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1. 发明授权

US08731686B2 Burr hole plug having dual slidable clamping mechanisms 有权
标题翻译：钻孔塞具有双滑动夹紧机构
公开(公告)号：US08731686B2
公开(公告)日：2014-05-20
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61N1/00
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译：毛刺孔塞包括构造成围绕钻孔安装的塞子基座。插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二夹紧机构将医疗装置固定在其间。

2. 发明申请

US20110066197A1 METHODS AND SYSTEMS FOR FACILITATING STIMULATION OF ONE OR MORE STIMULATION SITES 有权
标题翻译：促进一个或多个刺激部位的刺激的方法和系统
公开(公告)号：US20110066197A1
公开(公告)日：2011-03-17
申请号：US12948416
申请日：2010-11-17
申请人： Kristen N. Jaax , James C. Makous , Laurence Dale Watkins , Daniel S. Bennett
发明人： Kristen N. Jaax , James C. Makous , Laurence Dale Watkins , Daniel S. Bennett
IPC分类号： A61N1/372
CPC分类号： A61N1/36071 , A61N1/0534 , A61N1/37211 , A61N1/3787 , A61N2001/0582
摘要： Methods of facilitating stimulation of a stimulation site within a patient include implanting a distal portion of a first stimulating member such that the distal portion of the first stimulating member is in communication with a first stimulation site located within a patient, securing the distal portion of the first stimulating member at a first securing site with a first securing device positioned proximal to the first stimulation site, forming a first loop of at least 360 degrees with a portion of the first stimulating member proximal to the first securing device, securing the first loop with a second securing device at a second securing site having a position that is greater than or equal to substantially 180 degrees but less than or equal to substantially 315 degrees along the first loop from the first securing site, and positioning the second securing device and a stimulator to be coupled to a proximal end of the first stimulating member to maintain a curve in the first stimulating member of at least 45 degrees between the second securing device and the stimulator.
摘要翻译：促进刺激患者内的刺激部位的方法包括植入第一刺激部件的远侧部分，使得第一刺激部件的远端部分与位于患者体内的第一刺激部位连通，固定位于患者体内的第一刺激部位在第一固定位置处的第一刺激构件具有位于第一刺激位置附近的第一固定装置，形成至少360度的第一环，第一刺激构件的一部分靠近第一固定装置，将第一环与第在第二固定位置处的第二固定装置，其具有大于或等于基本上180度但小于或等于基本上为315度的位置，沿着第一环路从第一固定位置，并且定位第二固定装置和刺激器以联接到第一刺激构件的近端以保持第一刺激中的曲线在第二固定装置和刺激器之间至少45度的元件。

3. 发明授权

US08364280B2 Engagement tool for implantable medical devices 有权
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US08364280B2
公开(公告)日：2013-01-29
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

4. 发明申请

US20080132961A1 IMPLANT TOOL FOR USE WITH A MICROSTIMULATOR 失效
标题翻译：用微型计算机使用的植入式工具
公开(公告)号：US20080132961A1
公开(公告)日：2008-06-05
申请号：US11565564
申请日：2006-11-30
申请人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
发明人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/36071
摘要： A stimulation system is described that includes an implantable microstimulator. A tail may be coupled to a distal end of the implantable microstimulator. In one embodiment, the stimulation system includes an implantation tool that includes an insertion cannula, a handle, a bushing, and a detachable blunt dissector tip. The bushing is situated within the insertion cannula and may position the implantable microstimulator longitudinally within the insertion cannula when the implantable microstimulator is placed within the insertion cannula. The detachable blunt dissector tip may be attached to the tail of the implantable microstimulator. The stimulation system may further comprise an end cap that includes an upper portion and a base portion conformable over at least a portion of curved tissue. An open trough extends through the base upper portions and may be configured to guide the implantation tool through the tissue at various angles.
摘要翻译：描述了包括可植入微型刺激器的刺激系统。尾部可以联接到可植入微型刺激器的远端。在一个实施例中，刺激系统包括植入工具，其包括插入套管，手柄，衬套和可拆卸的钝性解剖器尖端。衬套位于插入套管内，并且当可植入微型刺激器放置在插入套管内时，可以将可植入的微型刺激器纵向定位在插入套管内。可拆卸的钝性解剖器尖端可以附接到可植入微型刺激器的尾部。所述刺激系统还可以包括端盖，所述端盖包括在至少一部分弯曲组织上的上部和基部。开口槽延伸穿过基底上部，并且可构造成以各种角度引导植入工具穿过组织。

5. 发明授权

US09411935B2 User interface for segmented neurostimulation leads 有权
标题翻译：分段神经刺激导联用户界面
公开(公告)号：US09411935B2
公开(公告)日：2016-08-09
申请号：US13212063
申请日：2011-08-17
申请人： Michael A. Moffitt , Sridhar Kothandaraman , James C. Makous
发明人： Michael A. Moffitt , Sridhar Kothandaraman , James C. Makous
IPC分类号： A61N1/36 , A61N1/37 , G06F19/00 , A61N1/372 , A61N1/05
CPC分类号： A61N1/37247 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36182 , A61N1/36185 , G06F19/00 , G16H40/63
摘要： An external control device for use with a neurostimulation system having a plurality of electrodes capable of conveying an electrical stimulation field into tissue in which the electrodes are implanted is provided. The external control device comprises a user interface having one or more control elements, a processor configured for generating stimulation parameters designed to modify the electrical stimulation field relative to one or more neurostimulation lead carrying the electrodes. The external control device further comprises output circuitry configured for transmitting the stimulation parameters to the neurostimulation system.
摘要翻译：提供了一种与神经刺激系统一起使用的外部控制装置，其具有能够将电刺激场传送到其中植入电极的组织中的多个电极。外部控制装置包括具有一个或多个控制元件的用户界面，被配置为产生刺激参数的处理器，该刺激参数旨在相对于承载电极的一个或多个神经刺激引线来修改电刺激场。外部控制装置还包括被配置为将刺激参数传送到神经刺激系统的输出电路。

6. 发明授权

US08731674B2 Method of stimulating fastigium nucleus to treat neurological disorders 有权
标题翻译：刺激ium核治疗神经系统疾病的方法
公开(公告)号：US08731674B2
公开(公告)日：2014-05-20
申请号：US13347434
申请日：2012-01-10
申请人： Michael P. Wallace , James C. Makous
发明人： Michael P. Wallace , James C. Makous
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/36103
摘要： A method of treating a neurological disorder comprises introducing an electrical stimulation lead within a patient's head, locating the stimulation lead within the 4th ventricle of the patient's head, and placing the stimulation lead adjacent the fastigium nucleus of the patient's brain. The method may further comprise stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder, for example, by increasing the flow of blood within the patient's brain.
摘要翻译：治疗神经障碍的方法包括在患者头部内引入电刺激引线，将刺激引线置于患者头部的第四脑室内，并将刺激引线放置在患者大脑的快速核附近。该方法可以进一步包括用刺激引线刺激快镰核，以治疗神经障碍，例如通过增加患者脑内血液的流动。

7. 发明授权

US08224451B2 Methods and systems for facilitating stimulation of one or more stimulation sites 有权
标题翻译：促进刺激一个或多个刺激部位的方法和系统
公开(公告)号：US08224451B2
公开(公告)日：2012-07-17
申请号：US12948416
申请日：2010-11-17
申请人： Kristen N. Jaax , James C. Makous , Laurence Dale Watkins , Daniel S. Bennett
发明人： Kristen N. Jaax , James C. Makous , Laurence Dale Watkins , Daniel S. Bennett
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0534 , A61N1/37211 , A61N1/3787 , A61N2001/0582
摘要： Methods of facilitating stimulation of a stimulation site within a patient include implanting a distal portion of a first stimulating member such that the distal portion of the first stimulating member is in communication with a first stimulation site located within a patient, securing the distal portion of the first stimulating member at a first securing site with a first securing device positioned proximal to the first stimulation site, forming a first loop of at least 360 degrees with a portion of the first stimulating member proximal to the first securing device, securing the first loop with a second securing device at a second securing site having a position that is greater than or equal to substantially 180 degrees but less than or equal to substantially 315 degrees along the first loop from the first securing site, and positioning the second securing device and a stimulator to be coupled to a proximal end of the first stimulating member to maintain a curve in the first stimulating member of at least 45 degrees between the second securing device and the stimulator.
摘要翻译：促进刺激患者内的刺激部位的方法包括植入第一刺激部件的远侧部分，使得第一刺激部件的远端部分与位于患者体内的第一刺激部位连通，固定位于患者体内的第一刺激部位在第一固定位置处的第一刺激构件具有位于第一刺激位置附近的第一固定装置，形成至少360度的第一环，第一刺激构件的一部分靠近第一固定装置，将第一环与第在第二固定位置处的第二固定装置，其具有大于或等于基本上180度但小于或等于基本上为315度的位置，沿着第一环路从第一固定位置，并且定位第二固定装置和刺激器以耦合到第一刺激构件的近端以保持第一刺激中的曲线在第二固定装置和刺激器之间至少45度的元件。

8. 发明申请

US20110160797A1 METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS 审中-公开
标题翻译：同时刺激不同脑部目标的方法
公开(公告)号：US20110160797A1
公开(公告)日：2011-06-30
申请号：US12976764
申请日：2010-12-22
申请人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
发明人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/00 , A61N1/0534 , A61N1/36064 , A61N1/36171
摘要： A method for treating a patient having a dysfunction using a stimulation lead within the brain of a patient is provided. The stimulation lead carries a plurality of electrodes adjacent to a plurality of brain regions. Pulsed electrical waveforms having different sets of stimulation parameters are generated and then concurrently delivered to the plurality of electrodes, thereby concurrently stimulating the plurality of brain regions to treat the dysfunction.
摘要翻译：提供了一种使用患者脑内的刺激铅治疗具有功能障碍的患者的方法。刺激引线携带与多个脑区域相邻的多个电极。产生具有不同组刺激参数的脉冲电波形，然后同时传送到多个电极，从而同时刺激多个脑区域来治疗功能障碍。

9. 发明授权

US07493171B1 Treatment of pathologic craving and aversion syndromes and eating disorders by electrical brain stimulation and/or drug infusion 有权
标题翻译：通过电脑刺激和/或药物输注治疗病理性渴望和厌恶综合征和进食障碍
公开(公告)号：US07493171B1
公开(公告)日：2009-02-17
申请号：US11140152
申请日：2005-05-27
申请人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
发明人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2005/1726 , A61M2205/054 , A61M2205/3523 , A61M2205/50 , A61M2210/06 , A61M2210/0693 , A61N1/00 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/36089
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to at least treat or prevent obesity and/or other eating disorders, as well as drug, nicotine and alcohol addiction, uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以至少治疗或预防肥胖症和/或其他进食障碍以及药物，尼古丁和酒精成瘾的系统和方法使用至少一个系统控制单元（SCU）产生通过植入在脑中的电极递送的电脉冲和/或产生药物输注脉冲，其中刺激性药物被递送到脑中的目标区域。

10. 发明授权

US07440806B1 Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion 有权
标题翻译：通过电脑刺激和/或药物输注治疗糖尿病的系统和方法
公开(公告)号：US07440806B1
公开(公告)日：2008-10-21
申请号：US11140126
申请日：2005-05-27
申请人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
发明人： Todd K Whitehurst , James C Makous , Rafael Carbunaru , Kristen N Jaax
IPC分类号： A61N1/00
CPC分类号： A61M5/1723 , A61M5/14276 , A61M5/172 , A61M2205/054 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/08 , A61N1/36082 , A61N1/37205
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to at least treat or prevent diabetes uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以至少治疗或预防糖尿病的系统和方法使用至少一个系统控制单元（SCU），其产生通过植入脑内的电极递送的电脉冲和/或产生药物输注脉冲，其中刺激性药物被递送到脑中的目标区域。

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