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1. 发明授权

US09956170B2 Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof 有权
公开(公告)号：US09956170B2
公开(公告)日：2018-05-01
申请号：US12995319
申请日：2009-06-22
申请人： Adam S. Cantor , Jacqueline M. Ganser , Michael W. Mueting , Stephen W. Stein
发明人： Adam S. Cantor , Jacqueline M. Ganser , Michael W. Mueting , Stephen W. Stein
IPC分类号： A61K9/14 , A61K31/56 , A61K31/58 , A61P11/06 , A61P29/00 , A61K9/00 , A61K31/00
CPC分类号： A61K9/0075 , A61K31/00 , A61K31/58
摘要： A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles; providing a micronized active ingredient; mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and then mixing the micronized active ingredient with the inactive ingredient; the dry powder compositions made by the method; a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.

2. 发明授权

US09861580B2 Method of making a dry powder pharmaceutical composition 有权
公开(公告)号：US09861580B2
公开(公告)日：2018-01-09
申请号：US13001630
申请日：2009-06-22
申请人： Michael W. Mueting , Daniel C. Duan , Stephen W. Stein
发明人： Michael W. Mueting , Daniel C. Duan , Stephen W. Stein
IPC分类号： B05D1/28 , A61K9/14 , A61K9/00 , A61K31/137
CPC分类号： A61K9/143 , A61K9/0075 , A61K9/146 , A61K31/137
摘要： A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed.

3. 发明授权

US07659725B2 Method for assessing the suitability of metered dose inhaler actuators 失效
标题翻译：评估计量吸入器执行器适用性的方法
公开(公告)号：US07659725B2
公开(公告)日：2010-02-09
申请号：US12293195
申请日：2007-03-22
申请人： Michael W. Mueting , Stephen W. Stein
发明人： Michael W. Mueting , Stephen W. Stein
IPC分类号： G01R29/12 , A61M11/00
CPC分类号： A61M15/009 , A61M2209/02
摘要： A method of assessing the suitability of a metered dose inhaler actuator A test canister equipped with a valve and containing a pressurized propellant is provided. One or more actuators manufactured for use in a metered dose inhaler is provided and tested, wherein each actuator is tested by coupling the canister to the actuator, positioning the actuator with respect to an electrostatic measurement device and firing the canister such that electrostatic charge from an aerosol emitted by the canister is measured by the electrostatic measurement device. The measured electrostatic charge is compared to a predetermined specification range to make a determination whether the measured electrostatic charge is within or outside the predetermined specification range and accordingly whether the actuator is or is not acceptable.
摘要翻译：评估计量剂量吸入器致动器的适用性的方法提供了配备有阀并包含加压推进剂的测试罐。提供并测试了用于定量吸入器中制造的一个或多个致动器，其中通过将所述罐连接到致动器来测试每个致动器，使致动器相对于静电测量装置定位并且对罐进行点火，使得来自通过静电测量装置测量由罐发出的气溶胶。将测量的静电电荷与预定的规格范围进行比较，以确定测量的静电电荷是否在预定规格范围内或之外，并且因此致动器是否是不可接受的。

4. 发明授权

US07459146B2 Stabilized aerosol dispersions 有权
标题翻译：稳定的气溶胶分散体
公开(公告)号：US07459146B2
公开(公告)日：2008-12-02
申请号：US10449443
申请日：2003-05-30
申请人： Jimmie R. Baran, Jr. , Brian J. Gabrio , James S. Stefely , Stephen W. Stein , Thomas E. Wood
发明人： Jimmie R. Baran, Jr. , Brian J. Gabrio , James S. Stefely , Stephen W. Stein , Thomas E. Wood
IPC分类号： A61K9/14 , A61K9/10
CPC分类号： A61K9/008 , A61K47/02 , B01F17/0078 , B01F17/0085 , B01J13/0095 , Y10S514/937
摘要： The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant.
摘要翻译：本发明涉及包含用于给药药物的纳米颗粒的稳定分散体。分散体包括赋形剂纳米颗粒，包含药物的分散相和包含推进剂的连续相。

5. 发明申请

US20080268062A1 STABILIZED PARTICLE DISPERSIONS CONTAINING SURFACE-MODIFIED INORGANIC NANOPARTICLES 审中-公开
标题翻译：含有表面改性无机纳米颗粒的稳定颗粒分散体
公开(公告)号：US20080268062A1
公开(公告)日：2008-10-30
申请号：US12167714
申请日：2008-07-03
申请人： Jimmie R. Baran , Brian J. Gabrio , James S. Stefely , Stephen W. Stein , Thomas E. Wood
发明人： Jimmie R. Baran , Brian J. Gabrio , James S. Stefely , Stephen W. Stein , Thomas E. Wood
IPC分类号： A61K9/51
CPC分类号： B01F17/0078 , A61K9/10 , A61K47/02 , A61K47/24
摘要： This invention relates to particle-in-liquid dispersions containing surface-modified inorganic nanoparticles.
摘要翻译：本发明涉及含有表面改性无机纳米粒子的粒子 - 液体分散体。

6. 发明授权

US09072664B2 Process for manufacturing flowable powder drug compositions 有权
标题翻译：制造可流动粉末药物组合物的方法
公开(公告)号：US09072664B2
公开(公告)日：2015-07-07
申请号：US12992633
申请日：2009-04-17
申请人： Stephen W. Stein , Michael W. Mueting , Timothy D. Dunbar
发明人： Stephen W. Stein , Michael W. Mueting , Timothy D. Dunbar
IPC分类号： B05D3/00 , A61K9/00
CPC分类号： A61K9/0075
摘要： Powder drug compositions exhibiting improved flow properties are manufactured by spraying a suspension of surface-modified nanoparticles having an average particle size diameter of less than 100 nm in a dryable liquid carrier onto particles of a powder ingredient of a drug composition. The liquid carrier is rapidly dried so as to leave the nanoparticles on the powder. Other ingredients of the powder drug composition can also be added.
摘要翻译：表现出改善的流动特性的粉末药物组合物是通过将平均粒度直径小于100nm的表面改性纳米颗粒的悬浮液在可干燥的液体载体中喷洒到药物组合物粉末成分的颗粒上而制成的。液体载体被快速干燥，以使纳米颗粒留在粉末上。还可以加入粉末药物组合物的其他成分。

7. 发明申请

US20120132203A1 DRY POWDER INHALERS 有权
标题翻译：干粉吸入器
公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译：干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内，载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。

8. 发明申请

US20110064867A1 PROCESS FOR MANUFACTURING FLOWABLE POWDER DRUG COMPOSITIONS 有权
标题翻译：制造流动性粉末药物组合物的方法
公开(公告)号：US20110064867A1
公开(公告)日：2011-03-17
申请号：US12992633
申请日：2009-04-17
申请人： Stephen W. Stein , Michael W. Mueting , Timothy D. Dunbar
发明人： Stephen W. Stein , Michael W. Mueting , Timothy D. Dunbar
IPC分类号： B05D3/00
CPC分类号： A61K9/0075
摘要： Powder drug compositions exhibiting improved flow properties are manufactured by spraying a suspension of surface-modified nanoparticles having an average particle size diameter of less than 100 nm in a dryable liquid carrier onto particles of a powder ingredient of a drug composition. The liquid carrier is rapidly dried so as to leave the nanoparticles on the powder. Other ingredients of the powder drug composition can also be added.
摘要翻译：表现出改善的流动特性的粉末药物组合物是通过将平均粒度直径小于100nm的表面改性纳米颗粒的悬浮液在可干燥的液体载体中喷射到药物组合物的粉末成分的颗粒上而制成的。液体载体被快速干燥，以使纳米颗粒留在粉末上。还可以加入粉末药物组合物的其他成分。

9. 发明申请

US20090121722A1 Method for Assessing the Suitability of Metered Dose Inhaler Actuators 失效
标题翻译：评估计量吸入式致动器适用性的方法
公开(公告)号：US20090121722A1
公开(公告)日：2009-05-14
申请号：US12293195
申请日：2007-03-22
申请人： Michael W. Mueting , Stephen W. Stein
发明人： Michael W. Mueting , Stephen W. Stein
IPC分类号： G01R29/12
CPC分类号： A61M15/009 , A61M2209/02
摘要： A method of assessing the suitability of a metered dose inhaler actuator A test canister equipped with a valve and containing a pressurized propellant is provided. One or more actuators manufactured for use in a metered dose inhaler is provided and tested, wherein each actuator is tested by coupling the canister to the actuator, positioning the actuator with respect to an electrostatic measurement device and firing the canister such that electrostatic charge from an aerosol emitted by the canister is measured by the electrostatic measurement device. The measured electrostatic charge is compared to a predetermined specification range to make a determination whether the measured electrostatic charge is within or outside the predetermined specification range and accordingly whether the actuator is or is not acceptable.
摘要翻译：评估计量剂量吸入器致动器的适用性的方法提供了配备有阀并包含加压推进剂的测试罐。提供并测试了用于定量吸入器中制造的一个或多个致动器，其中通过将所述罐连接到致动器来测试每个致动器，使致动器相对于静电测量装置定位并且对罐进行点火，使得来自通过静电测量装置测量由罐发出的气溶胶。将测量的静电电荷与预定的规格范围进行比较，以确定测量的静电电荷是否在预定规格范围内或之外，并且因此致动器是否是不可接受的。

10. 发明申请

US20120272951A1 FORMULATIONS AND METHODS FOR CONTROLLING MDI PARTICLE SIZE DELIVERY 审中-公开
标题翻译：用于控制MDI颗粒尺寸传送的配方和方法
公开(公告)号：US20120272951A1
公开(公告)日：2012-11-01
申请号：US13515399
申请日：2010-12-08
申请人： Stephen W. Stein
发明人： Stephen W. Stein
IPC分类号： A61M11/00
CPC分类号： A61K9/008 , A61K9/14
摘要： Provided herein are formulations, methods, and metered dose inhaler drug delivery devices. The formulations and methods may provide for controlled particle size delivery in metered dose inhaler drug delivery devices. Further provided are metered dose inhaler drug delivery devices that may themselves deliver controlled sized particles to the airways.
摘要翻译：本文提供了制剂，方法和计量剂量吸入器药物递送装置。制剂和方法可以提供计量剂量吸入器药物递送装置中的受控粒度输送。进一步提供的是计量吸入器药物递送装置，其本身可以向气道输送受控尺寸的颗粒。

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