the circumferential sealing surface of the valve stem; and wherein the metering gasket in an unbiased configuration is an annular disc having a substantially planar form and where the valve is constructed and arranged such that the inner periphery of the metering gasket is urged out of said substantially planar form at the rest position of the valve stem, or wherein the metering gasket is pre-biased into a dished-shape.
摘要翻译：一种气溶胶计量阀，包括：（a）可在静止位置和击发位置之间移动的阀杆，包括：主体部分，其包括周向密封表面（b）阀体，所述阀体包括：主体壁和至少限定的内部腔部分由身体壁; 和（c）具有限定孔的内周边的计量垫片，其设置在内室的最内端附近，并且构造成能够形成一个瞬时的，基本上是流体密封的，面对密封面阀杆，其中在阀杆的静止位置处，阀杆的主体部分位于内部腔室内，并且当阀杆从其静止位置朝向其击发位置移动时，阀杆的圆周密封表面接触计量垫圈以形成面密封件，从而封闭计量室，此后阀杆朝向其点火位置的进一步运动导致计量垫片偏转，同时保持与阀杆的周向密封表面的密封; 并且其中所述计量垫片为无偏置构型，是具有基本上平面形状的环形盘，并且所述阀被构造和布置成使得所述计量垫片的内周边在所述阀的静止位置处被推出所述基本平坦的形式杆，或其中计量垫片预偏置成碟形。

8. 发明申请

US20110042419A1 METERED DOSE VALVE 有权
标题翻译：计量式阀门
公开(公告)号：US20110042419A1
公开(公告)日：2011-02-24
申请号：US12681280
申请日：2008-10-02
申请人： Peter D. Hodson , Matthew A. Goring , Stephen J. Howgill , John Fielding , Rachel V. Shaw , Paul A. Charnock , Stuart A. McGlasson , Stephen D. Helm , Graham V. Jackson , Anthony W. Balkwill , Jason A. Graves
发明人： Peter D. Hodson , Matthew A. Goring , Stephen J. Howgill , John Fielding , Rachel V. Shaw , Paul A. Charnock , Stuart A. McGlasson , Stephen D. Helm , Graham V. Jackson , Anthony W. Balkwill , Jason A. Graves
IPC分类号： B65D83/00
CPC分类号： A61M15/009 , B65D83/54
摘要： An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gasket to deflect while maintaining the seal with the circumferential sealing surface of the valve stem; and wherein the metering gasket in an unbiased configuration is an annular disc having a substantially planar form and where the valve is constructed and arranged such that the inner periphery of the metering gasket is urged out of said substantially planar form at the rest position of the valve stem, or wherein the metering gasket is pre-biased into a dished-shape.
摘要翻译：一种气溶胶计量阀，包括：（a）可在静止位置和击发位置之间移动的阀杆，包括：主体部分，其包括周向密封表面（b）阀体，所述阀体包括：主体壁和至少限定的内部腔部分由身体壁; 和（c）具有限定孔的内周边的计量垫片，其设置在内室的最内端附近，并且构造成能够形成一个瞬时的，基本上是流体密封的，面对密封面阀杆，其中在阀杆的静止位置处，阀杆的主体部分位于内部腔室内，并且当阀杆从其静止位置朝向其击发位置移动时，阀杆的圆周密封表面接触计量垫圈以形成面密封件，从而封闭计量室，此后阀杆朝向其点火位置的进一步运动导致计量垫片偏转，同时保持与阀杆的周向密封表面的密封; 并且其中所述计量垫片为无偏置构型，是具有基本上平面形状的环形盘，并且所述阀被构造和布置成使得所述计量垫片的内周边在所述阀的静止位置处被推出所述基本平坦的形式杆，或其中计量垫片预偏置成碟形。

9. 发明授权

US07299801B2 Metering valve for a metered dose inhaler providing consistent delivery 有权
公开(公告)号：US07299801B2
公开(公告)日：2007-11-27
申请号：US10655419
申请日：2003-09-04
申请人： Peter D. Hodson
发明人： Peter D. Hodson
IPC分类号： A61M11/00
CPC分类号： B65D83/54 , A61M15/009
摘要： The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2° to about 90°; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.

10. 发明授权

US08517019B2 Method and apparatus for metered dose dispensing 有权
标题翻译：计量剂量分配的方法和装置
公开(公告)号：US08517019B2
公开(公告)日：2013-08-27
申请号：US12281559
申请日：2007-03-01
申请人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
发明人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
IPC分类号： A62B7/00 , A62B9/00 , A61M11/00
CPC分类号： A61M15/009 , A61M15/0065 , A61M15/0073 , G06M1/04
摘要： This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction. The cap is then moved in a second opposite direction, which causes the slider to move in a second opposite linear direction, which in turn causes rotation of the first counter ring through a second arc in the first circumferential direction about the axis of the container. A sum of the first and second arcs of movement of the first counter ring defines a circumferential extent of movement of the first counter ring relative to the cap that indicates a single dose of aerosol medication dispensed from the container.
摘要翻译：本申请公开了一种用于在具有气溶胶容器和致动器的气溶胶分配组件上使用的剂量计数装置。剂量计数器装置用于指示通过在轴向上施加在气溶胶分配组件上的力引起的剂量的气溶胶药物的释放。剂量计数装置具有帽，滑块和第一计数器环。盖沿着容器的轴线沿第一方向移动，这导致滑块相对于容器的轴线在第一线性方向上相对于容器的轴线的移动，这是沿着第一方向的运动的函数。随着滑块在第一直线方向的移动，第一计数器环围绕容器的轴线在第一圆周方向上旋转通过第一弧。然后，盖沿第二相反方向移动，这导致滑块在第二相对的线性方向上移动，这又导致第一计数器环围绕容器的轴线沿第一圆周方向旋转第二弧。第一计数器环的第一和第二运动弧的总和限定了第一计数器环相对于盖的周向运动范围，其指示从容器分配的单剂量的气溶胶药物。

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