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1. 发明授权

US09440079B2 Management of stimulation safety limits in a neurostimulation system 有权
标题翻译：神经刺激系统刺激安全限制的管理
公开(公告)号：US09440079B2
公开(公告)日：2016-09-13
申请号：US13470328
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K. L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K. L. Peterson
IPC分类号： A61N1/37 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
摘要翻译：用于管理刺激安全限值的神经刺激系统。系统确定每个电极处的组织电荷注入度量，将该度量与硬停止电荷限制进行比较，并且根据比较来防止神经刺激器将刺激能量递送至组织区域。硬停止极限可以是用户可编程的，或者可以响应于电极特性的检测而被自动修改。该系统可以定量地向使用者通知注入到组织中的注入电荷的值。电极可以组织成不同的组，在这种情况下，系统可以在每个电极组中独立地直接控制组织电荷。如果提供电流转向，则系统可以沿着一个方向沿着组织区域移位电刺激能量，同时防止每个电极处的电荷注入值达到或超过硬停止充电极限。

2. 发明授权

US09950172B2 Management of stimulation safety limits in a neurostimulation system 有权
公开(公告)号：US09950172B2
公开(公告)日：2018-04-24
申请号：US13470326
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K. L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K. L. Peterson
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

3. 发明申请

US20120290038A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 审中-公开
公开(公告)号：US20120290038A1
公开(公告)日：2012-11-15
申请号：US13470158
申请日：2012-05-11
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

4. 发明授权

US09411935B2 User interface for segmented neurostimulation leads 有权
标题翻译：分段神经刺激导联用户界面
公开(公告)号：US09411935B2
公开(公告)日：2016-08-09
申请号：US13212063
申请日：2011-08-17
申请人： Michael A. Moffitt , Sridhar Kothandaraman , James C. Makous
发明人： Michael A. Moffitt , Sridhar Kothandaraman , James C. Makous
IPC分类号： A61N1/36 , A61N1/37 , G06F19/00 , A61N1/372 , A61N1/05
CPC分类号： A61N1/37247 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36182 , A61N1/36185 , G06F19/00 , G16H40/63
摘要： An external control device for use with a neurostimulation system having a plurality of electrodes capable of conveying an electrical stimulation field into tissue in which the electrodes are implanted is provided. The external control device comprises a user interface having one or more control elements, a processor configured for generating stimulation parameters designed to modify the electrical stimulation field relative to one or more neurostimulation lead carrying the electrodes. The external control device further comprises output circuitry configured for transmitting the stimulation parameters to the neurostimulation system.
摘要翻译：提供了一种与神经刺激系统一起使用的外部控制装置，其具有能够将电刺激场传送到其中植入电极的组织中的多个电极。外部控制装置包括具有一个或多个控制元件的用户界面，被配置为产生刺激参数的处理器，该刺激参数旨在相对于承载电极的一个或多个神经刺激引线来修改电刺激场。外部控制装置还包括被配置为将刺激参数传送到神经刺激系统的输出电路。

5. 发明申请

US20120290040A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
公开(公告)号：US20120290040A1
公开(公告)日：2012-11-15
申请号：US13470328
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

6. 发明授权

US08311644B2 Short duration pre-pulsing to reduce stimulation-evoked side-effects 有权
标题翻译：短脉冲预脉冲以减少刺激诱发的副作用
公开(公告)号：US08311644B2
公开(公告)日：2012-11-13
申请号：US12782589
申请日：2010-05-18
申请人： Michael A. Moffitt , David K. L. Peterson
发明人： Michael A. Moffitt , David K. L. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

7. 发明授权

US08473061B2 Deep brain stimulation current steering with split electrodes 有权
公开(公告)号：US08473061B2
公开(公告)日：2013-06-25
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K. L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K. L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.

8. 发明申请

US20120046715A1 USER INTERFACE FOR SEGMENTED NEUROSTIMULATION LEADS 有权
标题翻译：用于SEGMENTED NEUROSTIMULATION LEADS的用户界面
公开(公告)号：US20120046715A1
公开(公告)日：2012-02-23
申请号：US13212063
申请日：2011-08-17
申请人： Michael A. Moffitt , Sridhar Kothandaraman , James C. Makous
发明人： Michael A. Moffitt , Sridhar Kothandaraman , James C. Makous
IPC分类号： A61N1/08
CPC分类号： A61N1/37247 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36182 , A61N1/36185 , G06F19/00 , G16H40/63
摘要： An external control device for use with a neurostimulation system having a plurality of electrodes capable of conveying an electrical stimulation field into tissue in which the electrodes are implanted is provided. The external control device comprises a user interface having one or more control elements, a processor configured for generating stimulation parameters designed to modify the electrical stimulation field relative to one or more neurostimulation lead carrying the electrodes. The external control device further comprises output circuitry configured for transmitting the stimulation parameters to the neurostimulation system.
摘要翻译：提供了一种与神经刺激系统一起使用的外部控制装置，其具有能够将电刺激场传送到其中植入电极的组织中的多个电极。外部控制装置包括具有一个或多个控制元件的用户界面，被配置为产生刺激参数的处理器，该刺激参数旨在相对于承载电极的一个或多个神经刺激引线来修改电刺激场。外部控制装置还包括被配置为将刺激参数传送到神经刺激系统的输出电路。

9. 发明申请

US20120290039A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
标题翻译：神经系统中刺激安全限制的管理
公开(公告)号：US20120290039A1
公开(公告)日：2012-11-15
申请号：US13470326
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
摘要翻译：用于管理刺激安全限值的神经刺激系统。系统确定每个电极处的组织电荷注入度量，将该度量与硬停止电荷限制进行比较，并且根据比较来防止神经刺激器将刺激能量递送至组织区域。硬停止极限可以是用户可编程的，或者可以响应于电极特性的检测而被自动修改。该系统可以定量地向使用者通知注入到组织中的注入电荷的值。电极可以组织成不同的组，在这种情况下，系统可以在每个电极组中独立地直接控制组织电荷。如果提供电流转向，则系统可以沿着一个方向沿着组织区域移位电刺激能量，同时防止每个电极处的电荷注入值达到或超过硬停止充电极限。

10. 发明授权

US07742810B2 Short duration pre-pulsing to reduce stimulation-evoked side-effects 有权
标题翻译：短脉冲预脉冲以减少刺激诱发的副作用
公开(公告)号：US07742810B2
公开(公告)日：2010-06-22
申请号：US11752895
申请日：2007-05-23
申请人： Michael A. Moffitt , David K. L. Peterson
发明人： Michael A. Moffitt , David K. L. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is placed in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。将至少一个电极放置成与患者的组织接触。从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

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